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The amorphous form and understanding stabilisation

Preparation of amorphous forms to increase dissolution rate and bioavailability of poorly water-soluble drug is now well established. Though there are many reports describing methods of preparation and application of the amorphous form, it is equally important to note that devitrification of amorphous drugs has limited their applications to a great extent.

The commercial use of such systems has been limited, primarily because of manufacturing difficulties and stability problems. Several attempts have been made to obtain and stabilize drugs in amorphous state.

The research team at CPES are experts in the preparation and stabilisation of amorphous forms using a range of in-house enabling technologies including hot melt extrusion, melt granulation, spray and freeze drying.

Placing vials in the freeze dryer