Dr Krzysztof Paluch
Associate Professor
| Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
|---|---|
| k.j.paluch@bradford.ac.uk | |
| Telephone | +441274 236110 |
Biography
Krzysztof J. Paluch is an Assoc. Prof. in Medicines Development and Pharmaceutical Sciences, Director of Postgraduate Studies and Dep. Assoc. Dean of Research and Innovation in Faculty of Life Sciences, University of Bradford.
Krzysztof is a pharmacist with a particular interest in pharmaceutical technology, pharmaceutical sciences (PhD, Trinity College Dublin, 2011) and project management (Assoc. Project Manager).
His research interests focus on synthesis, physicochemical and biopharmaceutical characterisation of drugs particularly pro-antibiotics and pro-antioxidants. Krzysztof has expertise in screening and characterisation of novel salts, co-crystals and characterization of amorphous forms. Process technologies applied in his research group comprise; production of nanoparticles, spray drying, freeze-drying, hot-melt extrusion, tabletting and others. Krzysztof has supervised 8 PhD students.
Krzysztof teaches undergraduate and postgraduate programmes namely: Pharmacy, Clinical Sciences and Pharmaceutical Technology and Medicines Control MSc. Krzysztof developed and as a Programme Lead oversees the delivery of Social Sciences Research for Healthcare Programme affiliated with White Rose Social Sciences Research Doctoral Training Partnership.
In his role as the Director of Postgraduate Studies In the Faculty of Life Sciences, he oversees the wellbeing and successful progression of PhD Students in Schools of Pharmacy and Medical Sciences, Chemistry and Biosciences, Optometry and Vision Sciences and Archaeology and Forensic Sciences.
As Dep. Assoc. Dean of Research and Innovation, Krzysztof has shared responsibility for the development and delivery of the Faculty's Research and Innovation strategy promoting interdisciplinary themes of Interface of Chemistry, Biology and Materials, The Life Course, Computational and Data-driven Science and, Health Society People and Place.
Currently, Krzysztof's research group comprises four research students:
- Hanan El Bsir, e-mail: h.elbsir@bradford.ac.uk
- Patricia Achi, e-mail: i.p.k.achi@bradford.ac.uk
- Dania Al Hyari, e-mail: d.h.s.alhyari@bradford.ac.uk
- Bruno Dzokwe Kene: e-mail: b.a.dzokwekene@bradford.ac.uk
And several collaborators:
To apply for PhD with Dr Paluch please visit:
- Formulation and biopharmaceutical characterisation of novel pro-antibiotics for improved oral permeability
- Formulation of heterogeneous solid dispersions produced by spray drying and hot-melt extrusion for improved delivery of amorphous drugs
You may submit your own proposal. To find out more visit: https://www.bradford.ac.uk/postgraduate/research-degrees/write-research-proposal/
Once you’re ready to apply, complete our application form. You’ll need to include your proposal, along with a CV/résumé, and your degree certificates and transcripts. The easiest way to apply is online.
- Apply for 2021/22 (September 2021 - July 2022 start dates)
- Apply for 2022/23 (September 2022 - July 2023 start dates)
Research
Research Interests
- Synthesis of pro-antibiotics and pro-antioxidants
- Physicochemical, micromeritic and biopharmaceutical characterisation of drugs
- Co-crystallisation and amorphisation of drugs for improved solubility
- Pharmaceutical processing and preformulation; spray-drying, hot-melt extrusion, nanonisation, tabletting.
