Skip to content

Professor Paul Loadman,
Professor

Information about Professor Paul Loadman at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
Email:
p.m.loadman@bradford.ac.uk
Telephone:
+44 1274 233228
Photo of Professor Paul Loadman

Biography

Pharmacokinetics and tumour drug metabolism of anti-cancer drugs Professor Paul Loadman heads the drug metabolism team at the Institute of Cancer Therapeutics, University of Bradford and has >20years experience studying the pharmacokinetics and metabolism of anti-cancer drugs. The team in Bradford have studied a wide range of clinically available and novel small molecules including antimetabolites, platinating and alkylating agents, peptides and antivascular compounds. Prof Loadman is actively involved in the design, analysis and reporting of pre-clinical and clinical pharmacokinetic studies and acts as a pharmacokinetic and drug metabolism consultant for numerous pharmaceutical and biotechnology companies. Together with Prof Twelves (Clinical Director,) the DMPK team have established a Quality Management System within the ICT which has enabled a strong involvement in the pharmacokinetic monitoring of small molecules in major clinical trials. Other major clinical collaborations include with Professor Mark Hull at the University of Leeds (The seAFOod Polyp Prevention Trial, www.seafood-trial.co.uk) where the laboratory in Bradford are analyzing a series of bioactive lipid mediators such as ω-3 PUFAs, resolvin E1 and PGE-M in plasma, urine, erythrocytes and rectal mucosa in order to gain insights into the mechanism of action of EPA and aspirin.

Research

Pharmacokinetics and tumour drug metabolism of anti cancer drugs Matrix metalloproteinases as targets for tumour-selective delivery of anticancer therapeutics Drug delivery and prodrug design Novel advances in analytical techniques. HPLC, GC, CE and LC/MS/MS Drug interactions both in vitro and in vivo

Professional activities

Information about education, employment and areas of particular interest for Professor Paul Loadman is as follows:

Education

  • University of Bradford - PhD

Publications

There are 122 publications involving or that are attributed to Professor Paul Loadman. They are listed as:

  • book chapter (4)
  • journal article (1)
  • letter (1)
  • peer reviewed journal (111)
  • reviews (5)

Book Chapter

Professor Paul Loadman has 4 publication(s) listed under book chapter.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Development of tumour-selective and endoprotease-activated anticancer therapeutics 2008 The Cancer Degradome: Proteases and Cancer Biology The Cancer Degradome: Proteases and Cancer Biology 853 - 876 Gill J.;Loadman P. 9780387690568 10.1007/978-0-387-69057-5_40
Wnt Signaling as a Therapeutic Target in Cancer and Metastasis 2017 Morgan, Richard; Ankrah, R.; El-Tanani, S.; Patterson, Laurence H.; Loadman, Paul M.; Rudland, P.S.; El-Tanani, Mohamed
Practical aspects of pharmacokinetics and pharmacodynamics 2015 Loadman, Paul M.
Development of tumour selective and endoprotease-activated anticancer therapeutics. 2008 Gill, Jason H.; Loadman, Paul M.

Journal Article

Professor Paul Loadman has 1 publication(s) listed under journal article.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Maleimide-Thiol Linkages Alter the Biodistribution of SN38 Therapeutic Microbubbles Compared to Biotin-Avidin While Preserving Parity in Tumoral Drug Delivery 2024 Pharmaceutics 16 434 Nicola Ingram;Radwa H Abou-Saleh;Amanda Race;Paul M Loadman;Richard J Bushby;Stephen D Evans;Louise Coletta MDPI DOI: 10.3390/pharmaceutics16030434

Letter

Professor Paul Loadman has 1 publication(s) listed under letter.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging 2008 Rapid Communications In Mass Spectrometry 22 1615 - 1618 Djidja M.;Carolan V.;Loadman P.;Clench M. 0951-4198 10.1002/rcm.3503

