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Dr. Peter Nicholls

Information about Dr. Peter Nicholls at the University of Bradford.

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Dr Nicholls graduated with a Bachelor of Biomedical Sciences (Hons) in 2007, and received his PhD from the Hudson Institute of Medical Research and Monash University (2012, Australia) on the development and endocrine regulation of the reproductive tract. Dr Nicholls then undertook postdoctoral research at the Whitehead Institute, based within the Massachusetts Institute of Technology (USA). In this research, Dr Nicholls described how embryonic cells of the germline – the precursors of both eggs and sperm – become committed to produce gametes in adulthood, and no other cell type. When this commitment fails to occur, these embryonic cells may instead form germ cell tumours of the gonads, one of the most common cancers of young children, and the most common cancer in men under 45 years of age. Dr Nicholls has been awarded several honours, including the New Investigator Award from the Society for Reproductive Biology (Australia), and postdoctoral research fellowships awarded by the National Health and Medical Research Council (Australia) and the Hope Funds for Cancer Research (USA). In 2020, Dr Nicholls joined the Faculty of Life Sciences and the Institute of Cancer Therapeutics. In ongoing studies, Dr Nicholls uses a number of model organisms to explore how genetic and environmental factors influence the development of gonadal tumours from embryonic cells, and the molecular pathways that govern the sensitivity of tumours to chemotherapy.

Professional activities

Information about education, employment and areas of particular interest for Dr. Peter Nicholls is as follows:


  • Whitehead Institute (USA) - Postdoctoral Research Fellow in the year 2013 (specified as 28/01/2013)
  • University of Bradford - Lecturer in Molecular Biology in the year 2020 (specified as 01/12/2020)


  • Monash University (Australia) - Bachelor of Biomedical Sciences
  • Monash University (Australia) - Bachelor of Biomedical Science Honours
  • Monash University - PhD


There are 29 publications involving or that are attributed to Dr. Peter Nicholls.

