2019 - Group Lead Pharmacology & Experimental Therapeutics, University of Bradford
2013 - Lecturer in Therapeutics, University of Bradford
2011 - 2013 Postdoctoral researcher, College of Life Sciences, University of Dundee
2008 - 2011 Postdoctoral researcher, School of Medicine, University of Dundee
2001 - 2004 Alzheimer's Society Research Fellowship, Institute of Psychiatry, King's College London
1997 - 2001 Phd, Institute of Psychiatry, King's College London
1996 - 1997 MSc Neuroscience, Institute of Psychiatry, King's College London
1992 -1996 BSc Biochemistry, University of Bath
Research in my laboratory focuses on identifying molecular mechanisms that underlie age-related cognitive decline and dementia. Increasing data from observational studies has identified a number of potentially modifiable risk factors associated with an increased risk of developing dementia including diabetes, obesity, physical inactivity, low educational attainment, depression, smoking, and hypertension. In addition, these risk factors are additive suggesting that common signaling pathways underlie these risk factors. A key observation of a number of these risk factors is that they display alterations in energy intake/expenditure and glucose metabolism. It has previously been established that there is a link between altered energy intake, insulin sensitivity and poor cognitive performance. However, the precise molecular mechanisms that underlies the observed decrease in cognitive performance remains to be established. One possible mechanism is protein O-GlcNAcylation (a glucose-dependent post translational modification). Protein O-GlcNAcylation is altered in Alzheimer’s disease. Other than a well-established role in gene expression, how protein O-GlcNAcylation effects protein function is still to be fully determined. Work in my laboratory aims to elucidate the links between glucose-dependent alterations in protein modifications, nutritional status, and ageing to molecular mechanisms underlying dementia.
Malik B.;Fernandes C.;Killick R.;Usardi A.;Williamson R.;Kellie S.;Anderton B.;Reynolds C. (2014) Microarrays: Principles, Applications and Technologies. 269-295.
Thompson AJ;Williamson R; (2010) LC-Ms/MS in Proteomics: Methods and Applications. Springer.
Bolanle IO;Riches-Suman K;Williamson R;Palmer TM; (2021) Pharmacological Research. 165
Bolanle IO;Riches-Suman K;Loubani M;Williamson R;Palmer TM; (2021) Nutrition, metabolism, and cardiovascular diseases : NMCD. 31
Muha, V.; Williamson, Ritchie; Hills, R.; McNeilly, A.D.; McWilliams, T.G.; Alonso, J.; Schimpl, M.; Leney, A.C.; Heck, A.J.R.; Sutherland, C.; Read, K.D.; McCrimmon, R.J.; Brooks, S.P.; van Aalten, D.M.F. (2019)
Selvan, N.; Williamson, Ritchie; Mariappa, D.; Campbell, D.G.; Gourlay, R.; Ferenbach, A.T.; Aristotelous, T.; Hopkins-Navratilova, I.; Trost, M.; van Aalten, D.M.F. (2017)
Grasso, L.; Suska, O.; Davidson, L.; Gonatopolous-Pournatzis, T.; Williamson, Ritchie; Wasmus, L.; Wiedlich, S.; Peggie, M.; Stavridis, M.P.; Cowling, V.H. (2016)
Killick R;Ribe EM;Al-Shawi R;Malik B;Hooper C;Fernandes C;Dobson R;Nolan PM;Lourdusamy A;Furney S;Lin K;Breen G;Wroe R;To AW;Leroy K;Causevic M;Usardi A;Robinson M;Noble W;Williamson R;Lunnon K;Kellie S;Reynolds CH;Bazenet C;Hodges A;Brion JP;Stephenson J;Simons JP;Lovestone S; (2014) Molecular Psychiatry. 19
Williamson R;McNeilly A;Sutherland C; (2012) Biochemical Pharmacology. 84
Malik B;Fernandes C;Killick R;Wroe R;Usardi A;Williamson R;Kellie S;Anderton BH;Reynolds CH; (2012) Neurochemistry International. 61
McNeilly, A.D.; Williamson, Ritchie; Balfour, D.J.; Stewart, C.A.; Sutherland, C. (2012)
Usardi A;Pooler AM;Seereeram A;Reynolds CH;Derkinderen P;Anderton B;Hanger DP;Noble W;Williamson R; (2011) FEBS Journal. 278
Williamson R;van Aalten L;Mann DM;Platt B;Plattner F;Bedford L;Mayer J;Howlett D;Usardi A;Sutherland C;Cole AR; (2011) Journal of Alzheimer's Disease. 27
Williamson R;Sutherland C; (2011) Current Alzheimer Research. 8
Scales TM;Derkinderen P;Leung KY;Byers HL;Ward MA;Price C;Bird IN;Perera T;Kellie S;Williamson R;Anderton BH;Reynolds CH; (2011) Molecular Neurodegeneration. 6
McNeilly AD;Williamson R;Sutherland C;Balfour DJ;Stewart CA; (2011) BEHAVIOURAL BRAIN RESEARCH. 217
Williamson R;Thompson AJ;Abu M;Hye A;Usardi A;Lynham S;Anderton BH;Hanger DP; (2010) BMC Neuroscience. 11
Kickstein, E.; Krauss, S.; Thornhill, P.; Rutschow, D.; Zeller, R.; Sharkey, J.; Williamson, Ritchie; Fuchs, M.; Kohler, A.; Glossmann, H.; Schneider, R.; Sutherland, C.; Schweiger, S. (2010)
Soutar, M.P.; Kim, W.Y.; Williamson, Ritchie; Peggie, M.; Hastie, C.J.; McLauchlan, H.; Snider, W.D.; Gordon-Weeks, P.R.; Sutherland, C. (2010)
Thompson AJ;Williamson R;Schofield E;Stephenson J;Hanger D;Anderton B; (2009) Proteomics. 9
Lebouvier T;Scales TM;Williamson R;Noble W;Duyckaerts C;Hanger DP;Reynolds CH;Anderton BH;Derkinderen P; (2009) Journal of Alzheimer's Disease. 18
Williamson, Ritchie; Usardi, A.; Hanger, D.P.; Anderton, B.H. (2008)
Derkinderen P;Scales TM;Hanger DP;Leung KY;Byers HL;Ward MA;Lenz C;Price C;Bird IN;Perera T;Kellie S;Williamson R;Noble W;Van Etten RA;Leroy K;Brion JP;Reynolds CH;Anderton BH; (2005) The Journal of neuroscience : the official journal of the Society for Neuroscience. 25
Pariante CM;Hye A;Williamson R;Makoff A;Lovestone S;Kerwin RW; (2003) Neuropsychopharmacology. 28
Williamson R;Scales T;Clark BR;Gibb G;Reynolds CH;Kellie S;Bird IN;Varndell IM;Sheppard PW;Everall I;Anderton BH; (2002) The Journal of neuroscience : the official journal of the Society for Neuroscience. 22
Terry A.;Williamson R.;Gattu M.;Beach J.;McCurdy C.;Sparks J.;Pauly J. (1998) Neuropharmacology. 37, 93-102.
Bolanle I.O.;Riches-Suman K.;Loubani M.;Williamson R.;Palmer T.M. (2021) Nutrition, metabolism, and cardiovascular diseases : NMCD.
Bolanle I.O.;Riches-Suman K.;Williamson R.;Palmer T.M. (2021) Pharmacological Research.
Williamson R.;Sutherland C. (2011) Current Alzheimer Research.