Professor Robert Falconer
Professor of Medicinal Chemistry
Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
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r.a.falconer1@bradford.ac.uk | |
Telephone | +441274 235842 |
Biography
He has served as Deputy Director of the ICT since Feb 2017, overseeing medicinal chemistry and drug discovery, and was promoted to Professor of Medicinal Chemistry in 2019. He is a founder of University spin-out company Incanthera plc, leads the ICT's £2m Doctoral Training Centre. He is a member of several professional and learned societies, notably the Royal Pharmaceutical Society and is a registered pharmacist with the General Pharmaceutical Council. As a Fellow of the Royal Society of Chemistry, he has previously served as Honorary Treasurer for the RSC Central Yorkshire Local Section Trust (2012-18).
Research
We have a particular interest in osteosarcoma, and in developing kinder treatments for this deadly disease that mainly affects children and young adults. Funded by the Bone Cancer Research Trust (BCRT) through a PhD studentship (2018-22), and a project grant (2023-26), our aim is to achieve preclinical proof-of-concept for an MMP-activated tumour-targeted prodrug of methotrexate. We will evaluate our lead molecules in clinically-relevant orthotopic models of the disease in collaboration with Prof Allie Gartland (University of Sheffield).
We continue our long-standing collaboratiion with the Daldrup-Link group (Standford University, USA) to further develop a novel theranostics, which have shown efficacy in breast cancer (see Small, 2014, 10, 566-575) and glioblastoma (see Molecular Cancer Therapeutics, 2017, 16, 1909-1921 and Nanotheranostics, 2019, 3, 299-310).
Current projects are additionally focused on development of treatments for breast cancer, prostate cancer and neuroblastoma. Our research is currently funded by Breast Cancer Now, Bone Cancer Research Trust, Worldwide Cancer Research, and the ICT Doctoral Training Centre.
Zubeda Khatoon (ICT DTC 2022-26)
Louise Stevenson (DiMeN/University of Sheffield with Prof Sherif El-Khamisy 2021-24)
Athina Polykandritou (ICT DTC 2019-23)
Alexandra Serre (ICT DTC 2019-23)
Post-Doctoral Researchers
Dr Hannah Spencer (BCRT 2023-26)
Dr April Baral (Worldwide Cancer Research 2023-25)
Masters students
Mr Gabriel Nwokolo (MRes Cancer Drug Discovery 2022-23)
Mr Nosakhare Osagie (MSc Cancer Pharmacology 2022-23)
Date | Role | Title / Description | Funder | Award |
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01-OCT-18 - 30-APR-23 | PI | Bone Cancer Research Trust - PhD studentship | 116626 | |
01-OCT-18 - 30-SEP-28 | PI | Incanthera plc - ICT Doctoral Training Centre | 2000000 | |
01-JAN-19 - 28-JAN-24 | PI | Breast Cancer Now - project grant | 191037 | |
01-OCT-19 - 30-SEP-23 | Co-I | Kidscan - PhD studentship | 63675 | |
09-JAN-23 - 08-JAN-26 | PI | Bone Cancer Research Trust - project grant | 249760 | |
01-APR-23 - 31-DEC-25 | PI | Worldwide Cancer Research - project grant | 194381 |
Teaching
Teaching interests
Professional activities
- 01-JAN-97: Dartford & Gravesham NHS Trust - MRPharmS
- 01-JAN-96: University of London, School of Pharmacy - BPharm (Hons)
- 01-JAN-00: University of London, School of Pharmacy - PhD
- 16-DEC-19: University of Bradford - Professor of Medicinal Chemistry
- 01-SEP-13: University of Bradford - Reader in Medicinal Chemistry
- 01-SEP-05: University of Bradford - Lecturer in Medicinal Chemistry
- 01-JUN-03: UCL School of Pharmacy - Lecturer in Pharmaceutical Sciences
