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Del-COrS LTC

Development of a core outcome set for effectiveness trials of interventions to prevent and/or treat delirium in long-term care (Del-COrS LTC).

http://www.comet-initiative.org/studies/details/796?result=true

Overview of the Project

Delirium is a common, serious, and potentially preventable condition with devastating impact on the quality of life, which has led to numerous intervention trials. To help patients, doctors and other health professionals make decisions about treatments, we need evidence about what works best. Treatments are developed and tested by researchers to make sure they work and are safe. To do this, researchers need to look at the effects those treatments have on patients. Researchers do this by measuring an ‘outcome’.

If two studies are looking at treatment for the same condition (delirium) but are looking at different outcomes, then we cannot compare or combine results. If all studies in a particular health condition used the same outcomes, they could all be compared and combined. This would reduce waste by making best use of all the research. When a set of main outcomes has been agreed for a health condition, it’s called a ‘core outcome set’. This study aims to develop international agreement on a core outcome set for research studies to either prevent or treat delirium in long-term care.

A core outcome set is an agreed standardised set of outcomes that should be measured and reported, as a minimum, in all clinical trials in specific areas of health or health care. This helps in combining results in meta-analyses and identifying important areas in clinical practice. This study seeks to develop international agreement on a core outcome set for research studies to either prevent or treat delirium in long-term care.

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Aims of the study:

This study is part of a bigger project aiming to develop Core Outcome Set for Delirium. There are four studies in this project carried out in different settings: hospital wards, intensive care units, palliative care and long-term care. This study aims to develop a core outcome set for effectiveness trials of interventions to prevent and/or treat delirium in long-term care.

Methods

Systematic literature review

We have completed a systematic literature review examining the evidence base to establish existing study outcomes for studies of interventions to prevent or treat delirium.

Interviews

We will conduct one-to-one interviews with patients who have experienced delirium as well as, family and staff members. This will help us understand what is important to people with lived experience of delirium and their family members and staff working with this population, to help develop and finalise core outcomes.

Delphi rounds & Consensus workshop

We will conduct a Delphi exercise followed by an international consensus workshop to establish the outcomes to inform the core outcome set.

Related publications

Project protocol

https://bmjopen.bmj.com/content/7/9/e016371

 

Systematic review of outcomes and measures of delirium interventional studies in palliative care:

https://journals.sagepub.com/doi/10.1177/02692163211040186

 

Hospital wards study

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02015-3

 

Intensive care study

https://pubmed.ncbi.nlm.nih.gov/33870914/

Research Team

Dr Anas Shehadeh

Research Fellow – lead researcher for the study

Centre for Applied Dementia Studies

https://www.bradford.ac.uk/staff/ashehadeh

 

Dr Kathryn Lord

Senior Research Fellow

Centre for Applied Dementia Studies

https://www.bradford.ac.uk/staff/klord1

 

Dr Gregor Russell

Honorary Senior Lecturer

Centre for Applied Dementia Studies

https://www.bdct.nhs.uk/person/gregor-russell-2/

 

Prof. Siobhan Reilly  Professor of Applied Dementia Research

Director of the Centre for Applied Dementia Studies

https://www.bradford.ac.uk/staff/sreilly

 

Dr Sahdia Parveen

Senior Research Fellow

Centre for Applied Dementia Studies

https://www.bradford.ac.uk/staff/sparveen27

 

Dr Anas Shehadeh

Research Fellow – lead researcher for the study

Centre for Applied Dementia Studies

https://www.bradford.ac.uk/staff/ashehadeh

 

Prof. Louise Rose

Professor of Nursing

Kings College London, London, UK

https://www.kcl.ac.uk/people/louise-rose

 

Dr Valerie Page

Consultant Critical Care

West Hertfordshire NHS Foundation Trust

https://www.linkedin.com/in/valerie-page-35759332/?originalSubdomain=uk

 

Dr Elizabeth Teale

Clinical Senior Lecturer in Geriatric Medicine/Bradford Teaching Hospitals/NHS Foundation Trust

https://www.bradfordresearch.nhs.uk/our-research-teams/academic-unit-for-ageing-and-stroke-research/our-team/elizabeth-teale/

 

Professor Mike Clarke

Professor of Public Health/Queen’s University Belfast

https://pure.qub.ac.uk/en/persons/mike-clarke

 

Amirah Akhtar

Research Assistant

Email: a.akhtar46@bradford.ac.uk  

https://www.bradford.ac.uk/staff/aakhtar46

 

 

Funding

This part of the study is being funded by Bradford District Care NHS Foundation Trust.

For further information or to take part in the study, please contact Dr Anas Shehadeh.

Tel: +44 (0) 1274 238667

Email:   a.shehadeh@bradford.ac.uk