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Recent Publications & books

2021

Dermal adipose tissue secretes HGF to promote human hair growth and pigmentation. Carina Nicu, James D.B. O’Sullivan, Raul Ramos, Ludovica Timperi, Tiffany Lai, Nilofer Farjo, Bessam Farjo, Jenny People, Ranjit Bhogal, Jonathan A. Hardman, Maksim V. Plikus, David M. Ansell, Ralf Paus Journal of Investigative Dermatology 2021 https://doi.org/10.1016/j.jid.2020.12.019 
 
Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports on the 14th of January 2021. ww.nature.com/articles/s41598-020-80072-z

2020

Rachael Williams, Gillian E. Westgate, Alison D. Pawlus, Stephen K. Sikkink, M. Julie Thornton. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging. Journal of Investigative Dermatology, 2020, http://www.sciencedirect.com/science/article/pii/S0022202X20323496

Williams R, Castellano Pellicena I, Sikkink S, Baker R, Riches-Suman K, Thornton M. Laser capture microdissection on surgical tissues to identify aberrant gene expression in impaired wound healing in Type 2 diabetes. J. Journal of Visualized Experiments (accepted 03/12/2020). 

Al-Rikabi AHA, Tobin DJ, Riches-Suman K, Thornton MJ. Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports (accepted 02/12/2020). 

Dell’Acqua, G.; Richards, A.; Thornton, M.J. The Potential Role of Nutraceuticals as an Adjuvant in Breast Cancer Patients to Prevent Hair Loss Induced by Endocrine Therapy. Nutrients 2020, 12, 3537.

Buscone, S, Mardaryev, AN, Westgate, GE, Uzunbajakava, NE, Botchkareva, NV. Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth. Exp Dermatol. 2020; 00: 1– 7. https://doi.org/10.1111/exd.14231

Sikkink, S.K., Mine, S., Freis, O. et al. Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp. Sci Rep 10, 18711 (2020). https://doi.org/10.1038/s41598-020-75334-9

Salgado D, Armean IM, Baudis M et al. The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research [version 1; peer review: awaiting peer review]. F1000Research 2020, 9(ELIXIR):1229 (https://doi.org/10.12688/f1000research.24887.1)

Williams, R., Pawlus, A.D. and Thornton, M.J. (2020), Getting under the skin of hair aging: the impact of the hair follicle environment. Exp Dermatol. Accepted Author Manuscript. https://doi.org/10.1111/exd.14109

Trevor, L.V.; Riches-Suman, K.; Mahajan, A.L.; Thornton, M.J. Adipose Tissue: A Source of Stem Cells with Potential for Regenerative Therapies for Wound Healing. J. Clin. Med. 2020, 9, 2161.

Katarzyna Murat, Björn Grüning, Paulina Wiktoria Poterlowicz, Gillian Westgate, Desmond J Tobin, Krzysztof Poterlowicz. Ewastools: Infinium Human Methylation BeadChip pipeline for population epigenetics integrated into Galaxy, GigaScience, Volume 9, Issue 5, May 2020, giaa049, https://doi.org/10.1093/gigascience/giaa049

Abubakar, A., Ugail, H., Smith, K.M. et al. Burns Depth Assessment Using Deep Learning Features. J. Med. Biol. Eng. 40, 923–933 (2020). https://doi.org/10.1007/s40846-020-00574-z

Baker R., Thornton M.J. (2020) Isolation of Epidermal and Hair Follicle Melanocytes. In: Botchkareva., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_3

Williams R., Thornton M.J. (2020) Isolation of Different Dermal Fibroblast Populations from the Skin and the Hair Follicle. In: Botchkareva ., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_2

Castellano-Pellicena I., Thornton M.J. (2020) Isolation of Epidermal Keratinocytes from Human Skin: The Scratch-Wound Assay for Assessment of Epidermal Keratinocyte Migration. In: Botchkareva ., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_1
 
Mardaryev A.N., Fessing M.Y. (2020) 3D-FISH Analysis of the Spatial Genome Organization in Skin Cells in Situ. In: Botchkareva ., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_18
 
Mardaryev A.N. (2020) Method to Study Skin Cancer: Two-Stage Chemically Induced Carcinogenesis in Mouse Skin. In: Botchkareva ., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_19
 
Wang E.H.C., McElwee K.J. (2020) Nonsurgical Induction of Alopecia Areata in C3H/HeJ Mice via Adoptive Transfer of Cultured Lymphoid Cells. In: Botchkareva ., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_10
 
Zhang, X, Ye, Y, Zhu, Z, et al. Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time. Exp Dermatol. 2020; 29: 223– 230. https://doi.org/10.1111/exd.13799
 
Bertolini, M, McElwee, K, Gilhar, A, Bulfone‐Paus, S, Paus, R. Hair follicle immune privilege and its collapse in alopecia areata. Exp Dermatol. 2020; 29: 703–725. https://doi.org/10.1111/exd.14155
 
Thomas Swift, Gillian Westgate, Julie Van Onselen, and Stewart Lee. Developments in silicone technology for use in stoma care. British Journal of Nursing 2020 29:6, S6-S15. https://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2020.29.6.S6