- 01-OCT-00: UCL School of Pharmacy - Research & Teaching Fellow
- Royal Society of Chemistry, Fellow
- British Association for Cancer Research, Member
- European Association for Cancer Research, Member
- Amercian Association for Cancer Research, Member
- Royal Pharmaceutical Society / General Pharmaceutical Council, Member
- 01-JAN-17: Vice-Chancellor's Award for Excellence
- 01-JAN-19: Fellow, Royal Society of Chemistry
- 01-JAN-22: Commendation - Outstanding Achievement Award (PhD student supervision)
- Deputy Director, ICT
- Research Group Leadership: School of Pharmacy and Medical Sciences Team Leadership Group Member
- Programme & Module Management: Teaching Module Leadership: INC7014-B (Principles of Drug Discovery)
- External Examiner: MPharm Pharmacy, BSc Pharmaceutical Sciences, BSc Pharmaceutical Biotechnology School of Pharmacy, Queen’s University Belfast (2020-24)
- Scientific Advisory Board Member: Health Research Charities Ireland/ Health Research Board Ireland Joint Funding Scheme (2020)
- External Examiner: MRes Drug Sciences, UCL School of Pharmacy Joint Postgraduate Board (2018-22)
- Scientific Advisory Board Member: Medical Research Charity Group/ Health Research Board Ireland Joint Funding Committee (2018)
- Scientific Committee Member: Kidscan Children’s Cancer Research (2016-)
- Scientific Advisory Board Member: Neuroblastoma UK (2016)
- Editorial Board Member: Scientific Reports (Nature publishing group) (2016-)
- Co-Founder, Member of Scientific Advisory Board: Incanthera plc (www.incanthera.com)
- Committee Member: RSC Central Yorkshire Local Section Member Network (2008-10; 2012-18)
- Honorary Treasurer: RSC Central Yorkshire Local Section Member Network (2012-18; 3 terms)
- Elected Member: EPSRC Peer Review College (2006-)
Publications
Title | Azodicarboxylate-mediated peptide cyclisation: application to disulfide bond formation in solution and solid phase. (2023) |
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Authors | Serre, A.R.E.; Nwokolo, G.C.; Spencer, H.L.M.; Bell, T.J.; Barnieh, F.M.; Hughes, L.; Falconer, R.A.; Ribeiro Morais, G. |
Journal | European Journal of Organic Chemistry |
DOI | DOI:10.1002/ejoc.202300789 |
Title | The role of MT1-MMP in the progression and metastasis of osteosarcoma (2022) |
Authors | Spencer, H.L.M.; Shnyder, S.D.; Loadman, P.M.; Falconer, R.A. |
Journal | Journal of Cancer Metastasis and Treatment |
DOI | DOI:10.20517/2394-4722.2021.174 |
Title | Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells. (2022) |
Authors | Barnieh FM;Ribeiro Morais G;Garland H;Loadman PM;Falconer RA; |
Journal | Biochemical Pharmacology |
DOI | 10.1016/j.bcp.2022.115095 |
Title | Chemoselective Solution- and Solid-Phase Synthesis of Disulfide-Linked Glycopeptides. (2022) |
Authors | Banisalman KAF;Polykandritou A;Barnieh FM;Ribeiro Morais G;Falconer RA; |
Journal | Journal of Organic Chemistry |
DOI | 10.1021/acs.joc.2c01651 |
Title | Is tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique? (2021) |
Authors | Barnieh FM;Loadman PM;Falconer RA; |
Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
DOI | 10.1016/j.bbcan.2021.188641 |
Title | Progress towards a clinically-successful ATR inhibitor for cancer therapy (2021) |
Authors | Barnieh, F.M.; Loadman, P.M.; Falconer, R.A. |
Journal | Current Research in Pharmacology and Drug Discovery |
DOI | 10.1016/j.crphar.2021.100017 |
Title | An assay for quantitative analysis of polysialic acid expression in cancer cells (2021) |
Authors | Guo, X.; Elkashef, S.M.; Patel, A.; Ribeiro Morais, G.; Shnyder S.D.; Loadman, P.M.; Patterson, L.H.; Falconer, R.A. |
