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Professor Sherif El-Khamisy

Director/Associate Dean(R & I)

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Telephone +441274 238458


I am a pharmacist interested in understanding how cells maintain genomic integrity. I use interdisciplinary approach fusing genetics, cell biology, biochemistry and spectroscopy with clinical expertise. To further strengthen our translational agenda, I recently took up a joint appointment between the University of Sheffield and the University of Bradford to head the Institute of Cancer Therapeutics. My contributions led to discovery of novel genetic pathways, influenced healthcare practice and developed new technologies. My early work demonstrated a role for PARP1 and CK2 during chromosomal single-strand break (SSB) repair (NAR 2003, Cell 2004). I then moved into more translational aspects, which led to the identification, for the first time, of a defect in SSB repair in two human disorders (Nature 2005 and 2006). Following training at St Jude Hospital in the US, I employed mice to demonstrate the importance of SSB repair for organismal function (EMBO J 2007 and Nature Neuroscience 2009). My interest in this area led to a search for novel activities that repair topoisomerase-linked DNA breaks and resulted in the discovery of the enzyme that repairs topoisomerase 2 - mediated DNA damage, TDP2 (Nature 2009). This seminal finding is critical for a broad range of human disease including cancer. I demonstrated that topoisomerase-induced DNA breaks are pathogenic in other disorders (Hum Mol Gent 2010, Nature Genetics 2014, Nature Neuroscience 2017) and identified key posttranslational modifications and functions (Nature Communications 2012, NAR 2012 & 2016 and Cell Reports 2018). I reviewed the importance of topoisomerase-mediated DNA repair (Nature Rev Cancer 2015, Brain 2018) and described how it maintains mitochondrial gene transcription (Science Advances 2017). We uncovered a novel mechanism by which typhoid toxin exhausts the DNA repair machinery (Nature Communications 2019) and identified TEX264 as a novel component of the topoisomerase-mediated DNA repair pathway (Nature Communications 2020).


Teaching interests

For lab details please visit:

Professional activities

  • 01-JAN-05: University of Sussex - PhD
  • 01-JAN-02: American university in Cairo - Diploma in Business Administration
  • 01-JAN-00: Ain Shams University - Pharm Sciences
  • 01-JAN-97: Cairo University - PharmB

  • University of Sheffield - Co-Founder of the Healthy Lifespan institute
  • University of Sheffield - Director of Research and Innovation DoMBB
  • University of Sussex - Group Leader and Wellcome Trust Fellow

  • Royal Society of Chemistry, Fellow
  • Royal Society of Biology , Fellow
  • The Lister Institute, Fellow
  • The Pharmaceutical Society, Member

  • HELSI Exec Board,
  • Neuroscience Exec Board ,
  • Res Exec Board,
  • Promotion Committee,

  • 01-JAN-18: Fellow of the Royal Society of Chemistry
  • 01-JAN-17: Fellow of the Royal Society of Biology
  • 01-JAN-16: Shoman Award for Medical Sciences
  • 01-JAN-15: Wellcome Trust Investigator Award
  • 01-JAN-15: Lister Research Fellowship Prize
  • 01-JAN-11: The State Award for Medical Sciences
  • 01-JAN-08: Welcome Trust Fellowship
  • 01-JAN-04: Biochemical Society Award

