Dr Colin Seaton
Associate Professor
| Faculty/Dept/School |
School of Chemistry and Bioscience (Faculty of Life Sciences) |
|---|---|
| c.seaton@bradford.ac.uk | |
| Telephone | +441274 236155 |
Biography
Dr Colin Seaton received a first class BSc(Hons.) in Chemistry from the University of St. Andrews and a PhD in Chemistry froth University of Birmingham with a thesis entitled "Novel Methods of Crystal Structure Determination from Powder X-ray Diffraction Data".
His Research lies in the field of crystal engineering with key interests in polymorphism, creation of multi-component crystals, crystal growth and habit modification. His work brings together both experimental and computational approaches to these problems with a interest in the application of biologically inspired computational methods such as evolutionary algorithms.
Teaching covers atomic and molecular structures, solid-state chemistry and computational chemistry.
Research
My research lies in the field of solid-state molecular chemistry, with the major focus on crystal engineering, the study of crystalline phases and controlling their formation. A key aim is the determination of the factors controlling the creation of crystal phases and using this understanding to design and create new materials. My work covers the development of both experimental (crystallisation processes, phase diagram construction, crystal structural determination by single crystal and powder diffraction methods) and computational methodologies (ab initio calculations, evolutionary algorithms) to gain the insight required.Current topics of interest include work on understanding influence of experimental conditions on polymorphism through molecular modelling of solvent/solute interactions and molecular conformation, the influence of chemical and crystallographic factors on proton transfer in crystal materials and the creation of multi-component crystals (salts and co-crystals). Development of new computational methodologies to model additive/crystal interactions, molecule/molecule interactions and location of low energy molecular conformations.
| Research collaborators | |
|---|---|
| Name | Prof Ian Scowen |
| Company | University of Lincoln |
| Country | UNITED KINGDOM |
| Type | E |
| Theme | Crystal Engineering |
| Name | Dr Tasmin Munshi |
| Company | University of Lincoln |
| Country | UNITED KINGDOM |
| Type | E |
| Theme | Crystal Engineering |
Professional activities
- 01-JAN-03: University of Birmingham - PhD
- 01-JAN-99: University of St. Andrews - BSc (Hons)
- 01-FEB-14: University of Bradford - Lecturer in Chemistry
- 01-JUL-11: University of Limerick - Postdoctoral Research Fellow
- 01-SEP-10: University of Manchester - Part-Time Postdoctoral Research Associate
- 01-SEP-10: University of Bradford - Part-Time Teaching Associate
- 01-JUN-10: University of Manchester - Postdoctoral Research Associate
- 01-OCT-09: University of Bradford - Scientific Officer
- 01-MAY-08: University of Manchester - Postdoctoral Research Associate
- 01-JUL-03: University of Bradford - Postdoctoral Research Associate/Teaching Associate
- Royal Society of Chemistry, Member (MRSC)
- Institute of Chemical Engineers (IChemE), Affiliate Member
- British Crystallographic Association, Member
- British Association of Crystal Growth, Member
- 01-JAN-12: BACG Young Scientist Award
Publications
| Title | Investigation into the development of novel lanthanide-based luminescent colorants for application to textiles and paper materials (2023) |
|---|---|
