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Professor Anne Graham,
Head of School of Chemistry & Bioscience

Information about Professor Anne Graham at the University of Bradford.

School of Chemistry & Biosciences
(Faculty of Life Sciences)
+44 1274 233570
Photo of Professor Anne Graham


Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels are master regulators of acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have an important inflammatory vascular component. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.

Outside the lab, interventions which reduce cardiovascular complications in diabetes, through development of patient self management is an active area of research, in collaboration with pharmacists and researchers in the School of Pharmacy and Medical Sciences and collaborators in Bangladesh (Professor Fatema Ashraf, Surawahardy Hospital and Medical College


Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis)Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes.

Research supervision

Professor Anne Graham is responsible for the supervision of 1 postgraduate researchers at the University of Bradford.

Research collaborators

Information about people or organisations that Professor Anne Graham collaborates with.
Name Company Country Type Role Theme Description
First Affiliated Hospital, Sun Yat-Sen University CN EXTERNAL Common interest in hypertension and cell signalling hypertension and atherosclerosis Development of projects for exchanges between groups


Details on teaching interests, highlights and modules are available for Professor Anne Graham as follows:

Teaching highlights

We run engaging workshops where groups of final year students apply knowledge about MAP kinase signalling pathways from lectures to drug development for anti-cancer agents.

Second year Clinical and Analytical Biochemistry workshops allow students to diagnose medical conditions based on clinical test results. Small group sessions build confidence and help develop understanding oc complex disease conditions.

Professional activities

Information about education, employment and areas of particular interest for Professor Anne Graham is as follows:


  • University of Bradford -  PGCert
  • HEA - Fellow Higher Education Academy
  • University of Glasgow - PhD
  • Strathclyde University -  Bsc (Hons)


  •  University of Bradford  - Member Research Degrees Committee in the year 2011 (specified as 01/01/2011)
  •  University of Bradford  - Member Ethics Committee in the year 2015 (specified as 01/01/2015)
  • British Heart Foundation  - in the year 1994 (specified as 01/01/1994)
  • Wellcome Trust - Postdoctoral researcher in the year 1991 (specified as 01/01/1991)
  •  University of Bradford  - Acting Dean of Graduate Studies in the year 2013 (specified as 01/01/2013)
  •  University of Bradford  - Chair Director PGR Forum in the year 2015 (specified as 01/01/2015)


There are 22 publications involving or that are attributed to Professor Anne Graham.

