Anant Paradkar

Biography

Professor Anant Paradkar holds an Interdisciplinary Chair in Pharmaceutical Engineering Science and is Director of the Centre for Pharmaceutical Engineering Science. He completed his PhD in Pharmaceutics and joined Bradford following a 20 year academic career in India. He has worked on various interdisciplinary collaborative research projects in the areas of process development and crystal and particle engineering, developing techniques such as crystallo-co-agglomeration, melt granulation, sono-crystallisation, spray drying of low Tg materials and liquid crystal precursors. He is currently working on the application of hot melt extrusion and sono-crystallisation to generate co-crystals and has been awarded a EPSRC funding and Yorkshire Enterprise Fellowship to strengthen exploitation and impact of this work. In India, he received research funding from the All India Council for Technical Education, University Grants Commission, Department of Science and Technology and the Ministry of Defence. He has received an India-JSPS International Joint project on liquid crystalline systems, UK-India Education and Research Initiative (UKIERI) Fellowship and a Royal Society UK-India Science Network award He has supervised 10 PhD and 45 MPharm candidates and published over 90 research papers. Currently, he is supervising/ co-supervising 15 PhD students in various areas of research. Awards and Recognition: 2010: Business Innovation Award, University of Bradford 2010: Finalist, Yorkshire Forward Innovator10 Award 2009: Yorkshire Enterprise Fellowship 2009: Research and Knowledge Transfer Showcase Award for interdisciplinary research presentation 2007: UK India Education and Research Initiative (UKIERI) Fellowship 2006: Bharati Vidyapeeth Best Employee of the University 2005: Indo-UK Science Network Scheme (Royal Society and DST, India) 2005: India-JSPS funded India-Japan Cooperation Programme (IJCP) 2005: Young Pharmacy Teacher Award by Association of Pharmaceutical Teachers of India (APTI) Professor Anant Paradkar holds an Interdisciplinary Chair in Pharmaceutical Engineering Science and is Director of the Centre for Pharmaceutical Engineering Science. He completed his PhD in Pharmaceutics and joined Bradford following a 20 year academic career in India. He has worked on various interdisciplinary collaborative research projects in the areas of process development and crystal and particle engineering, developing techniques such as crystallo-co-agglomeration, melt granulation, sono-crystallisation, spray drying of low Tg materials and liquid crystal precursors. He is currently working on the application of hot melt extrusion and sono-crystallisation to generate co-crystals and has been awarded a EPSRC funding and Yorkshire Enterprise Fellowship to strengthen exploitation and impact of this work. In India, he received research funding from the All India Council for Technical Education, University Grants Commission, Department of Science and Technology and the Ministry of Defence. He has received an India-JSPS International Joint project on liquid crystalline systems, UK-India Education and Research Initiative (UKIERI) Fellowship and a Royal Society UK-India Science Network award He has supervised 10 PhD and 45 MPharm candidates and published over 90 research papers. Currently, he is supervising/ co-supervising 15 PhD students in various areas of research. Awards and Recognition: 2010: Business Innovation Award, University of Bradford 2010: Finalist, Yorkshire Forward Innovator10 Award 2009: Yorkshire Enterprise Fellowship 2009: Research and Knowledge Transfer Showcase Award for interdisciplinary research presentation 2007: UK India Education and Research Initiative (UKIERI) Fellowship 2006: Bharati Vidyapeeth Best Employee of the University 2005: Indo-UK Science Network Scheme (Royal Society and DST, India) 2005: India-JSPS funded India-Japan Cooperation Programme (IJCP) 2005: Young Pharmacy Teacher Award by Association of Pharmaceutical Teachers of India (APTI)

Research

Process Development: Currently my research focus is on non-infringing processing technologies for pharmaceuticals with special emphasis on Hot Melt Extrusion ( HME) and Ultrasound Assisted processing. Our interdisciplinary team has developed application of HME for co-crystallization. This solvent free continuous technology offers many advantages and easy for scale-up and commercialization. In process development we also focus on process optimization and characterization of process related properties like extensional rheology. In this area our group has linkages with Professor Guos group at Sichuan University, China and Dr. Kumarswamy and Dr. Suresh Bhat at National Chemical Laboratory, India. Technology Opportunity Solvent-Free Continuous Technology for Co-crystallization Formulation Development: In the area of formulation development my focus is poorly soluble drug and nutraceutical molecules. Development of amorphous systems and liquid crystalline systems are adopted for different purposes. The novel drug delivery concepts are also extended to molecules from natural products. We are developing nanoparticulate delivery systems for treatment of neurodegenerative conditions, cancers and endometriosis. METRC Process Analytical Technology: The interdisciplinary group provides us with strong engineering expertise required for process analytics. Application of in-line measurement systems are being used to understand the mechanisms of novel products developed and process optimization. Solid State Pharmaceutics: Crystal and Particle Engineering: Green technologies for particle engineering including Extrusion, ultrasound and microwaves Amorphous State Pharmaceuticals: Hot Melt Extrusion, Spray Drying especially low Tg drugs and stabilization using amphiphilic lipids Molecular Pharmaceutics: Rheological basis for process and formulation performance Molecular aspects in biopharmaceutical performance of targeted systems Molecular basis for stabilized amorphous systems Role of extensional rheology in melt extrusion Novel Drug Delivery Systems: Polymeric controlled release systems. Major focus on transdermal drug delivery system Microneedle and Magnetic Microarray Technologies for transdermal drug delivery Liquid crystalline phases and their solid state precursors Inhaled drug delivery systems Moulded tablets, Porous polymer matrices Nanoparticulate delivery systems Phytopharmaceuticals and Nutraceuticals: Applications of modern principles in design of extraction processes and delivery systems for phytochemicals and nutraceuticals QbD and Process Analytical Technology (PAT): In –line rheology, spectroscopy (NIR, Raman) and ultrasound transmission Advanced statistical techniques: DoE, modelling, response surface methods Computational and Predictive Pharmaceutics: ANN, Neurofuzzy logic, Mesoscale simulations Process Development: Currently my research focus is on non-infringing processing technologies for pharmaceuticals with special emphasis on Hot Melt Extrusion ( HME) and Ultrasound Assisted processing. Our interdisciplinary team has developed application of HME for co-crystallization. This solvent free continuous technology offers many advantages and easy for scale-up and commercialization. In process development we also focus on process optimization and characterization of process related properties like extensional rheology. In this area our group has linkages with Professor Guos group at Sichuan University, China and Dr. Kumarswamy and Dr. Suresh Bhat at National Chemical Laboratory, India. Technology Opportunity Solvent-Free Continuous Technology for Co-crystallization Formulation Development: In the area of formulation development my focus is poorly soluble drug and nutraceutical molecules. Development of amorphous systems and liquid crystalline systems are adopted for different purposes. The novel drug delivery concepts are also extended to molecules from natural products. We are developing nanoparticCurrent Projects A Novel Continuous Method for Co-crystal Formation, EPSRC (EP/J003360/1) Development of Propolis Products, Technology Strategy Board KTP Scheme Nanoparticulate Curcumin System with enhancers from Traditional Chinese Medicine (TCM) for treatment of Alzheimers, Changzhou People’s Hospital

Publications