| Authors | D M Lewis, P J Broadbent, M L A Rigout, C M Carr*, C C Seaton, and T Swift |
| Journal | Coloration Technology |
| DOI | https://doi.org/10.1111/cote.12675 |
| Title | Artemisinin-acetylenedicarboxylic acid cocrystal: Screening, structure determination, and physicochemical property characterisation (2022) |
| Authors | Makadia J.;Madu S.J.;Arroo R.;Seaton C.C.;Li M. |
| Journal | CrystEngComm |
| DOI | 10.1039/d1ce01400e |
| Title | Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria. (2022) |
| Authors | Nolan VC;Rafols L;Harrison J;Soldevila-Barreda JJ;Crosatti M;Garton NJ;Wegrzyn M;Timms DL;Seaton CC;Sendron H;Azmanova M;Barry NPE;Pitto-Barry A;Cox JAG; |
| Journal | Current Research In Microbial Sciences |
| DOI | 10.1016/j.crmicr.2021.100099 |
| Title | Construction of Ternary Phase Diagrams: Application of Quantitative NMR (2022) |
| Authors | Telford R.;Obule W.;Seaton C.C. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/acs.cgd.1c01311 |
| Title | Interfacial Cocrystallization Using Oily Phase via Liquid−Liquid Phase Separation (2022) |
| Authors | M. Asim Sajid Al-Hanafi, Mhd Bashir Alsirawan, Colin C. Seaton, Thomas Swift, Sudhir Pagire, Venu R. Vangala, Adrian L. Kelly, and Anant Paradkar |
| Journal | CRYSTAL GROWTH & DESIGN (ONLINE) |
| DOI | https://doi.org/10.1021/acs.cgd.2c00263 |
| Title | Anticancer water-soluble organoruthenium complexes: synthesis and preclinical evaluation. (2022) |
| Authors | Pitto-Barry A;Azmanova M;Rafols L;Cooper PA;Seaton CC;Shnyder SD; |
| Journal | ChemBioChem |
| DOI | 10.1002/cbic.202200259 |
| Title | Influence of Terminal Functionality on the Crystal Packing Behaviour and Cytotoxicity of Aromatic Oligoamides. (2021) |
| Authors | Delfosse P;Seaton CC;Male L;Lord RM;Pike SJ; |
| Journal | FRONTIERS IN CHEMISTRY |
| DOI | 10.3389/fchem.2021.709161 |
| Title | Isostructurality of quinoxaline crystal phases: The interplay of weak hydrogen bonds and halogen bonding (2021) |
| Authors | Saidykhan A.;Fenwick N.W.;Bowen R.D.;Telford R.;Seaton C.C. |
| Journal | CrystEngComm |
| DOI | 10.1039/d1ce00878a |
| Title | Ortho -Substituent effect on the crystal packing and solid state speciation of aromatic C -nitroso compounds (2020) |
| Authors | Pike S.J.;Heliot A.;Seaton C.C. |
| Journal | CrystEngComm |
| DOI | 10.1039/d0ce00728e |
| Title | Structural similarity in chiral-achiral multi-component crystals (2020) |
| Authors | Scowen I.J.;Alomar T.S.;Munshi T.;Seaton C.C. |
| Journal | CrystEngComm |
| DOI | 10.1039/d0ce00301h |
| Title | Improving Stability of Effervescent Products by Co-Crystal Formation: A Novel Application of Crystal Engineered Citric Acid (2020) |
| Authors | Pagire, SK; Seaton, CC; Paradkar, A |
| Journal | Crystal Growth and Design |
| Publisher | ACS |
| DOI | https://doi.org/10.1021/acs.cgd.0c00616 |
| Title | Intriguing High Z″ Cocrystals of Emtricitabine (2020) |
| Authors | Palanisamy V.;Sanphui P.;Bolla G.;Narayan A.;Seaton C.C.;Vangala V.R. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/acs.cgd.0c00744 |
| Title | Structural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs (2018) |
| Authors | Seaton, Colin C.; Rayan, R.T.; Essifaow, E.A.A.; Nauha, E.; Munshi, Tasnim; Scowen, Ian J. |
| Title | Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology (2018) |
| Authors | Korde, Sachin A.; Pagire, Sudhir K.; Pan, H.; Seaton, Colin C.; Kelly, Adrian L.; Chen, Y.; Wang, Q.; Coates, Philip D.; Paradkar, Anant R. |
| Title | Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology (2018) |
