Dr Ritchie Williamson
Associate Professor
| Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
|---|---|
| r.williamson7@bradford.ac.uk | |
| Telephone | +441274 236073 |
Biography
2019 - Group Lead Pharmacology & Experimental Therapeutics, University of Bradford
2013 - Lecturer in Therapeutics, University of Bradford
2011 - 2013 Postdoctoral researcher, College of Life Sciences, University of Dundee
2008 - 2011 Postdoctoral researcher, School of Medicine, University of Dundee
2001 - 2004 Alzheimer's Society Research Fellowship, Institute of Psychiatry, King's College London
1997 - 2001 Phd, Institute of Psychiatry, King's College London
1996 - 1997 MSc Neuroscience, Institute of Psychiatry, King's College London
1992 -1996 BSc Biochemistry, University of Bath
Research
Research in my laboratory focuses on identifying molecular mechanisms that underlie age-related cognitive decline and dementia. Increasing data from observational studies has identified a number of potentially modifiable risk factors associated with an increased risk of developing dementia including diabetes, obesity, physical inactivity, low educational attainment, depression, smoking, and hypertension. In addition, these risk factors are additive suggesting that common signaling pathways underlie these risk factors. A key observation of a number of these risk factors is that they display alterations in energy intake/expenditure and glucose metabolism. It has previously been established that there is a link between altered energy intake, insulin sensitivity and poor cognitive performance. However, the precise molecular mechanisms that underlies the observed decrease in cognitive performance remains to be established. One possible mechanism is protein O-GlcNAcylation (a glucose-dependent post translational modification). Protein O-GlcNAcylation is altered in Alzheimer’s disease. Other than a well-established role in gene expression, how protein O-GlcNAcylation effects protein function is still to be fully determined. Work in my laboratory aims to elucidate the links between glucose-dependent alterations in protein modifications, nutritional status, and ageing to molecular mechanisms underlying dementia.Publications
| Title | Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets. (2021) |
|---|---|
| Authors | Bolanle IO;Riches-Suman K;Williamson R;Palmer TM; |
| Journal | Pharmacological Research |
| DOI | 10.1016/j.phrs.2021.105467 |
| Title | Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation. (2021) |
| Authors | Bolanle IO;Riches-Suman K;Loubani M;Williamson R;Palmer TM; |
| Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD |
| DOI | 10.1016/j.numecd.2021.01.017 |
| Title | Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice (2019) |
| Authors | Muha, V.; Williamson, Ritchie; Hills, R.; McNeilly, A.D.; McWilliams, T.G.; Alonso, J.; Schimpl, M.; Leney, A.C.; Heck, A.J.R.; Sutherland, C.; Read, K.D.; McCrimmon, R.J.; Brooks, S.P.; van Aalten, D.M.F. |
| Title | Endoplasmic reticulum stress signalling induces casein kinase 1-dependent formation of cytosolic TDP-43 Inclusions in motor neuron-like cells (2019) |
| Authors | Hicks, D.A.; Cross, Laura L.; Williamson, Ritchie; Rattray, Marcus |
| Journal | Neurochemical Research |
| DOI | 10.1007/s11064-019-02832-2 |
| Title | A mutant O-GlcNAcase enriches Drosophila developmental regulators (2017) |
| Authors | Selvan, N.; Williamson, Ritchie; Mariappa, D.; Campbell, D.G.; Gourlay, R.; Ferenbach, A.T.; Aristotelous, T.; Hopkins-Navratilova, I.; Trost, M.; van Aalten, D.M.F. |
| Title | mRNA Cap Methylation in Pluripotency and Differentiation (2016) |
| Authors | Grasso, L.; Suska, O.; Davidson, L.; Gonatopolous-Pournatzis, T.; Williamson, Ritchie; Wasmus, L.; Wiedlich, S.; Peggie, M.; Stavridis, M.P.; Cowling, V.H. |
| Title | Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. (2014) |
| Authors | Killick R;Ribe EM;Al-Shawi R;Malik B;Hooper C;Fernandes C;Dobson R;Nolan PM;Lourdusamy A;Furney S;Lin K;Breen G;Wroe R;To AW;Leroy K;Causevic M;Usardi A;Robinson M;Noble W;Williamson R;Lunnon K;Kellie S;Reynolds CH;Bazenet C;Hodges A;Brion JP;Stephenson J;Simons JP;Lovestone S; |
| Journal | Molecular Psychiatry |
| DOI | 10.1038/mp.2012.163 |
| Title | Insulin resistance in the brain: an old-age or new-age problem? (2012) |
| Authors | Williamson R;McNeilly A;Sutherland C; |
| Journal | Biochemical Pharmacology |
| DOI | 10.1016/j.bcp.2012.05.007 |
| Title | A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin (2012) |
| Authors | McNeilly, A.D.; Williamson, Ritchie; Balfour, D.J.; Stewart, C.A.; Sutherland, C. |
| Title | Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons. (2012) |
| Authors | Malik B;Fernandes C;Killick R;Wroe R;Usardi A;Williamson R;Kellie S;Anderton BH;Reynolds CH; |
| Journal | Neurochemistry International |
| DOI | 10.1016/j.neuint.2012.05.006 |
| Title | Neuronal membranes are key to the pathogenesis of Alzheimer's disease: the role of both raft and non-raft membrane domains. (2011) |