  • Head of ICT
  • Mol Biol and Biotechnology
  • Healthy Life Span Institute

  • Arabic
  • German


TitleTEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. (2020)
AuthorsFielden J;Wiseman K;Torrecilla I;Li S;Hume S;Chiang SC;Ruggiano A;Narayan Singh A;Freire R;Hassanieh S;Domingo E;Vendrell I;Fischer R;Kessler BM;Maughan TS;El-Khamisy SF;Ramadan K;
JournalNature Communications
TitleInvestigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. (2020)
AuthorsKim HR;Santhakumar K;Markham E;Baldera D;Greenald D;Bryant HE;El-Khamisy SF;van Eeden FJ;
TitleNucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells. (2020)
AuthorsHalliwell JA;Frith TJR;Laing O;Price CJ;Bower OJ;Stavish D;Gokhale PJ;Hewitt Z;El-Khamisy SF;Barbaric I;Andrews PW;
JournalStem Cell Reports
TitleNucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. (2019)
AuthorsOsman DI;El-Sheikh SM;Sheta SM;Ali OI;Salem AM;Shousha WG;El-Khamisy SF;Shawky SM;
JournalBiosensors and Bioelectronics
TitleDNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms. (2019)
AuthorsAbugable AA;Morris JLM;Palminha NM;Zaksauskaite R;Ray S;El-Khamisy SF;
JournalDNA Repair
TitleTyphoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. (2019)
AuthorsIbler AEM;ElGhazaly M;Naylor KL;Bulgakova NA;F El-Khamisy S;Humphreys D;
JournalNature Communications
TitleUVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy. (2018)
AuthorsKassouf N;Kay CWM;Volkov A;Chiang SC;Birch-Machin MA;El-Khamisy SF;Haywood RM;
JournalFree Radical Biology and Medicine
TitleStudying TDP1 Function in DNA Repair. (2018)
AuthorsChiang SC;Liversidge K;El-Khamisy SF;
JournalMethods in molecular biology (Clifton, N.J.)
TitleUCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. (2018)
AuthorsLiao C;Beveridge R;Hudson JJR;Parker JD;Chiang SC;Ray S;Ashour ME;Sudbery I;Dickman MJ;El-Khamisy SF;
JournalCell Reports
TitleIncreased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. (2018)
AuthorsHegazy MT;Allam WR;Hussein MA;Zoheir N;Quartuccio L;El-Khamisy SF;Ragab G; ;
TitleGold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. (2018)
AuthorsShawky SM;Awad AM;Abugable AA;El-Khamisy SF;
JournalInternational journal of nanomedicine
TitleRecent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's. (2018)
AuthorsFleifel D;Rahmoon MA;AlOkda A;Nasr M;Elserafy M;El-Khamisy SF;
JournalGenetic Engineering and Biotechnology Journal
TitlemiR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. (2018)
AuthorsMohamed Z;Hassan MK;Okasha S;Mitamura T;Keshk S;Konno Y;Kato T;El-Khamisy SF;Ohba Y;Watari H;
TitlePerturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. (2018)
AuthorsWalker C;El-Khamisy SF;
TitleStudy of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells. (2018)
AuthorsMoradzadeh M;Ghorbani A;Erfanian S;Mohaddes ST;Rahimi H;Karimiani EG;Mashkani B;Chiang SC;El-Khamisy SF;Tabarraei A;Sadeghnia HR;
JournalJournal of Cellular Biochemistry
TitleCompeting endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer. (2018)
AuthorsSamir N;Matboli M;El-Tayeb H;El-Tawdi A;Hassan MK;Waly A;El-Akkad HAE;Ramadan MG;Al-Belkini TN;El-Khamisy S;El-Asmar F;
JournalJournal of Cellular Biochemistry
TitleRad5, HLTF, and SHPRH: A Fresh View of an Old Story. (2018)
AuthorsElserafy M;Abugable AA;Atteya R;El-Khamisy SF;
JournalTrends in Genetics
TitleA thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. (2018)
AuthorsSoutham HM;Smith TW;Lyon RL;Liao C;Trevitt CR;Middlemiss LA;Cox FL;Chapman JA;El-Khamisy SF;Hippler M;Williamson MP;Henderson PJF;Poole RK;
JournalRedox Biology
TitleChoose your yeast strain carefully: the RAD5 gene matters. (2018)
AuthorsElserafy M;El-Khamisy SF;
JournalNature Reviews Molecular Cell Biology
TitleGold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. (2017)
AuthorsShawky SM;Awad AM;Allam W;Alkordi MH;El-Khamisy SF;
JournalBiosensors and Bioelectronics
TitleC9orf72 expansion disrupts ATM-mediated chromosomal break repair. (2017)
AuthorsWalker C;Herranz-Martin S;Karyka E;Liao C;Lewis K;Elsayed W;Lukashchuk V;Chiang SC;Ray S;Mulcahy PJ;Jurga M;Tsagakis I;Iannitti T;Chandran J;Coldicott I;De Vos KJ;Hassan MK;Higginbottom A;Shaw PJ;Hautbergue GM;Azzouz M;El-Khamisy SF;
JournalNature Neuroscience
TitleViral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits. (2017)
AuthorsHerranz-Martin S;Chandran J;Lewis K;Mulcahy P;Higginbottom A;Walker C;Valenzuela IMY;Jones RA;Coldicott I;Iannitti T;Akaaboune M;El-Khamisy SF;Gillingwater TH;Shaw PJ;Azzouz M;