| Authors | Korde, S.; Pagire, S.; Pan, H.; Seaton, C.; Kelly, A.; Chen, Y.; Wang, Q.; Coates, P.; Paradkar, A. |
| Journal | Crystal Growth and Design |
| DOI | https://doi.org/10.1021/acs.cgd.7b01733 |
| Title | Poly(acrylic acid) interpolymer complexes (2017) |
| Authors | Swift, Thomas; Seaton, Colin C.; Rimmer, Stephen |
| Journal | RSC Soft Matter |
| Title | An unusual Cu(II) complex of a Schiff-base ligand of 3-aminoquinoline with a hydronated pyridine unit: Synthesis, characterizations, and computational studies (2016) |
| Authors | Nayak S.;Pevec A.;Seaton C.;Gamez P.;Reedijk J. |
| Journal | Polyhedron |
| DOI | 10.1016/j.poly.2016.01.009 |
| Title | Stabilisation of metastable polymorphs: the case of paracetamol form III (2016) |
| Authors | Telford, Richard; Seaton, Colin C.; Clout, A.; Buanz, A.B.M.; Gaisford, S.; Williams, G.R.; Prior, T.J.; Okoye, C.H.; Munshi, Tasnim; Scowen, Ian J. |
| Title | Are the Crystal Structures of Enantiopure and Racemic Mandelic Acids Determined by Kinetics or Thermodynamics? (2015) |
| Authors | Hylton, R.K.; Tizzard, G.J.; Threlfall, T.L.; Ellis, A.L.; Coles, S.J.; Seaton, Colin C.; Schulze, E.; Lorenz, H.; Seidel-Morgenstern, A.; Stein, M.; Price, S.L. |
| Title | Investigation into solid and solution properties of quinizarin (2015) |
| Authors | Cheuk, D.; Svärd, M.; Seaton, Colin C.; McArdle, P.; Rasmuson, Å.C. |
| Title | Thermal Behavior of Benzoic Acid/Isonicotinamide Binary Cocrystals (2015) |
| Authors | Buanz, A.B.M.; Prior, T.J.; Burley, J.C.; Raimi-Abraham, B.T.; Telford, Richard; Hart, M.; Seaton, Colin C.; Davies, P.J.; Scowen, Ian J.; Gaisford, S.; Williams, G.R. |
| Title | Insight into the Mechanism of Formation of Channel Hydrates via Templating (2014) |
| Authors | Stokes, S.P.; Seaton, Colin C.; Eccles, K.S.; Maguire, A.R.; Lawrence, S.E. |
| Title | Proton location in acid⋯pyridine hydrogen bonds of multi-component crystals (2014) |
| Authors | Seaton, Colin C. |
| Title | Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents (2014) |
| Authors | Maher, A.; Croker, D.M.; Seaton, Colin C.; Rasmuson, Å.C.; Hodnett, B.K. |
| Title | Complete Colloidal Synthesis of Cu2SnSe3 Nanocrystals with Crystal Phase and Shape Control (2014) |
| Authors | Wang, J.; Liu, P.; Seaton, Colin C.; Ryan, K.M. |
| Title | Racemic compound versus conglomerate: concerning the crystal chemistry of the triazoylketone, 1-(4-chlorophenyl)-4,4- dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-one (2014) |
| Authors | Davey, R.J.; Sadiq, G.; Seaton, Colin C.; Pritchard, R.G.; Coquerel, G.; Rougeot, C. |
| Title | Creation of a ternary complex between a crown ether, 4-aminobenzoic acid and 3,5-dinitrobenzoic acid (2014) |
| Authors | Boardman, N.D.; Munshi, Tasnim; Scowen, Ian J.; Seaton, Colin C. |
| Title | Investigating the dissolution of the metastable triclinic polymorph of carbamazepine using in situ microscopy (2014) |
| Authors | O'Mahony, M.; Seaton, Colin C.; Croker, D.M.; Veesler, S.; Rasmuson, A.K.; Hodnett, B.K. |
| Title | Proton transfer and hydrogen bonding in the organic solid state: a combined XRD/XPS/ssNMR study of 17 organic acid–base complexes (2014) |
| Authors | Stevens, J.S.; Byard, S.J.; Seaton, Colin C.; Sadiq, G.; Davey, R.J.; Schroeder, S.L.M. |
| Title | Tuning proton disorder in 3,5-dinitrobenzoic acid dimers: The effect of local environment (2013) |
| Authors | Jones A.;Blagden N.;McIntyre G.;Parkin A.;Seaton C.;Thomas L.;Wilson C. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg300906j |