Kang, H, Wu, W‐Y, Yu, M, Shapiro, J, McElwee, KJ. Increased expression of TLR7 and TLR9 in alopecia areata. Exp Dermatol. 2020; 29: 254–258. https://doi.org/10.1111/exd.14043

Siah, TW, Guo, H, Chu, T, et al. Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study. Exp Dermatol. 2020; 29: 334– 340. https://doi.org/10.1111/exd.14074

Zhang, X, McElwee, KJ. Allergy promotes alopecia areata in a subset of patients. Exp Dermatol. 2020; 29: 239– 242. https://doi.org/10.1111/exd.14027

 

2019

Mohammed I. Ahmed, Maximilian E. Pickup, Alexander G. Rimmer, Majid Alam, Andrei N. Mardaryev, Krzysztof Poterlowicz, Natalia V. Botchkareva, Vladimir A. Botchkarev. Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging, Journal of Investigative Dermatology, Volume 139, Issue 12, 2019, Pages 2538-2542.e2

Daniels, G., Akram, S., Westgate, G.E. and Tamburic, S. (2019), Can plant‐derived phytochemicals provide symptom relief for hair loss? A critical review. Int J Cosmet Sci, 41: 332-345. https://doi.org/10.1111/ics.12554
 
Castellano‐Pellicena, I., Uzunbajakava, N.E., Mignon, C., Raafs, B., Botchkarev, V.A. and Thornton, M.J. (2019), Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing?. Lasers Surg. Med., 51: 370-382. https://doi.org/10.1002/lsm.23015
 
Broadley, D, McElwee, KJ. A “hair‐raising” history of alopecia areata. Exp Dermatol. 2020; 29: 208– 222. https://doi.org/10.1111/exd.14073
 
Adhikari, K., Mendoza-Revilla, J., Sohail, A. et al. A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia. Nat Commun 10, 358 (2019). https://doi.org/10.1038/s41467-018-08147-0
 
Town, G., Botchkareva, N.V., Uzunbajakava, N.E., Nuijs, T., van Vlimmeren, M., Ash, C. and Dierickx, C. (2019), Light‐based home‐use devices for hair removal: Why do they work and how effective they are?. Lasers Surg. Med., 51: 481-490. https://doi.org/10.1002/lsm.23061
 
Shalbaf M, Alase AA, Berekmeri A, et al. Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature.  Lupus Science & Medicine 2019;6:e000328. doi: 10.1136/lupus-2019-000328
 
Tsakok T, Wilson N, Dand N, et al. Association of Serum Ustekinumab Levels With Clinical Response in Psoriasis. JAMA Dermatol. 2019;155(11):1235–1243. doi:10.1001/jamadermatol.2019.1783
 
 
2018
 
Botchkarev VA and Millar S (Eds) (2018) Epigenetic Regulation of Skin Development and Regeneration. New York: Humana Press.

Nwogu N, Boyne JR, Dobson SJ, Poterlowicz K, Blair GE, Macdonald A, Mankouri J, Whitehouse A. Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness. PLoS Pathog. 2018 Sep 6;14(9):e1007276. doi: 10.1371/journal.ppat.1007276. eCollection 2018 Sep. PMID: 30188954

Joly‐Tonetti, N., Wibawa, J., Bell, M. and Tobin, D. (2018), An explanation for the mysterious distribution of melanin in human skin: a rare example of asymmetric (melanin) organelle distribution during mitosis of basal layer progenitor keratinocytes. Br J Dermatol, 179: 1115-1126. https://doi.org/10.1111/bjd.16926

Fajuyigbe, D., Lwin, S.M., Diffey, B.L., Baker, R., Tobin, D.J., Sarkany, R.P.E. and Young, A.R. (2018), Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes. The FASEB Journal, 32: 3700-3706. https://doi.org/10.1096/fj.201701472R

Akhbari P, Tobin D, Poterlowicz K, Roberts W, Boyne JR.MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis. J Invest Dermatol. 2018 May 17. pii: S0022-202X(18)31958-4. doi: 10.1016/j.jid.2018.03.1527. [Epub ahead of print]

Mignon C, Uzunbajakava NE, Castellano-Pellicena I, Botchkareva NV, Tobin DJ. Differential response of human dermal fibroblast subpopulations to visible and near-infrared light: Potential of photobiomodulation for addressing cutaneous conditions. Lasers Surg Med. 2018 Apr 17. doi: 10.1002/lsm.22823. [Epub ahead of print]

Mignon C, Tobin DJ, Zeitouny M, Uzunbajakava NE. Shedding light on the variability of optical skin properties: finding a path towards more accurate prediction of light propagation in human cutaneous compartments. Biomed Opt Express. 2018 Jan 29;9(2):852-872. doi: 10.1364/BOE.9.000852. eCollection 2018 Feb 1.

Stakaitytė G, Nwogu N, Lippiat JD, Blair GE, Poterlowicz K, Boyne JR, Macdonald A, Mankouri J, Whitehouse A. The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility. J Biol Chem. 2018 Mar 23;293(12):4582-4590. doi: 10.1074/jbc.RA117.001343. Epub 2018 Feb 8.

