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Dr. Richard Wheelhouse,

Information about Dr. Richard Wheelhouse at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
+44 1274 234710


2016– Honorary Professor, Faculty of Pharmacy, University of Khartoum, Sudan.2014– Reader in Medicinal Chemistry.2006– EPSRC Peer Review College, nominated by the community.


Medicinal Chemistry Biophysics Anticancer Drugs Drug-Nucleic Acid Interactions Imidazotetrazines NMRUV

Research projects

Research projects involving Dr. Richard Wheelhouse.
Role Date Title/description Funder Award

Professional activities

Information about education, employment and areas of particular interest for Dr. Richard Wheelhouse is as follows:


  • Brown Cancer Center, University of Louisville, Kentucky, USA - Visiting Research Scientist in the year 2009 (specified as 01/04/2009)
  • Bradford School of Pharmacy - Head, Division of Pharmaceutics and Pharmaceutical Chemistry in the year 2006 (specified as 01/01/2006)
  • Bradford School of Pharmacy - Lecturer in the year 1998 (specified as 01/03/1998)
  • The University of Texas at Austin, USA - Research Fellow in the year 1996 (specified as 01/01/1996)
  • The University of Nottingham, UK - Senior Research Fellow in the year 1992 (specified as 01/01/1992)
  • Aston University,  Birmingham, UK - Research Associate in the year 1990 (specified as 01/01/1990)


There are 39 publications involving or that are attributed to Dr. Richard Wheelhouse. They are listed as:

  • book chapter (2)
  • peer reviewed journal (35)
  • reviews (2)

Book Chapter

Dr. Richard Wheelhouse has 2 publication(s) listed under book chapter.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Heterocyclic N-oxidation Using Urea-Hydrogen Peroxide: a Safe, Convenient and Effective source of Hydrogen Peroxide. 2009 Current Issues in Organic Chemistry Current Issues in Organic Chemistry 63 - 71 D. Rong, V.A. Phillips, R.T. Wheelhouse. Heron Press
NMR and Molecular Modelling Studies on the Mechanism of Action of the Antitumour Drug Temozolomide. 1995 Contributions to Oncology 49: Novel Approaches in Anticancer Drug Design Contributions to Oncology 49: Novel Approaches in Anticancer Drug Design 40 - 49 R.T. Wheelhouse,* B.J. Denny, M.F.G. Stevens S. Karger