| Title | Investigation into the mechanism of solution-mediated transformation from FI to FIII carbamazepine: The role of dissolution and the interaction between polymorph surfaces (2013) |
| Authors | O'Mahony M.;Seaton C.;Croker D.;Veesler S.;Rasmuson A.;Hodnett B. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg301456m |
| Title | Solution mediated phase transformations between co-crystals (2013) |
| Authors | Croker D.;Davey R.;Rasmuson A.;Seaton C. |
| Journal | CrystEngComm |
| DOI | 10.1039/c2ce26801a |
| Title | Multi-component crystals of 4-phenylpyridine: challenging the boundaries between co-crystal and organic salt formation with insight into solid-state proton transfer (2013) |
| Authors | Seaton, Colin C.; Munshi, Tasnim; Williams, Sara E.; Scowen, Ian J. |
| Title | Building Multi-Component Crystals From Cations and Co-crystals: The Use of Chaperones (2013) |
| Authors | Bukenya S.;Munshi T.;Scowen I.;Skyner R.;Whitaker D.;Seaton C. |
| Journal | CrystEngComm |
| DOI | 10.1039/c2ce26498f |
| Title | Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions (2013) |
| Authors | Seaton, Colin C.; Blagden, Nicholas; Munshi, Tasnim; Scowen, Ian J. |
| Title | Nucleation in the p-toluenesulfonamide/triphenylphosphine oxide co-crystal system (2013) |
| Authors | Croker D.;Davey R.;Rasmuson A.;Seaton C. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg400780e |
| Title | Investigation of the solid-state polymorphic transformations of piracetam (2012) |
| Authors | Maher A.;Seaton C.;Hudson S.;Croker D.;Rasmuson A.;Hodnett B. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg301418c |
| Title | The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach (2012) |
| Authors | Davey R.;Sadiq G.;Back K.;Wilkinson L.;Seaton C. |
| Journal | Chemical Communications |
| DOI | 10.1039/c1cc16173c |
| Title | Creating carboxylic acid co-crystals: The application of Hammett substitution constants (2011) |
| Authors | Seaton C. |
| Journal | CrystEngComm |
| DOI | 10.1039/c1ce05645j |
| Title | Epitaxial growth of polymorphic systems: The case of sulfathiazole (2011) |
| Authors | Munroe A.;Croker D.;Hodnett B.;Seaton C. |
| Journal | CrystEngComm |
| DOI | 10.1039/c1ce05585b |
| Title | Crystallography aided by atomic core-level binding energies: Proton transfer versus hydrogen bonding in organic crystal structures (2011) |
| Authors | Stevens J.;Byard S.;Seaton C.;Sadiq G.;Davey R.;Schroeder S. |
| Journal | Angewandte Chemie - International Edition |
| DOI | 10.1002/anie.201103981 |
| Title | Making benzamide cocrystals with benzoic acids: The influence of chemical structure (2011) |
| Authors | Seaton C.;Parkin A. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg101403j |
| Title | The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate (2011) |
| Authors | Lorenz H.;Von Langermann J.;Sadiq G.;Seaon C.;Davey R.;Seidel-Morgenstern A. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg1015077 |
| Title | Tuning proton behavior in a ternary molecular complex. (2010) |
| Authors | Thomas, L.H.; Blagden, Nicholas; Gutmann, M.J.; Kallay, A.A.; Parkin, A.; Seaton, Colin C.; Wilson, C.C. |
| Title | Solubility, metastable zone width measurement and crystal growth of the 1:1 benzoic acid/isonicotinamide cocrystal in solutions of variable stoichiometry (2010) |
| Authors | Boyd S.;Back K.;Chadwick K.;Davey R.;Seaton C. |
| Journal | Journal of Pharmaceutical Sciences |
| DOI | 10.1002/jps.22184 |
| Title | Co-crystallization in the caffeine/maleic acid system: Lessons from phase equilibria (2010) |