Fajuyigbe D, Lwin SM, Diffey BL, Baker R, Tobin DJ, Sarkany RPE, Young AR. Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes. FASEB J. 2018 Jul;32(7):3700-3706. doi: 10.1096/fj.201701472R. Epub 2018 Feb 2.

Tafazzoli A, Forstner AJ, Broadley D, Hofmann A, Redler S, Petukhova L, Giehl KA, Kruse R, Blaumeiser B, Böhm M, Bertolini M, Rossi A, Garcia Bartels N, Lutz G, Wolff H, Blume-Peytavi U, Soreq H, Christiano AM, Botchkareva NV, Nöthen MM, Betz RC. Genome-Wide MicroRNA Analysis Implicates miR-30b/d in the Etiology of Alopecia Areata. J Invest Dermatol. 2018 Mar;138(3):549-556. doi: 10.1016/j.jid.2017.09.046. Epub 2017 Dec 6.

Miranda BH, Charlesworth MR, Tobin DJ, Sharpe DT, Randall VA. Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life. FASEB J. 2018 Feb;32(2):795-806. doi: 10.1096/fj.201700260RR. Epub 2018 Jan 4.

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR. Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1.

Botchkarev V.A., Sharov A.A., Fessing M.Y. (2018) All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration. In: Botchkarev V., Millar S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_1

Botchkareva N.V., Yi R. (2018) Orchestrated Role of microRNAs in Skin Development and Regeneration. In: Botchkarev V., Millar S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_7

Mardaryev A.N. (2018) Epigenetic Regulation of Skin Wound Healing. In: Botchkarev V., Millar S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_12

Miranda, B.H., Charlesworth, M.R., Tobin, D.J., Sharpe, D.T. and Randall, V.A. (2018), Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life. The FASEB Journal, 32: 795-806. https://doi.org/10.1096/fj.201700260RR

Bertolini M, Botchkareva N, Westgate G, et al. Bridging the "Dead Hair"-"Live Follicle" Divide in Applied Hair Research. Journal of Cosmetic Science. 2018 Sep/Oct;69(5):315-322.

Nwogu N, Boyne JR, Dobson SJ, Poterlowicz K, Blair GE, Macdonald A, et al. (2018) Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness. PLoS Pathog 14(9): e1007276. https://doi.org/10.1371/journal.ppat.1007276

 

2017

Buscone, S., Mardaryev, A.N., Raafs, B., Bikker, J.W., Sticht, C., Gretz, N., Farjo, N., Uzunbajakava, N.E. and Botchkareva, N.V. (2017), A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle. Lasers Surg. Med., 49: 705-718. https://doi.org/10.1002/lsm.22673

Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY. 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells. PLoS Genet. 2017 Sep 1;13(9):e1006966. doi: 10.1371/journal.pgen.1006966. eCollection 2017 Sep. PubMed PMID: 28863138.

Alharbi RA, Pandha HS, Guy R. Simpson GR, Pettengell R, Poterlowicz K, Thompson A, Harrington K, El-Tanani M, Morgan R. Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells. Oncotarget. 2017; 8:89566-89579. https://doi.org/10.18632/oncotarget.20023

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR. Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. J Invest Dermatol. 2017 Aug 31. pii: S0022-202X(17)32834-8. doi: 10.1016/j.jid.2017.08.019. [Epub ahead of print] PubMed PMID: 28867657.

Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017 Feb;26(1):37-46. doi: 10.1016/j.jtv.2016.03.002. Epub 2016 Mar 14. PubMed PMID:27020864.

Botchkarev VA. Second International Symposium-Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases. J Invest Dermatol. 2017 Aug;137(8):1604-1608. doi: 10.1016/j.jid.2017.01.037. Epub 2017 Jun 2. PubMed PMID: 28583676.

Messenger AG, Botchkareva NV. Unraveling the secret life of the hair follicle: from fungi to innovative hair loss therapies. Exp Dermatol. 2017 Jun;26(6):471. doi: 10.1111/exd.13384. PubMed PMID: 28608517.

Westgate GE, Ginger RS, Green MR. The biology and genetics of curly hair. Exp Dermatol. 2017;26:483–490. https://doi.org/10.1111/exd.13347

Singh, SK, Baker, R, Sikkink, SK, et al. E‐cadherin mediates ultraviolet radiation‐ and calcium‐induced melanin transfer in human skin cells. Exp Dermatol. 2017; 26: 1125– 1133. https://doi.org/10.1111/exd.13395

Aunin, E., Broadley, D., Ahmed, M.I. et al. Exploring a Role for Regulatory miRNAs In Wound Healing during Ageing:Involvement of miR-200c in wound repair. Sci Rep 7, 3257 (2017). https://doi.org/10.1038/s41598-017-03331-6

Mignon, C., Uzunbajakava, N.E., Raafs, B. et al. Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome. Sci Rep 7, 2797 (2017). https://doi.org/10.1038/s41598-017-02802-0