Peer Reviewed Journal

Professor Paul Loadman has 111 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Cytochrome P450 1B1 (CYP1B1) is over-expressed in human colon adeno-carcinomas relative to normal colon: Implications for drug development. 2003 Gibson, Paul; Gill, Jason H.; Khan, Parveen A.; Seargent, Jill M.; Martin, Sandie W.; Batman, Philip A.; Griffith, John; Bradley, C.; Double, John A.; Bibby, Michael C.; Loadman, Paul M.
Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells 2022 Biochemical Pharmacology 10.1016/j.bcp.2022.115095
Randomised, placebo-controlled, phase 3 trial of the effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver metastases: EPA for Metastasis Trial 2 (EMT2) study protocol 2023 BMJ Open 13 Mark A Hull , Pei Loo Ow, Sharon Ruddock, Tim Brend, Alexandra F Smith, Helen Marshall, Mingyang Song, Andrew T Chan, Wendy S Garrett, Omer Yilmaz, David A Drew, Fiona Collinson, Andrew J Cockbain, Robert Jones, Paul M Loadman , Peter S Hall, Catherine Moriarty, David A Cairns, Giles J Toogood BMJ doi:10.1136/bmjopen-2023-077427
Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. 2023 Iscience 26 Barnieh FM;Galuska SP;Loadman PM;Ward S;Falconer RA;El-Khamisy SF; 2589-0042 10.1016/j.isci.2023.108219
Polymorphisms in Cyclooxygenase, Lipoxygenase and TP53 genes predict colorectal polyp risk reduction by aspirin in the seAFOod polyp prevention tria 2023 Cancer Prevention Research september John R Davies, Tracey Mell, Harriett Fuller, Mark Harland, Rasha N M Saleh, Amanda D Race, Colin J Rees, Louise C Brown, Paul M Loadman, Amy Downing, Anne Marie Minihane, Elizabeth A Williams Mark A Hull 1940-6215 AACR https://doi.org/10.1158/1940-6207.CAPR-23-0111
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds 2021 BIOORGANIC & MEDICINAL CHEMISTRY 40 Natalia Ortuzar, Kersti Karu, Daniela Presa, Goreti R. Morais, Helen M. Sheldrake, Steve D. Shnyder, Francis M. Barnieh, Paul M. Loadman, Laurence H. Patterson, Klaus Pors, Mark Searcey 10.1016/j.bmc.2021.116167
Plasma and rectal mucosal oxylipin levels during aspirin and eicosapentaenoic acid treatment in the seAFOod polyp prevention trial. 2023 Prostaglandins Leukotrienes and Essential Fatty Acids 192 Fuller H;Race AD;Fenton H;Burke L;Downing A;Williams EA;Rees CJ;Brown LC;Loadman PM;Hull MA; 1532-2823 10.1016/j.plefa.2023.102570
Colorectal polyp outcomes after participation in the seAFOod polyp prevention trial: Evidence of rebound elevated colorectal polyp risk after short-term aspirin use. 2023 Alimentary Pharmacology and Therapeutics Downing A;Fenton H;Nickerson C;Loadman PM;Williams EA;Rees CJ;Brown LC;Morris EJA;Hull MA; 1365-2036 10.1111/apt.17646
Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects 2022 Cancer Medicine 11 Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Róisín M. Dwyer, Annette T. Byrne https://doi.org/10.1002/cam4.4756
A Single Short 'Tone Burst' Results in Optimal Drug Delivery to Tumours Using Ultrasound-Triggered Therapeutic Microbubbles. 2022 Pharmaceutics 14 Ingram N;McVeigh LE;Abou-Saleh RH;Batchelor DVB;Loadman PM;McLaughlan JR;Markham AF;Evans SD;Coletta PL; 1999-4923 10.3390/pharmaceutics14030622
