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Dr. Samantha McLean,
Associate Professor

Information about Dr. Samantha McLean at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
+44 1274 235809
Photo of Dr. Samantha McLean


Dr Samantha McLean (PhD in Neuropharmacology, University of Bradford, 2010) is a Pharmacologist (University of Leeds, 2006). Sam is appointed as an Associate Professor in Pharmacology, Director of Admissions and Marketing for the School of Pharmacy and Medical Sciences and Deputy Director of Research at Health, Society, People and Place in the Faculty of Life Sciences. Sam is a Senior Fellow of the Higher Education Academy, UK (2020). She has experience in leading, developing and accreditation of innovative programmes of study in life sciences at undergraduate and postgraduate levels, including MPharm (GPhC). As Director of Marketing and Admissions, Sam is managing marketing and recruitment activities across all programme levels: MPharm, BSc Clinical Sciences, BSc Pharmaceutical and Cosmetic Science and a portfolio of postgraduate MSc and Research taught programmes in the School of Pharmacy and Medical Sciences, Centre for Pharmaceutical Engineering Science, and the Institute of Cancer Therapeutics. Her outreach and recruitment agenda spans a variety of projects aimed at improving access to and widening participation in higher education among home students and managing strategic partnerships with internal and external stakeholders focused on recruitment across international markets. She is an external examiner at Kings College London for the MSc Neuroscience programme, Associate Editor for the Journal of Neuroscience Research and a member of the Pharmacy and Pharmacogenomics Working Group for the Genomic Medicine Service Alliance (Northeast and Yorkshire). As a Trustee and Board member of the Cellar Trust (a UK-registered mental health charity), Sam is responsible for the charity, it’s activities and management supporting people's mental health across the Bradford district, Craven and surrounding areas.


Sam is an expert in developing preclinical models of psychiatry and behavioural paradigms to study novel receptor targets. She has experience in managing research projects within academia as well as commercial environments and collaborates with major pharmaceutical stakeholders focusing on research and development of antipsychotic and cognitive-enhancing drugs, including their regulatory (FDA) approval.As a Research Fellow at Wolfson Centre for Applied Health Research she has experience in applied health research related to mental health and pharmacogenomics. Sam has supervised 5 PhD students and led several MSc projects. She has acted as an independent chair, internal and external examiner for several PhD students. Her research has received funding from the Royal Society UK, Alzheimer's Research UK and Bradford District Care NHS Foundation Trust. As deputy research director (Health Society People and Place) she is leading the integration of interdisciplinary research themes across the Faculty of Life Sciences, including postgraduate research programmes (PhD, MD). Current research projects include:Exploration of the role of glutamatergic pharmacology and receptor modifications underlying cognitive function in rodent models of schizophreniaInvestigation of the importance of the biological rhythms and the dopamine system in cognitive dysfunctionValidation of a stem-cell secretome as a therapeutic for neurodegeneration · Implementation of pharmacogenomic testing in mental health settings to inform and improve medicines optimisation and personalised prescribingStudies on students’ views about team-based learning and implications of online teaching.


There are 19 publications involving or that are attributed to Dr. Samantha McLean. They are listed as:

  • anet/cos (1)
  • peer reviewed journal (18)


Dr. Samantha McLean has 1 publication(s) listed under anet/cos.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Pharmacogenomics is the future of prescribing inpsychiatry 2022 309 Jameson A, Fylan B, Bristow GC, Sagoo GS, Dalton C, Cardno A, Sohal J, McLean SL 0031-6873 10.1211/PJ.2022.1.152215

Peer Reviewed Journal

Dr. Samantha McLean has 18 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field 2010 McLean, Samantha L.; Woolley, M.L.; Neill, Joanna C.
The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis 2022 Frontiers in Physiology 30 May 2022 Yun, H: Dumbell, R: Hanna, K: Bowen, J; McLean, SL; Kantamneni, S; Pors, K; Wu, QF; Helfer, G
What Are the Barriers and Enablers to the Implementation of Pharmacogenetic Testing in Mental Health Care Settings? 2021 Frontiers in Genetics 12 Jameson A, Fylan B, Bristow GC, Sagoo GS, Dalton C, Cardno A, Sohal J, McLean SL
The effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 rats. 2021 Physiology and Behavior McLean SL;Yun H;Tedder A;Helfer G; 1873-507X 10.1016/j.physbeh.2021.113496
(3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) - a novel cortical-preferring catecholamine transmission- and cognition-promoting agent. 2020 Journal of Pharmacology and Experimental Therapeutics 374 404 - 419 Hjorth S; Waters S; Waters N; Tedroff J; Svensson P; Fagerberg A; Edling M; Svanberg B; Ljung E; Gunnergren J; McLean SL; Grayson B; Idris NF; Neill JC; Sonesson C 1521-0103 10.1124/jpet.120.000037
Stabilized low-n amyloid-ß oligomers induce robust novel object recognition deficits associated with inflammatory, synaptic, and GABAergic dysfunction in the rat 2018 Watremez, W.; Jackson, J.; Almari, B.; McLean, Samantha L.; Grayson, B.; Neilla, J.C.; Fischer, N.; Allouche, A.; Koziel, V.; Pillot, T.; Harte, M.K.
Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation 2017 McLean, Samantha L.; Harte, Michael K.; Neill, Joanna C.; Young, A.M.J.
D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia 2009 McLean, Samantha L.; Idris, Nagi F.; Woolley, M.L.; Neill, Joanna C.
Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat 2009 McLean, Samantha L.; Woolley, M.L.; Thomas, D.; Neill, Joanna C.
Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat 2010 McLean, Samantha L.; Neill, Joanna C.; Idris, Nagi F.; Marston, H.M.; Wong, E.H.F.; Shahid, M.
Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia 2011 McLean, Samantha L.; Grayson, Ben; Idris, Nagi F.; Lesage, A.S.; Pemberton, D.J.; Mackie, C.; Neill, Joanna C.
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidineinduced cognitive deficit in the attentional set-shifting task in female rats 2012 McLean, Samantha L.; Idris, Nagi F.; Grayson, Ben; Gendle, D.F.; Mackie, C.; Lesage, A.S.; Pemberton, D.J.; Neill, Joanna C.
Using haloperidol as an anti-emetic in palliative care: informing practice through evidence from cancer treatment and post-operative contexts 2013 McLean, Samantha L.; Blenkinsopp, Alison; Bennett, M.I.
Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism 2010 Neill, Joanna C.; Barnes, Samuel; Cook, Samantha; Grayson, Ben; Idris, Nagi F.; McLean, Samantha L.; Snigdha, S.; Rajagopal, Lakshmi; Harte, Michael K.
Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders 2016 McLean, Samantha L.; Grayson, Ben; Marsh, S.; Zarroug, S.H.O.; Harte, Michael K.; Neill, Joanna C.
Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain 2011 Snigdha, S.; Neill, Joanna C.; McLean, Samantha L.; Shemar, G.K.; Cruise, L.; Shahid, M.; Henry, B.
A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats 2008 McLean, Samantha L.; Beck, J.P.; Woolley, M.L.; Neill, Joanna C.
Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats 2010 McLean, Samantha L.; Grayson, Ben; Harris, M.; Protheroe, C.; Bate, S.; Woolley, M.L.; Neill, Joanna C.