Journal | Carbohydrate Polymers |
DOI | 10.1016/j.carbpol.2021.117741 |
Title | Glycosyl disulfides: importance, synthesis and application to chemical and biological systems (2021) |
Authors | Ribeiro Morais, G.; Falconer, R.A. |
Journal | Organic and Biomolecular Chemistry |
DOI | 10.1039/D0OB02079F |
Title | An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors. (2020) |
Authors | Guo X; Malcolm J.R.; Ali M.M.; Ribeiro Morais G; Shnyder S.D.; Loadman P.M.; Patterson L.H.; Falconer R.A. |
Journal | ANALYST (PRINT) |
DOI | 10.1039/d0an00721h |
Title | Theranostic nanoparticles enhance the response of glioblastomas to radiation (2019) |
Authors | Wu, W.; Klockow, J.L.; Mohanty, S.; Ku, K.S.; Aghighi, M.; Melemenidis, S.; Chen, Z.; Li, K.; Ribeiro Morais, Goreti; Zhao, N.; Schlegel, J.; Graves, E.E.; Rao, J.; Loadman, Paul M.; Falconer, R.A.; Mukherjee, S.; Chin, F.T.; Daldrup-Link, H.E. |
Journal | Nanotheranostics |
DOI | 10.7150/ntno.35342 |
Title | Recent advances in the analysis of polysialic acid from complex biological systems (2019) |
Authors | Xiaoxiao Guo, Sara M. Elkashef, Mark Sutherland, Paul M. Loadman and Robert A. Falconer |
Journal | Carbohydrate Polymers |
DOI | 10.1016/j.carbpol.2019.115145 |
Title | Novel Ran-RCC1 inhibitory peptide-loaded nanoparticles have anti-cancer efficacy in vitro and in vivo (2019) |
Authors | Haggag, Y.A.; Matchett, K.B.; Falconer, R.A.; Isreb, M.; Jones, J.; Faheem, A.; McCarron, P.; El-Tanani, Mohamed |
Journal | Cancers |
DOI | 10.3390/cancers11020222 |
Title | A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival (2017) |
Authors | Mohanty, S.; Chen, Z.; Li, K.; Ribeiro Morais, G.; Klockow, J.; Yerneni, K.; Pasani, L.; Chin, F.T.; Mitra, S.; Cheshier, S.; Chang, E.; Gambhir, S.S.; Rao, J.; Loadman, P.M.; Falconer, R.A.; Daldrup-Link, H.E. |
Journal | Molecular Cancer Therapeutics |
DOI | 10.1158/1535-7163.MCT-17-0022 |
Title | Membrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting (2017) |
Authors | Falconer, R.A.; Loadman, P.M. |
Journal | Journal of Cancer Metastasis and Treatment |
DOI | 10.20517/2394-4722.2017.40 |
Title | Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs (2017) |
Authors | Jain, M.; Harburn, J.J.; Gill, J.H.; Loadman, P.M.; Falconer, R.A.; Mooney, C.A.; Cobb, S.L.; Berry, David J. |
Journal | Journal of Medicinal Chemistry |
DOI | 10.1021/acs.jmedchem.6b01472 |
Title | Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen (2017) |
Authors | Ehrit, J.; Keys, T.G.; Sutherland, Mark H.; Wolf, S.; Meier, C.; Falconer, R.A.; Gerardy-Schahn, R. |
Journal | ChemBioChem |
DOI | 10.1002/cbic.201700157 |
Title | Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment (2016) |
Authors | Elkashef, Sara M.; Allison, Simon J.; Sadiq, Maria; Basheer, Haneen A.; Ribeiro Morais, Goreti; Loadman, Paul M.; Pors, Klaus; Falconer, Robert A. |
Journal | Scientific Reports |
DOI | 10.1038/srep33026 |
Title | The use of thermographic imaging to evaluate therapeutic response in human tumour xenograft models (2016) |
Authors | Hussain, Nosheen; Connah, David; Ugail, Hassan; Cooper, Patricia A.; Falconer, Robert A.; Patterson, Laurence H.; Shnyder, Steven D. |
Journal | Scientific Reports |
DOI | 10.1038/srep31136 |
Title | The Effect of Polysialic Acid Expression on Glioma Cell Nano-mechanics (2016) |
Authors | Grant, Colin A.; Twigg, Peter C.; Saeed, Rida F.; Lawson, G.; Falconer, Robert A.; Shnyder, Steven D. |
Journal | BioNanoScience |
DOI | 10.1007/s12668-016-0192-2 |
Title | Novel strategies for the synthesis of unsymmetrical glycosyl disulfides (2016) |