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs. 2022 Nature 605 Eschweiler S;Ramírez-Suástegui C;Li Y;King E;Chudley L;Thomas J;Wood O;von Witzleben A;Jeffrey D;McCann K;Simon H;Mondal M;Wang A;Dicker M;Lopez-Guadamillas E;Chou TF;Dobbs NA;Essame L;Acton G;Kelly F;Halbert G;Sacco JJ;Schache AG;Shaw R;McCaul JA;Paterson C;Davies JH;Brennan PA;Singh RP;Loadman PM;Wilson W;Hackshaw A;Seumois G;Okkenhaug K;Thomas GJ;Jones TM;Ay F;Friberg G;Kronenberg M;Vanhaesebroeck B;Vijayanand P;Ottensmeier CH; 1476-4687 10.1038/s41586-022-04685-2
Is tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique? 2021 Biochimica et Biophysica Acta - Reviews on Cancer 1876 Barnieh FM;Loadman PM;Falconer RA; 1879-2561 10.1016/j.bbcan.2021.188641
Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer. 2021 Scientific Reports 11 Presa D;Khurram SA;Zubir AZA;Smarakan S;Cooper PA;Morais GR;Sadiq M;Sutherland M;Loadman PM;McCaul J;Shnyder SD;Patterson LH;Pors K; 2045-2322 10.1038/s41598-021-98217-z
Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents. 2021 Drug Metabolism And Disposition: The Biological Fate Of Chemicals Bart AG;Morais G;Vangala VR;Loadman PM;Pors K;Scott EE; 1521-009X 10.1124/dmd.121.000642
The role of MT1-MMP in the progression and metastasis of osteosarcoma 2022 Journal of Cancer Metastasis and Treatment 9 Spencer, H.L.M.; Shnyder, S.D.; Loadman, P.M.; Falconer, R.A. DOI:10.20517/2394-4722.2021.174
Progress towards a clinically-successful ATR inhibitor for cancer therapy 2021 Current Research in Pharmacology and Drug Discovery 2 100017 Barnieh, F.M.; Loadman, P.M.; Falconer, R.A. 10.1016/j.crphar.2021.100017
An assay for quantitative analysis of polysialic acid expression in cancer cells 2021 Carbohydrate Polymers 259 Guo, X.; Elkashef, S.M.; Patel, A.; Ribeiro Morais, G.; Shnyder S.D.; Loadman, P.M.; Patterson, L.H.; Falconer, R.A. 10.1016/j.carbpol.2021.117741
How can the potential of the duocarmycins be unlocked for cancer therapy? 2021 Drug Discovery Today 26 Jukes Z;Morais GR;Loadman PM;Pors K; 1878-5832 10.1016/j.drudis.2020.11.020
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds. 2021 Bioorganic and Medicinal Chemistry 40 Ortuzar N;Karu K;Presa D;Morais GR;Sheldrake HM;Shnyder SD;Barnieh FM;Loadman PM;Patterson LH;Pors K;Searcey M; 1464-3391 10.1016/j.bmc.2021.116167
Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, Combretastatin A4. 2021 Nanomedicine: Nanotechnology, Biology, and Medicine Charalambous A;Mico V;McVeigh LE;Marston G;Ingram N;Volpato M;Peyman SA;McLaughlan JR;Wierzbicki A;Loadman P;Bushby RJ;Markham AF;Evans SD;Coletta PL; 1549-9642 10.1016/j.nano.2021.102401
Luminal bioavailability in the distal small intestine and changes to the ileal microbiome after oral administration of omega-3 polyunsaturated fatty acids 2021 Journal of Nutrition may24 Gael Nana, Henry Watson, Suparna Mitra, Caroline Young, Henry M Wood, Sarah L Perry, Amanda D Race, Philip Quirke, Giles J Toogood, Paul M Loadman, Mark A Hull doi: 10.1093/jn/nxab113
Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues 2020 Theranostics 10 Nicola Ingram1*, Laura E. McVeigh1*, Radwa H. Abou-Saleh2,3, Juliana Maynard4, Sally A. Peyman2, James R. McLaughlan5, Michael Fairclough6, Gemma Marston1, Elizabeth M.A. Valleley 1, Jorge L. Jimenez-Macias1, Antonia Charalambous1, William Townley4, Malcolm Haddrick4, Antonia Wierzbicki7, Alexander Wright1, Milène Volpato1, Peter B. Simpson4, Darren E. Treanor1, Neil H. Thomson8, Paul M. Loadman7, Richard J. Bushby2,9, Benjamin R.G. Johnson2, Pamela F. Jones1, Tony Evans1, Steven Freear5, Alexander F. Markham1, Stephen D. Evans2,*, P. Louise Coletta1,* ISSN: 1838-7640 Ivy Spring DOI: 10.7150/thno.49670
