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Excellent research facilities and equipment

The Centre for Pharmaceutical Engineering Science is located across the University’s city campus having laboratories in the Norcroft Building and the Polymer IRC the centre provides a wide range of excellent research facilities and equipment. Our clean room melt extrusion and injection moulding processing facilities are housed in the Polymer IRC building

IRC building front

Pharmaceutical development and analytical laboratories

Modern pharmaceutical development and analytical laboratories are housed in the impressive Norcroft Building at the heart of the University campus. The laboratories provide an impressive range of enabling process equipment and analytical support instrumentation including:

  • Spray and Freeze drying
  • Micro and nano-processing
  • Solid dosage form processing including lab-scale granulation, tableting and coating
  • Structural and molecular analysis (PXRD, NMR, Raman, Mass Spectrometry)
  • Chromatographic (UPLC, HPLC, GLP, GC) and Thermal (TGA,DSC,DMA) analysis
  • Bulk powder and particle characterisation
  • Dissolution and Disintegration testing
  • Controlled stability testing cabinets (temperature/humidity/light)
Norcroft Building reduced size

Clean room facilities for melt extrusion

S‌cientists at the Centre for Pharmaceutical Engineering Science have access to clean room facilities (ISO8) for the provision of hot melt extrusion processing.

The clean room houses a PharmaLab (Thermo Scientific) 16mm twin screw extruder and is ideal for scale-up and optimisation studies as well as the manufacture of preclinical technical batches of pharmaceutical and healthcare related products.

Adjusting HME equipment

Enabling process technology


  • Pharmalab, Thermo Scientific, UK (16 mm twin screw extruder)
  • Eurolab, Haake (16 mm twin screw extruder)
  • Minilab, Haake (mini twin screw extruder)
  • Prism, Haake (16 mm twin screw extruder)
  • Randcastle Single screw extruder
  • Roland single screw extruder
  • Powder feeder (Brabender, Germany)
  • Liquid injection system Chill roller and flaker
  • Pelletizer
  • Conveyer belt
Adjusting control on HME 1

Enabling process technology


  • Micropower 15-(Wittmann Battenfeld)
  • Micropower 15 (2nd generation model)-(Wittmann Battenfeld)
  • Microsystem 50-(Wittmann Battenfeld)
  • Ultrasound Injection Moulding Unit-(Ultrasion)
Adjusting Injection Moulding equipment

Enabling process technology


  • Spray Drying- Lab Scale LU228 with inert loop for organic solvents (Lab Ultima)
  • Freeze Drying- Lab Scale “Advantage Pro” with intellitronics (Virtis)


  • Course Milling and Micronisation- Hammer/Cutter Mill MF10 (IKA)
  • Micronisation- Planetary bead mill (Retsch)
  • Micronisation-Small Scale Lab Air Jet Milling- Pilot Mill Zero (FPS)
  • Nanoprocessing- APV Laboratory High Pressure Homogeniser (SPX Flow Technology)
  • Nanoprocessing-V500 wet bead milling technology (Dena Technologies)
Nitin at Spray dryer controls

Enabling process technology


  • Granulation- High Shear Mixer GMX-Lab Micro (Freund Vector) capacity 1L and 4L
  • Granulation- High Shear Granulator (Mini RMG, Karnavati Engineering Limited)
  • Compaction- Roller compactor (KERC-200/50, Karnavati Engineering Limited)
  • Compression (tabletting)-Single punch compression (Cavela)
  • Compression (tabletting)-8 station tableting press (Mini Press II, Karnavati Engineering Limited)
  • Coating- Lab scale tablet coater HCT Mini HiCoater (Freund Vector)
  • Blending/Mixing-KMix planetary mixer (Kenwood)
  • Blending/Mixing-T2F Turbula Blender System (Willy A Bachofen AG)
  • Sifting- Vibratory Sieve Shaker AS 200 (Retsch)
Adjusting roller compactor controls

Supporting analytical techniques

Structural and Molecular Analysis

  • PXRD
  • NMR including solid state
  • Raman and IR Spectroscopy
  • Mass Spectrometry LCMSMS, GCMS

Thermal Analysis

  • Direct Scanning Calorimetry (DSC)
  • Thermal Gravimetric Analysis (TGA)
  • Dynamic Mechanical Analysis (DMA)

Chromatographic Analysis  

  • uHPLC (Waters)
  • Gel Permeation Chromatography
  • Gas Chromatography (Agilent)
Loading HPLC Carousel

Supporting analytical techniques

Powder/Particle Characterisation

  • Particle Morphology/Size-Environmental Scanning Electron Microscopy (ESEM)-Quanta 400 (FEI)
  • Hygroscopicity/amorphous content- Intrinsic Dynamic Vapour Sorption (DVS) (SMS)
  • Particle Size Analysis (powders)-Laser Diffraction HELOS/KF Rodos-M range 1-100microns (Sympatec)
  • Particle Size Analysis/Zeta potential (suspensions/emulsions)-DLS NanoSizerS range 10nm-103nm(Malvern)
  • Surface Area Measurements (BET)- iGC Surface Energy Analyser includes film surface analysis option (SMS)
  • Particle or True Density- Helium Pycnometry- AccuPyc 1330 (Micrometrics)
  • Compressibility-Texture Analyser TA XP+ (Stable Microsystems)
  • Flowability- Angle of repose method-Texture Analyser TA XP+ (Stable Microsystems)
  • Rheometry- Rotational and Capillary Rheometers-(AntonParr)
  • KF Moisture analysis- 701 KF Titrino (Metrohm)
  • Loss on Drying (LOD)- Halogen moisture balance (Mettler Toledo)
Changing column on IGC

Supporting analytical techniques

Physical Characterisation

  • Capillary rheometer for extensional rheology
  • Rotational Rheometry
  • Rotational rheometer
  • Atomic Force Microscope
  • Hardness Testing- 4M Hardness Tester (Schleuniger)
  • Friability Testing-(Copley Scientific Instruments)
  • Compactness Testing- Texture Analyser TA XP+ (Stable Microsystems)
  • Osmometer
USP II dissolution apparatus close-up

Supporting Analytical Techniques


  • USP II – DS800 with sample collector (Lab India)
  • USP IV- USP Apparatus 4 Flow-Through Cell Dissolution Systems CP7 (Sotax)
  • Disintegration testing station DTG 3000 (Copley Scientific)‌
  • In-line dissolution/disintegration studies for real-time particle size analysis general analysis image
  • Particle Visual Microscopy (PVM) “Particle View” Probe (Mettler Toledo)
  • Focused Beam Reflectance Measurement (FBRM) G400 (Mettler Toledo)
Aniket Dissolution equipment

Controlled Stability Cabinets

  • Bespoke or ICH stability studies using a range of analytical techniques
  • Temperature and Humidity controlled stability storage cabinets set at ICH stability storage conditions standard and accelerated or bespoke
  • x4 Universal Stability Ovens (Memmert)
  • Controlled temperature refrigerated storage- LEC Medica
  • Light controlled stability cabinet
Sudhir stability cabinet