JournalDisease models & mechanisms
TitleChemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. (2017)
AuthorsAtteya R;Ashour ME;Ibrahim EE;Farag MA;El-Khamisy SF;
JournalMechanisms of Ageing and Development
TitleMitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. (2017)
AuthorsChiang SC;Meagher M;Kassouf N;Hafezparast M;McKinnon PJ;Haywood R;El-Khamisy SF;
JournalScience Advances
TitleRole of Protein Linked DNA Breaks in Cancer. (2017)
AuthorsAllam WR;Ashour ME;Waly AA;El-Khamisy S;
JournalAdvances in Experimental Medicine and Biology
TitlePersonalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism. (2017)
AuthorsAbugable AA;Awwad DA;Fleifel D;Ali MM;El-Khamisy S;Elserafy M;
JournalAdvances in Experimental Medicine and Biology
TitleBuilding Bridges through Science. (2017)
AuthorsLissek T;Adams M;Adelman J;Ahissar E;Akaaboune M;Akil H;al'Absi M;Arain F;Arango-Lasprilla JC;Atasoy D;Avila J;Badawi A;Bading H;Baig AM;Baleriola J;Belmonte C;Bertocchi I;Betz H;Blakemore C;Blanke O;Boehm-Sturm P;Bonhoeffer T;Bonifazi P;Brose N;Campolongo P;Celikel T;Chang CC;Chang TY;Citri A;Cline HT;Cortes JM;Cullen K;Dean K;Delgado-Garcia JM;Desroches M;Disterhoft JF;Dowling JE;Draguhn A;El-Khamisy SF;El Manira A;Enam SA;Encinas JM;Erramuzpe A;Esteban JA;Fariñas I;Fischer E;Fukunaga I;Gabilondo I;Ganten D;Gidon A;Gomez-Esteban JC;Greengard P;Grinevich V;Gruart A;Guillemin R;Hariri AR;Hassan B;Häusser M;Hayashi Y;Hussain NK;Jabbar AA;Jaber M;Jahn R;Janahi EM;Kabbaj M;Kettenmann H;Kindt M;Knafo S;Köhr G;Komai S;Krugers H;Kuhn B;Ghazal NL;Larkum ME;London M;Lutz B;Matute C;Martinez-Millan L;Maroun M;McGaugh J;Moustafa AA;Nasim A;Nave KA;Neher E;Nikolich K;Outeiro T;Palmer LM;Penagarikano O;Perez-Otano I;Pfaff DW;Poucet B;Rahman AU;Ramos-Cabrer P;Rashidy-Pour A;Roberts RJ;Rodrigues S;Sanes JR;Schaefer AT;Segal M;Segev I;Shafqat S;Siddiqui NA;Soreq H;Soriano-García E;Spanagel R;Sprengel R;Stuart G;Südhof TC;Tønnesen J;Treviño M;Uthman BM;Venter JC;Verkhratsky A;Weiss C;Wiesel TN;Yaksi E;Yizhar O;Young LJ;Young P;Zawia NH;Zugaza JL;Hasan MT;
TitleSRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. (2017)
AuthorsHautbergue GM;Castelli LM;Ferraiuolo L;Sanchez-Martinez A;Cooper-Knock J;Higginbottom A;Lin YH;Bauer CS;Dodd JE;Myszczynska MA;Alam SM;Garneret P;Chandran JS;Karyka E;Stopford MJ;Smith EF;Kirby J;Meyer K;Kaspar BK;Isaacs AM;El-Khamisy SF;De Vos KJ;Ning K;Azzouz M;Whitworth AJ;Shaw PJ;
JournalNature Communications
TitleEpigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. (2017)
AuthorsMeisenberg C;Ashour ME;El-Shafie L;Liao C;Hodgson A;Pilborough A;Khurram SA;Downs JA;Ward SE;El-Khamisy SF;
JournalNucleic Acids Research
TitleA Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. (2016)
AuthorsMazouzi A;Stukalov A;Müller AC;Chen D;Wiedner M;Prochazkova J;Chiang SC;Schuster M;Breitwieser FP;Pichlmair A;El-Khamisy SF;Bock C;Kralovics R;Colinge J;Bennett KL;Loizou JI;
JournalCell Reports
TitleIsoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. (2016)
AuthorsElsayed W;El-Shafie L;Hassan MK;Farag MA;El-Khamisy SF;
JournalScientific Reports
TitleClinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. (2015)
AuthorsMeisenberg C;Gilbert DC;Chalmers A;Haley V;Gollins S;Ward SE;El-Khamisy SF;
JournalMolecular Cancer Therapeutics
TitleTopoisomerase-mediated chromosomal break repair: an emerging player in many games. (2015)
AuthorsAshour ME;Atteya R;El-Khamisy SF;
JournalNature Reviews. Cancer
TitleP18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane. (2015)
AuthorsHassan MK;Watari H;Mitamura T;Mohamed Z;El-Khamisy SF;Ohba Y;Sakuragi N;
TitleExpression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. (2015)
AuthorsCarroll J;Page TK;Chiang SC;Kalmar B;Bode D;Greensmith L;Mckinnon PJ;Thorpe JR;Hafezparast M;El-Khamisy SF;
JournalHuman Molecular Genetics
TitleTDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. (2014)
AuthorsMeisenberg C;Ward SE;Schmid P;El-Khamisy SF;
JournalJournal of Cancer Science and Therapy
TitleTDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. (2014)
AuthorsAlagoz M;Wells OS;El-Khamisy SF;
JournalNucleic Acids Research
TitleDevelopment of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. (2014)
AuthorsWalker S;Meisenberg C;Bibby RA;Askwith T;Williams G;Rininsland FH;Pearl LH;Oliver AW;El-Khamisy S;Ward S;Atack JR;
