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researcher

Steven Shnyder

Senior Lecturer

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emails.d.shnyder@bradford.ac.uk
Telephone +441274 235898

Biography

Dr Steve Shnyder, is a Senior Lecturer in Cancer Biology at the ICT. He has thirty years’ experience as a research scientist: 24 years post-doctoral, 18 months in a start-up pharma, with the past 18 years in a preclinical cancer pharmacology environment at Bradford. He has over 25 years’ experience of working with small mammals, mainly in the preclinical cancer pharmacology field. In his current position he is a Home Office Project and Personal Licence holder and is involved in the management and practical execution of Research and Knowledge Transfer in vivo and in vitro studies carried out at the ICT, working with both UK-based and international clients. His team has contributed to the screening packages of several novel anti-cancer compounds which have subsequently progressed to clinical trials and beyond, using both cell-based and in vivo technologies. He is an author on 65+ journal articles and numerous conference publications as well as three book chapters on in vivo methodology. In addition he has significant experience in the areas of histopathology, biochemistry and cell biology. He line manages an Experimental Officer whose focus is in vivo studies, and a Research Technician whose focus is in vitro screening. He is a strong proponent of 3Rs philosophy, always striving to apply the 3Rs to all the work he does, and he has been a co-investigator on 2 project grants and a studentship specifically aimed at improving methodology in preclinical cancer pharmacology from a 3Rs standpoint.

Research

Characterisation of the reticuloplasmins as anticancer drug targets. Pharmacology of vascular disrupting agents. Development of 3Rs methodologies. Exploitation of the fluorescent properties of anti-cancer therapeutics for utilisation in assessment of pharmacodynamic and pharmacokinetic end-points. Evaluation of the drugability of the tumour cell glycocalyx. Research Team Patricia Cooper, Experimental Officer Gary Lawson, Research Technician Marcella Sini, YCR Programme Grant Postdoctoral Researcher (with L Patterson, P Loadman, R Falconer & K Pors)

Professional activities

  • London - PhD
  • Bradford - MPhil
  • Bradford - BSc
  • , British Association of Cancer Research (BACR)
  • , British Society of Cell Biology (BSCB)

Publications

Peer Reviewed Journal
TitleTumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer (2019)
AuthorsO'Flaherty, L.; Shnyder, Steven D.; Cooper, Patricia A.; Cross, S.J.; Wakefield, J.G.; Pardo, O.E.; Seckl, M.J.; Tavare, J.M.
 
TitleHypoxia modulates CCR7 expression in head and neck cancers (2018)
AuthorsBasheer, Haneen A.; Pakanavicius, E.; Cooper, Patricia A.; Shnyder, Steven D.; Martin, L.; Hunter, K.D.; Vinader, Victoria; Afarinkia, Kamyar
 
TitleEvaluation of Alangium lamarckii bark for antiplasmodial and cytotoxic constituents and isolation of a novel tubulosine analogue (2018)
AuthorsKantamreddi V.;Marston G.;Shnyder S.;Wright C.
JournalNatural product communications
 
TitleAgarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines /631/1647/767/70 /631/154/1435 /123 /13/21 /14/63 /13/31 article (2017)
AuthorsAhmed M.;Basheer H.;Ayuso J.;Ahmet D.;Mazzini M.;Patel R.;Shnyder S.;Vinader V.;Afarinkia K.
JournalScientific Reports
DOI10.1038/s41598-017-00949-4
 
TitlePreclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands. (2017)
AuthorsAllison SJ;Sadiq M;Baronou E;Cooper PA;Dunnill C;Georgopoulos NT;Latif A;Shepherd S;Shnyder SD;Stratford IJ;Wheelhouse RT;Willans CE;Phillips RM;
JournalCancer Letters
DOI10.1016/j.canlet.2017.04.041
 
TitleTubulin-binding dibenz[c,e]oxepines: Part 2.1Structural variation and biological evaluation as tumour vasculature disrupting agents (2017)
AuthorsRossington S.;Hadfield J.;Shnyder S.;Wallace T.;Williams K.
JournalBioorganic and Medicinal Chemistry
DOI10.1016/j.bmc.2017.01.027
 
TitleRGD-Binding Integrins in Head and Neck Cancers (2017)
AuthorsAhmedah, H.T.; Patterson, Laurence H.; Shnyder, Steven D.; Sheldrake, Helen M.
 
TitlePreclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands (2017)
AuthorsAllison, Simon J.; Sadiq, Maria; Baronou, Efstathia; Cooper, Patricia A.; Dunnill, C.; Georgopoulos, N.T.; Latif, A.; Shepherd, S.L.; Shnyder, Steven D.; Stratford, I.J.; Wheelhouse, Richard T.; Willans, C.; Phillips, Roger M.
 
TitleAgarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines (2017)
AuthorsAhmed, Mohaned S.A.; Basheer, Haneen A.; Ayuso, J.M.; Ahmet, Djevdet; Mazzini, Marco; Patel, Roshan; Shnyder, Steven D.; Vinader, Victoria; Afarinkia, Kamyar
 
TitleTubulin-binding dibenz[c,e]oxepines. Part 2. 1 Structural variation and biological evaluation as tumour vasculature disrupting agents (2017)
AuthorsRossington, S.B.; Hadfield, J.A.; Shnyder, Steven D.; Wallace, T.W.; Williams, K.J.
 
TitleThe use of thermographic imaging to evaluate therapeutic response in human tumour xenograft models (2016)
AuthorsHussain, Nosheen; Connah, David; Ugail, Hassan; Cooper, Patricia A.; Falconer, Robert A.; Patterson, Laurence H.; Shnyder, Steven D.
JournalScientific Reports
 
TitlePIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma (2016)
AuthorsRoss, R.L.; McPherson, H.R.; Kettlewell, L.; Shnyder, Steven D.; Hurst, C.D.; Alder, O.; Knowles, M.A.
 
TitleThe Effect of Polysialic Acid Expression on Glioma Cell Nano-mechanics (2016)
AuthorsGrant, Colin A.; Twigg, Peter C.; Saeed, Rida F.; Lawson, G.; Falconer, Robert A.; Shnyder, Steven D.
JournalBioNanoScience
 
TitleStudy of the chemotactic response of multicellular spheroids in a microfluidic device (2015)
AuthorsAyuso, J.M.; Basheer, Haneen A.; Monge, R.; Sánchez-Álvarez, P.; Doblare, M.; Shnyder, Steven D.; Vinader, Victoria; Afarinkia, Kamyar; Fernandez, L.J.; Ochoa, I.
 
TitleThin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA (2015)
AuthorsBatubara, A.; Carolan, V.A.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Clench, M.R.
 
TitleProbing cytochrome P450-mediated activation with a truncated azinomycin analogue (2015)
AuthorsVinader, Victoria; Sadiq, Maria; Sutherland, Mark H.; Huang, M.Y.; Loadman, Paul M.; Elsalem, Lina M.I.; Shnyder, Steven D.; Cui, H.J.; Afarinkia, Kamyar; Searcey, M.; Patterson, Laurence H.; Pors, Klaus
 
TitleTumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity (2014)
AuthorsGill J.;Loadman P.;Shnyder S.;Cooper P.;Atkinson J.;Ribeiro Morais G.;Patterson L.;Falconer R.
JournalMolecular Pharmaceutics
DOI10.1021/mp400760b
 
TitlePotent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells (2014)
Authorsvan Rijt, S.H.; Romero-Canelón, I.; Fu, Y.; Shnyder, Steven D.; Sadler, P.J.
 
TitleTumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity (2014)
AuthorsGill, Jason H.; Loadman, Paul M.; Shnyder, Steven D.; Cooper, Patricia A.; Atkinson, Jennifer M.; Ribeiro Morais, Goreti; Patterson, Laurence H.; Falconer, Robert A.
JournalMolecular Cancer Therapeutics
 
TitleNCAM polysialylation during adherence transitions: Live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7 (2013)
AuthorsSmith P.;Furon E.;Wiltshire M.;Chappell S.;Patterson L.;Shnyder S.;Falconer R.;Errington R.
JournalCytometry Part A
DOI10.1002/cyto.a.22306
 
TitlePharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration (2013)
AuthorsAl-Saraireh, Yousef M.J.; Sutherland, Mark H.; Springett, Bradley R.; Freiberger, F.; Ribeiro Morais, Goreti; Loadman, Paul M.; Errington, R.J.; Smith, P.J.; Fukuda, M.; Gerardy-Schahn, R.; Patterson, Laurence H.; Shnyder, Steven D.; Falconer, Robert A.
JournalPLoS ONE
 
TitleParallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer (2013)
AuthorsHerrera-Abreu, M.T.; Pearson, A.; Campbell, J.; Shnyder, Steven D.; Knowles, M.A.; Ashworth, A.; Turner, N.C.
 
TitleTargeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging (2013)
AuthorsDjidja, M-C.; Francese, S.; Claude, E.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Cooper, Patricia A.; Patterson, Laurence H.; Carolan, V.A.; Clench, M.R.
 
TitleColon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins (2013)
AuthorsTravica, S.; Pors, Klaus; Loadman, Paul M.; Shnyder, Steven D.; Johansson, I.; Alandas, Mohammed N.; Sheldrake, Helen M.; Mkrtchian, S.; Patterson, Laurence H.; Ingelman-Sundberg, M.
 
TitleAntitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder (2013)
AuthorsSutherland, Mark H.; Gill, Jason H.; Loadman, Paul M.; Laye, Jonathan P.; Sheldrake, Helen M.; Illingworth, Nicola A.; Alandas, Mohammed N.; Cooper, Patricia A.; Searcey, M.; Pors, Klaus; Shnyder, Steven D.; Patterson, Laurence H.
 
TitleRe-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity (2013)
AuthorsSheldrake, Helen M.; Travica, S.; Johansson, I.; Loadman, Paul M.; Sutherland, Mark H.; Elsalem, Lina M.I.; Illingworth, Nicola A.; Cresswell, Alexander J.; Reuillon, Tristan; Shnyder, Steven D.; Mkrtchian, S.; Searcey, M.; Ingelman-Sundberg, M.; Patterson, Laurence H.; Pors, Klaus
 
TitlePolysialyltransferase: A new target in metastatic cancer (2012)
AuthorsFalconer R.;Errington R.;Shnyder S.;Smith P.;Patterson L.
JournalCurrent Cancer Drug Targets
DOI10.2174/156800912803251225
 
TitleSynthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties (2012)
AuthorsCosentino L.;Redondo-Horcajo M.;Zhao Y.;Santos A.;Chowdury K.;Vinader V.;Abdallah Q.;Abdel-Rahman H.;Fournier-Dit-Chabert J.;Shnyder S.;Loadman P.;Fang W.;Díaz J.;Barasoain I.;Burns P.;Pors K.
JournalJournal of Medicinal Chemistry
DOI10.1021/jm301151t
 
TitleSynthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation (2012)
AuthorsFournier-Dit-Chabert J.;Vinader V.;Santos A.;Redondo-Horcajo M.;Dreneau A.;Basak R.;Cosentino L.;Marston G.;Abdel-Rahman H.;Loadman P.;Shnyder S.;Díaz J.;Barasoain I.;Falconer R.;Pors K.
JournalBioorganic and Medicinal Chemistry Letters
DOI10.1016/j.bmcl.2012.09.104
 
TitleAnti-colorectal cancer activity of an organometallic osmium arene azopyridine complex (2011)
AuthorsShnyder S.;Fu Y.;Habtemariam A.;Van Rijt S.;Cooper P.;Loadman P.;Sadler P.
JournalMedChemComm
DOI10.1039/c1md00075f
 
TitleUse of the hollow fiber assay for the evaluation of DNA damaging agents (2011)
AuthorsVeiga J.;Cooper P.;Pors K.;Patterson L.;Bibby M.;Shnyder S.
JournalJournal of Pharmacological and Toxicological Methods
DOI10.1016/j.vascn.2011.04.006
 
TitleAn agarose spot chemotaxis assay for chemokine receptor antagonists (2011)
AuthorsVinader V.;Al-Saraireh Y.;Wiggins H.;Rappoport J.;Shnyder S.;Patterson L.;Afarinkia K.
JournalJournal of Pharmacological and Toxicological Methods
DOI10.1016/j.vascn.2011.01.004
 
TitleThe microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo (2011)
AuthorsBurns, C.J.; Fantino, E.; Powell, A.K.; Shnyder, Steven D.; Cooper, Patricia A.; Nelson, S.; Christophi, C.; Malcontenti-Wilson, C.; Dubljevic, V.; Harte, M.F.; Joffe, M.; Phillips, I.D.; Segal, D.; Wilks, A.F.; Smith, G.D.
 
