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CPES Global e-Seminar: Flexible Crystals: Relevance to Pharmaceutical Formulations?

CPES are delighted to announce the first of our Global e-Seminar Series entitled:

Flexible Crystals: Relevance to Pharmaceutical Formulations?

presented by Prof Malla Reddy from the Department of Chemical Sciences, IISER -Kolkata, India

The e-seminar will be held on 12th May 2020 at 14:00 PM (UK time)

Highlights of the Seminar:

  • Challenges and gaps in crystal structure based prediction of bulk properties.
  • First principles for designing mechanical performance of pharmaceutical solids by crystal engineering approach.

To join the e-seminar via Skype for Business please follow the link below:

https://meet.bradford.ac.uk/vgrvanga/BSPPS1M1

For information on how to join the seminar please contact

Prof Anant Paradkar at A.Paradkar1@Bradford.ac.uk

or Dr. Venu Vengala at V.G.R.Vangala@bradford.ac.uk

 

 

Pharmaceutical Formulation image

Reddy et al., Angew. Chem. Int. Ed., 2020, 59, 2-12.

Effershield technology wins the BioNow Project of the Year Award

The Centre for Pharmaceutical Engineering Science's Team “EfferShield” won the Bionow Project of the Year Award for 2019. Prof Anant Paradkar, Director of the Centre accepted the prestigious Award at the Mere Hotel on Thursday Nov 28th.

EfferShield: A novel approach for low sodium effervescent products was developed at the Centre for Pharmaceutical Engineering Science (CPES) at the University of Bradford and is a crystal engineering based technology. EfferShield addresses the manufacturing and packaging issues of effervescent formulations whilst also providing an alternative low sodium effervescent product. The EfferShield patent is licensed to Octopoda Innovations. CPES and Octopoda Innovations have partnered with Health Innovations and Vitrition UK for EfferShield scale-up and commercialisation. The consortium received support from Innovate UK and Leeds City Region Enterprise Zone.

The EfferShield team is led by Prof Anant Paradkar consists of Sudhir K Pagire, Sachin Korde, Niten Jadav, Suyog Aher, Azad Mohammed, Kalpana Durga, Jason Jones and Clare Campbell.

CPES is exploring global partnership opportunities for EfferShield and other technologies in the area of veterinary, pharmaceutical and biopharmaceutical sectors. Innovate UK has supported market validation of CPES innovations viz EfferShield, SelfGel, FastAct and ARCage through it’s ICURe scheme.

CPES is an interdisciplinary research and industrial collaboration centre, which has expertise across the pharmaceutical sciences, chemistry and polymer engineering disciplines with an excellent reputation for developing innovative technologies, contract research and working with industry. 

For more information on CPES please see our Capabilities brochure

Team accepting the Award

CPES team accepting award from Dr. Phil Hammond (Compare) and Kevin Giles (Waters Corporation), Dr. Nitin Jadav, Dr. Jason Jones, Prof. Anant Paradkar and Dr. Suyog Aher

CPES and Health Innovations attend the KTP Best of the Best Awards 2019

The Centre for Pharmaceutical Engineering Science (CPES) and their commercial partners Health Innovations recently attended the Innovate UK KTP awards at the Royal Society of Chemistry, the team were finalists in the Best Business Impact Category.

The KTP project shortlisted for the award was focused on research into the materials, regulations and processes connected to the company’s supplements and led to significant impact for the company, including the company investing in an additional manufacturing capability to allow them to compete in new product categories, enter new markets, and increase international export.

CPES has an excellent track record in collaborating with industry through KTP partnerships and being shortlisted for this KTP award is indicative of the excellent standards that the team has attained. For more information on the research and services performed and how to work with CPES please visit Contract Research pages

 

 

KTP Awards

Health Innovations–CPES KTP Team and KTP Advisor from L to R Clare Campbell (CEO Health Innovations), Dr. John Clayton (KTP Advisor), Prof. Anant Paradkar (CPES Director) and Dr. Suyog Aher (KTP Associate)

CPES wins InnovateUK ICURe Market Validation funding for “ARCage Technology” an innovative Abuse Resistant Drug Delivery Platform

The team at CPES has developed “ARCageTechnology” it's ground breaking invention related to overcoming the abuse and misuse of prescription opioid analgesics which is creating a serious and growing public health problem.

Dr MHD Bashir Alsirawan, a Post-Doctoral Researcher at CPES was successful in securing £35,000 of funding from Innovate UK which will be used to accelerate the “Innovation to Commercialisation” journey of the Technology. This initial funding will enable CPES to carry out market validation of the research-based business idea and Dr. Alsirawan will also receive intensive support in developing a structured business model. Professor Adrian Kelly will be the academic lead for the project. 

Technology commercialisation is a major focus of CPES. Dr Sudhir Pagire and Dr Sachin Korde at CPES have recently been awarded ICURe funding for its “SelfGel” and “FastAct” technology respectively. CPES is one of very few Research Centres to receive three ICURe awards for its innovation.   

