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Research studies

Ethical Tissue has been involved with a range of projects where we have supplied the tissues or bioscamples direct to the researchers. Examples are shown below of ways we have helped researchers in their projects and illustrates the importance of ethical supply of fresh human tissues and biofluids within the biomedical and healthcare sciences and demonstrates the wide variety of sample types we can supply.

Case studies of research projects

A baby and their toddler sibling lying next to eachother.

Paediatric Biliary Atresia

Paediatric Biliary Atresia is a rare liver disorder in newborns. Leeds General Infirmary Children's Hospital is one of three centres in the country who see children with this condition. Consultant surgeon, Mr N Alizai, banked tissue obtained at the corrective surgery of these children, and the protocols for a pilot study into this condition is being developed. The results from this study will allow funding applications for more extensive research into this distressing disorder.

Close up of a persons neck

Head and neck cancer

In collaboration with Mr J McCaul, a Head and Neck cancer specialist at Bradford Royal Infirmary, we banked a large number of donated tissues. Mr McCaul funded for a PhD student to conduct studies using this tissue and the associated FFPE blocks. Consultant Pathologist Dr D Gouldesborough (Bradford Royal Infirmary), selected 20 of the most appropriate blocks for the study, these were linked by us through the donors unique donation code to fresh tissue in the bank. 

Hands pinching the skin on a persons back

Staff volunteer donors

A major Clinical Research Organisation (CRO) required biological blanks from their workforce. Ethical Tissue set up an independent system within the company to approach staff to volunteer to be a healthy donor, restricted the number of blood samples they could give (in the donors interest), supported trained staff in the process of taking consent and worked with the company to develop a system that maintained donor confidentiality. 

The Community Ageing Research 75 (CARE75+) Study

CARE75+ is a national cohort study of community-dwelling older people (≥75 years). One of the aims of CARE75+ is to study longitudinal frailty transitions so we can better understand ageing and what contributes to people remaining fit in later life or becoming frail, and how we might moderate or slow down frailty transitions.

CARE75+ started recruitment in 2014 and has collected data from over 1000 older people. The cohort has well-characterised frailty status derived from the electronic Frailty Index (eFI) to allow the identification and severity grading of frailty and to investigate frailty trajectories (how frailty changes over time and what might influence it).

CARE75+ assessments include detailed information on the demographic, health and social circumstances of participants. An extensive range of measures are collected using validated instruments, including assessments of frailty, cognition, mood, health-related quality of life, comorbidity, medications, resilience, loneliness and self-efficacy. Measures have been chosen to ensure that CARE75+ includes measures for applied epidemiological investigation and randomised trial evaluation of future interventions. Data have been collected at baseline, 6 months, 12 months, 18 months, 24 months and 48 months.

Blood samples are collected from consenting Leeds and Bradford participants at baseline and at 12 month follow-up, to provide a resource to potentially investigate associations of a range of organ specific, immunological, endocrine and genetic markers with frailty. CARE75+ blood samples are stored at Ethical Tissue, University of Bradford.

For the full list of data outcomes collected, please see the study protocol (

The cohort is currently funded by the Yorkshire & Humber Applied Research Collaboration (ARC), National Institute for Health Research (NIHR). The study lead is Professor Andrew Clegg, University of Leeds & Bradford Teaching Hospitals NHS Foundation Trust (BTHFT).

If you would like more information on the study and how you can access the data or the samples, please contact the CARE75+ project manager, Lesley Brown, Wayne Burrill at Ethical Tissue (Website contact link)

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