Professor Colin Wright,Professor of Pharmacognosy
Information about Professor Colin Wright at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- c.w.wright@bradford.ac.uk
- Telephone:
- +44 1274 234739
Biography
I started my career as a hospital pharmacist and became interested intropical diseases as well as traditional medicine while working as a pharmacistin India (1980-1982). This led to my long-term interest in pharmacognosy andresearch in traditional medicines used in the treatment of infectious diseasesand cancer. I have taught pharmacognosy for more than 20 years with theprincipal aims of highlighting the importance of natural products in medicine& drug discovery as well as revealing their fascinating chemistry andpharmacological effects. When I started at Bradford School of Pharmacy in 1994,the teaching of Pharmacognosy was fairly traditional including analyticalmicroscopy. Working with Dr Peter Linley, I developed this subject area toprovide modules that were more relevant to modern pharmacy practice byillustrating through lectures and lab workshops why a knowledge of herbalmedicines and natural products is necessary for the practising pharmacist.Similarly, I developed a module on natural products for the (former) M.Sc inPharmaceutical Services and Medicines Control. Although pharmacognosy as asubject is no longer in the new pharmacy curriculum, I have been able toinclude some content e.g. in unit FS2 which includes the origins of drugs and eco-pharmacyand a number of applications exercises present problems involving herbalmedicines/natural products. Also, herbal medicines is a topic for studentselected components and I offer natural product-related laboratory researchprojects. My research has focussed mainly on the investigation of traditionalmedicines used for the treatment of malaria with the aim of identifying leadantimalarial compounds. In collaboration with Bradford’s Institute for CancerResearch I have also investigated plants including marine algae (seaweeds) fortheir potential to yield anticancer compounds. I also have an interest inanti-TB natural products. My main research achievement has been the study ofcryptolepine for which I received funding from WHO and is described in moredetail below. I have successfully supervised 20 PhD students whose work,together with the help of many collaborators has resulted in the publication of98 research papers and more than 100 conference contributions. In addition, Iam regularly invited to present my research at conferences and seminars. I actively participate in two of the research groups in the School ofPharmacy especially in the Medicines Development and Pharmaceutical Sciencegroup in which I line manage 7 academic staff and have a role in facilitatingthe group’s research ambitions and strategy.Publications
There are 94 publications involving or that are attributed to Professor Colin Wright.
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. | 2001 | Lisgarten, J.N.; Coll, M.; Portugal, J.; Wright, Colin W.; Aymami, J. | |||||||||
| Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. | 2001 | Wright, Colin W.; Addae-Kyereme, Jonathan A.; Breen, Anthony G.; Brown, John E.; Cox, Marlene F.; Croft, S.L.; Gokcek, Yaman; Kendrick, H.; Phillips, Roger M.; Pollet, Pamela L. | |||||||||
| Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. | 2005 | Wright, Colin W.; Onyeibor, O.; Phillips, Roger M.; Shnyder, Steven D.; Croft, S.L.; Dodson, Hilary I. | |||||||||
| Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone. | 2003 | Wright, Colin W.; Kirby, G.C; Phillipson, J.D; Warhurst, D.C.; Lang'at-Thoruwa, C.; Watt, R.A. | |||||||||
| Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. | 2008 | Watjen, W.; Suckow-Schnitker, A-K.; Rohrig, R.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Passreiter, C.M. | |||||||||
| Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. | 2009 | Laryea, D.; Isaksson, A.; Wright, Colin W.; Larsson, R.; Nygren, P. | |||||||||
| Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis. | 2009 | Oluwafemi, A.J.; Okanla, O.; Camps, P.; Muñoz-Torrero, D.; Mackey, Z.B.; Chiang, P.K.; Seville, Scott; Wright, Colin W. | |||||||||
| Anti-inflammatory properties of cryptolepine. | 2010 | Olajide, O.A.; Ajayi, A.A.; Wright, Colin W. | |||||||||
| Phytotherapy used in Orissa State India, for treating malaria. | 2009 | Kantamreddi, Venkata Siva Satya Narayana; Parida, S.; Kommula, S.M.; Wright, Colin W. | |||||||||
| Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus. | 2010 | Maregesi, S.; Van Miert, S.; Pannecouque, C.; Feiz-Haddad, M.H.; Hermans, N.; Wright, Colin W.; Vlietinck, A. J.; Aspers, S.; Pieters, L. | |||||||||
| Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. | 2010 | Wright, Colin W.; Linley, Peter A.; Brun, R.; Wittlin, S.; Hsu, E. | |||||||||
| New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly). | 2010 | Rao, T.S.P.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.; Parameswaran, P.S. | |||||||||
| Antiplasmodial compounds from Cassia siamea stem bark extract. | 2008 | Ajaiyeoba, E.O.; Ashidi, J.S.; Okpako, Larry Commander; Houghton, P.J.; Wright, Colin W. | |||||||||
| Structure of the antiplasmodial compound 7,9-dinitrocryptolepine hydrochloride methanol solvate. | 2008 | Lisgarten, J.N.; Potter, B.S.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W. | |||||||||
| X-ray crystallographic structure of the potent antiplasmodial compound 2,7-dibromocryptolepine acetic acid solvate. | 2008 | Potter, B.S.; Lisgarten, J.N.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W. | |||||||||
| A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations in Ghana | 2008 | Bayor, M.T.; Ayim, J.S.K.; Marston, G.; Phillips, Roger M.; Shnyder, Steven D.; Wheelhouse, Richard T.; Wright, Colin W. | |||||||||
| Genomewide expression profiling of the cryptolepine-induced toxicity in Saccharomyces cerevisiae. | 2008 | Rojas, M.; Wright, Colin W.; Pina, B.; Portugal, J. | |||||||||
| Screening Indian plant species for antiplasmodial properties – ethnopharmacological compared to random selection. | 2012 | Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. | |||||||||
| Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38 MAPK inhibition. | 2013 | Olajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L. | |||||||||
| Cajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extract | 2013 | Ajaiyeoba, E.O.; Ogbole, O.O.; Abiodun, O.O.; Ashidi, J.S.; Houghton, P.J.; Wright, Colin W. | |||||||||
| Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine. | 2013 | Olajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L. | Olajide, O.A., Bhatia, H., A.C., de Oliveira, A.C.P., Wright, C.W. and Fiebich, B.L. (2013) Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evidence-Based Complementary and Alternative Medicine, Article ID 459723. http://dx.doi.org/10.1155/2013/459723 | ||||||||
| Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. | 2014 | Sola, I.; Artigas, A.; Taylor, M.C.; Gbedema, Stephen Y.; Perez, B.; Clos, M.V.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. | |||||||||
| Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection. | 2015 | Gbedema, Stephen Y.; Bayor, M.T.; Annan, K.; Wright, Colin W. | |||||||||
| Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death | 2015 | Passreiter, C.M.; Suckow-Schnitker, A-K.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Wätjen, W. | |||||||||
| Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity. | 2015 | Sola, I.; Castellà, S.; Viayna, E.; Galdeano, C.; Taylor, M.C.; Gbedema, Stephen Y.; Pérez, B.; Clos, M.V.; Jones, D.C.; Fairlamb, A.H.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. | |||||||||
