Professor Anne Graham,Head of School of Chemistry & Bioscience
Information about Professor Anne Graham at the University of Bradford.
- School of Chemistry & Biosciences
(Faculty of Life Sciences) - Email:
- a.graham@bradford.ac.uk
- Telephone:
- +44 1274 233570
Biography
Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels are master regulators of acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have an important inflammatory vascular component. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.Outside the lab, interventions which reduce cardiovascular complications in diabetes, through development of patient self management is an active area of research, in collaboration with pharmacists and researchers in the School of Pharmacy and Medical Sciences and collaborators in Bangladesh (Professor Fatema Ashraf, Surawahardy Hospital and Medical College
Research
Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis)Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes.
Research supervision
Professor Anne Graham is responsible for the supervision of 1 postgraduate researchers at the University of Bradford.
Research collaborators
| Name | Company | Country | Type | Role | Theme | Description |
|---|---|---|---|---|---|---|
| First Affiliated Hospital, Sun Yat-Sen University | CN | EXTERNAL | Common interest in hypertension and cell signalling | hypertension and atherosclerosis | Development of projects for exchanges between groups |
Teaching
Details on teaching interests, highlights and modules are available for Professor Anne Graham as follows:
Teaching highlights
We run engaging workshops where groups of final year students apply knowledge about MAP kinase signalling pathways from lectures to drug development for anti-cancer agents.Second year Clinical and Analytical Biochemistry workshops allow students to diagnose medical conditions based on clinical test results. Small group sessions build confidence and help develop understanding oc complex disease conditions.
Professional activities
Information about education, employment and areas of particular interest for Professor Anne Graham is as follows:
Education
- University of Bradford - PGCert
- HEA - Fellow Higher Education Academy
- University of Glasgow - PhD
- Strathclyde University - Bsc (Hons)
Employment
- University of Bradford - Member Research Degrees Committee in the year 2011 (specified as 01/01/2011)
- University of Bradford - Member Ethics Committee in the year 2015 (specified as 01/01/2015)
- British Heart Foundation - in the year 1994 (specified as 01/01/1994)
- Wellcome Trust - Postdoctoral researcher in the year 1991 (specified as 01/01/1991)
- University of Bradford - Acting Dean of Graduate Studies in the year 2013 (specified as 01/01/2013)
- University of Bradford - Chair Director PGR Forum in the year 2015 (specified as 01/01/2015)
Publications
There are 22 publications involving or that are attributed to Professor Anne Graham.
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis | 2004 | Singh, J.C.I.; Cruickshank, S.M.; Newton, D.J.; Wakenshaw, L.; Graham, Anne M.; Lan, J.; Lodge, J.P.A.; Felsburg, P.J.; Carding, S.R. | |||||||||
| Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. | 2007 | Graham, Anne M.; Homer-Vanniasinkam, Shervanthi; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Roberts, Wayne | |||||||||
| Nuclear factor kappa B is involved in lipopolysaccharide- stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. | 2001 | Graham, Anne M.; Bryant, C.; Liu, L.; Plevin, R.; Andrew, P.; Mackenzie, C. | |||||||||
| cGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide | 2007 | Graham, Anne M.; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Riba, Rocio; Roberts, Wayne; Homer-Vanniasinkam, Shervanthi | |||||||||
| Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endotheliium in vitro. | 2001 | Yazici, Zihni A.; Raschi, E.; Patel, Anjana; Testoni, C.; Borghi, M.O.; Graham, Anne M.; Meroni, P.L.; Lindsey, Nigel J. | |||||||||
