Dr Sneha Swaroop is an Assistant Professor in Cell and Molecular Biology at the School of Pharmacy and Medical Sciences. Her research focuses on stem cells in cancer, with the goal of identifying novel ways to target them and develop effective therapies for cancer patients. After earning her Master’s degree in Biotechnology, Dr Swaroop pursued a Ph.D. in the field of Oncology from the renowned Cancer Institute (WIA), India, where she extensively researched the role of the hedgehog pathway in maintaining cancer stem cells in serous adenocarcinoma of the ovary. As a testament to her excellent research capabilities, Dr Swaroop was awarded the prestigious Schlumberger Faculty for the Future (FFTF) Fellowship, allowing her to undertake post- doctoral research in drug discovery at the Institute of Cancer Therapeutics (ICT), University of Bradford. In this role, she evaluated novel cancer stem cell-targeted chemical probes and drug candidates in breast and prostate cancer, which has the potential to transform cancer treatment. Aside from her research, Dr Swaroop is also a dedicated STEM ambassador and educator, mentoring and training the next generation of scientists. She is also committed to engaging with wider community, participating in public engagement activities increasing awareness and understanding of cancer research.
Dr Sneha Swaroop’s research interests
are centered around understanding the intricate biology of cancer stem cells
and identifying novel ways to target them. Her research includes several noteworthy
studies such as:
1)
Characterising ovarian cancer stem cells (CSCs) using
spheroid culture and evaluating the significance of embryonic signaling
pathways.
2) Identifying
novel biomarkers for ovarian cancer stem cells using in silico approaches, establishing
in vitro and in vivo models to study CSCs and evaluating novel therapeutic
targets for improved treatment.
3) Evaluation
of the effect of a dual PI3K δ/γ inhibitors on cancer stem cell proliferation
in serous ovarian carcinoma.
4)
Investigating stem cell gene expression in
spheroids and deciphering splice variants of stem cell specific genes in
teratoma and human embryonic stem cells followed by their analysis in two and three
dimensional culture.
5)
Establishing the role of CSCs in tumour
angiogenesis and lymph angiogenesis in ovarian cancer.
Moving
forward, Dr Swaroop aims to continue exploring the biology of cancer stem cells
in relation to the tumour microenvironment with the ultimate aim of developing
more effective treatments for cancer patients.
Currently Dr Swaroop is seeking motivated and passionate PhD students and Post Docs to explore the intricate self regulatory mechanisms of CSCs in ovarian cancer. Fellowship applications such as Schlumberger, Newton and Commonwealth from ideal candidates will be supported for conducting research in the filed of CSCs at the Institute of Cancer Therapeutics, Bradford. Please contact s.swaroop@bradford.ac.uk for more details.
Elisabet Batlle Rocafort; Ali I. Ibrahim; Maria Sadiq; Sneha Smarakan; Vibhu Jha; Tiziano Tuccinardi; Fiona Frame; Norman Maitland; Rafael Jiménez Aguilar; Raquel Pequerul Pavón; Xavier Parés Casampera; Goreti Ribeiro Morais; Jaume Farrés Vicen; Klaus Pors (2022) Proceedings: AACR Annual Meeting.
Ali I M Ibrahim, Elisabet Batlle, Smarakan Sneha, Rafael Jiménez, Raquel Pequerul, Xavier Parés, Till Rüngeler, Vibhu Jha, Tiziano Tuccinardi, Maria Sadiq, Fiona Frame, Norman J Maitland, Jaume Farrés, Klaus Pors (2022) Journal of Medicinal Chemistry. 65
Sidhanth C;Bindhya S;Shabna A;Krishnapriya S;Manasa P;Nagare RP;Joshua T;Sneha S;Murhekar K;Ganesan TS; (2022) Biochemical Journal. 479
Sneha S;Baker SC;Green A;Storr S;Aiyappa R;Martin S;Pors K; (2021) Biomedicines. 9
Presa D;Khurram SA;Zubir AZA;Smarakan S;Cooper PA;Morais GR;Sadiq M;Sutherland M;Loadman PM;McCaul J;Shnyder SD;Patterson LH;Pors K; (2021) Scientific Reports. 11
Nagare RP;Sneha S;Krishnapriya S;Ramachandran B;Murhekar K;Vasudevan S;Shabna A;Ganesan TS; (2020) Experimental Cell Research. 392
Nagare RP;Sneha S;Sidhanth C;Roopa S;Murhekar K;Shirley S;Swaminathan R;Sridevi V;Ganesan TS; (2020) Cancer Biomarkers : Section A Of Disease Markers. 28
Sneha S;Nagare RP;Sidhanth C;Krishnapriya S;Garg M;Ramachandran B;Murhekar K;Sundersingh S;Ganesan TS; (2020) Cellular Oncology (Dordrecht). 43
Krishnapriya S;Sidhanth C;Manasa P;Sneha S;Bindhya S;Nagare RP;Ramachandran B;Vishwanathan P;Murhekar K;Shirley S;Ganesan TS; (2019) Angiogenesis. 22
Sneha S;Nagare RP;Manasa P;Vasudevan S;Shabna A;Ganesan TS; (2019) Cellular Reprogramming. 21
Nagare RP;Sneha S;Ramesh S;Ganesan TS; (2019) International Journal of Biochemistry and Cell Biology. 109
Sidhanth C;Manasa P;Krishnapriya S;Sneha S;Bindhya S;Nagare RP;Garg M;Ganesan TS; (2018) Biochemistry and cell biology = Biochimie et biologie cellulaire. 96
Sneha S;Nagare RP;Priya SK;Sidhanth C;Pors K;Ganesan TS; (2017) Cancer Immunology, Immunotherapy. 66
Nagare RP;Sneha S;Priya SK;Ganesan TS; (2017) Current Stem Cell Research and Therapy. 12
Garg M;Kanojia D;Mayakonda A;Ganesan TS;Sadhanandhan B;Suresh S;S S;Nagare RP;Said JW;Doan NB;Ding LW;Baloglu E;Shacham S;Kauffman M;Koeffler HP; (2017) Scientific Reports. 7
Krishna Priya S;Nagare RP;Sneha VS;Sidhanth C;Bindhya S;Manasa P;Ganesan TS; (2016) International Journal of Cancer. 139
Vinodhini MT;Sneha S;Nagare RP;Bindhya S;Shetty V;Manikandan D;Ganesan P;Sagar TG;Ganesan TS; Indian Heart Journal. 70