| Huprines as a new family of dual acting trypanocidal–antiplasmodial agents | 2011 | Defaux, J.; Sala, M.; Formosa, X.; Galdeano, C.; Taylor, M.C.; Kelly, J.M.; Wright, Colin W.; Camps, P.; Muñoz-Torrero, D.; Alobaid, Waleed A.A. | |||||||||
| Anticandida Agents from a Tanzanian Plant Albizia anthelmintica. | 2015 | Runyoro, D.K.B.; Joseph, C.C.; Ngassapa, O.D.; Darokar, M.P.; Srivastava, S.K.; Matee, M.I.N.; Wright, Colin W. | |||||||||
| A new embelin from the mangrove Aegiceras corniculatum. | 2015 | Thota, S.P.R.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. | |||||||||
| Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. | 2011 | Sengupta, S.; Chowdhury, S.; BoseDasgupta, S.; Wright, Colin W.; Majumder, H.K. | |||||||||
| Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | 2011 | Rasoanaivo, P.; Wright, Colin W.; Willcox, M.L.; Gilbert, B. | |||||||||
| Low Temperature X-Ray Crystallographic Structure of the Antiplasmodial Compound 5-N-Hydroxyethanequindoline Hydrochloride 0.5CH3OH. | 2011 | Hampson, Hannah C.; Ho, Chung Y.; Palmer, R.A.; Potter, B.S.; Helliwell, M.; Wright, Colin W. | |||||||||
| Effects of the antimalarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay | 2011 | Gopalan, Rajendran C.; Emerce, E.; Wright, Colin W.; Karahalil, B.; Karakaya, A.E.; Anderson, Diana | |||||||||
| Complete NMR assignments of tubulosine | 2012 | Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. | |||||||||
| Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase | 2012 | Stell, J. Godfrey P.; Wheelhouse, Richard T.; Wright, Colin W. | |||||||||
| Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes. | 2012 | Hazra, S.; Ghosh, S.; Debnath, S.; Seville, Scott; Prajapati, V.K.; Wright, Colin W.; Sundar, S.; Hazra, B. | |||||||||
| Recent developments in research on terrestrial plants used for the treatment of malaria. | 2010 | Wright, Colin W. | |||||||||
| Traditional remedies: an ally in the fight against infectious diseases? | 2012 | Wright, Colin W. | |||||||||
| Synthesis and biological evaluation of N-cyanoalkyl-, Naminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents | 2016 | Sola, I.; Artigas, A.; Taylor, M.C.; Perez-Areales, F.J.; Viayna, E.; Clos, M.V.; Perez, B.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. | |||||||||
| Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae) | 2017 | Taiwo, Bamigboye J.; Fatokun, Amos A.; Olubiyi, O.O.; Bamigboye-Taiwo, O.T.; van Heerden, F.R.; Wright, Colin W. | |||||||||
| In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine | 2017 | Forkuo, A.D.; Ansah, C.; Mensah, K.B.; Annan, K.; Gyan, B.; Theron, A.; Mancama, D.; Wright, Colin W. | |||||||||
| Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats | 2017 | Forkuo, A.D.; Ansah, C.; Pearson, D.; Gertsch, W.; Cirello, A.; Amaral, A.; Spear, J.; Wright, Colin W.; Rynn, C. | |||||||||
| Investigation of Indian Diospyros species for antiplasmodial properties | 2008 | Evidence-based Complementary and Alternative Medicine | 5 | 187 - 190 | Kantamreddi V.;Wright C. | 1741-427X | 10.1093/ecam/nem019 | ||||
| Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer | 2004 | Phytotherapy Research | 18 | 507 - 510 | Khamis S.;Bibby M.;Brown J.;Cooper P.;Scowen I.;Wright C. | 0951-418X | 10.1002/ptr.1318 | ||||
| In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers | 2004 | Journal of Natural Products | 67 | 1445 - 1449 | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wheelhouse R.;Wright C. | 0163-3864 | 10.1021/np0305268 | ||||
| Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae | 2008 | Antimicrobial Agents and Chemotherapy | 52 | 3844 - 3850 | Rojas M.;Wright C.;Piña B.;Portugal J. | 0066-4804 | 10.1128/AAC.00532-08 | ||||
