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Dr. Karthic Swaminathan,
Lecturer in Skin Sciences

Information about Dr. Karthic Swaminathan at the University of Bradford.

School of Chemistry & Biosciences
(Faculty of Life Sciences)
+44 1274 234174
Photo of Dr. Karthic Swaminathan


Dr Swaminathan graduated with a Bachelor in Biochemistry in 2004(University of Madras, India) and with a dual degree in master’s inbiotechnology and a Post Graduate Diploma in Bioinformatics (2006) from BharathidasanUniversity, India. After completing his master’s education, he obtainedInternational Graduate School Scholarship (IGSDHD) to pursue PhD studies at Universityof Cologne and received his PhD from Institute of Biochemistry (2013, Cologne, Germany)on the role of coronin actin binding proteins in cell migration. His researchduring his PhD studies have identified a novel role of coronin proteins in cellmigration through modulation of GTPase signalling and myosin II dynamics (Swaminathanet al, PNAS 2014, Swaminathan et al, Sci Rep 2016). He then received a Cancer Research UK (CRUK) postdoctoral fellowshipto continue his research on understanding cell migration during organismaldevelopment and cancer metastasis at Beatson Institute of Cancer Research (CRUK),Glasgow. He has uncovered several cytoskeletal signalling pathways required forefficient colonization of melanocyte during embryonic development and demonstratedhow these signalling pathways are altered during the development of melanoma (Swaminathanet al JID, 2021, Papalazarou et al Development 2020, Woodham etal Curr Biol 2017, Reid et al, EMBO J 2017). In 2020, Dr Swaminathan joined as a Lecturer at the Centrefor Skin Sciences, Faculty of Life Sciences at University of Bradford. He haswon research awards from Wellcome Trust, Royal Society, and British Skin Foundation.


Cancer Metastasis and Genomics Group (CMG) The overarching goal of his research group at UoB is tounderstand how cancer cells spread (metastasis) and identify novel translatablepathways/targets to treat metastatic disease. Nearly 90% of cancer related deaths is due to metastasis.Cancer metastasis is defined as a process in which cancer cells spread todistant tissues and organs generating tumours away from the original site. Thecomplex metastatic process relies on cancer cells penetrating the surroundingtissue, gaining access to circulatory system, and seeding and growth in distantorgans. The group focuses on elucidating molecular mechanisms underpinningcancer metastatic process within the context of three broad research themes: Theme 1: Sugars, Cell Adhesion, and Migration Altered cell attachment (adhesion) to the Extra CellularMatrix (ECM), which is a meshwork of proteins that holds the cells in place, isa hallmark of cancer cells. We investigate how addition of sugars to signallingproteins (process known as sialylation) influences cancer cell behaviour suchas their attachment to ECM, invasion, and migration. Theme 2: Epigenetics of Stem Cell Biology and CancerEpigenetic programs are crucial to maintain the homeostasisof embryonic and adult stem cells. Our previous work has demonstrated that a healthyepigenetic program is required for embryonic development and to maintain lineagespecific transcriptional output during adult stem cell homeostasis. Altered epigeneticsignalling and associated transcriptional programs are commonly observed duringcancer metastasis. We investigate the epigenetic programs requiredfor stem cell homeostasis (development and adult stem cells) and aim to understandhow cancer cells leverage these epigenetic programs during metastaticprogression. Theme 3: Microbiome and Metastasis Recent emerging evidence has highlighted the importance anddiversity of microbiome within the tumour microenvironment. These tumours boundmicrobiome were demonstrated to influence tumour progression and treatmentoutcomes. We investigate the molecular mechanism underpinning the interplay(communication) between microbiome and tumour cells impacting tumour invasionand metastasis. We use an integrated approach combining biochemical,molecular biology, and cell culture methods with state-of-the-art genomics techniquesto unravel the mechanisms of cancer metastasis.