Current Projects
- Pro-antibiotics for improved permeability and oral bioavailability
- Pro-antibiotics for prolonged-release ocular drug delivery systems
- Semi-synthetic pro-antioxidants for improved oral bioavailability and targeted delivery
- Production of ternary, heterogenic solid dispersions for improved solubility and stability of amorphous drugs
Publications
| Title | Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide (2020) |
|---|---|
| Authors | Aloum F.;Al Ayoub Y.;Mohammad M.A.;Obeed M.;Paluch K.;Assi K.H. |
| Journal | Powder Technology |
| DOI | 10.1016/j.powtec.2020.06.037 |
| Title | Phase Diagrams of Polymer-Dispersed Liquid Crystal Systems of Itraconazole/Component Immiscibility Induced by Molecular Anisotropy (2018) |
| Authors | Kozyra A.;Mugheirbi N.;Paluch K.;Garbacz G.;Tajber L. |
| Journal | Molecular Pharmaceutics |
| DOI | 10.1021/acs.molpharmaceut.8b00724 |
| Title | Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection (2018) |
| Authors | Umerska A.;Paluch K.;Santos-Martinez M.;Corrigan O.;Medina C.;Tajber L. |
| Journal | International Journal of Pharmaceutics |
| DOI | 10.1016/j.ijpharm.2018.09.035 |
| Title | Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine (2017) |
| Authors | Dul, M.; Paluch, Krzysztof J.; Healy, A.M.; Sasse, A.; Tajber, L. |
| Title | Amorphous polymeric drug salts as ionic solid dispersion forms of ciprofloxacin (2017) |
| Authors | Mesallati, H.; Umerska, A.; Paluch, Krzysztof J.; Tajber, L. |
| Title | Cocrystal habit engineering to improve drug dissolution and alter derived powder properties (2016) |
| Authors | Serrano, D.R.; O'Connell, P.; Paluch, Krzysztof J.; Walsh, D.; Healy, A.M. |
| Title | Molecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems (2016) |
| Authors | Knapik, J.; Wojnarowska, Z.; Grzybowska, K.; Tajber, L.; Mesallati, H.; Paluch, Krzysztof J.; Paluch, M. |
| Title | Molecular origin of enhanced proton conductivity in anhydrous ionic systems (2015) |
| Authors | Wojnarowska, Z.; Paluch, Krzysztof J.; Shoifet, E.; Schick, C.; Tajber, L.; Knapik, J.; Wlodarczyk, P.; Grzybowska, K.; Hensel-Bielowka, S.; Verevkin, S.P.; Paluch, M. |
| Title | Molecular structure studies of (1,2)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2015) |
| Authors | Zhang, T.; Paluch, Krzysztof J.; Scalabrino, G.; Frankish, N.; Healy, A.M.; Sheridan, H. |
| Title | Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2015) |
| Authors | Zhang T.;Paluch K.;Scalabrino G.;Frankish N.;Healy A.;Sheridan H. |
| Journal | Journal of Molecular Structure |
| DOI | 10.1016/j.molstruc.2014.12.018 |
| Title | Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics (2015) |
| Authors | Dul, M.; Paluch, Krzysztof J.; Kelly, H.; Healy, A.M.; Sasse, A.; Tajber, L. |
| Title | Chondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics (2015) |
| Authors | Umerska, A.; Paluch, Krzysztof J.; Santos-Martinez, M.J.; Medina, C.; Corrigan, O.I.; Tajber, L. |
| Title | Cocrystal habit engineering to improve drug dissolution and alter derived powder properties. (2015) |
| Authors | Serrano DR;O'Connell P;Paluch KJ;Walsh D;Healy AM; |
| Title | Comparative study of different methods for the prediction of drug-polymer solubility (2015) |
| Authors | Knopp, M.M.; Tajber, L.; Tian, Y.; Olesen, N.E.; Jones, D.S.; Kozyra, A.; Lobmann, K.; Paluch, Krzysztof J.; Brennan, C.M.; Holm, R.; Healy, A.M.; Andrews, G.P.; Rades, T. |
| Title | Polymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties (2015) |
| Authors | Grossjohann, C.; Serrano, D.R.; Paluch, Krzysztof J.; O'Connell, P.; Vella-Zarb, L.; Manesiotis, P.; McCabe, T.; Tajber, L.; Corrigan, O.I.; Healy, A.M. |
| Title | Observation of highly decoupled conductivity in protic ionic conductors (2014) |