Peer Reviewed Journal

Professor Anne Graham has 22 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis 2004 Singh, J.C.I.; Cruickshank, S.M.; Newton, D.J.; Wakenshaw, L.; Graham, Anne M.; Lan, J.; Lodge, J.P.A.; Felsburg, P.J.; Carding, S.R.
Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. 2007 Graham, Anne M.; Homer-Vanniasinkam, Shervanthi; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Roberts, Wayne
Nuclear factor kappa B is involved in lipopolysaccharide- stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. 2001 Graham, Anne M.; Bryant, C.; Liu, L.; Plevin, R.; Andrew, P.; Mackenzie, C.
cGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide 2007 Graham, Anne M.; Naseem, Khalid M.; Oberprieler, Nikolaus G.; Riba, Rocio; Roberts, Wayne; Homer-Vanniasinkam, Shervanthi
Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endotheliium in vitro. 2001 Yazici, Zihni A.; Raschi, E.; Patel, Anjana; Testoni, C.; Borghi, M.O.; Graham, Anne M.; Meroni, P.L.; Lindsey, Nigel J.
The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction 2015 Sultan, S.A.; Liu, Wanting; Peng, Yonghong; Roberts, Wayne; Whitelaw, D.C.; Graham, Anne M.
IL-36γ has proinflammatory effects on human endothelial cells 2017 Bridgewood, Charlie; Stacey, M.; Alase, Adewonuola A.; Lagos, D.; Graham, Anne M.; Wittmann, Miriam
Reed-Sternberg cell-derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma 2014 Fhu, C.W.; Graham, Anne M.; Yap, C.T.; Al-Salam, S.; Castella, A.; Chong, S.M.; Lim, Yaw-Chyn
IL-36y is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis 2018 Bridgewood, Charlie; Fearnley, G.W.; Berekmeri, A.; Laws, P.; Macleod, T.; Ponnambalam, S.; Stacey, M.; Graham, Anne M.; Wittman, Miriam
Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch 2018 Anene, Chinedu; Graham, Anne M.; Boyne, James R.; Roberts, Wayne
α-Melanocyte-stimulating hormone modulates nitric oxide production in melanocytes 2000 Journal of Investigative Dermatology 114 520 - 526 Tsatmali M.;Graham A.;Szatkowski D.;Ancans J.;Manning P.;McNeil C.;Graham A.;Thody A. 0022-202X 10.1046/j.1523-1747.2000.00879.x
Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex 2008 Journal of Thrombosis and Haemostasis 6 1012 - 1020 Riba R.;Hughes C.;Graham A.;Watson S.;Naseem K. 1538-7933 10.1111/j.1538-7836.2008.02982.x
The Impact of Different Concentrations of Sodium Tetradecyl Sulphate and Initial Balloon Denudation on Endothelial Cell Loss and Tunica Media Injury in a Model of Foam Sclerotherapy 2010 European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 39 366 - 371 Ikponmwosa A.;Abbott C.;Graham A.;Homer-Vanniasinkam S.;Gough M. 1078-5884 10.1016/j.ejvs.2009.12.025
Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions 2011 European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 41 429 - 435 Alkhoury K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. 1078-5884 10.1016/j.ejvs.2010.11.012
The effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow 2004 Biorheology 41 641 - 653 Jordan A.;David T.;Homer-Vanniasinkam S.;Graham A.;Walker P. 0006-355X
cGMP-independent inhibition of integrin αIIbβ3-mediated platelet adhesion and outside-in signalling by nitric oxide 2007 FEBS Letters 581 1529 - 1534 Oberprieler N.;Roberts W.;Graham A.;Homer-Vanniasinkam S.;Naseem K. 0014-5793 10.1016/j.febslet.2007.02.072
Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow 2008 Atherosclerosis 200 69 - 79 Eccles K.;Sowden H.;Porter K.;Parkin S.;Homer-Vanniasinkam S.;Graham A. 0021-9150 10.1016/j.atherosclerosis.2007.12.018
Pathogenic mechanisms in varicose vein disease: The role of hypoxia and inflammation 2010 Pathology 42 446 - 453 Hossein Ghaderian S.;Lindsey N.;Graham A.;Homer-Vanniasinkam S.;Najar R. 0031-3025 10.3109/00313025.2010.493865
Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis 2005 American Journal of Physiology - Gastrointestinal and Liver Physiology 288 Singh J.;Cruickshank S.;Newton D.;Wakenshaw L.;Graham A.;Lan J.;Lodge J.;Felsburg P.;Carding S. 0193-1857 10.1152/ajpgi.00377.2004
An in vitro model of warm hypoxia-reoxygenation injury in human liver endothelial cells 2012 Journal of Surgical Research 178 Banga N.;Prasad K.;Burn J.;Homer-Vanniasinkam S.;Graham A. 0022-4804 10.1016/j.jss.2011.12.036
IL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis 2018 Frontiers in Immunology 9 Bridgewood C.;Fearnley G.;Berekmeri A.;Laws P.;Macleod T.;Ponnambalam S.;Stacey M.;Graham A.;Wittmann M. 1664-3224 10.3389/fimmu.2018.00200
Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro 2001 International Immunology 13 349 - 357 Yazici Z.;Raschi E.;Patel A.;Testoni C.;Borghi M.;Graham A.;Meroni P.;Lindsey N. 0953-8178 10.1093/intimm/13.3.349