TitleModification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity (2011)
AuthorsPors, Klaus; Loadman, Paul M.; Shnyder, Steven D.; Sutherland, Mark H.; Sheldrake, Helen M.; Guino, M.; Kiakos, K.; Hartley, J.A.; Searcey, M.; Patterson, Laurence H.
 
TitleSmall molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo (2011)
AuthorsLamont, F.R.; Tomlinson, D.C.; Cooper, Patricia A.; Shnyder, Steven D.; Chester, J.D.; Knowles, M.A.
 
TitleAdenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo (2011)
AuthorsHarvey T.;Hennig I.;Shnyder S.;Cooper P.;Ingram N.;Hall G.;Selby P.;Chester J.
JournalCancer Gene Therapy
DOI10.1038/cgt.2011.43
 
TitleDevelopment of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases (2010)
AuthorsAtkinson J.;Falconer R.;Edwards D.;Pennington C.;Siller C.;Shnyder S.;Bibby M.;Patterson L.;Loadman P.;Gill J.
JournalCancer Research
DOI10.1158/0008-5472.CAN-10-1440
 
TitleImproved preparation and detection of cytochrome P450 isoforms using MS methods (2010)
AuthorsSutton C.;Sutherland M.;Shnyder S.;Patterson L.
JournalProteomics
DOI10.1002/pmic.200900489
 
TitleDevelopment of a novel tumor-targeted vascular disrupting agent activated by Membrane-type Matrix Metalloproteinases (MT-MMPs) (2010)
AuthorsAtkinson, Jennifer M.; Falconer, Robert A.; Edwards, D.R.; Pennington, C.J.; Siller, Catherine S.; Shnyder, Steven D.; Bibby, Michael C.; Patterson, Laurence H.; Loadman, Paul M.; Gill, Jason H.
 
TitleOrganometallic osmium arene complexes with potent cancer cell cytotoxicity (2010)
AuthorsFu Y.;Habtemariam A.;Pizarro A.;Van Rijt S.;Healey D.;Cooper P.;Shnyder S.;Clarkson G.;Sadler P.
JournalJournal of Medicinal Chemistry
DOI10.1021/jm100560f
 
TitleRetargeted adenoviral cancer gene therapy for tumour cells overexpressing epidermal growth factor receptor or urokinase-type plasminogen activator receptor (2010)
AuthorsHarvey T.;Burdon D.;Steele L.;Ingram N.;Hall G.;Selby P.;Vile R.;Cooper P.;Shnyder S.;Chester J.
JournalGene Therapy
DOI10.1038/gt.2010.45
 
TitleUse of the hollow fibre assay for studies of tumor neovasculature. (2009)
AuthorsShnyder S.
JournalMethods in molecular biology (Clifton, N.J.)
DOI10.1007/978-1-59745-241-0_21
 
TitleIn vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts (2009)
AuthorsWilliams K.;Albertella M.;Fitzpatrick B.;Loadman P.;Shnyder S.;Chinje E.;Telfer B.;Dunk C.;Harris P.;Stratford I.
JournalMolecular Cancer Therapeutics
DOI10.1158/1535-7163.MCT-09-0396
 
TitleDevelopment of a modified hollow fibre assay for studying agents targeting the tumour neovasculature. (2009)
AuthorsShnyder, Steven D.; Jubb, E.; Hasan, J.; Cooper, Patricia A.; Bibby, Michael C.; Jayson, G.C.; Pilarinou, E.
 
TitleIn vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenograft. (2009)
AuthorsWilliams, K.J.; Albertella, M.R.; Fitzpatrick, B.; Loadman, Paul M.; Shnyder, Steven D.; Chinje, E.C.; Telfer, B.A.; Dunk, C.R.; Harris, P.A.; Stratford, I.J.
 
TitleFibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer (2009)
AuthorsTomlinson, D.C.; Lamont, F.R.; Shnyder, Steven D.; Knowles, M.A.
 
