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Chromatography, isolation and purification

The Centre houses a range of chromatographic techniques, including gas (GC) and liquid systems (HPLC, ion-exchange, size exclusion, capillary electrophoresis, column chromatography and preparative HPLC).

We have a range of sample introduction and detection systems that allow analysis of a range of materials with different characteristics:

  • Agilent 6890 and 7890 GCs with FID, TCD and MS detection; liquid and headspace introduction;
  • Waters 2695, 2790 and 2795 HPLCs with UV (VWD / PDA), Fluorescence, ELSD, RI, MS (Q) and MSMS (QQQ) detection;
  • Thermo Accela UPLC with Orbitrap LTQ Ion Trap MSn and HRMS (accurate mass);
  • Agilent 3D Capillary Electrophoresis with UV (PDA) detection.

Our core expertise covers:

  • Developing chromatographic methodology for complex, problematic mixtures and materials not easily detected;
  • Impurity isolation and identification;
  • High-resolution mass spectrometry for accurate mass / molecular formula determination.

Agilent 7890GC with 5975 EI/CI MSD