| Authors | Williamson R;Sutherland C; |
| Journal | Current Alzheimer Research |
| Title | CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases. (2011) |
| Authors | Williamson R;van Aalten L;Mann DM;Platt B;Plattner F;Bedford L;Mayer J;Howlett D;Usardi A;Sutherland C;Cole AR; |
| Journal | Journal of Alzheimer's Disease |
| DOI | 10.3233/JAD-2011-110617 |
| Title | Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. (2011) |
| Authors | Usardi A;Pooler AM;Seereeram A;Reynolds CH;Derkinderen P;Anderton B;Hanger DP;Noble W;Williamson R; |
| Journal | FEBS Journal |
| DOI | 10.1111/j.1742-4658.2011.08218.x |
| Title | Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn. (2011) |
| Authors | Scales TM;Derkinderen P;Leung KY;Byers HL;Ward MA;Price C;Bird IN;Perera T;Kellie S;Williamson R;Anderton BH;Reynolds CH; |
| Journal | Molecular Neurodegeneration |
| DOI | 10.1186/1750-1326-6-12 |
| Title | High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task. (2011) |
| Authors | McNeilly AD;Williamson R;Sutherland C;Balfour DJ;Stewart CA; |
| Journal | BEHAVIOURAL BRAIN RESEARCH |
| DOI | 10.1016/j.bbr.2010.10.017 |
| Title | Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling (2010) |
| Authors | Kickstein, E.; Krauss, S.; Thornhill, P.; Rutschow, D.; Zeller, R.; Sharkey, J.; Williamson, Ritchie; Fuchs, M.; Kohler, A.; Glossmann, H.; Schneider, R.; Sutherland, C.; Schweiger, S. |
| Title | Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain (2010) |
| Authors | Soutar, M.P.; Kim, W.Y.; Williamson, Ritchie; Peggie, M.; Hastie, C.J.; McLauchlan, H.; Snider, W.D.; Gordon-Weeks, P.R.; Sutherland, C. |
| Title | Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition. (2010) |
| Authors | Williamson R;Thompson AJ;Abu M;Hye A;Usardi A;Lynham S;Anderton BH;Hanger DP; |
| Journal | BMC Neuroscience |
| DOI | 10.1186/1471-2202-11-120 |
| Title | Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts. (2009) |
| Authors | Thompson AJ;Williamson R;Schofield E;Stephenson J;Hanger D;Anderton B; |
| Journal | Proteomics |
| DOI | 10.1002/pmic.200900006 |
| Title | The microtubule-associated protein tau is also phosphorylated on tyrosine. (2009) |
| Authors | Lebouvier T;Scales TM;Williamson R;Noble W;Duyckaerts C;Hanger DP;Reynolds CH;Anderton BH;Derkinderen P; |
| Journal | Journal of Alzheimer's Disease |
| DOI | 10.3233/JAD-2009-1116 |
| Title | Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism (2008) |
| Authors | Williamson, Ritchie; Usardi, A.; Hanger, D.P.; Anderton, B.H. |
| Title | Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. (2005) |
| Authors | Derkinderen P;Scales TM;Hanger DP;Leung KY;Byers HL;Ward MA;Lenz C;Price C;Bird IN;Perera T;Kellie S;Williamson R;Noble W;Van Etten RA;Leroy K;Brion JP;Reynolds CH;Anderton BH; |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| DOI | 10.1523/JNEUROSCI.1487-05.2005 |
| Title | The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. (2003) |
| Authors | Pariante CM;Hye A;Williamson R;Makoff A;Lovestone S;Kerwin RW; |
| Journal | Neuropsychopharmacology |
| DOI | 10.1038/sj.npp.1300195 |
| Title | Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. (2002) |
| Authors | Williamson R;Scales T;Clark BR;Gibb G;Reynolds CH;Kellie S;Bird IN;Varndell IM;Sheppard PW;Everall I;Anderton BH; |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Title | Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine (1998) |
| Authors | Terry A.;Williamson R.;Gattu M.;Beach J.;McCurdy C.;Sparks J.;Pauly J. |
| Journal | Neuropharmacology |
| DOI | 10.1016/S0028-3908(97)00142-1 |
| Title | Transcriptomic analysis of oligomeric amyloid-β treated primary cortical neurons reveals dysregulation of genes involved in the biosynthesis of steroids and cholesterol (2014) |
|---|---|
| Authors | Malik B.;Fernandes C.;Killick R.;Usardi A.;Williamson R.;Kellie S.;Anderton B.;Reynolds C. |
| Journal | Microarrays: Principles, Applications and Technologies |
| Title | Protocol for quantitative proteomics of cellular membranes and membrane rafts. (2010) |
| Authors | Thompson AJ;Williamson R; |
| Journal | LC-Ms/MS in Proteomics: Methods and Applications |
| Publisher | Springer |
| DOI | 10.1007/978-1-60761-780-8_14 |
| Other type | Reviews |
|---|---|
| Title | Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets (2021) |
| Authors | Bolanle I.O.;Riches-Suman K.;Williamson R.;Palmer T.M. |
| Journal | Pharmacological Research |
| DOI | 10.1016/j.phrs.2021.105467 |
| Other type | Reviews |
| Title | Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation (2021) |
| Authors | Bolanle I.O.;Riches-Suman K.;Loubani M.;Williamson R.;Palmer T.M. |
| Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD |
| DOI | 10.1016/j.numecd.2021.01.017 |
| Other type | Reviews |
| Title | Neuronal membranes are key to the pathogenesis of Alzheimer's disease: The role of both raft and non-raft membrane domains (2011) |
| Authors | Williamson R.;Sutherland C. |
| Journal | Current Alzheimer Research |
| DOI | 10.2174/156720511795256008 |