Peer Reviewed Journal

Dr. Peter Nicholls has 29 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Androgen initiates Sertoli cell tight junction formation in the hypogonadal (hpg) mouse. 2012 Biology of Reproduction 87 McCabe MJ;Allan CM;Foo CF;Nicholls PK;McTavish KJ;Stanton PG; 1529-7268 10.1095/biolreprod.111.094318
Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium. 2022 British Journal of Cancer 127 Fonseca A;Lobo J;Hazard FK;Gell J;Nicholls PK;Weiss RS;Klosterkemper L;Volchenboum SL;Nicholson JC;Frazier AL;Amatruda JF;Bagrodia A;Lockley M;Murray MJ; 1532-1827 10.1038/s41416-022-02000-4
A gene deriving from the ancestral sex chromosomes was lost from the X and retained on the Y chromosome in eutherian mammals. 2022 BMC Biology 20 Hughes JF;Skaletsky H;Nicholls PK;Drake A;Pyntikova T;Cho TJ;Bellott DW;Page DC; 1741-7007 10.1186/s12915-022-01338-8
Germ cell determination and the developmental origin of germ cell tumors. 2021 Development - Company of Biologists 148 Nicholls PK;Page DC; 1477-9129 10.1242/dev.198150
Lentiviral transduction of rat Sertoli cells as a means to modify gene expression. 2012 Spermatogenesis 2 Nicholls PK;Stanton PG;Rainczuk KE;Qian H;Gregorevic P;Harrison CA; 2156-5554 10.4161/spmg.22516
Activin signaling regulates Sertoli cell differentiation and function. 2012 Endocrinology 153 Nicholls PK;Stanton PG;Chen JL;Olcorn JS;Haverfield JT;Qian H;Walton KL;Gregorevic P;Harrison CA; 1945-7170 10.1210/en.2012-1821
A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium. 2013 Biology of Reproduction 88 Du M;Young J;De Asis M;Cipollone J;Roskelley C;Takai Y;Nicholls PK;Stanton PG;Deng W;Finlay BB;Vogl AW; 1529-7268 10.1095/biolreprod.112.104851
Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation. 2013 Molecular and Cellular Endocrinology 377 Nicholls PK;Harrison CA;Rainczuk KE;Wayne Vogl A;Stanton PG; 1872-8057 10.1016/j.mce.2013.06.034
Differential permeability of the blood-testis barrier during reinitiation of spermatogenesis in adult male rats. 2014 Endocrinology 155 Haverfield JT;Meachem SJ;Nicholls PK;Rainczuk KE;Simpson ER;Stanton PG; 1945-7170 10.1210/en.2013-1878
The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice. 2014 Journal of Biological Chemistry 289 Koenig PA;Nicholls PK;Schmidt FI;Hagiwara M;Maruyama T;Frydman GH;Watson N;Page DC;Ploegh HL; 1083-351X 10.1074/jbc.M114.604132
Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling. 2015 PLoS Genetics 11 Hu YC;Nicholls PK;Soh YQ;Daniele JR;Junker JP;van Oudenaarden A;Page DC; 1553-7404 10.1371/journal.pgen.1005019
A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends. 2016 Journal of Cell Biology 213 Kern DM;Nicholls PK;Page DC;Cheeseman IM; 1540-8140 10.1083/jcb.201510117
Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice. 2017 Reproduction, Fertility and Development 29 Haverfield JT;Stanton PG;Loveland KL;Zahid H;Nicholls PK;Olcorn JS;Makanji Y;Itman CM;Simpson ER;Meachem SJ; 1031-3613 10.1071/RD15239
Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing. 2019 G3: Genes, Genomes, Genetics 9 Nicholls PK;Bellott DW;Cho TJ;Pyntikova T;Page DC; 2160-1836 10.1534/g3.119.300582
Retinoic Acid and Germ Cell Development in the Ovary and Testis. 2019 Biomolecules 9 Endo T;Mikedis MM;Nicholls PK;Page DC;de Rooij DG; 2218-273X 10.3390/biom9120775
DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors. 2020 eLife 9 Mikedis MM;Fan Y;Nicholls PK;Endo T;Jackson EK;Cobb SA;de Rooij DG;Page DC; 2050-084X 10.7554/eLife.56523
Mammalian germ cells are determined after PGC colonization of the nascent gonad. 2019 Proceedings of the National Academy of Sciences of the United States of America 116 Nicholls PK;Schorle H;Naqvi S;Hu YC;Fan Y;Carmell MA;Dobrinski I;Watson AL;Carlson DF;Fahrenkrug SC;Page DC; 1091-6490 10.1073/pnas.1910733116
GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. 2020 Developmental Cell 52 Dokshin GA;Davis GM;Sawle AD;Eldridge MD;Nicholls PK;Gourley TE;Romer KA;Molesworth LW;Tatnell HR;Ozturk AR;de Rooij DG;Hannon GJ;Page DC;Mello CC;Carmell MA; 1878-1551 10.1016/j.devcel.2019.11.006
Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells. 2009 Molecular Endocrinology 23 Bilandzic M;Chu S;Farnworth PG;Harrison C;Nicholls P;Wang Y;Escalona RM;Fuller PJ;Findlay JK;Stenvers KL; 0888-8809 10.1210/me.2008-0300
Proteomic characterization of midproliferative and midsecretory human endometrium. 2009 Journal of Proteome Research 8 Chen JI;Hannan NJ;Mak Y;Nicholls PK;Zhang J;Rainczuk A;Stanton PG;Robertson DM;Salamonsen LA;Stephens AN; 1535-3893 10.1021/pr801024g
Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function. 2009 Endocrinology 150 Nicholls PK;Harrison CA;Gilchrist RB;Farnworth PG;Stanton PG; 1945-7170 10.1210/en.2008-1048
Extra-ovarian expression and activity of growth differentiation factor 9. 2009 Journal of Endocrinology 202 Wang Y;Nicholls PK;Stanton PG;Harrison CA;Sarraj M;Gilchrist RB;Findlay JK;Farnworth PG; 1479-6805 10.1677/JOE-08-0563
Expression of nodal signalling components in cycling human endometrium and in endometrial cancer. 2009 Reproductive biology and endocrinology : RB&E 7 Papageorgiou I;Nicholls PK;Wang F;Lackmann M;Makanji Y;Salamonsen LA;Robertson DM;Harrison CA; 1477-7827 10.1186/1477-7827-7-122
Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE. 2010 Journal of Proteome Research 9 Stephens AN;Hannan NJ;Rainczuk A;Meehan KL;Chen J;Nicholls PK;Rombauts LJ;Stanton PG;Robertson DM;Salamonsen LA; 1535-3907 10.1021/pr901131p
Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma. 2010 Reproductive biology and endocrinology : RB&E 8 Yap J;Salamonsen LA;Jobling T;Nicholls PK;Dimitriadis E; 1477-7827 10.1186/1477-7827-8-63
Spermiation: The process of sperm release. 2011 Spermatogenesis 1 O'Donnell L;Nicholls PK;O'Bryan MK;McLachlan RI;Stanton PG; 2156-5554 10.4161/spmg.1.1.14525
Hormonal regulation of sertoli cell micro-RNAs at spermiation. 2011 Endocrinology 152 Nicholls PK;Harrison CA;Walton KL;McLachlan RI;O'Donnell L;Stanton PG; 1945-7170 10.1210/en.2010-1341
Embryo implantation is closely associated with dynamic expression of proprotein convertase 5/6 in the rabbit uterus. 2011 Reproductive biology and endocrinology : RB&E 9 Nicholls PK;Sun Z;Heng S;Li Y;Wang J;Nie G; 1477-7827 10.1186/1477-7827-9-43
Proprotein convertases in post-menopausal endometrial cancer: distinctive regulation and non-invasive diagnosis. 2012 Biochemical and Biophysical Research Communications 419 Singh H;Heng S;Nicholls PK;Li Y;Tai LT;Jobling T;Salamonsen LA;Nie G; 1090-2104 10.1016/j.bbrc.2012.02.111