| Recent developments in naturally derived antimalarials: Cryptolepine analogues | 2007 | Journal of Pharmacy and Pharmacology | 59 | 899 - 904 | Wright C. | 0022-3573 | 10.1211/jpp.59.6.0017 | ||||
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids | 2000 | Journal of Natural Products | 63 | 1638 - 1640 | Wright C.;Marshall S.;Russell P.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff J. | 0163-3864 | 10.1021/np000144r | ||||
| Synthesis of novel halogenated cryptolepine analogues | 2006 | Journal of Heterocyclic Chemistry | 43 | 171 - 175 | Gouni S.;Carrington S.;Wright C. | 0022-152X | 10.1002/jhet.5570430126 | ||||
| Synthesis and antiplasmodial activities of some halogenated cryptolepine derivatives | 2000 | Journal of Pharmacy and Pharmacology | 52 | 296 | Wright C.;Addae-Kyereme J.;Brown J.;Cox M.;Gokcek Y.;Pollet P. | 0022-3573 | |||||
| Enhancement of the Antiplasmodial Activity of Quassin by Transformation into a γ-Lactone | 2003 | Journal of Natural Products | 66 | 1486 - 1489 | Lang'at-Thoruwa C.;Kirby G.;Phillipson J.;Warhurst D.;Watt R.;Wright C. | 0163-3864 | |||||
| Cryptolepine hydrochloride: A potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta | 2003 | Phytotherapy Research | 17 | 434 - 436 | Gibbons S.;Fallah F.;Wright C. | 0951-418X | 10.1002/ptr.1284 | ||||
| The antimalarial and cytotoxic drug cryptolepine intercalates into dna at cytosine-cytosine sites | 2002 | Nature Structural Biology | 9 | 57 - 60 | Lisgarten J.;Coll M.;Portugal J.;Wright C.;Aymami J. | 1072-8368 | 10.1038/nsb729 | ||||
| Synthetic cryptolepine inhibits DNA binding of NF-κB | 2007 | Bioorganic and Medicinal Chemistry | 15 | 43 - 49 | Olajide O.;Heiss E.;Schachner D.;Wright C.;Vollmar A.;Dirsch V. | 0968-0896 | 10.1016/j.bmc.2006.10.018 | ||||
| In-vitro antiplasmodial and cytotoxic activities of some British species of marine algae | 2000 | Journal of Pharmacy and Pharmacology | 52 | 311 | Shoeib N.;Bibby M.;Cooper P.;Blunden G.;Wright C. | 0022-3573 | |||||
| Synthesis of cryptolepine analogues as potential bioreducible anticancer agents | 2007 | Bioorganic and Medicinal Chemistry | 15 | 6353 - 6360 | Seville S.;Phillips R.;Shnyder S.;Wright C. | 0968-0896 | 10.1016/j.bmc.2007.06.062 | ||||
| The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis | 2002 | Journal of Ethnopharmacology | 79 | 57 - 67 | Newton S.;Lau C.;Gurcha S.;Besra G.;Wright C. | 0378-8741 | 10.1016/S0378-8741(01)00350-6 | ||||
| Seasonal variation in bromophenol content of Polysiphonia lanosa | 2006 | Natural product communications | 1 | 47 - 49 | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wright C. | 1934-578X | |||||
| Sesquiterpene lactones from Neurolaena oaxacana | 1999 | Journal of Natural Products | 62 | 1093 - 1095 | Passreiter C.;Sandoval-Ramirez J.;Wright C. | 0163-3864 | 10.1021/np990038t | ||||
| Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine | 2001 | Journal of Ethnopharmacology | 76 | 99 - 103 | Addae-Kyereme J.;Croft S.;Kendrick H.;Wright C. | 0378-8741 | 10.1016/S0378-8741(01)00212-4 | ||||
| Structure of the tetraphenyl borate complex of the indoloquinoline alkaloid cryptolepine | 1999 | Journal of Chemical Crystallography | 29 | 449 - 455 | Wright C.;Philpson J.;Lisgarten J.;Palmer R. | 1074-1542 | 10.1023/A:1009519211938 | ||||
| Low temperature X-ray crystallographic structure of the antiplasmodial compound 5-N-hydroxyethanequindoline hydrochloride 0.5CH |
2011 | Journal of Chemical Crystallography | 41 | 1757 - 1762 | Hampson H.;Ho C.;Palmer R.;Potter B.;Helliwell M.;Wright C. | 1074-1542 | 10.1007/s10870-011-0169-5 | ||||
| Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation | 2007 | Toxicology | 242 | 71 - 79 | Wätjen W.;Kulawik A.;Suckow-Schnitker A.;Chovolou Y.;Rohrig R.;Ruhl S.;Kampkötter A.;Addae-Kyereme J.;Wright C.;Passreiter C. | 0300-483X | 10.1016/j.tox.2007.09.010 | ||||
| Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: A preliminary study | 2003 | Journal of Psychopharmacology | 17 | 403 - 408 | Wright C.;Gott M.;Grayson B.;Hanna M.;Smith A.;Sunter A.;Neill J. | 0269-8811 | 10.1177/0269881103174018 | ||||
| Evaluation of Some Egyptian Plant Species for in vitro Antimycobacterial and Cytotoxic Activities | 2003 | Pharmaceutical Biology | 41 | 463 - 465 | Abou El Seoud K.;Bibby M.;Shoeib N.;Wright C. | 1388-0209 | 10.1076/phbi.41.6.463.17831 | ||||
| Huprines as a new family of dual acting trypanocidal-antiplasmodial agents | 2011 | Bioorganic and Medicinal Chemistry | 19 | 1702 - 1707 | Defaux J.;Sala M.;Formosa X.;Galdeano C.;Taylor M.;Alobaid W.;Kelly J.;Wright C.;Camps P.;Muñoz-Torrero D. | 0968-0896 | 10.1016/j.bmc.2011.01.028 | ||||
| Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone | 2000 | Phytotherapy Research | 14 | 356 - 358 | Marshall S.;Russell P.;Phillipson J.;Kirby G.;Warhurst D.;Wright C. | 0951-418X | 10.1002/1099-1573(200008)14:5<356::AID-PTR636>3.0.CO;2-Z | ||||
| Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: In vivo antimalarial activity and x-ray crystal structure of normelicopicine | 2002 | Journal of Natural Products | 65 | 956 - 959 | Muriithi M.;Abraham W.;Addae-Kyereme J.;Scowen I.;Croft S.;Gitu P.;Kendrick H.;Njagi E.;Wright C. | 0163-3864 | 10.1021/np0106182 | ||||
| In vitro anti-plasmodial and cytotoxic activities of plants used as antimalarial agents in the southwest Nigerian ethnomedicine | 2005 | Journal of Natural Remedies | 5 | 1 - 6 | Ajaiyeoba E.;Bolaji O.;Akinboye D.;Falade C.;Gbotosho G.;Ashidi J.;Okpako L.;Oduola O.;Falade M.;Itiola O.;Houghton P.;Wright C.;Ogundahunsi O.;Oduola A. | 0972-5547 | |||||
| Screening indian plant species for antiplasmodial properties - Ethnopharmacological compared with random selection | 2012 | Phytotherapy Research | 26 | 1793 - 1799 | Kantamreddi V.;Wright C. | 0951-418X | 10.1002/ptr.4651 | ||||
| Antiplasmodial principles from Cassia nigricans | 2004 | Pharmaceutical Biology | 42 | 626 - 628 | Obodozie O.;Okpako L.;Tarfa F.;Orisadipe A.;Okogun J.;Inyang U.;Ajaiyeoba E.;Wright C. | 1388-0209 | 10.1080/13880200490902545 | ||||
| Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt | 2004 | Pharmaceutical Biology | 42 | 588 - 591 | Ajaiyeoba E.;Ashidi J.;Abiodun O.;Okpako L.;Ogbole O.;Akinboye D.;Falade C.;Bolaji O.;Gbotosho G.;Falade M.;Itiola O.;Houghton P.;Wright C.;Oduola A. | 1388-0209 | 10.1080/13880200490902455 | ||||
| In-vitro antimycobacterial screening of some plant species used in traditional medicine for the treatment of tuberculosis | 2000 | Journal of Pharmacy and Pharmacology | 52 | 310 | Newton S.;Lau C.;Wright C. | 0022-3573 | |||||
| In-vitro cytotoxicity and thermodenaturation studies for cryptolepine and analogues | 2000 | Journal of Pharmacy and Pharmacology | 52 | 109 | Gokcek Y.;Pollet P.;Wright C.;Brown J. | 0022-3573 | |||||
| A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana | 2008 | Natural product communications | Bayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.; | ||||||||
| Pharmacy Education: Understanding drug abuse | 1993 | Pharmaceutical Journal | 250 | Wright, C.W. | |||||||
| Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. | 1988 | Antimicrobial Agents and Chemotherapy | 32 | Wright CW;O'Neill MJ;Phillipson JD;Warhurst DC; | 0066-4804 | ||||||
| Plants as sources of antimalarial drugs, part 6: Activities of Simarouba amara fruits | 1988 | Journal of Ethnopharmacology | 22 | 183 - 190 | O'Neill M.;Bray D.;Boardman P.;Wright C.;David Phillipson J.;Warhurst D.;Gupta M.;Correya M.;Solis P. | 0378-8741 | 10.1016/0378-8741(88)90126-2 | ||||
| Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. | 1991 | Planta Medica | 57 | Wright CW;Bray DH;O'Neill MJ;Warhurst DC;Phillipson JD;Quetin-Leclercq J;Angenot L; | 0032-0943 | 10.1055/s-2006-960112 | |||||