An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors. 2020 ANALYST (PRINT) 145 4512 - 4521 Guo X; Malcolm J.R.; Ali M.M.; Ribeiro Morais G; Shnyder S.D.; Loadman P.M.; Patterson L.H.; Falconer R.A. 1364-5528 10.1039/d0an00721h
Theranostic nanoparticles enhance the response of glioblastomas to radiation 2019 Nanotheranostics 3 299 - 310 Wu, W.; Klockow, J.L.; Mohanty, S.; Ku, K.S.; Aghighi, M.; Melemenidis, S.; Chen, Z.; Li, K.; Ribeiro Morais, Goreti; Zhao, N.; Schlegel, J.; Graves, E.E.; Rao, J.; Loadman, Paul M.; Falconer, R.A.; Mukherjee, S.; Chin, F.T.; Daldrup-Link, H.E. 10.7150/ntno.35342
Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance 2019 Critical Reviews in Oncology/Hematology 141 153 - 162 Jove, M.; Spencer, Jade A.; Clench, M.; Loadman, Paul M.; Twelves, C. DOI.org/10.1016/j.critrevonc.2019.06.008
Recent advances in the analysis of polysialic acid from complex biological systems 2019 Carbohydrate Polymers 16 Xiaoxiao Guo, Sara M. Elkashef, Mark Sutherland, Paul M. Loadman and Robert A. Falconer 10.1016/j.carbpol.2019.115145
Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models. 2019 Journal of Pharmacology and Experimental Therapeutics 371 Jove M;Spencer JA;Hubbard ME;Holden EC;O'Dea RD;Brook BS;Phillips RM;Smye SW;Loadman P;Twelves CJ; 1521-0103 10.1124/jpet.119.256693
Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer 2019 Cancer Chemotherapy and Pharmacology 83 Roger M. Phillips, Paul M. Loadman, Guru Reddy 10.1007/s00280-019-03812-7
Extraction of the synthetic lytic peptide, cecropin B, from biological fluid and analysis using reversed-phase high-performance liquid chromatography 1995 Journal of Chromatography - Biomedical Applications 672 225 - 231 Moore A.;Loadman P.;Devine D.;Bibby M. 0378-4347 10.1016/0378-4347(95)00233-9
APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps 2024 Prostaglandins Leukotrienes and Essential Fatty Acids 201 Ge SunJohn, R Davies ,Tracey Mell, Mark Harland, Rasha M H Saleh, Amanda D Race, Paul M Loadman, Elizabeth A Williams, Anne Marie Minihane, Mark A Hull doi: 10.1016/j.plefa.2024.102623
Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial 2018 Lancet 392 2583 - 2594 Hull, M.A.; Sprange, K.; Hepburn, T.; Tan, W.; Shafayat, A.; Rees, C.J.; Clifford, G.; Logan, R.F.; Loadman, Paul M.; Williams, E.A.; Whitham, D.; Montgomery, A.A. doi.org/10.1016/S0140-6736(18)31775-6
Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex 2011 MedChemComm 2 666 - 668 Shnyder S.;Fu Y.;Habtemariam A.;Van Rijt S.;Cooper P.;Loadman P.;Sadler P. 2040-2503 10.1039/c1md00075f
The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study 2007 Annals of Oncology 18 1098 - 1103 Steward W.;Middleton M.;Benghiat A.;Loadman P.;Hayward C.;Waller S.;Ford S.;Halbert G.;Patterson L.;Talbot D. 0923-7534 10.1093/annonc/mdm120
In vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans 1999 Drug Metabolism and Disposition 27 240 - 245 Calabrese C.;Loadman P.;Lim L.;Bibby M.;Double J.;Brown J.;Lamb J. 0090-9556
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties 2012 Journal of Medicinal Chemistry 55 11062 - 11066 Cosentino L.;Redondo-Horcajo M.;Zhao Y.;Santos A.;Chowdury K.;Vinader V.;Abdallah Q.;Abdel-Rahman H.;Fournier-Dit-Chabert J.;Shnyder S.;Loadman P.;Fang W.;Díaz J.;Barasoain I.;Burns P.;Pors K. 0022-2623 10.1021/jm301151t
