Polysialyl transferase inhibitors
Polysialic acid (polySia, an unusual carbohydrate polymer) found on the surface of neuroendocrine tumours, notably neuroblastoma. PolySia plays a key role in the metastatic spread of tumours. We have a focus on neuroblastoma, and are developing inhibitors targeting metastasis and prodrugs to tackle this deadly childhood disease.
Led by Prof Robert Falconer, this project is currently funded by a £1.5m Yorkshire Cancer Research programme, and the ICT Doctoral Training Centre. Find out more on Prof Robert Falconer's staff profile.