Stable Novel Polymorphs
Polymorphs are chemically identical but have different crystal lattice energies, melting points, intrinsic solubilities, rates of dissolution, densities, mechanical properties, chemical and physical stability, hygroscopicity, etc. Polymorphism has implications in biopharmaceutical properties, formulation/processing aspects and intellectual property considerations.
The different intrinsic solubilities may lead to differences in the rate of absorption – i.e. have therapeutic implications.
Scientists at CPES have developed novel methods to prepare metastable polymorphs that do not convert back to the thermodynamically stable polymorph over a long period of time under accelerated storage conditions. The stable polymorph has been shown to have desirable quality attributes and may be used to develop a superior drug product.