JournalAnalytical Biochemistry
TitleTDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. (2014)
AuthorsGómez-Herreros F;Schuurs-Hoeijmakers JH;McCormack M;Greally MT;Rulten S;Romero-Granados R;Counihan TJ;Chaila E;Conroy J;Ennis S;Delanty N;Cortés-Ledesma F;de Brouwer AP;Cavalleri GL;El-Khamisy SF;de Vries BB;Caldecott KW;
JournalNature Genetics
TitleATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. (2013)
AuthorsAlagoz M;Chiang SC;Sharma A;El-Khamisy SF;
JournalPLoS ONE
TitleTopoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets. (2012)
AuthorsGilbert DC;Chalmers AJ;El-Khamisy SF;
JournalBritish Journal of Cancer
TitleSUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair. (2012)
AuthorsHudson JJ;Chiang SC;Wells OS;Rookyard C;El-Khamisy SF;
JournalNature Communications
TitleDNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets. (2012)
AuthorsAlagoz M;Gilbert DC;El-Khamisy S;Chalmers AJ;
JournalCurrent Medicinal Chemistry
TitleTDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. (2012)
AuthorsZeng Z;Sharma A;Ju L;Murai J;Umans L;Vermeire L;Pommier Y;Takeda S;Huylebroeck D;Caldecott KW;El-Khamisy SF;
JournalNucleic Acids Research
TitleTyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites. (2012)
AuthorsLebedeva NA;Rechkunova NI;El-Khamisy SF;Lavrik OI;
TitleTo live or to die: a matter of processing damaged DNA termini in neurons. (2011)
AuthorsEl-Khamisy SF;
JournalEMBO Molecular Medicine
TitleTDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. (2011)
AuthorsZeng Z;Cortés-Ledesma F;El Khamisy SF;Caldecott KW;
JournalJournal of Biological Chemistry
TitleTDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage. (2010)
AuthorsChiang SC;Carroll J;El-Khamisy SF;
JournalCell Cycle
TitleMutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. (2010)
AuthorsKerzendorfer C;Whibley A;Carpenter G;Outwin E;Chiang SC;Turner G;Schwartz C;El-Khamisy S;Raymond FL;O'Driscoll M;
JournalHuman Molecular Genetics
TitleThe genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. (2009)
AuthorsLee Y;Katyal S;Li Y;El-Khamisy SF;Russell HR;Caldecott KW;McKinnon PJ;
JournalNature Neuroscience
TitleDefective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia (2009)
AuthorsReynolds J.;El-Khamisy S.;Katyal S.;Clements P.;McKinnon P.;Caldecott K.
JournalMolecular and Cellular Biology
TitleShort-patch single-strand break repair in ataxia oculomotor apraxia-1. (2009)
AuthorsReynolds JJ;El-Khamisy SF;Caldecott KW;
JournalBiochemical Society Transactions
TitleSynergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. (2009)
AuthorsEl-Khamisy SF;Katyal S;Patel P;Ju L;McKinnon PJ;Caldecott KW;
JournalDNA Repair
TitleA human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. (2009)
AuthorsCortes Ledesma F;El Khamisy SF;Zuma MC;Osborn K;Caldecott KW;
TitleTDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. (2007)
AuthorsEl-Khamisy SF;Hartsuiker E;Caldecott KW;
JournalDNA Repair
TitleTDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. (2007)
AuthorsKatyal S;el-Khamisy SF;Russell HR;Li Y;Ju L;Caldecott KW;McKinnon PJ;
JournalEMBO Journal
TitleDNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. (2007)
AuthorsEl-Khamisy SF;Caldecott KW;
TitleAPLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. (2007)
AuthorsIles N;Rulten S;El-Khamisy SF;Caldecott KW;
JournalMolecular and Cellular Biology
TitleTDP1-dependent DNA single-strand break repair and neurodegeneration. (2006)
AuthorsEl-Khamisy SF;Caldecott KW;
TitleMeasurement of Chromosomal DNA Single-Strand Breaks and Replication Fork Progression Rates (2006)
AuthorsBreslin C.;Clements P.;El-Khamisy S.;Petermann E.;Iles N.;Caldecott K.
JournalMethods in Enzymology
TitleThe neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. (2006)
AuthorsAhel I;Rass U;El-Khamisy SF;Katyal S;Clements PM;McKinnon PJ;Caldecott KW;West SC;
TitleDefective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. (2005)
AuthorsEl-Khamisy SF;Saifi GM;Weinfeld M;Johansson F;Helleday T;Lupski JR;Caldecott KW;
TitleThe protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks (2004)
AuthorsLoizou J.;El-Khamisy S.;Zlatanou A.;Moore D.;Chan D.;Qin J.;Sarno S.;Meggio F.;Pinna L.;Caldecott K.
TitleA requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. (2003)
AuthorsEl-Khamisy SF;Masutani M;Suzuki H;Caldecott KW;
JournalNucleic Acids Research