Tablets and soft gel capsules

Health Innovations – University of Bradford Finalists for Innovate UK KTP Best Business Impact Award 2019

Health Innovations collaborated with the Centre for Pharmaceutical Engineering Science (CPES), School of Pharmacy and Medical Sciences, University of Bradford to develop innovative granulation technology for nutritional supplements to replace imported pre-granulated materials

Dr Suyog Aher was the KTP Associate and worked with the academic team led by Professor Anant Paradkar and Company Supervisor Clare Campbell, CEO, Health Innovations on this Knowledge Transfer Partnership. Dr Sudhir Pagire and Dr Sachin Korde the Knowledge Transfer Officers at CPES were academic team members and Richard Doyle, Director Health Innovation represented Principle Healthcare Group.

The Award Ceremony will be held at on Thursday, 2nd May 2019 at the Royal Society of Chemistry, London.

ktn-uk.co.uk/news/ktp-best-of-the-best-awards-2019-finalists-announced

Research into the materials, regulations and processes connected to the Company’s supplements was carried out, and a Material Product Property Performance (MPPP) database was developed to predict the quality of granulating the materials and the re-formulation required. The changes, risks and costs related to new process was also investigated. The company then invested in an additional manufacturing capability as a direct consequence of the KTP project. Buying powder raw materials to convert into granulated products, rather than purchasing pre-granulated product, this has given the company access to wider range of UK suppliers.

The new manufacturing facility brings the capacity to compete in new product categories, enter new markets, and increase international export. The Knowledge Transfer Partnership has also inspired a new culture of open innovation, idea generation, and cross-disciplinary working. The MPPP database has strengthened the Company’s research base leading to further opportunities for collaborative research grant applications.

 

CPES team for KTP award

Health Innovations – University of Bradford KTP Team (L to R Sachin Korde, Sudhir Pagire, Anant Paradkar, Suyog Aher, Clare Campbell and Angela Rutherford)

Centre for Pharmaceutical Engineering Science wins ICURe Market Validation funding for its innovative “FastAct” Technology

The team at CPES has recently developed “FastAct” Technology which is a ground breaking invention related to enhanced bioavailability of drugs. FastAct is targeted to address poorly soluble actives in the pharmaceutical, nutraceutical and agrochemical sectors.

Poor water solubility of drugs is a significant challenge for the pharmaceutical industy and around 40% of the New Chemical Entities (NCE) does not reach the market due to low solubility issues. Dr Sachin Korde, a Post-Doctoral Researcher at the CPES was successful in securing £35,000 of funding from Innovate UK which will be used to accelerate the “Innovation to Commercialisation” journey of the “FastAct” Technology. This initial funding will enable CPES to carry out market validation of the research-based business idea and Dr. Korde will also receive intensive support in developing a structured business model.

bioavailability plot

Centre for Pharmaceutical Engineering Science wins ICURe Market Validation funding for its innovative “SelfGel” Technology

The team at CPES has recently developed “SelfGel” Technology which is a new bioadhesive gelling system. The novel technology was designed to address the challenges faced by current gel based formulations when used in topical applications. Dr Sudhir Pagire, a Research and Knowledge Transfer Officer at the CPES was successful in securing £35,000 of funding from Innovate UK which will be used to accelerate the “Innovation to Commercialisation” journey of the “SelfGel” Technology. This initial funding will enable CPES to carry out market validation of the research-based business idea and Dr. Pagire will also receive intensive support in developing a structured business model.

Self Gel

The nutritious gains of in-house granulation

Principle Healthcare worked with the Centre for Pharmaceutical Engineering Sciences to research the option of developing in-house granulation technology for their nutritional supplements.

The Company purchased pre-granulated materials for their nutritional vitamins, minerals and supplements and wanted to explore the benefits of granulating high volumes of their own materials instead, whilst still maintaining a quality product.

The Associate and academics carried out detailed research into the materials, regulations, and processes connected to the Company’s supplements and developed a Material Product Property Performance (MPPP) database to predict the quality of granulating the materials and the re-formulation required. They also investigated the changes, risks and costs needed to convert to in-house granulation.

Tablets and soft gel capsules

Decade long relationship enhanced by knowledge transfer partnerships

The Centre for Pharmaceutical Engineering Sciences (CPES) has secured its second Knowledge Transfer Partnership with Natures Laboratory to support their latest innovation goals using the healing properties of propolis. Natures Laboratory, a natural medicine manufacturer, have been working with the Centre for Pharmaceutical Engineering Science (CPES) since 2007. Propolis is a mixture of resin and wax made by honey bees to seal and sterilise their hive. It has a range of reported biological properties including antioxidant, anti-inflammatory, anti-microbial and analgesic due to it containing of a large variety of flavonoids, terpenes and phenolic compounds.

The latest 2 year KTP, led by Professor Anant Paradkar, Director of CPES, will bring together a multidisciplinary team with expertise in natural products to help Natures Lab refine, characterise and quantify these active compounds. The project will result in new refining processes and the establishment of a Propolis Activity Factor (PAF) based on a Composition-Activity Relationship (CAR) model which will allow the company to better understand the grade of propolis at the raw material stage as well as helping them develop and optimise potential new medicines.

bees propolis