Peer Reviewed Journal

Dr. Richard Wheelhouse has 35 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Polar, Functionalized Guanine-O6 Derivatives Resistant to Repair by O6-Alkylguanine-DNA Alkyltransferase: Implications for the Design of DNA-modifying Drugs. 2009 European Journal of Medicinal Chemistry 41 Wheelhouse, Richard T.; Bibby, Michael C.; Nicolaou, Anna; Pletsas, Dimitrios
Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth 2015 Molecular Cancer Therapeutics 14 Ramirez, Y.P.; Mladek, A.C.; Phillips, Roger M.; Gynther, M.; Rautio, J.; Ross, A.H.; Wheelhouse, Richard T.; Sakaria, J.N.
Probing the molecular recognition of a DNA·RNA hybrid duplex 2010 Angewandte Chemie - International Edition 49 3207 - 3210 Wheelhouse R.;Garbett N.;Buurma N.;Chaires J. 1433-7851 10.1002/anie.200907235
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells 1999 Cancer Research 59 639 - 644 Izbicka E.;Wheelhouse R.;Raymond E.;Davidson K.;Lawrence R.;Sun D.;Windle B.;Hurley L.;Von Hoff D. 0008-5472
Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles 2007 FEBS Journal 274 287 - 299 Banks E.;Doughty S.;Toms S.;Wheelhouse R.;Nicolaou A. 1742-464X 10.1111/j.1742-4658.2006.05583.x
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers 2004 Journal of Natural Products 67 1445 - 1449 Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wheelhouse R.;Wright C. 0163-3864 10.1021/np0305268
A novel, high-yielding synthesis of meso-substituted porphyrins via the direct arylation of porphine 2002 Tetrahedron Letters 43 9341 - 9342 Shi D.;Wheelhouse R. 0040-4039 10.1016/S0040-4039(02)02339-0
Antitumour imidazotetrazines. Part 39. Synthesis of bis(imidazotetrazine)s with saturated spacer groups 2000 Journal of the Chemical Society, Perkin Transactions 1 4432 - 4438 Arrowsmith J.;Jennings S.;Langnel D.;Wheelhouse R.;Stevens M. 1470-4358 10.1039/b005652i
A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea·hydrogen peroxide 2008 Tetrahedron Letters 49 6933 - 6935 Rong D.;Phillips V.;Rubio R.;Ángeles Castro M.;Wheelhouse R. 0040-4039 10.1016/j.tetlet.2008.09.124
Design, synthesis, and evaluation of novel biarylpyrimidines: A new class of ligand for unusual nucleic acid structures 2006 Journal of Medicinal Chemistry 49 5187 - 5198 Wheelhouse R.;Jennings S.;Phillips V.;Pletsas D.;Murphy P.;Garbett N.;Chaires J.;Jenkins T. 0022-2623 10.1021/jm060315a
Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase 2001 Journal of Medicinal Chemistry 44 4509 - 4523 Shi D.;Wheelhouse R.;Sun D.;Hurley L. 0022-2623 10.1021/jm010246u
Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos 1999 Anti-Cancer Drug Design 14 355 - 365 Izbicka E.;Nishioka D.;Marcell V.;Raymond E.;Davidson K.;Lawrence R.;Wheelhouse R.;Hurley L.;Wu R.;Von Hoff D. 0266-9536
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity 2012 Biochemical Pharmacology 83 1514 - 1522 Abdallah Q.;Phillips R.;Johansson F.;Helleday T.;Cosentino L.;Abdel-Rahman H.;Etzad J.;Wheelhouse R.;Kiakos K.;Bingham J.;Hartley J.;Patterson L.;Pors K. 0006-2952 10.1016/j.bcp.2012.02.017
Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position 2018 MedChemComm David Cousin;Marc G. Hummersone;Tracey D. Bradshaw;Jihong Zhang;Christopher J. Moody;Magdalena B. Foreiter;Helen S. Summers;William Lewis;Richard T. Wheelhouse;Malcolm F. G. Stevens; 10.1039/c7md00554g
Stabilization of a bimolecular triplex by 3'-S-phosphorothiolate modifications: An NMR and UV thermal melting investigation 2015 CHEMISTRY - A EUROPEAN JOURNAL 21 Evans, K.;Bhamra, I.;Wheelhouse, R.T.;Arnold, J.R.P.;Cosstick, R.;Fisher, J.; 10.1002/chem.201500369
The medicinal chemistry of imidazotetrazine prodrugs 2014 Pharmaceuticals Moody, C.L.;Wheelhouse, R.T.; 10.3390/ph7070797
Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA- methyltransferase, DNA mismatch repair, and p53 2013 Journal of Medicinal Chemistry 56 Pletsas, D.;Garelnabi, E.A.E.;Li, L.;Phillips, R.M.;Wheelhouse, R.T.; 10.1021/jm401121k
A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana 2008 Natural product communications Bayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.;