| Can ethnopharmacology contribute to the development of antimalarial agents? | 1991 | Journal of Ethnopharmacology | 32 | 155 - 165 | David Phillipson J.;Wright C. | 0378-8741 | 10.1016/0378-8741(91)90113-R | ||||
| Molecular modelling of usambarensine, tubulosine and emetine, three cytotoxic amoebicide alkaloids | 1991 | Journal de Pharmacie de Belgique | 46 | 85 - 92 | Quetin-Leclercq J.;Dupont L.;Wright C.;Phillipson J.;Warhurst D.;Angenot L. | 0047-2166 | |||||
| A new alkaloid from the roots of alstonia angustifolia | 1992 | Journal of Natural Products | 55 | 1323 - 1324 | Said I.;Din L.;Yusoff N.;Wright C.;Cai Y.;Phillipson J. | 0163-3864 | 10.1021/np50087a025 | ||||
| In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots | 1992 | Phytotherapy Research | 6 | 121 - 124 | Wright C.;Allen D.;Cai Y.;Phillipson J.;Said I.;Kirby G.;Warhurst D. | 0951-418X | 10.1002/ptr.2650060303 | ||||
| Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico). | 1992 | Journal of Ethnopharmacology | 36 | Heinrich M;Kuhnt M;Wright CW;Rimpler H;Phillipson JD;Schandelmaier A;Warhurst DC; | 0378-8741 | ||||||
| Determination of anti-giardial activity in vitro by means of soluble formazan production | 1992 | Transactions of the Royal Society of Tropical Medicine and Hygiene | 86 | 517 - 519 | Wright C.;Melwani S.;David Phillipson J.;Warhurst D. | 0035-9203 | 10.1016/0035-9203(92)90093-R | ||||
| In vitro antimalarial and cytotoxic activities of semisynthetic derivatives of brusatol | 1993 | European Journal of Medicinal Chemistry | 28 | 265 - 269 | Allen D.;Toth I.;Wright C.;Kirby G.;Warhurst D.;Phillipson J. | 0223-5234 | 10.1016/0223-5234(93)90143-3 | ||||
| Quassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro | 1993 | Journal of Eukaryotic Microbiology | 40 | 244 - 246 | WRIGHT C.;ANDERSON M.;ALLEN D.;PHILLIPSON J.;KIRBY G.;WARHURST D.;CHANG H. | 1066-5234 | 10.1111/j.1550-7408.1993.tb04910.x | ||||
| A microwell cytotoxicity assay using Artemia salina (brine shrimp) | 1993 | Planta Medica | 59 | 250 - 252 | Solis P.;Wright C.;Anderson M.;Gupta M.;Phillipson J. | 0032-0943 | |||||
| Alstonia species: are they effective in malaria treatment? | 1993 | Journal of Ethnopharmacology | 40 | 41 - 45 | Wright C.;Allen D.;Phillipson J.;Kirby G.;Warhurst D.;Massiot G.;Le Men-Olivier L. | 0378-8741 | 10.1016/0378-8741(93)90087-L | ||||
| Alkaloids from Cephaelis dichroa | 1993 | Phytochemistry | 33 | 1117 - 1119 | Solis P.;Wright C.;Gupta M.;Phillipson J. | 0031-9422 | 10.1016/0031-9422(93)85033-N | ||||
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids | 1994 | Antimicrobial Agents and Chemotherapy | 38 | 96 - 103 | Marshall S.;Russell P.;Wright C.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff P. | 0066-4804 | 10.1128/AAC.38.1.96 | ||||
| Selective antiprotozoal activity of some Strychnos alkaloids | 1994 | Phytotherapy Research | 8 | 149 - 152 | Wright C.;Allen D.;Cai Y.;Chen Z.;Phillipson J.;Kirby G.;Warhurst D.;Tits M.;Angenot L. | 0951-418X | 10.1002/ptr.2650080306 | ||||
| Toward the chemical ecology of medicinal plant use in chimpanzees: The case of Vernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases | 1994 | Journal of Chemical Ecology | 20 | 541 - 553 | Ohigashi H.;Huffman M.;Izutsu D.;Koshimizu K.;Kawanaka M.;Sugiyama H.;Kirby G.;Warhurst D.;Allen D.;Wright C.;David Phillipson J.;Timon-David P.;Delmas F.;Elias R.;Balansard G. | 0098-0331 | 10.1007/BF02059596 | ||||
| Alkaloids from Narcissus cantabricus | 1995 | Phytochemistry | 40 | 1549 - 1551 | Bastida J.;Contreras J.;Codina C.;Wright C.;David Phillipson J. | 0031-9422 | 10.1016/0031-9422(95)00448-G | ||||
| Antiprotozoal activities of Centipeda minima | 1994 | Phytotherapy Research | 8 | 436 - 438 | Yu H.;Wright C.;Cai Y.;Yang S.;Phillipson J.;Kirby G.;Warhurst D. | 0951-418X | 10.1002/ptr.2650080713 |