TitleTriplex profiling of functionally distinct chaperones (ERp29/PDI/BiP) reveals marked heterogeneity of the endoplasmic reticulum proteome in cancer (2008)
AuthorsShnyder S.;Mangum J.;Hubbard M.
JournalJournal of Proteome Research
DOI10.1021/pr800126n
 
TitleSingle-chain TNF, a TNF derivative with enhanced stability and antitumoral activity (2008)
AuthorsKrippner-Heidenreich A.;Grunwald I.;Zimmermann G.;Kühnle M.;Gerspach J.;Sterns T.;Shnyder S.;Gill J.;Männel D.;Pfizenmaier K.;Scheurich P.
JournalJournal of Immunology
DOI10.4049/jimmunol.180.12.8176
 
TitleGuaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv. (2008)
AuthorsStavri, M.; Matthew, K.T.; Gordon, Andrew; Shnyder, Steven D.; Falconer, Robert A.; Gibbons, S.
JournalPhytochemistry
 
TitleA cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations in Ghana (2008)
AuthorsBayor, M.T.; Ayim, J.S.K.; Marston, G.; Phillips, Roger M.; Shnyder, Steven D.; Wheelhouse, Richard T.; Wright, Colin W.
 
TitleA cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana (2008)
AuthorsBayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.;
JournalNatural product communications
 
TitleA cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana (2008)
AuthorsBayor M.;Ayim J.;Marston G.;Phillips R.;Shnyder S.;Wheelhouse R.;Wright C.
JournalNatural product communications
 
TitleSodium pancratistatin 3,4-O-cyclic phosphate, a water-soluble synthetic derivative of pancratistatin, is highly effective in a human colon tumor model (2008)
AuthorsShnyder S.;Cooper P.;Millington N.;Gill J.;Bibby M.
JournalJournal of Natural Products
DOI10.1021/np070477p
 
TitleAuristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models. (2007)
AuthorsShnyder, Steven D.; Cooper, Patricia A.; Millington, Nicola J.; Pettit, G.R.; Bibby, Michael C.
 
TitleSynthesis of cryptolepine analogues as potential bioreducible anticancer agents (2007)
AuthorsSeville S.;Phillips R.;Shnyder S.;Wright C.
JournalBioorganic and Medicinal Chemistry
DOI10.1016/j.bmc.2007.06.062
 
TitleReducing the cost of screening novel agents using the hollow fibre assay (2006)
AuthorsShnyder S.;Cooper P.;Scally A.;Bibby M.
JournalAnticancer Research
 
TitleSynthesis of DNA-Directed Pyrrolidinyl and Piperidinyl Confined Alkylating Chloroalkylaminoanthraquinones: Potential for Development of Tumor-Selective N-Oxides (2006)
AuthorsPatterson, Laurence H.; Pors, Klaus; Shnyder, Steven D.; Teesdale-Spittle, P.H.; Hartley, J.A.; Searcey, M.; Zloh, M.
 
TitleDesign, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates (2006)
AuthorsWells G.;Martin C.;Howard P.;Sands Z.;Laughton C.;Tiberghien A.;Woo C.;Masterson L.;Stephenson M.;Hartley J.;Jenkins T.;Shnyder S.;Loadman P.;Waring M.;Thurston D.
JournalJournal of Medicinal Chemistry
DOI10.1021/jm051199z
 
TitleThe hollow fibre model - Facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare (2006)
AuthorsSuggitt M.;Cooper P.;Shnyder S.;Bibby M.
JournalInternational Journal of Oncology
 
TitleDevelopment of a modified hollow fibre assay for studying agents targeting the tumour neovasculature (2005)
AuthorsShnyder S.;Hasan J.;Cooper P.;Pilarinou E.;Jubb E.;Jayson G.;Bibby M.
JournalAnticancer Research
 
TitleHeparin octasaccharides inhibit angiogenesis in vivo. (2005)
AuthorsHasan, J.; Shnyder, Steven D.; Clamp, A.R.; McGown, A.T.; Bicknell, R.; Presta, M.; Bibby, Michael C.; Double, John A.; Craig, S.; Leeming, D.; Stevenson, K.; Gallagher, J.T.; Jayson, G.C.
 
TitleSynthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. (2005)
AuthorsWright, Colin W.; Onyeibor, O.; Phillips, Roger M.; Shnyder, Steven D.; Croft, S.L.; Dodson, Hilary I.
 