Authors | Ribeiro Morais, Goreti; Springett, Bradley R.; Pauze, Martin; Schröder, Lisa; Northrop, Matthew; Falconer, Robert A. |
Journal | Organic and Biomolecular Chemistry |
DOI | 10.1039/c6ob00230g |
Title | An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity (2016) |
Authors | Elkashef, Sara M.; Sutherland, Mark H.; Patterson, Laurence H.; Loadman, Paul M.; Falconer, Robert A. |
Journal | ANALYST (PRINT) |
DOI | 10.1039/c6an01073c |
Title | Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity (2014) |
Authors | Gill, Jason H.; Loadman, Paul M.; Shnyder, Steven D.; Cooper, Patricia A.; Atkinson, Jennifer M.; Ribeiro Morais, Goreti; Patterson, Laurence H.; Falconer, Robert A. |
Journal | Molecular Cancer Therapeutics |
DOI | 10.1021/mp400760b |
Title | Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy (2014) |
Authors | Ansari, C.; Tikhomirov, G.A.; Hong, S.H.; Falconer, Robert A.; Loadman, Paul M.; Gill, Jason H.; Castaneda, R.; Hazard, F.K.; Tong, L.; Lenkov, O.D.; Felsher, D.W.; Rao, J.; Daldrup-Link, H.E. |
Journal | Small |
DOI | 10.1002/smll.201301456 |
Title | Carbohydrate-based molecules for Molecular Imaging in Nuclear Medicine (2013) |
Authors | Ribeiro Morais G.;Falconer R.;Santos I. |
Journal | European Journal of Organic Chemistry |
DOI | 10.1002/ejoc.201201457 |
Title | NCAM polysialylation during adherence transitions: Live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7 (2013) |
Authors | Smith P.;Furon E.;Wiltshire M.;Chappell S.;Patterson L.;Shnyder S.;Falconer R.;Errington R. |
Journal | Cytometry Part A |
DOI | 10.1002/cyto.a.22306 |
Title | Micro-community cytometry: Sensing changes in cell health and glycoconjugate expression by imaging and flow cytometry (2013) |
Authors | Smith P.;Falconer R.;Errington R. |
Journal | Journal of Microscopy |
DOI | 10.1111/jmi.12060 |
Title | Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration (2013) |
Authors | Al-Saraireh, Yousef M.J.; Sutherland, Mark H.; Springett, Bradley R.; Freiberger, F.; Ribeiro Morais, Goreti; Loadman, Paul M.; Errington, R.J.; Smith, P.J.; Fukuda, M.; Gerardy-Schahn, R.; Patterson, Laurence H.; Shnyder, Steven D.; Falconer, Robert A. |
Journal | PLoS ONE |
DOI | 10.1371/journal.pone.0073366 |
Title | Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation (2012) |
Authors | Fournier-Dit-Chabert J.;Vinader V.;Santos A.;Redondo-Horcajo M.;Dreneau A.;Basak R.;Cosentino L.;Marston G.;Abdel-Rahman H.;Loadman P.;Shnyder S.;Díaz J.;Barasoain I.;Falconer R.;Pors K. |
Journal | Bioorganic and Medicinal Chemistry Letters |
DOI | 10.1016/j.bmcl.2012.09.104 |
Title | Polysialyltransferase: A new target in metastatic cancer (2012) |
Authors | Falconer R.;Errington R.;Shnyder S.;Smith P.;Patterson L. |
Journal | Current Cancer Drug Targets |
DOI | 10.2174/156800912803251225 |
Title | An optimized method for the synthesis of amino-functionalized phosphatidylcholine (2012) |
Authors | Kong F.;Morais G.;Falconer R.;Sutton C. |
Journal | Tetrahedron Letters |
DOI | 10.1016/j.tetlet.2011.11.100 |
Title | Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases (2010) |
Authors | Atkinson J.;Falconer R.;Edwards D.;Pennington C.;Siller C.;Shnyder S.;Bibby M.;Patterson L.;Loadman P.;Gill J. |
Journal | Cancer Research |
DOI | 10.1158/0008-5472.CAN-10-1440 |
Title | Identification of an acetyl disulfide derivative in the synthesis of thiosialosides (2010) |
Authors | Morais G.;Oliveira I.;Humphrey A.;Falconer R. |
Journal | Carbohydrate Research |
DOI | 10.1016/j.carres.2009.10.017 |