Dr Sneha Swaroop
Lecturer
| Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
|---|---|
| s.swaroop@bradford.ac.uk |
Biography
Dr Sneha Swaroop is a Lecturer in Cell and Molecular Biology at the School of Pharmacy and Medical Sciences. Her research focuses on stem cells in cancer, with the goal of identifying novel ways to target them and develop effective therapies for cancer patients. After earning her Master’s degree in Biotechnology, Dr Swaroop pursued a Ph.D. in the field of Oncology from the renowned Cancer Institute (WIA), India, where she extensively researched the role of the hedgehog pathway in maintaining cancer stem cells in serous adenocarcinoma of the ovary. As a testament to her excellent research capabilities, Dr Swaroop was awarded the prestigious Schlumberger Faculty for the Future (FFTF) Fellowship, allowing her to undertake post- doctoral research in drug discovery at the Institute of Cancer Therapeutics (ICT), University of Bradford. In this role, she evaluated novel cancer stem cell-targeted chemical probes and drug candidates in breast and prostate cancer, which has the potential to transform cancer treatment. Aside from her research, Dr Swaroop is also a dedicated STEM ambassador and educator, mentoring and training the next generation of scientists. She is also committed to engaging with wider community, participating in public engagement activities increasing awareness and understanding of cancer research.
Research
Dr Sneha Swaroop’s research interests are centered around understanding the intricate biology of cancer stem cells and identifying novel ways to target them. Her research includes several noteworthy studies such as:1) Characterising ovarian cancer stem cells (CSCs) using spheroid culture and evaluating the significance of embryonic signaling pathways.
2) Identifying novel biomarkers for ovarian cancer stem cells using in silico approaches, establishing in vitro and in vivo models to study CSCs and evaluating novel therapeutic targets for improved treatment.
3) Evaluation of the effect of a dual PI3K δ/γ inhibitors on cancer stem cell proliferation in serous ovarian carcinoma.
4) Investigating stem cell gene expression in spheroids and deciphering splice variants of stem cell specific genes in teratoma and human embryonic stem cells followed by their analysis in two and three dimensional culture.
5) Establishing the role of CSCs in tumour angiogenesis and lymph angiogenesis in ovarian cancer.
Moving forward, Dr Swaroop aims to continue exploring the biology of cancer stem cells in relation to the tumour microenvironment with the ultimate aim of developing more effective treatments for cancer patients.
Professional activities
- 01-JAN-10: UGC Research Fellowship
- 01-JAN-13: UGC Senior Research Fellowship
- 01-JAN-19: Schlumberger Faculty For the Future Fellowship
- 01-JAN-20: Schlumberger Faculty For The Future- Renewal
- 01-JAN-21: Schlumberger Faculty For the Future-Renewal
Publications
| Title | Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer (2022) |
|---|---|
| Authors | Ali I M Ibrahim, Elisabet Batlle, Smarakan Sneha, Rafael Jiménez, Raquel Pequerul, Xavier Parés, Till Rüngeler, Vibhu Jha, Tiziano Tuccinardi, Maria Sadiq, Fiona Frame, Norman J Maitland, Jaume Farrés, Klaus Pors |
| Journal | Journal of Medicinal Chemistry |
| DOI | 10.1021/acs.jmedchem.1c01367 |
| Title | LASP-1 interacts with ErbB2 in ovarian cancer cells. (2022) |
| Authors | Sidhanth C;Bindhya S;Shabna A;Krishnapriya S;Manasa P;Nagare RP;Joshua T;Sneha S;Murhekar K;Ganesan TS; |
| Journal | Biochemical Journal |
