Drug metabolism and pharmacokinetics

ICT has an experienced Drug Metabolism and Pharmacokinetic (DMPK) Team, led by Prof Paul Loadman, who have worked on numerous contract research projects with industrial partners within efficient and well-resourced GCP laboratories. The team undertake analytical method development (LC-MS/MS) and a range of bioavailability and pharmacokinetic studies from simple evaluation of parent molecule in plasma to full ADME and tissue distribution.

Advantages of working with the DMPK team at ICT:

• Excellent knowledge and experience in this area- expert opinion from leading academics
• GCP accredited laboratories and high quality research and reporting
• Projects are managed to meet commercial timelines and we ensure our partners are fully updated on progress
• Examples of studies include the analysis of complex metabolic profiles and the development of analytical methods for the PK analysis of highly reactive and potent molecules in the picomolar range.

We have also successfully monitored low concentrations of highly potent metabolites and pharmacodynamic markers in small clinical biopsy samples as in a recent Phase I clinical trial.