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Dr. Yvonne Nyathi

Information about Dr. Yvonne Nyathi at the University of Bradford.

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Dr Yvonne Nyathi joined the University of Bradford in February 2020 as a Lecturer in Biochemistry. The field of protein quality control (proteostasis) broadly covers Yvonne’s previous and present research interests. Her PhD research focused on elucidating the mechanisms regulating the targeting, localisation and function of an ABCD1 transporter protein pivotal in peroxisomal fatty acid beta-oxidation. In 2010 when Yvonne finished her PHD, she worked as a R&D scientist at Aptuscan Ltd (a spin-out company of the University of Leeds which is now part of the Avacta Group), developing proprietary combinatorial libraries and reagents for the platform Affimer technology (antibody mimetics with tuneable affinity and avidity) that underpins one of the key technologies in the company to date. The transition from an academic research environment to a commercial setting at a very early stage in her research career sparked her interest in translational research, which she is currently very keen to pursue. Following the acquisition of Aptuscan by The Avacta Group, Yvonne joined Dr Martin Pool’s lab at the University of Manchester, studying mechanisms that regulate protein quality control at the ribosome. Yvonne’s work showed that the quality control factors at the ribosome compete for bind and all events are tightly regulated to reduce the chances of mistakes during protein synthesis. This work led to a publication in the Journal of Cell Biology and attracted a commentary in Nature reviews. In 2014, Yvonne then joined Prof Stephen High’ lab at the University of Manchester, working collaboratively with the chemical biology/structural biology group of Dr Rivka Isaacson (Kings College) focusing on the role of chaperones in mislocalised protein quality control. In 2017, Yvonne joined the University of Lincoln to pursue her research interests in protein quality control focusing on the role of the co-chaperone SGTA in protein misfolding/aggregation in the context of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases and in the signalling pathways that regulate cancer .


Protein Quality Control MechanismsProtein folding and DynamicsProtein Aggregation and DiseaseLiquid-Liquid Phase SeparationProtein Engineering for Improved Functions

Research collaborators

Information about people or organisations that Dr. Yvonne Nyathi collaborates with.
Name Company Country Type Role Theme Description
Yokohama City University Graduate School of Medicine JP EXTERNAL Neuroscientist with expertise in Huntington's disease Protein quality control in Neurodegeneration Looking into of SGTA in Huntington's disease
University of Bradford GB INTERNAL Structural Biologist with Crystallography Expertise Cataracts Investigating molecular mechanisms of cataract formation
University of Bradford GB INTERNAL Co-I Molecular dynamic simulation Simulation of structure for disordered chaperone proteins
University of Leeds GB EXTERNAL Co-I Affimer technology for the identification of novel affinity reagents Combinatorial phage display libraries will be screened for binders which can discriminate isoforms and mutants of selected chaperones
University of Leicester GB EXTERNAL PI Molecular imprinted polymers Lead in polymer chemistry and molecular imprinted polymers to provide a platform technology for identifying binding sites and probing conformational changes of proteins upon substrate binding.


Details on teaching interests, highlights and modules are available for Dr. Yvonne Nyathi as follows:

Teaching interests

Currently teaching on the following modules:Development of Practical Skills 1 BIS4003 Level 4Introductory Biochemistry – BIS4007 Level 4- Module leaderDevelopment of Practical Skills 2 BIS5003 Level 5Clinical and Analytical Biochemistry BIS5013 Level 5Research Projects BIS6026 Level Research Topics 1 BIS6009 Level 6 -Module leaderResearch Topics 2 BIS6010 Level 6Biology of Disease BIS6012 Level 6Neuroendocrine Basis of Regulation and Metabolism BIS7021 Level 7Research Project BIS7026 Level 7 Supervised 15 undergraduate students, 2 MSc students and 2 PhD student over the past 3 years.

Teaching highlights

One of the complaints raised by students during the module evaluation was that for the Biological Analysis module (which I led while working at the University of Lincoln), the content they were required to remember was in many cases very abstract as they could not perform wet lab for all the techniques covered on the module. In response to this, I applied and successfully secured a Teaching Innovation Fund to develop multimedia resources by filming and recording laboratory techniques performed in the labs at the University of Lincoln. This was a one-year student-led project which involved filming, video editing and subtitling. I introduced these resources to support teaching and learning of the module. This was accompanied by an improvement in student satisfaction scores from 69 % to 85 % compared to the previous year. Moreover, the average module mark for a cohort of 175 students increased from 62% to 69%, suggesting this approach was accompanied by significant learning gains. This is very important to me as it highlights that we need to listen to the students and make an effort to improve their learning experience.


There are 10 publications involving or that are attributed to Dr. Yvonne Nyathi.

Peer Reviewed Journal

Dr. Yvonne Nyathi has 10 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Binding of SGTA to Rpn13 selectively modulates protein quality control. 2015 Journal of Cell Science 128 Leznicki P;Korac-Prlic J;Kliza K;Husnjak K;Nyathi Y;Dikic I;High S; 1477-9137 10.1242/jcs.165209
USP5 enhances SGTA mediated protein quality control. 2022 PLoS ONE 17 Hill J;Nyathi Y; 1932-6203 10.1371/journal.pone.0257786
Co-translational targeting and translocation of proteins to the endoplasmic reticulum. 2013 Biochimica et biophysica acta 1833 Nyathi Y;Wilkinson BM;Pool MR; 0006-3002 10.1016/j.bbamcr.2013.02.021
Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity. 2012 FEBS Letters 586 Nyathi Y;Zhang X;Baldwin JM;Bernhardt K;Johnson B;Baldwin SA;Theodoulou FL;Baker A; 1873-3468 10.1016/j.febslet.2012.05.065
The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity. 2010 Journal of Biological Chemistry 285 Nyathi Y;De Marcos Lousa C;van Roermund CW;Wanders RJ;Johnson B;Baldwin SA;Theodoulou FL;Baker A; 1083-351X 10.1074/jbc.M110.151225
Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant. 2011 Protein Engineering, Design and Selection 24 Stadler LK;Hoffmann T;Tomlinson DC;Song Q;Lee T;Busby M;Nyathi Y;Gendra E;Tiede C;Flanagan K;Cockell SJ;Wipat A;Harwood C;Wagner SD;Knowles MA;Davis JJ;Keegan N;Ferrigno PK; 1741-0134 10.1093/protein/gzr019
Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds. 2014 Journal of Biological Chemistry 289 Yamashita M;Shepherd M;Booth WI;Xie H;Postis V;Nyathi Y;Tzokov SB;Poole RK;Baldwin SA;Bullough PA; 1083-351X 10.1074/jbc.M114.590414
Analysis of the interplay of protein biogenesis factors at the ribosome exit site reveals new role for NAC. 2015 Journal of Cell Biology 210 Nyathi Y;Pool MR; 1540-8140 10.1083/jcb.201410086
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control. 2018 BMC Biology 16 Martínez-Lumbreras S;Krysztofinska EM;Thapaliya A;Spilotros A;Matak-Vinkovic D;Salvadori E;Roboti P;Nyathi Y;Muench JH;Roessler MM;Svergun DI;High S;Isaacson RL; 1741-7007 10.1186/s12915-018-0542-3
SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism. 2016 Scientific Reports 6 Thapaliya A;Nyathi Y;Martínez-Lumbreras S;Krysztofinska EM;Evans NJ;Terry IL;High S;Isaacson RL; 2045-2322 10.1038/srep36622