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Recent publications of the Cardiovascular Research Group


VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
Mondru AK, Aljasir MA, Alrumayh A, Nithianandarajah GN, Ahmed K, Müller J, Goldring CEP, Wilm B, Cross MJ
Cells (2023): 12(6): 967.

Development and Optimisation of Inhalable EGCG Nano-Liposomes as a Potential Treatment for Pulmonary Arterial Hypertension by Implementation of the Design of Experiments Approach.
Haddad F, Mohammed N, Gopalan RC, Ayoub YA, Nasim MT, Assi KH
Pharmaceutics. 2023; 15(2):539. 

Non-canonical role of the sympathetic nervous system in the circadian rhythm in heart rate.
Anderson C, Forte G, Hu W, Zhang H, Boyett MR, D’Souza A
Philosophical Transactions of the Royal Society B Biological Sciences 378(1879):20220179 (2023)

Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.
Logantha SJRJ, Yamanushi TT, Absi M, Temple IP, Kabuto H, Hirakawa E, Quigley G, Zhang X, Gurney AM, Hart G, Zhang H, Dobrzynski H, Boyett MR, Yanni J
Philosophical Transactions of the Royal Society B Biological Sciences 378(1879):20220178. (2023)

Atrioventricular node dysfunction in pressure overload-induced heart failure Involvement of the immune system and transcriptomic remodelling
Wilson, C., Zi, M., Smith, M., Hussain, M., D’Souza, A., Dobrzynski, H., Boyett, M.R.
Frontiers in Pharmacology, 14:1083910.


Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing.
Riches-Suman K, Hussain A.
Biochim Biophys Acta Mol Basis Dis. 2022 Jul 1;1868(7):166403.
doi: 10.1016/j.bbadis.2022.166403

Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis.
Ross RL, Mavria G, Del Galdo F, Elies J
Front Physiol. 2022 May 5;13:900631
doi: 10.3389/fphys.2022.900631

Efficacy of interval exercise training to improve vascular health in sedentary postmenopausal females.
Lyall GK, Birk GK, Harris E, Ferguson C, Riches-Suman K, Kearney MT, Porter KE, Birch KM.
Physiol Rep. 2022 Aug;10(16):e15441
doi: 10.14814/phy2.15441

Impact of Pharmacist-Led Interventions to Improve Clinical Outcomes for Adults With Type 2 Diabetes at Risk of Developing Cardiovascular Disease: A Systematic Review and Meta-analysis.
Alabkal RM, Medlinskiene K, Silcock J, Graham A.
J Pharm Pract. 2022 May 17:8971900211064459
doi: 10.1177/08971900211064459

Preservation of Smooth Muscle Cell Integrity and Function: A Target for Limiting Abdominal Aortic Aneurysm Expansion?
Clark ER, Helliwell RJ, Bailey MA, Hemmings KE, Bridge KI, Griffin KJ, Scott DJA, Jennings LM, Riches-Suman K, Porter KE.
Cells. 2022 Mar 19;11(6):1043
doi: 10.3390/cells11061043



The Functional Role of Hyperpolarization Activated Current (I f) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study.
Bai X, Wang K, Boyett MR, Hancox JC, Zhang H.
Front Physiol. 2021 Aug 19;12:582037.
doi: 10.3389/fphys.2021.582037.

Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease.
Riches-Suman K.
Biochem Soc Trans. 2021 Feb 26;49(1):353-363.
doi: 10.1042/BST20200679.

Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering.
Bazgir M, Zhang W, Zhang X, Elies J, Saeinasab M, Coates P, Youseffi M, Sefat F.
Materials (Basel). 2021 Oct 22;14(21):6295.
doi: 10.3390/ma14216295.

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease.
Boyett MR, Yanni J, Tellez J, Bucchi A, Mesirca P, Cai X, Logantha SJRJ, Wilson C, Anderson C, Ariyaratnam J, Stuart L, Nakao S, Abd Allah E, Jones S, Lancaster M, Stephenson R, Chandler N, Smith M, Bussey C, Monfredi O, Morris G, Billeter R, Mangoni ME, Zhang H, Hart G, D'Souza A.
Prog Biophys Mol Biol. 2021 Nov;166:61-85.
doi: 10.1016/j.pbiomolbio.2021.06.008.

Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering.
Bazgir M, Zhang W, Zhang X, Elies J, Saeinasab M, Coates P, Youseffi M, Sefat F.
Materials (Basel). 2021 Aug 24;14(17):4773.
doi: 10.3390/ma14174773. PMID: 34500862 Free PMC article.

Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets.
Bolanle IO, Riches-Suman K, Williamson R, Palmer TM.
Pharmacol Res. 2021 Mar;165:105467.
doi: 10.1016/j.phrs.2021.105467.

Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit.
Logantha SJRJ, Cai XJ, Yanni J, Jones CB, Stephenson RS, Stuart L, Quigley G, Monfredi O, Nakao S, Oh IY, Starborg T, Kitmitto A, Vohra A, Hutcheon RC, Corno AF, Jarvis JC, Dobrzynski H, Boyett MR, Hart G.
Circ Heart Fail. 2021 Jul;14(7):e007505.
doi: 10.1161/CIRCHEARTFAILURE.120.007505.

Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation.
Bolanle IO, Riches-Suman K, Loubani M, Williamson R, Palmer TM.
Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1349-1356.
doi: 10.1016/j.numecd.2021.01.017. Epub 2021 Feb 2.

Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension.
Sharmin N, Nganwuchu CC, Nasim MT.
Trends Pharmacol Sci. 2021 Jul;42(7):510-513.
doi: 10.1016/

Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes.
Mesirca P, Nakao S, Nissen SD, Forte G, Anderson C, Trussell T, Li J, Cox C, Zi M, Logantha S, Yaar S, Cartensen H, Bidaud I, Stuart L, Soattin L, Morris GM, da Costa Martins PA, Cartwright EJ, Oceandy D, Mangoni ME, Jespersen T, Buhl R, Dobrzynski H, Boyett MR, D'Souza A.
Circ Res. 2021 Jun 25;129(1):e1-e20.
doi: 10.1161/CIRCRESAHA.119.316386.

Role of MicroRNA-145 in DNA Damage Signalling and Senescence in Vascular Smooth Muscle Cells of Type 2 Diabetic Patients.
Hemmings KE, Riches-Suman K, Bailey MA, O'Regan DJ, Turner NA, Porter KE.
Cells. 2021 Apr 16;10(4):919.
doi: 10.3390/cells10040919.

RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart.
Wang Y, Anderson C, Dobrzynski H, Hart G, D'Souza A, Boyett MR.
Sci Rep. 2021 Feb 11;11(1):3565.
doi: 10.1038/s41598-021-82202-7.

Laser Capture Microdissection on Surgical Tissues to Identify Aberrant Gene Expression in Impaired Wound Healing in Type 2 Diabetes.
Williams R, Castellano-Pelicena I, Al-Rikabi AHA, Sikkink SK, Baker R, Riches-Suman K, Thornton MJ. J
Vis Exp. 2021 Jan 13;(167).
doi: 10.3791/62091.

Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia.
Bidaud I, D'Souza A, Forte G, Torre E, Greuet D, Thirard S, Anderson C, Chung You Chong A, Torrente AG, Roussel J, Wickman K, Boyett MR, Mangoni ME, Mesirca P.
Front Physiol. 2021 Jan 20;11:519382.
doi: 10.3389/fphys.2020.519382.

Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses.
Al-Rikabi AHA, Tobin DJ, Riches-Suman K, Thornton MJ.
Sci Rep. 2021 Jan 14;11(1):1474.
doi: 10.1038/s41598-020-80072-z.

A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate.
D'Souza A, Wang Y, Anderson C, Bucchi A, Baruscotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, Black N, Cox C, Wegner S, Bano-Otalora B, Petit C, Gill E, Logantha SJRJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, da Costa Martins PA, Piggins HD, DiFrancesco D, Boyett MR.
Heart Rhythm. 2021 May;18(5):801-810.
doi: 10.1016/j.hrthm.2020.11.026.