Dr. Francis Mprah Barnieh is a STARTER Research Fellow at the University of Bradford.
Francis graduated with BSc (First Class Hon) in Biochemistry from the University of Ghana and went on to receive MSc (Distinction) in Cancer Pharmacology and PhD in Cancer Drug Discovery from the University of Bradford. His PhD was focused on the development of protease-activated peptide prodrugs of DNA Damage Response (DDR) inhibitors. He previously undertook a post-doctoral fellowship as part of the Institute of Cancer Therapeutics' YCR programme, developing an LC-MS based assay to investigate the CYP-mediated metabolism of novel duocarmycin prodrugs, and additionally a high-throughput microplate ELISA assay for screening of both competitive polysialyltransferase inhibitors, and inhibitors of the NCAM-polyST protein-protein interaction.
Dr. Barnieh is currently undertaking his independent research, which is focused on understanding the tumour-specific glycosylation patterns of proteins, and the associated impact on the tumour-specific functions of these proteins. Additionally, he has keen interest in DDR inhibitors with particular emphasis on targeted tumour delivery of these agents.
Francis M. Barnieh,* Goreti Ribeiro Morais, Paul M. Loadman, Robert A. Falconer, and Sherif F. El-Khamisy (2024) Advanced Science. 2403831, 1-20.
Stevenson LK;Page AJ;Matthew Dowson;ElBadry SK;Barnieh FM;Falconer RA (2024) Frontiers In Cell And Developmental Biology. 12
Barnieh FM;Galuska SP;Loadman PM;Ward S;Falconer RA;El-Khamisy SF; (2023) Iscience. 26
Kyle K. Greenland;Kathryn A. F. Pennel;Giorgia Cioccoloni;Connor Rogerson;Francis M. Barnieh (2023) Biology Open. 12
Francis M. Barnieh,1,4,* Sebastian P. Galuska,2 Paul M. Loadman,1 Simon Ward,3 Robert A. Falconer,1 and Sherif F. El-Khamisy1 (2023) Iscience., 1-13.
Banisalman KAF;Polykandritou A;Barnieh FM;Ribeiro Morais G;Falconer RA; (2022) Journal of Organic Chemistry. 87
Francis M. Barnieh, Goreti Ribeiro Morais, Herbie Garland, Paul M. Loadman, Robert A. Falconer (2022) Biochemical Pharmacology.
Natalia Ortuzar, Kersti Karu, Daniela Presa, Goreti R. Morais, Helen M. Sheldrake, Steve D. Shnyder, Francis M. Barnieh, Paul M. Loadman, Laurence H. Patterson, Klaus Pors, Mark Searcey (2021) BIOORGANIC & MEDICINAL CHEMISTRY. 40
Barnieh F.M.;Loadman P.M.;Falconer R.A. (2021) Biochimica et Biophysica Acta - Reviews on Cancer.
Barnieh F.M.;Loadman P.M.;Falconer R.A. (2021) Current Research in Pharmacology and Drug Discovery.