| DOI | 10.1042/BCJ20210173 |
| Title | Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer. (2021) |
| Authors | Presa D;Khurram SA;Zubir AZA;Smarakan S;Cooper PA;Morais GR;Sadiq M;Sutherland M;Loadman PM;McCaul J;Shnyder SD;Patterson LH;Pors K; |
| Journal | Scientific Reports |
| DOI | 10.1038/s41598-021-98217-z |
| Title | Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies. (2021) |
| Authors | Sneha S;Baker SC;Green A;Storr S;Aiyappa R;Martin S;Pors K; |
| Journal | Biomedicines |
| DOI | 10.3390/biomedicines9030290 |
| Title | Expression of cancer stem cell markers CD24, EPHA1 and CD9 and their correlation with clinical outcome in epithelial ovarian tumours. (2020) |
| Authors | Nagare RP;Sneha S;Sidhanth C;Roopa S;Murhekar K;Shirley S;Swaminathan R;Sridevi V;Ganesan TS; |
| Journal | Cancer Biomarkers : Section A Of Disease Markers |
| DOI | 10.3233/CBM-201463 |
| Title | ALDH1A1+ ovarian cancer stem cells co-expressing surface markers CD24, EPHA1 and CD9 form tumours in vivo. (2020) |
| Authors | Nagare RP;Sneha S;Krishnapriya S;Ramachandran B;Murhekar K;Vasudevan S;Shabna A;Ganesan TS; |
| Journal | Experimental Cell Research |
| DOI | 10.1016/j.yexcr.2020.112009 |
| Title | The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary. (2020) |
| Authors | Sneha S;Nagare RP;Sidhanth C;Krishnapriya S;Garg M;Ramachandran B;Murhekar K;Sundersingh S;Ganesan TS; |
| Journal | Cellular Oncology (Dordrecht) |
| DOI | 10.1007/s13402-020-00504-w |
| Title | Analysis of hematopoietic stem cells using a composite approach. (2019) |
| Authors | Nagare RP;Sneha S;Ramesh S;Ganesan TS; |
| Journal | International Journal of Biochemistry and Cell Biology |
| DOI | 10.1016/j.biocel.2019.02.003 |
| Title | Cancer stem cells contribute to angiogenesis and lymphangiogenesis in serous adenocarcinoma of the ovary. (2019) |
| Authors | Krishnapriya S;Sidhanth C;Manasa P;Sneha S;Bindhya S;Nagare RP;Ramachandran B;Vishwanathan P;Murhekar K;Shirley S;Ganesan TS; |
| Journal | Angiogenesis |
| DOI | 10.1007/s10456-019-09669-x |
| Title | Analysis of Human Stem Cell Transcription Factors. (2019) |
| Authors | Sneha S;Nagare RP;Manasa P;Vasudevan S;Shabna A;Ganesan TS; |
| Journal | Cellular Reprogramming |
| DOI | 10.1089/cell.2019.0005 |
| Title | A systematic understanding of signaling by ErbB2 in cancer using phosphoproteomics. (2018) |
| Authors | Sidhanth C;Manasa P;Krishnapriya S;Sneha S;Bindhya S;Nagare RP;Garg M;Ganesan TS; |
| Journal | Biochemistry and cell biology = Biochimie et biologie cellulaire |
| DOI | 10.1139/bcb-2017-0020 |
| Title | Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin. (2017) |
| Authors | Garg M;Kanojia D;Mayakonda A;Ganesan TS;Sadhanandhan B;Suresh S;S S;Nagare RP;Said JW;Doan NB;Ding LW;Baloglu E;Shacham S;Kauffman M;Koeffler HP; |
| Journal | Scientific Reports |
| DOI | 10.1038/s41598-017-10325-x |
| Title | Therapeutic antibodies against cancer stem cells: a promising approach. (2017) |
| Authors | Sneha S;Nagare RP;Priya SK;Sidhanth C;Pors K;Ganesan TS; |
| Journal | Cancer Immunology, Immunotherapy |
| DOI | 10.1007/s00262-017-2049-0 |
| Title | Cancer Stem Cells - Are Surface Markers Alone Sufficient? (2017) |
| Authors | Nagare RP;Sneha S;Priya SK;Ganesan TS; |
| Journal | Current Stem Cell Research and Therapy |
| DOI | 10.2174/1574888x11666160607211436 |
| Title | Tumour angiogenesis-Origin of blood vessels. (2016) |
| Authors | Krishna Priya S;Nagare RP;Sneha VS;Sidhanth C;Bindhya S;Manasa P;Ganesan TS; |
| Journal | International Journal of Cancer |
| DOI | 10.1002/ijc.30067 |