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Dr. Khaled Assi,
Associate Professor

Information about Dr. Khaled Assi at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
Email:
k.h.a.assi@bradford.ac.uk
Telephone:
+44 1274 234703
Photo of Dr. Khaled Assi

Biography

Dr Khaled H Assi was awarded the PhD in pharmaceuticalanalysis by the University of Bradford, in 1999. He then took up a postdoctoralpost at university of Bradford between 1999-2001 working on the inhaledtherapies. His postdoctoral program was extended for one more year through anawarded grant from Glaxo SmithKline. In 2002, he was accepted a researchfellowship at Bradford School of Pharmacy. Dr Assi was appointed as a Lecturerat the Bradford School of Pharmacy and then promoted to senior lecturer , in March2016 and has continued developing his research in the inhaled therapies area.In this position he is teaching the MPharm students at different levels and heis also leading the MSc Pharmaceutical Technology and Medicines Controlprogramme. The modules he delivers cover the area of respiratory drug delivery,pharmaceutical analysis, Quality assurance and quality control ofpharmaceuticals. He is also active in the research. His principal research interests lie in the fieldof drug delivery to the lung, this encompass formulation development forinhalation products. The work involves the development of new formulations forinhaled products including dry powder, nanosuspension and nanoemaulsion for both dry powderinhalers and nebulisers. It also involves selecting a suitable inhalationdevice for doses of dry powder inhalers and nebulised solutions based on thetargeted peripheral lung areas for both locally and systemically actingpharmaceuticals. He also has researchinterest in the following: o Determination of the in-vitro characteristics ofinhaled products and assessing the in-vitro quality of the dose emitted frominhalation systems (dry powder inhalers [DPIs], metered dose inhalers [MDIs]and nebulisers) and in the determination of the resistance characteristics andcomparative product features of various marketed DPIs to identify the optimuminhalation flow rate and appropriate DPI for different patients. In additionto the inhaled therapy I have research in the development of pharmaceutical andbioanalytical assay methods. This includes the optimisation and validation ofbioanalytical techniques for qualitative and quantitative determination ofinhaled drugs and its metabolites in aqueous and biological fluids forbioequivalence and pharmacokinetic studies.

Research

My main research area lie in the field of drug delivery to the lung, this encompass formulation development for inhalation products. The work involves the development of new formulations for inhaled products including dry powder, nanosuspension and nanoemaulsion for both dry powder inhalers and nebulisers. It also involves selecting a suitable inhalation device for doses of dry powder inhalers and nebulised solutions based on the targeted peripheral lung areas for both locally and systemically acting pharmaceuticals.I also have research interest in the following: Investigationinto the effect of the adhesion and cohesion energy on performance of the DPIformulations. Determination of the in vitro characteristics of inhaled products and assessing the in vitro quality of the dose emitted from inhalation systems (dry powder inhalers [DPIs], metered dose inhalers [MDIs] and nebulisers) and in the determination of the resistance characteristics and comparative product features of various marketed DPIs to identify the optimum inhalation flow rate and appropriate DPI for different patients.In addition to the inhaled therapy I have research in the development of pharmaceutical and bioanalytical assay methods. This includes the optimisation and validation of bioanalytical techniques for qualitative and quantitative determination of inhaled drugs in aqueous and biological fluids for bioequivalence and pharmacokinetic studies.

Publications

There are 8 publications involving or that are attributed to Dr. Khaled Assi.

Peer Reviewed Journal

Dr. Khaled Assi has 8 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
In vitro aerodynamic characterization of the dose emitted during nebulization of tobramycin high strength solution by novel and jet nebulizer delivery systems 2016 Mashat, M.; Clark, Brian J.; Assi, Khaled H.; Chrystyn, Henry
Microemulsion High Performance Liquid Chromatography (MELC) for Determination of Terbutaline in Urine Samples 2016 Althanyan, Mohammed S.; Nasser, A.; Assi, H.; Clark, Brian J.; Assi, Khaled H.
Development and Validation of Micro Emulsion High Performance Liquid Chromatography(MELC) Method for the Determination of Nifedipine in Pharmaceutical Preparation 2015 Al-Jammal, M.K.H.; Al Ayoub, Yuosef; Assi, Khaled H.
Smart nanocrystals of artemether: fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation 2016 Shah, S.M.H.; Ullah, F.; Khan, Shahzeb; Shah, S.M.M.; de Matas, Marcel; Hussain, Z.; Minhas, M.U.; AbdEl-Salam, N.M.; Assi, Khaled H.; Isreb, Mohammad
Assessment of recent nebulizer delivery systems using urinary pharmacokinetics method and aerodynamic characteristics of TOBI® nebulized dose following inhalation 2017 Mashat, M.; Clark, Brian J.; Assi, Khaled H.; Chrystyn, Henry
Assessment of recent nebulizer delivery systems using urinary pharmacokinetics method and aerodynamic characteristics of TOBI®nebulized dose following inhalation 2017 Journal of Drug Delivery Science and Technology 39 428 - 434 Mashat M.;Clark B.;Assi K.;Chrystyn H. 1773-2247 10.1016/j.jddst.2017.04.007
Structural and reactivity analyses of nitrofurantoin 4 dimethylaminopyridine salt using spectroscopic and density functional theory calculations 2019 Crystals 9 Khan E; Shukla A; Srivastava K; Gangopadhyay D; Assi K; Tandon P; Vangala V
Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide 2020 Powder Technology 372 685 - 693 Aloum F.;Al Ayoub Y.;Mohammad M.A.;Obeed M.;Paluch K.;Assi K.H. 0032-5910 10.1016/j.powtec.2020.06.037