| Authors | Wojnarowska, Z.; Wang, Y.; Paluch, Krzysztof J.; Sokolov, A.P.; Paluch, M. |
| Title | Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. (2014) |
| Authors | StojkoviÄ A;Tajber L;Paluch KJ;DjuriÄ Z;ParojÄiÄ J;Corrigan OI; |
| DOI | 10.2478/acph-2014-0007 |
| Title | Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: Synthesis, stability, biocompatibility and potential use as peptide carriers (2014) |
| Authors | Umerska, A.; Paluch, Krzysztof J.; Santos Martinez, M.-J.; Corrigan, O.I.; Medina, C.; Tajber, L. |
| Title | Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole (2014) |
| Authors | Mugheirbi, N.A.; Paluch, Krzysztof J.; Tajber, L. |
| Title | Dry powders for oral inhalation free of lactose carrier particles. (2014) |
| Authors | Healy AM;Amaro MI;Paluch KJ;Tajber L; |
| DOI | 10.1016/j.addr.2014.04.005 |
| Title | The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil. (2014) |
| Authors | Wlodarski K;Sawicki W;Paluch KJ;Tajber L;Grembecka M;Hawelek L;Wojnarowska Z;Grzybowska K;Talik E;Paluch M; |
| DOI | 10.1016/j.ejps.2014.05.026 |
| Title | Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability (2013) |
| Authors | Paluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M. |
| Title | Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid (2013) |
| Authors | Paluch, Krzysztof J.; McCabe, T.; Müller-Bunz, B.; Corrigan, O.I.; Healy, A.M.; Tajber, L. |
| Title | Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. (2013) |
| Authors | Tewes F;Paluch KJ;Tajber L;Gulati K;Kalantri D;Ehrhardt C;Healy AM; |
| DOI | 10.1016/j.ejpb.2013.03.020 |
| Title | Decoupling of conductivity relaxation from structural relaxation in protic ionic liquids and general properties. (2013) |
| Authors | Wojnarowska Z;KoÅodziejczyk K;Paluch KJ;Tajber L;Grzybowska K;Ngai KL;Paluch M; |
| DOI | 10.1039/c3cp50627d |
| Title | Molecular dynamics, physical stability and solubility advantage from amorphous indapamide drug. (2013) |
| Authors | Wojnarowska Z;Grzybowska K;Hawelek L;Dulski M;Wrzalik R;Gruszka I;Paluch M;Pienkowska K;Sawicki W;Bujak P;Paluch KJ;Tajber L;Markowski J; |
| DOI | 10.1021/mp400116q |
| Title | Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers. (2012) |
| Authors | Umerska A;Paluch KJ;Inkielewicz-StÄpniak I;Santos-Martinez MJ;Corrigan OI;Medina C;Tajber L; |
| DOI | 10.1016/j.ijpharm.2012.07.011 |
| Title | Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system (2012) |
| Authors | Paluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M. |
| Title | Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials (2012) |
| Authors | Paluch, Krzysztof J.; Tajber, L.; Amaro, M.I.; Corrigan, O.I.; Healy, A.M. |
| Title | A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability (2012) |
| Authors | Paluch, Krzysztof J.; Tajber, L.; Adamczyk, B.; Corrigan, O.I.; Healy, A.M. |
| Title | Biopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction. (2011) |
| Authors | ParojÄiÄ J;StojkoviÄ A;Tajber L;GrbiÄ S;Paluch KJ;DjuriÄ Z;Corrigan OI; |
| DOI | 10.1002/jps.22707 |
| Title | Solid-state characterization of novel active pharmaceutical ingredients: cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt. (2011) |
| Authors | Paluch KJ;Tajber L;Elcoate CJ;Corrigan OI;Lawrence SE;Healy AM; |
| DOI | 10.1002/jps.22569 |
| Title | Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: Intermolecular self assembly suprastructures. (2011) |
| Authors | Paluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM; |
| DOI | 10.1016/j.ejps.2010.11.012 |
| Title | Preparation and solid state characterisation of chlorothiazide sodium intermolecular self-assembly suprastructure. (2010) |
| Authors | Paluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM; |
| DOI | 10.1016/j.ejps.2010.08.013 |