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Dr. Krzysztof Paluch,
Associate Professor

Information about Dr. Krzysztof Paluch at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
+44 1274 236110
Photo of Dr. Krzysztof Paluch


Krzysztof J. Paluch is an Assoc. Prof. in Medicines Development and Pharmaceutical Sciences, Director of Postgraduate Studies and Dep. Assoc. Dean of Research and Innovation in Faculty of Life Sciences, University of Bradford. Krzysztof is a pharmacist with a particular interest in pharmaceutical technology, pharmaceutical sciences (PhD, Trinity College Dublin, 2011) and project management (Assoc. Project Manager). His research interests focus on synthesis, physicochemical and biopharmaceutical characterisation of drugs particularly pro-antibiotics and pro-antioxidants. Krzysztof has expertise in screening and characterisation of novel salts, co-crystals and characterization of amorphous forms. Process technologies applied in his research group comprise; production of nanoparticles, spray drying, freeze-drying, hot-melt extrusion, tabletting and others. Krzysztof has supervised 8 PhD students. Krzysztof teaches undergraduate and postgraduate programmes namely: Pharmacy, Clinical Sciences and Pharmaceutical Technology and Medicines Control MSc. Krzysztof developed and as a Programme Lead oversees the delivery of Social Sciences Research for Healthcare Programme affiliated with White Rose Social Sciences Research Doctoral Training Partnership. In his role as the Director of Postgraduate Studies In the Faculty of Life Sciences, he oversees the wellbeing and successful progression of PhD Students in Schools of Pharmacy and Medical Sciences, Chemistry and Biosciences, Optometry and Vision Sciences and Archaeology and Forensic Sciences. As Dep. Assoc. Dean of Research and Innovation, Krzysztof has shared responsibility for the development and delivery of the Faculty's Research and Innovation strategy promoting interdisciplinary themes of Interface of Chemistry, Biology and Materials, The Life Course, Computational and Data-driven Science and, Health Society People and Place. Currently, Krzysztof's research group comprises four research students: Hanan El Bsir, e-mail: Achi, e-mail: Al Hyari, e-mail: Dzokwe Kene: e-mail: And several collaborators:Dr Helen SheldrakeDr Beverly StewartDr Maria KatsikogianniDr Mohammed IsrebDr Sriharsha Kantamneni To apply for PhD with Dr Paluch please visit: Formulation and biopharmaceutical characterisation of novel pro-antibiotics for improved oral permeability Formulation of heterogeneous solid dispersions produced by spray drying and hot-melt extrusion for improved delivery of amorphous drugsYou may submit your own proposal. To find out more visit: you’re ready to apply, complete our application form. You’ll need to include your proposal, along with a CV/résumé, and your degree certificates and transcripts. The easiest way to apply is online. Apply for 2021/22 (September 2021 - July 2022 start dates)Apply for 2022/23 (September 2022 - July 2023 start dates) What happens next: Once we receive your application it will be reviewed by the Director of Postgraduate Research and potential supervisors. At this stage, we may contact you to arrange an interview.


Research InterestsSynthesis of pro-antibiotics and pro-antioxidantsPhysicochemical, micromeritic and biopharmaceutical characterisation of drugsCo-crystallisation and amorphisation of drugs for improved solubilityPharmaceutical processing and preformulation; spray-drying, hot-melt extrusion, nanonisation, tabletting.Current Projects Pro-antibiotics for improved permeability and oral bioavailability Pro-antibiotics for prolonged-release ocular drug delivery systemsSemi-synthetic pro-antioxidants for improved oral bioavailability and targeted deliveryProduction of ternary, heterogenic solid dispersions for improved solubility and stability of amorphous drugs


There are 34 publications involving or that are attributed to Dr. Krzysztof Paluch.