Professional activities

Information about education, employment and areas of particular interest for Dr. Karthic Swaminathan is as follows:


  • University of Bradford - Lecturer in Skin Sciences in the year 2019 (specified as 05/12/2019)
  • Cancer Research UK (BICR, Glasgow) - Postdoctoral Researcher in the year 2014 (specified as 01/04/2014)


  • Bharathidasan University - Master of Science
  • University of cologne - PhD
  • Bharathidasan University - Master of Philosophy
  • Bharathidasan University - Post Graduate Diploma
  • University of Madras - Bachelor of Science


There are 12 publications involving or that are attributed to Dr. Karthic Swaminathan.

Peer Reviewed Journal

Dr. Karthic Swaminathan has 12 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization. 2019 Current Biology : Cb 29 Amato C;Thomason PA;Davidson AJ;Swaminathan K;Ismail S;Machesky LM;Insall RH; 1879-0445 10.1016/j.cub.2019.10.036
Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin. 2017 Current Biology : Cb 27 Woodham EF;Paul NR;Tyrrell B;Spence HJ;Swaminathan K;Scribner MR;Giampazolias E;Hedley A;Clark W;Kage F;Marston DJ;Hahn KM;Tait SW;Larue L;Brakebusch CH;Insall RH;Machesky LM; 1879-0445 10.1016/j.cub.2017.01.033
Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. 2016 Scientific Reports 6 Bhattacharya K;Swaminathan K;Peche VS;Clemen CS;Knyphausen P;Lammers M;Noegel AA;Rastetter RH; 2045-2322 10.1038/srep25411
The Dictyostelium discoideum RACK1 orthologue has roles in growth and development. 2014 Cell Communication And Signaling : Ccs 12 Omosigho NN;Swaminathan K;Plomann M;Müller-Taubenberger A;Noegel AA;Riyahi TY; 1478-811X 10.1186/1478-811X-12-37
A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin. 2014 Proceedings of the National Academy of Sciences of the United States of America 111 Swaminathan K;Müller-Taubenberger A;Faix J;Rivero F;Noegel AA; 1091-6490 10.1073/pnas.1315368111
Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations. 2013 PLoS ONE 8 Yang L;Munck M;Swaminathan K;Kapinos LE;Noegel AA;Neumann S; 1932-6203 10.1371/journal.pone.0071850
The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility. 2013 Cell Communication And Signaling : Ccs 11 Müller R;Herr C;Sukumaran SK;Omosigho NN;Plomann M;Riyahi TY;Stumpf M;Swaminathan K;Tsangarides M;Yiannakou K;Blau-Wasser R;Gallinger C;Schleicher M;Kolanus W;Noegel AA; 1478-811X 10.1186/1478-811X-11-54
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium 2017 EMBO Journal 36 Reid, SE; Kay, EJ; Neilson, LJ; Henze, AT; Serneels, J; McGhee, EJ; Dhayade, S; Nixon, C; Mackey, JB; Santi, A; Swaminathan, Karthic; Athineos, D; Papalazarou, V; Patella, F; Roman-Fernandez, A; ElMaghloob, Y; Hernandez-Fernaud, JR; Adams, RH; Ismail, S; Bryant, DM; Salmeron-Sanchez, M; Machesky, LM; Carlin, LM; Blyth, K; Mazzone, M; Zanivan, S
Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins 2015 Scientific Reports 5 Swaminathan, Karthic; Stumpf, M; Mueller, R; Horn, AC; Schmidbauer, J; Eichinger, L; Mueller Taubenberger, A; Faix, J; Noegel, AA
The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration. 2020 Cells 9 Whitelaw JA;Swaminathan K;Kage F;Machesky LM; 2073-4409 10.3390/cells9071635
The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice. 2020 Journal of Investigative Dermatology Swaminathan K;Campbell A;Papalazarou V;Jaber-Hijazi F;Nixon C;McGhee E;Strathdee D;Sansom OJ;Machesky LM; 1523-1747 10.1016/j.jid.2020.06.029
The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts. 2020 Development - Company of Biologists Papalazarou V;Swaminathan K;Jaber-Hijazi F;Spence H;Lahmann I;Nixon C;Salmeron-Sanchez M;Arnold HH;Rottner K;Machesky LM; 1477-9129 10.1242/dev.194555