TitleSecretory phospholipase A2as tumor-specific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids (2004)
AuthorsJensen S.;Andresen T.;Davidsen J.;Høyrup P.;Shnyder S.;Bibby M.;Gill J.;Jørgensen K.
JournalMolecular Cancer Therapeutics
 
TitleVinflunine Pierre Fabre/Bristol-Myers Squibb (2004)
AuthorsShnyder S.
JournalIDrugs : the investigational drugs journal
 
TitleComparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate (2004)
AuthorsKirwan, Ian G.; Loadman, Paul M.; Swaine, David J.; Anthoney, Alan; Pettit, G.R.; Lippert III, J.W.; Shnyder, Steven D.; Cooper, Patricia A.; Bibby, Michael C.
 
TitlePreliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent. (2004)
AuthorsWilkinson, Gary P.; Taylor, James P.; Shnyder, Steven D.; Loadman, Paul M.; Cooper, Patricia A.; Howard, P.W.; Thurston, D.E.; Jenkins, Terence C.
 
TitlePharmacological and biological evaluation of a series of substituted 1,4 naphthoquinone bioreductive drugs. (2004)
AuthorsPhillips, Roger M.; Loadman, Paul M.; Maitland, Derek J.; Shnyder, Steven D.; Jaffar, M.; Steans, Gillian; Cooper, Patricia A.; Race, Amanda D.; Patterson, A.V.; Stratford, I.J.
 
TitleSecretory phospholipase A2 as a tumor specific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids (2004)
AuthorsGill, Jason H.; Bibby, Michael C.; Jensen, S.S.; Shnyder, Steven D.
 
TitleVinflunine Potentiates the Activity of Cisplatin but Not 5-Fluorouracil in A Transplantable Murine Adenocarcinoma Model (2003)
AuthorsShnyder S.;Cooper P.;Gyselinck N.;Hill B.;Double J.;Bibby M.
JournalAnticancer Research
 
TitleCombretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model (2003)
AuthorsShnyder S.;Cooper P.;Pettit G.;Lippert J.;Bibby M.
JournalAnticancer Research
 
TitleIn vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine (2002)
AuthorsNicholson K.;Phillips R.;Shnyder S.;Bibby M.
JournalEuropean Journal of Cancer. Part A
DOI10.1016/S0959-8049(01)00341-0
 
TitleCombretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours (2002)
AuthorsHolwell S.;Cooper P.;Grosios K.;Lippert J.;Pettit G.;Shnyder S.;Bibby M.
JournalAnticancer Research
 
Book Chapter
TitleOncology Activity (2015)
AuthorsGill J.;Shnyder S.
JournalDrug Discovery and Evaluation: Pharmacological Assay, Fourth Edition
DOI10.1007/978-3-319-05392-9_113
 
Other Publication
Other typeReviews
TitleRGD-binding integrins in head and neck cancers (2017)
AuthorsAhmedah H.;Patterson L.;Shnyder S.;Sheldrake H.
JournalCancers
DOI10.3390/cancers9060056
 
Other typeReviews
TitleNon-invasive molecular imaging for preclinical cancer therapeutic development (2013)
AuthorsO'Farrell A.;Shnyder S.;Marston G.;Coletta P.;Gill J.
JournalBritish Journal of Pharmacology
DOI10.1111/bph.12155
 
Other typeReviews
TitleRGD-binding integrins in prostate cancer: Expression patterns and therapeutic prospects against bone metastasis (2012)
AuthorsSutherland M.;Gordon A.;Shnyder S.;Patterson L.;Sheldrake H.
JournalCancers
DOI10.3390/cancers4041106
 
Other typeReviews
TitleQuantitative angiogenesis assays in vivo - A review (2004)
AuthorsHasan J.;Shnyder S.;Bibby M.;Double J.;Bicknel R.;Jayson G.
JournalAngiogenesis
DOI10.1023/B:AGEN.0000037338.51851.d1
 
Title Author(s)
Proceedings - 2017 International Conference on Cyberworlds, CW 2017 - in cooperation with: Eurographics Association International Federation for Information Processing ACM SIGGRAPH (2017)Hussain N.;Cooper P.;Shnyder S.;Ugail H.;Bukar A.;Connah D.
A Non-invasive 2D Digital Imaging Method for Detection of Surface Lesions Using Machine Learning (2017)Hussain, Nosheen; Cooper, Patricia A.; Shnyder, Steven D.; Ugail, Hassan; Bukar, Ali M.; Connah, David