Biarylpyrimidines: a new class of ligand for high-order DNA recognition. 2003 CHEMICAL COMMUNICATIONS (PRINT) 0 Murphy PM;Phillips VA;Jennings SA;Garbett NC;Chaires JB;Jenkins TC;Wheelhouse RT; 10.1039/b301554h
A 15N NMR investigation of a series of benzotriazinones and related antitumour heterocycles 2002 Magnetic Resonance in Chemistry Vaughan, K.;Wilman, D.E.V.;Wheelhouse, R.T.;Stevens, M.F.G.; 10.1002/mrc.994
G-quadruplexes as targets for drug design 2000 Pharmacology and Therapeutics Hurley, L.H.;Wheelhouse, R.T.;Sun, D.;Kerwin, S.M.;Salazar, M.;Fedoroff, O.Y.;Han, F.X.;Han, H.;Izbicka, E.;Von Hoff, D.D.; 10.1016/S0163-7258(99)00068-6
Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition 1999 Journal of the American Chemical Society Han, F.X.;Wheelhouse, R.T.;Hurley, L.H.; 10.1021/ja984153m
Antitumour imidazotetrazines. Part 36. Conversion of 5-aminoimidazole-4-carboxamide to imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-ones and imidazo[1,5-a][1,3,5]triazin-4(3H)-ones related in structure to the antitumour agents temozolomide and mitozolomide 1998 Journal of the Chemical Society, Perkin Transactions 1 Wang, Y.;Wheelhouse, R.T.;Zhao, L.;Langnel, D.A.F.;Stevens, M.F.G.;
Cationic porphyrins as telomerase inhibitors: The interaction of tetra- (N-methyl-4-pyridyl)porphine with quadruplex DNA [1] 1998 Journal of the American Chemical Society Wheelhouse, R.T.;Sun, D.;Han, H.;Han, F.X.;Hurley, L.H.; 10.1021/ja973792e
Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2 1998 Journal of the American Chemical Society Moore II, B.M.;Seaman, F.C.;Wheelhouse, R.T.;Hurley, L.H.; 10.1021/ja974109r
Temozolomide: A review of its discovery, chemical properties, pre-clinical development and clinical trials 1997 Cancer Treatment Reviews Newlands, E.S.;Stevens, M.F.G.;Wedge, S.R.;Wheelhouse, R.T.;Brock, C.; 10.1016/S0305-7372(97)90019-0
Antitumour benzothiazoles. Part 4. An NMR study of the sites of protonation of 2-(4-aminophenyl)benzothiazoles 1996 Journal of the Chemical Society, Perkin Transactions 2 Wheelhouse, R.T.;Shi, D.-F.;Wilman, D.E.V.;Stevens, M.F.G.;
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. 1995 Medicinal Chemistry Clark AS;Deans B;Stevens MF;Tisdale MJ;Wheelhouse RT;Denny BJ;Hartley JA; 10.1021/jm00009a010
Antitumour imidazotetrazines. Part 31. The synthesis of isotopically labelled temozolomide and a multinuclear (1H, 13C, 15N) magnetic resonance investigation of temozolomide and mitozolomide 1995 Journal of the Chemical Society, Perkin Transactions 1 0 R.T. Wheelhouse,* D.E.V. Wilman, W. Thomson, M.F.G. Stevens
NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. 1994 Journal of Biochemistry Denny BJ;Wheelhouse RT;Stevens MF;Tsang LL;Slack JA; 10.1021/bi00197a003
Decomposition of the antitumour drug temozolomide in deuteriated phosphate buffer: Methyl group transfer is accompanied by deuterium exchange 1993 Journal of the Chemical Society - Series Chemical Communications Wheelhouse, R.T.;Stevens, M.F.G.;
Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate. 1992 Cancer Research Holley JL;Mather A;Wheelhouse RT;Cullis PM;Hartley JA;Bingham JP;Cohen GM;
Targeting of cytotoxic agents by polyamines: Synthesis of a chlorambucil-spermidine conjugate 1992 Chemical Communications 0 Cohen, G.M.;Cullis, P.M.;Hartley, J.A.;Mather, A.;Symons, M.C.R.;Wheelhouse, R.T.;
Motion of polyammonium ions on aqueous solutions of DNA 1990 Chemical Physics Letters Besley, S.;Cullis, P.M.;Partridge, R.;Symons, M.C.R.;Wheelhouse, R.T.; 10.1016/0009-2614(90)85415-9
Structural studies on bioactive compounds. Part 27. Chemistry of the immunomodulatory agent bropirimine. 1995 Anti-Cancer Drug Design 10 Stevens MF;Baig GU;Gate EN;Wheelhouse RT;


Dr. Richard Wheelhouse has 2 publication(s) listed under reviews.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Glioblastoma multiforme therapy and mechanisms of resistance 2013 Pharmaceuticals 6 1475 - 1506 Ramirez Y.;Weatherbee J.;Wheelhouse R.;Ross A. 1424-8247 10.3390/ph6121475
The medicinal chemistry of imidazotetrazine prodrugs 2014 Pharmaceuticals 7 797 - 838 Moody C.;Wheelhouse R. 1424-8247 10.3390/ph7070797