| The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction | 2015 | Sultan, S.A.; Liu, Wanting; Peng, Yonghong; Roberts, Wayne; Whitelaw, D.C.; Graham, Anne M. | |||||||||
| IL-36γ has proinflammatory effects on human endothelial cells | 2017 | Bridgewood, Charlie; Stacey, M.; Alase, Adewonuola A.; Lagos, D.; Graham, Anne M.; Wittmann, Miriam | |||||||||
| Reed-Sternberg cell-derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma | 2014 | Fhu, C.W.; Graham, Anne M.; Yap, C.T.; Al-Salam, S.; Castella, A.; Chong, S.M.; Lim, Yaw-Chyn | |||||||||
| IL-36y is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis | 2018 | Bridgewood, Charlie; Fearnley, G.W.; Berekmeri, A.; Laws, P.; Macleod, T.; Ponnambalam, S.; Stacey, M.; Graham, Anne M.; Wittman, Miriam | |||||||||
| Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch | 2018 | Anene, Chinedu; Graham, Anne M.; Boyne, James R.; Roberts, Wayne | |||||||||
| α-Melanocyte-stimulating hormone modulates nitric oxide production in melanocytes | 2000 | Journal of Investigative Dermatology | 114 | 520 - 526 | Tsatmali M.;Graham A.;Szatkowski D.;Ancans J.;Manning P.;McNeil C.;Graham A.;Thody A. | 0022-202X | 10.1046/j.1523-1747.2000.00879.x | ||||
| Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex | 2008 | Journal of Thrombosis and Haemostasis | 6 | 1012 - 1020 | Riba R.;Hughes C.;Graham A.;Watson S.;Naseem K. | 1538-7933 | 10.1111/j.1538-7836.2008.02982.x | ||||
| The Impact of Different Concentrations of Sodium Tetradecyl Sulphate and Initial Balloon Denudation on Endothelial Cell Loss and Tunica Media Injury in a Model of Foam Sclerotherapy | 2010 | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | 39 | 366 - 371 | Ikponmwosa A.;Abbott C.;Graham A.;Homer-Vanniasinkam S.;Gough M. | 1078-5884 | 10.1016/j.ejvs.2009.12.025 | ||||
| Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions | 2011 | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | 41 | 429 - 435 | Alkhoury K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. | 1078-5884 | 10.1016/j.ejvs.2010.11.012 | ||||
| The effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow | 2004 | Biorheology | 41 | 641 - 653 | Jordan A.;David T.;Homer-Vanniasinkam S.;Graham A.;Walker P. | 0006-355X | |||||
| cGMP-independent inhibition of integrin αIIbβ3-mediated platelet adhesion and outside-in signalling by nitric oxide | 2007 | FEBS Letters | 581 | 1529 - 1534 | Oberprieler N.;Roberts W.;Graham A.;Homer-Vanniasinkam S.;Naseem K. | 0014-5793 | 10.1016/j.febslet.2007.02.072 | ||||
| Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow | 2008 | Atherosclerosis | 200 | 69 - 79 | Eccles K.;Sowden H.;Porter K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. | 0021-9150 | 10.1016/j.atherosclerosis.2007.12.018 | ||||
| Pathogenic mechanisms in varicose vein disease: The role of hypoxia and inflammation | 2010 | Pathology | 42 | 446 - 453 | Hossein Ghaderian S.;Lindsey N.;Graham A.;Homer-Vanniasinkam S.;Najar R. | 0031-3025 | 10.3109/00313025.2010.493865 | ||||
| Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis | 2005 | American Journal of Physiology - Gastrointestinal and Liver Physiology | 288 | Singh J.;Cruickshank S.;Newton D.;Wakenshaw L.;Graham A.;Lan J.;Lodge J.;Felsburg P.;Carding S. | 0193-1857 | 10.1152/ajpgi.00377.2004 | |||||
| An in vitro model of warm hypoxia-reoxygenation injury in human liver endothelial cells | 2012 | Journal of Surgical Research | 178 | Banga N.;Prasad K.;Burn J.;Homer-Vanniasinkam S.;Graham A. | 0022-4804 | 10.1016/j.jss.2011.12.036 | |||||
| IL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis | 2018 | Frontiers in Immunology | 9 | Bridgewood C.;Fearnley G.;Berekmeri A.;Laws P.;Macleod T.;Ponnambalam S.;Stacey M.;Graham A.;Wittmann M. | 1664-3224 | 10.3389/fimmu.2018.00200 | |||||
| Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro | 2001 | International Immunology | 13 | 349 - 357 | Yazici Z.;Raschi E.;Patel A.;Testoni C.;Borghi M.;Graham A.;Meroni P.;Lindsey N. | 0953-8178 | 10.1093/intimm/13.3.349 |