Peer Reviewed Journal

Dr. Krzysztof Paluch has 34 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Molecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems 2016 Knapik, J.; Wojnarowska, Z.; Grzybowska, K.; Tajber, L.; Mesallati, H.; Paluch, Krzysztof J.; Paluch, M.
Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide 2020 Powder Technology 372 685 - 693 Aloum F.;Al Ayoub Y.;Mohammad M.A.;Obeed M.;Paluch K.;Assi K.H. 0032-5910 10.1016/j.powtec.2020.06.037
Preparation and solid state characterisation of chlorothiazide sodium intermolecular self-assembly suprastructure. 2010 Paluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM; 10.1016/j.ejps.2010.08.013
Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: Intermolecular self assembly suprastructures. 2011 Paluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM; 10.1016/j.ejps.2010.11.012
Solid-state characterization of novel active pharmaceutical ingredients: cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt. 2011 Paluch KJ;Tajber L;Elcoate CJ;Corrigan OI;Lawrence SE;Healy AM; 10.1002/jps.22569
Biopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction. 2011 Parojčić J;Stojković A;Tajber L;Grbić S;Paluch KJ;Djurić Z;Corrigan OI; 10.1002/jps.22707
Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers. 2012 Umerska A;Paluch KJ;Inkielewicz-Stępniak I;Santos-Martinez MJ;Corrigan OI;Medina C;Tajber L; 10.1016/j.ijpharm.2012.07.011
Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. 2013 Tewes F;Paluch KJ;Tajber L;Gulati K;Kalantri D;Ehrhardt C;Healy AM; 10.1016/j.ejpb.2013.03.020
Decoupling of conductivity relaxation from structural relaxation in protic ionic liquids and general properties. 2013 Wojnarowska Z;Kołodziejczyk K;Paluch KJ;Tajber L;Grzybowska K;Ngai KL;Paluch M; 10.1039/c3cp50627d
Molecular dynamics, physical stability and solubility advantage from amorphous indapamide drug. 2013 Wojnarowska Z;Grzybowska K;Hawelek L;Dulski M;Wrzalik R;Gruszka I;Paluch M;Pienkowska K;Sawicki W;Bujak P;Paluch KJ;Tajber L;Markowski J; 10.1021/mp400116q
Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. 2014 Stojković A;Tajber L;Paluch KJ;Djurić Z;Parojčić J;Corrigan OI; 10.2478/acph-2014-0007
Dry powders for oral inhalation free of lactose carrier particles. 2014 Healy AM;Amaro MI;Paluch KJ;Tajber L; 10.1016/j.addr.2014.04.005
The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil. 2014 Wlodarski K;Sawicki W;Paluch KJ;Tajber L;Grembecka M;Hawelek L;Wojnarowska Z;Grzybowska K;Talik E;Paluch M; 10.1016/j.ejps.2014.05.026
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties. 2015 Serrano DR;O'Connell P;Paluch KJ;Walsh D;Healy AM;
Phase Diagrams of Polymer-Dispersed Liquid Crystal Systems of Itraconazole/Component Immiscibility Induced by Molecular Anisotropy 2018 Molecular Pharmaceutics 15 5192 - 5206 Kozyra A.;Mugheirbi N.;Paluch K.;Garbacz G.;Tajber L. 1543-8384 10.1021/acs.molpharmaceut.8b00724
Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection 2018 International Journal of Pharmaceutics 552 27 - 38 Umerska A.;Paluch K.;Santos-Martinez M.;Corrigan O.;Medina C.;Tajber L. 0378-5173 10.1016/j.ijpharm.2018.09.035
Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol 2015 Journal of Molecular Structure 1083 286 - 299 Zhang T.;Paluch K.;Scalabrino G.;Frankish N.;Healy A.;Sheridan H. 0022-2860 10.1016/j.molstruc.2014.12.018
Observation of highly decoupled conductivity in protic ionic conductors 2014 Wojnarowska, Z.; Wang, Y.; Paluch, Krzysztof J.; Sokolov, A.P.; Paluch, M.
Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability 2013 Paluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid 2013 Paluch, Krzysztof J.; McCabe, T.; Müller-Bunz, B.; Corrigan, O.I.; Healy, A.M.; Tajber, L.
Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: Synthesis, stability, biocompatibility and potential use as peptide carriers 2014 Umerska, A.; Paluch, Krzysztof J.; Santos Martinez, M.-J.; Corrigan, O.I.; Medina, C.; Tajber, L.
Comparative study of different methods for the prediction of drug-polymer solubility 2015 Knopp, M.M.; Tajber, L.; Tian, Y.; Olesen, N.E.; Jones, D.S.; Kozyra, A.; Lobmann, K.; Paluch, Krzysztof J.; Brennan, C.M.; Holm, R.; Healy, A.M.; Andrews, G.P.; Rades, T.
Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole 2014 Mugheirbi, N.A.; Paluch, Krzysztof J.; Tajber, L.
Polymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties 2015 Grossjohann, C.; Serrano, D.R.; Paluch, Krzysztof J.; O'Connell, P.; Vella-Zarb, L.; Manesiotis, P.; McCabe, T.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties 2016 Serrano, D.R.; O'Connell, P.; Paluch, Krzysztof J.; Walsh, D.; Healy, A.M.
A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability 2012 Paluch, Krzysztof J.; Tajber, L.; Adamczyk, B.; Corrigan, O.I.; Healy, A.M.
Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials 2012 Paluch, Krzysztof J.; Tajber, L.; Amaro, M.I.; Corrigan, O.I.; Healy, A.M.
Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system 2012 Paluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
Amorphous polymeric drug salts as ionic solid dispersion forms of ciprofloxacin 2017 Mesallati, H.; Umerska, A.; Paluch, Krzysztof J.; Tajber, L.
Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine 2017 Dul, M.; Paluch, Krzysztof J.; Healy, A.M.; Sasse, A.; Tajber, L.
Chondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics 2015 Umerska, A.; Paluch, Krzysztof J.; Santos-Martinez, M.J.; Medina, C.; Corrigan, O.I.; Tajber, L.
Molecular structure studies of (1,2)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol 2015 Zhang, T.; Paluch, Krzysztof J.; Scalabrino, G.; Frankish, N.; Healy, A.M.; Sheridan, H.
Molecular origin of enhanced proton conductivity in anhydrous ionic systems 2015 Wojnarowska, Z.; Paluch, Krzysztof J.; Shoifet, E.; Schick, C.; Tajber, L.; Knapik, J.; Wlodarczyk, P.; Grzybowska, K.; Hensel-Bielowka, S.; Verevkin, S.P.; Paluch, M.
Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics 2015 Dul, M.; Paluch, Krzysztof J.; Kelly, H.; Healy, A.M.; Sasse, A.; Tajber, L.