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Dr. Amalia Ruiz Estrada

Information about Dr. Amalia Ruiz Estrada at the University of Bradford.

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Dr Ruiz graduated in Biochemistry from the University of Havana, Cuba. She completed her PhD in Advanced Materials and Nanotechnology at the Autonomous University of Madrid. Her PhD research project focused on developing magnetic nanoparticles for different biotechnological and biomedical applications. Previously, Dr Ruiz held different postdoctoral positions across Cuba and Europe. In 2014 she joined the Centre for Advanced Studies in Cuba to investigate novel formulations of iron oxide nanoparticles and their toxicological evaluation in different in vitro and in vivo models. In 2016, she joined the University of East Anglia in Norwich as Senior Research Associate (Marie Skłodowska-Curie Fellow) to work in the DNA-TRAP EU funded project to develop a range of antimicrobial nanoformulations and assess their therapeutic efficacy in in vitro models. Later, she moved to the Molecular and Cellular Biology Institute in Strasbourg to be part of the Graphene Flagship project, the European Union's biggest scientific research initiative, to assess the pharmacological behaviour of different graphene-based materials and their innovative application in cancer treatment. In November 2018, she started at the School of Pharmacy at Queen’s University Belfast, where her research was focused on the development of smart nanocarriers for targeted cancer therapy, as well as engineering novel nanoformulations to detect and treat aggressive metastatic prostate cancer. Currently, Dr Ruiz’s research focuses on the fabrication of multifunctional nanomaterials to target cancer and other diseases, developing novel nanomedicines for combinatory therapy and theragnostic applications and the safety evaluation of these nanomaterials applied to human health. Her long-term research career objective is to facilitate the translation of nanoparticle-based therapeutics from the lab to the clinic.


I'm always open to PhD applications in the field of Nanomedicine, drugdelivery systems, smart nanomaterials, nanotoxicology, hyperthermia,photothermal, photodynamic therapy, combination therapies and theragnosticapplications


There are 24 publications involving or that are attributed to Dr. Amalia Ruiz Estrada. They are listed as:

  • peer reviewed journal (22)
  • reviews (2)