TitleStudying TDP1 function in DNA repair (2018)
AuthorsChiang S.;Liversidge K.;El-Khamisy S.
JournalMethods in Molecular Biology
PublisherDNA repair
TitleRole of protein linked DNA breaks in cancer (2017)
AuthorsAllam W.;Ashour M.;Waly A.;El-Khamisy S.
JournalAdvances in Experimental Medicine and Biology
PublisherDNA repair

Other typeReviews
TitleNucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis (2019)
AuthorsOsman D.I.;El-Sheikh S.M.;Sheta S.M.;Ali O.I.;Salem A.M.;Shousha W.G.;EL-Khamisy S.F.;Shawky S.M.
JournalBiosensors and Bioelectronics
Other typeReviews
TitleDNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms (2019)
AuthorsAbugable A.A.;Morris J.L.M.;Palminha N.M.;Zaksauskaite R.;Ray S.;El-Khamisy S.F.
JournalDNA Repair
Other typeReviews
TitlePerturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia (2018)
AuthorsWalker C.;El-Khamisy S.
Other typeReviews
TitleTopoisomerase i inhibition in colorectal cancer: Biomarkers and therapeutic targets (2012)
AuthorsGilbert D.;Chalmers A.;El-Khamisy S.
JournalBritish Journal of Cancer
Other typeReviews
TitleTo live or to die: A matter of processing damaged DNA termini in neurons (2011)
AuthorsEl-Khamisy S.
JournalEMBO Molecular Medicine
Other typeReviews
TitleDNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 (2007)
AuthorsEl-Khamisy S.;Caldecott K.
Other typeReviews
TitleTDP1-dependent DNA single-strand break repair and neurodegeneration (2006)
AuthorsEl-Khamisy S.;Caldecott K.