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Cell lines and xenograft models

ICT scientists have access to an extensive range of human tumour cell lines which are available for use in in vitro assays with many having been validated for use as subcutaneous xenograft models for efficacy studies.

Cell lines and xenograft models are available for various cancer types including:

  • Bladder
  • Brain
  • Breast
  • Colon
  • Melanoma
  • Ovarian
  • Prostate
  • Pancreas
  • Renal
  • SCLC

In addition we have murine colon adenocarcinoma (MAC) models available.

For more information regarding our expertise in preclinical pharmacology contact Dr. Steve Shynder

Cell image ICT

Xenograft tumour models

  • Human and other tumour cell line
  • High expression vs. low/negative expression
  • Isogenic tumour models 
  • Direct measurement of anti-tumour response
  • Tumour vasculature analysis
  • Histological analysis
  • Biochemical analysis
  • Assessment of tumourigenicity
  • Efficacy and PK/PD analysis of small molecules
  • Efficacy and PK/PD analysis of biologics
Histology image

Hollow Fibre Assay

We evaluate:

  • Anti-proliferative activity
  • Pharmacodynamic endpoints
  • Drug effects in non-tumourigenic cell lines
  • Vascular targeting agents

Site Specific Tumours

We evaluate:

  • Response in specific site e.g. colon
  • Response at site of metastasis e.g. liver, lung