Peer Reviewed Journal

Dr. Amalia Ruiz Estrada has 22 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Hypoxia-targeted cupric-tirapazamine liposomes potentiate radiotherapy in prostate cancer spheroids. 2021 International Journal of Pharmaceutics 607 Silva VL;Ruiz A;Ali A;Pereira S;Seitsonen J;Ruokolainen J;Furlong F;Coulter J;Al-Jamal WT; 1873-3476 10.1016/j.ijpharm.2021.121018
Dually targeted bioinspired nanovesicle delays advanced prostate cancer tumour growth in vivo. 2021 Acta Biomaterialia 134 Ma G;Severic M;Barker M;Pereira S;Ruiz A;Cheung CCL;Al-Jamal WT; 1878-7568 10.1016/j.actbio.2021.07.021
PD1 blockade potentiates the therapeutic efficacy of photothermally-activated and MRI-guided low temperature-sensitive magnetoliposomes. 2021 Journal of Controlled Release 332 Ma G;Kostevšek N;Monaco I;Ruiz A;Markelc B;Cheung CCL;Hudoklin S;Kreft ME;Hassan HAFM;Barker M;Conyard J;Hall C;Meech S;Mayes AG;Serša I;Čemažar M;Marković K;Ščančar J;Franchini MC;Al-Jamal WT; 1873-4995 10.1016/j.jconrel.2021.03.002
Genetically-engineered anti-PSMA exosome mimetics targeting advanced prostate cancer in vitro and in vivo 2021 Journal of Controlled Release 330 101 - 110 Severic M.;Ma G.;Pereira S.G.T.;Ruiz A.;Cheung C.C.L.;Al-Jamal W.T. 0168-3659 10.1016/j.jconrel.2020.12.017
Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes 2020 ACS Sustainable Chemistry and Engineering 8 15243 - 15249 McCalmont A.S.;Ruiz A.;Lagunas M.C.;Al-Jamal W.T.;Crawford D.E. 2168-0485 10.1021/acssuschemeng.0c04950
Encapsulated doxorubicin crystals influence lysolipid temperature-sensitive liposomes release and therapeutic efficacy in vitro and in vivo 2020 Journal of Controlled Release 328 665 - 678 Ruiz A.;Ma G.;Seitsonen J.;Pereira S.G.T.;Ruokolainen J.;Al-Jamal W.T. 0168-3659 10.1016/j.jconrel.2020.09.032
Toxicological evaluation of highly water dispersible few-layer graphene in vivo 2020 Carbon 170 347 - 360 Ruiz A.;Lucherelli M.A.;Murera D.;Lamon D.;Ménard-Moyon C.;Bianco A. 0008-6223 10.1016/j.carbon.2020.08.023
Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery. 2020 Colloids and Surfaces B: Biointerfaces 195 Montis C;Joseph P;Magnani C;Marín-Menéndez A;Barbero F;Estrada AR;Nepravishta R;Angulo J;Checcucci A;Mengoni A;Morris CJ;Berti D; 1873-4367 10.1016/j.colsurfb.2020.111266
EGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells. 2020 Colloids and Surfaces B: Biointerfaces 194 Eloy JO;Ruiz A;de Lima FT;Petrilli R;Raspantini G;Nogueira KAB;Santos E;de Oliveira CS;Borges JC;Marchetti JM;Al-Jamal WT;Chorilli M; 1873-4367 10.1016/j.colsurfb.2020.111185
Microfluidic production of lysolipid-containing temperature-sensitive liposomes 2020 Journal of Visualized Experiments 2020 Cheung C.C.L.;Ma G.;Ruiz A.;Al-Jamal W.T. 1940-087X 10.3791/60907
Toxicity and biodegradation of zinc ferrite nanoparticles in Xenopus laevis 2019 Journal of Nanoparticle Research 21 Rivero M.;Marín-Barba M.;Gutiérrez L.;Lozano-Velasco E.;Wheeler G.N.;Sánchez-Marcos J.;Muñoz-Bonilla A.;Morris C.J.;Ruiz A. 1388-0764 10.1007/s11051-019-4631-1
A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy 2019 Advanced Functional Materials 29 Martín C.;Ruiz A.;Keshavan S.;Reina G.;Murera D.;Nishina Y.;Fadeel B.;Bianco A. 1616-301X 10.1002/adfm.201901761
Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles. 2019 Materials 12 Ruiz A;Alpízar A;Beola L;Rubio C;Gavilán H;Marciello M;Rodríguez-Ramiro I;Ciordia S;Morris CJ;Morales MDP; 1996-1944 10.3390/ma12142218
"Ultramixing": A Simple and Effective Method To Obtain Controlled and Stable Dispersions of Graphene Oxide in Cell Culture Media. 2019 ACS applied materials & interfaces 11 Reina G;Ruiz A;Murera D;Nishina Y;Bianco A; 1944-8252 10.1021/acsami.8b18304
Unravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model. 2018 Nanoscale 10 Marín-Barba M;Gavilán H;Gutiérrez L;Lozano-Velasco E;Rodríguez-Ramiro I;Wheeler GN;Morris CJ;Morales MP;Ruiz A; 2040-3372 10.1039/c7nr06020c
Oriented Attachment of Recombinant Proteins to Agarose-Coated Magnetic Nanoparticles by Means of a β-Trefoil Lectin Domain. 2016 Bioconjugate Chemistry 27 Acebrón I;Ruiz-Estrada AG;Luengo Y;Morales MD;Guisán JM;Mancheño JM; 1520-4812 10.1021/acs.bioconjchem.6b00504
Dose-Response Bioconversion and Toxicity Analysis of Magnetite Nanoparticles 2016 IEEE Magnetics Letters 7 Ruiz A.;Mancebo A.;Beola L.;Sosa I.;Gutiérrez L. 1949-307X 10.1109/LMAG.2016.2535414
Biotransformation of magnetic nanoparticles as a function of coating in a rat model. 2015 Nanoscale 7 Ruiz A;Gutiérrez L;Cáceres-Vélez PR;Santos D;Chaves SB;Fascineli ML;Garcia MP;Azevedo RB;Morales MP; 2040-3372 10.1039/c5nr03780h
Hematotoxicity of magnetite nanoparticles coated with polyethylene glycol: In vitro and in vivo studies 2015 Toxicology Research 4 1555 - 1564 Ruiz A.;Ali L.M.A.;Cáceres-Vélez P.R.;Cornudella R.;Gutiérrez M.;Moreno J.A.;Piñol R.;Palacio F.;Fascineli M.L.;De Azevedo R.B.;Morales M.P.;Millán A. 2045-452X 10.1039/c4tx00241e
Biodistribution and pharmacokinetics of uniform magnetite nanoparticles chemically modified with polyethylene glycol. 2013 Nanoscale 5 Ruiz A;Hernández Y;Cabal C;González E;Veintemillas-Verdaguer S;Martínez E;Morales MP; 2040-3372 10.1039/c3nr01412f
Short-chain PEG molecules strongly bound to magnetic nanoparticle for MRI long circulating agents. 2013 Acta Biomaterialia 9 Ruiz A;Salas G;Calero M;Hernández Y;Villanueva A;Herranz F;Veintemillas-Verdaguer S;Martínez E;Barber DF;Morales MP; 1878-7568 10.1016/j.actbio.2012.12.032
Detection of PEGylated proteins in polyacrylamide gels by reverse staining with zinc and imidazole salts. 2008 Electrophoresis 29 Hardy E;Ramón J;Saez V;Báez R;Tejeda Y;Ruiz A; 0173-0835 10.1002/elps.200700781


Dr. Amalia Ruiz Estrada has 2 publication(s) listed under reviews.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Does black phosphorus hold potential to overcome graphene oxide? A comparative review of their promising application for cancer therapy 2021 3 4029 - 4036 Ruiz A.;Martín C.;Reina G. 2516-0230 10.1039/d1na00203a
Magnetic nanoparticles coated with dimercaptosuccinic acid: development, characterization, and application in biomedicine 2014 Journal of Nanoparticle Research 16 Ruiz A.;Morais P.C.;Bentes de Azevedo R.;Lacava Z.G.M.;Villanueva A.;del Puerto Morales M. 1388-0764 10.1007/s11051-014-2589-6