| Authors | Guo K.;Sadiq G.;Seaton C.;Davey R.;Yin Q. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg900885n |
| Title | Designing acid/acid co-crystals through the application of hammett substituent constants (2010) |
| Authors | Seaton C.;Chadwick K.;Sadiq G.;Guo K.;Davey R. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg9011235 |
| Title | Controlling the Formation of Benzoic Acid: Isonicotinamide Molecular Complexes. (2009) |
| Authors | Seaton, Colin C.; Parkin, A.; Wilson, C.C.; Blagden, Nicholas |
| Title | Formation of a hybrid coordination-molecular complex. (2009) |
| Authors | Seaton, Colin C.; Scowen, Ian J.; Blagden, Nicholas |
| Title | Applying hot-stage microscopy to co-crystal screening: A study of nicotinamide with seven active pharmaceutical ingredients. (2008) |
| Authors | Berry, David J.; Seaton, Colin C.; Clegg, W.; Harrington, R.W.; Coles, S.J.; Horton, P.N.; Hursthouse, M.B.; Storey, Richard; Jones, W.; Friščić, T.; Blagden, Nicholas |
| Title | Growth of an organic co-crystal upon a component subphase. (2008) |
| Authors | Seaton, Colin C.; Parkin, A.; Wilson, C.C.; Blagden, Nicholas |
| Title | Current directions in co-crystal growth (2008) |
| Authors | Blagden N.;Berry D.;Parkin A.;Javed H.;Ibrahim A.;Gavan P.;De Matos L.;Seaton C. |
| Journal | New Journal of Chemistry |
| DOI | 10.1039/b803866j |
| Title | Designing hydrogen bonds with temperature-dependent proton disorder: The effect of crystal environment (2007) |
| Authors | Parkin A.;Seaton C.;Blagden N.;Wilson C. |
| Journal | Crystal Growth and Design |
| DOI | 10.1021/cg060777p |
| Title | Molecular versus crystal symmetry in tri-substituted triazine, benzene and isocyanurate derivatives (2006) |
| Authors | Chong S.;Seaton C.;Kariuki B.;Tremayne M. |
| Journal | Acta Crystallographica Section B: Structural Science |
| DOI | 10.1107/S0108768106020921 |
| Title | Ordered Aggregation of Benzamide Crystals Induced using a "Motif Capper" Additive. (2005) |
| Authors | Blagden, Nicholas; Song, M.; Davey, R.J.; Seton, L.; Seaton, Colin C. |
| Title | Characterization of complicated new polymorphs of chlorothalonil by X-ray diffraction and computer crystal structure prediction (2004) |
| Authors | Tremayne M.;Grice L.;Pyatt J.;Seaton C.;Kariuki B.;Tsui H.;Price S.;Cherryman J. |
| Journal | Journal of the American Chemical Society |
| DOI | 10.1021/ja0498235 |
| Title | Structures of three substituted arenesulfonamides from X-ray powder diffraction data using the differential evolution technique (2002) |
| Authors | Tremayne M.;Seaton C.;Glidewell C. |
| Journal | Acta Crystallographica Section B: Structural Science |
| DOI | 10.1107/S0108768102011928 |
| Title | Differential evolution: Crystal structure determination of a triclinic polymorph of adipamide from powder diffraction data (2002) |
| Authors | Seaton C.;Tremayne M. |
| Journal | Chemical Communications |
| DOI | 10.1039/b200436d |
| Title | A combination of X-ray Single-crystal diffraction and Monte Carlo Structure Solution from X-ray Powder Diffraction Data in a structural investigation of 5-bromonicotinic acid and solvates thereof (2001) |
| Authors | Aakeroy CB; Beatty, AM; Tremayne, M; Rowe, DM; Seaton CC |
| Journal | Crystal Growth and Design |
| Title | Building Up Co-crystals: Structural Motif Consistencies Across Families of Co-crystals (2021) |
|---|---|
| Authors | Colin C. Seaton |
| Journal | Proceedings |
| Publisher | MDPI |
| DOI | https://doi.org/10.3390/IECP2020-08708 |