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice 2000 Biochemical Pharmacology 59 831 - 837 Loadman P.;Phillips R.;Lim L.;Bibby M. 0006-2952 10.1016/S0006-2952(99)00391-3
Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action. 2003 Teratogenesis Carcinogenesis and Mutagenesis Suppl 2 13 - 29 Suggitt M.;Fearnley J.;Swaine D.;Volpato M.;Phillips R.;Bibby M.;Loadman P.;Anderson D. 0270-3211
The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility 2012 British Journal of Pharmacology 166 1724 - 1737 Hawcroft G.;Volpato M.;Marston G.;Ingram N.;Perry S.;Cockbain A.;Race A.;Munarini A.;Belluzzi A.;Loadman P.;Coletta P.;Hull M. 0007-1188 10.1111/j.1476-5381.2012.01882.x
Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity 2005 European Journal of Cancer. Part A 41 1331 - 1338 Volpato M.;Seargent J.;Loadman P.;Phillips R. 0959-8049 10.1016/j.ejca.2005.03.014
Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma 2005 Urology 65 815 - 820 Seargent J.;Loadman P.;Martin S.;Naylor B.;Bibby M.;Gill J. 0090-4295 10.1016/j.urology.2004.11.016
A preclinical pharmacokinetic study of the bioreductive drug AQ4N 2001 Drug Metabolism and Disposition 29 422 - 426 Loadman P.;Swaine D.;Bibby M.;Welham K.;Patterson L. 0090-9556
Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: Results of a phase I study 2008 Clinical Cancer Research 14 1096 - 1104 Albertella M.;Loadman P.;Jones P.;Phillips R.;Rampling R.;Burnet N.;Alcock C.;Anthoney A.;Vjaters E.;Dunk C.;Harris P.;Wong A.;Lalani A.;Twelves C. 1078-0432 10.1158/1078-0432.CCR-07-4020
Pharmacokinetics of PK1 and doxorubicin in experimental colon tumor models with differing responses to PK1 1999 Clinical Cancer Research 5 3682 - 3688 Loadman P.;Bibby M.;Double J.;Al-Shakhaa W.;Duncan R. 1078-0432
Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9 2002 British Journal of Pharmacology 137 701 - 709 Loadman P.;Bibby M.;Phillips R. 0007-1188 10.1038/sj.bjp.0704916
FGFR1-induced Epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms 2012 PLoS ONE 7 Tomlinson D.;Baxter E.;Loadman P.;Hull M.;Knowles M. 1932-6203 10.1371/journal.pone.0038972
Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases 2010 Cancer Research 70 6902 - 6912 Atkinson J.;Falconer R.;Edwards D.;Pennington C.;Siller C.;Shnyder S.;Bibby M.;Patterson L.;Loadman P.;Gill J. 0008-5472 10.1158/0008-5472.CAN-10-1440
In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts 2009 Molecular Cancer Therapeutics 8 3266 - 3275 Williams K.;Albertella M.;Fitzpatrick B.;Loadman P.;Shnyder S.;Chinje E.;Telfer B.;Dunk C.;Harris P.;Stratford I. 1535-7163 10.1158/1535-7163.MCT-09-0396
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates 2006 Journal of Medicinal Chemistry 49 5442 - 5461 Wells G.;Martin C.;Howard P.;Sands Z.;Laughton C.;Tiberghien A.;Woo C.;Masterson L.;Stephenson M.;Hartley J.;Jenkins T.;Shnyder S.;Loadman P.;Waring M.;Thurston D. 0022-2623 10.1021/jm051199z
A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): Study protocol for a randomized controlled trial 2013 Trials 14 Hull M.;Sandell A.;Montgomery A.;Logan R.;Clifford G.;Rees C.;Loadman P.;Whitham D. 1745-6215 10.1186/1745-6215-14-237
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study 2003 British Journal of Cancer 88 1160 - 1167 Rustin G.;Bradley C.;Galbraith S.;Stratford M.;Loadman P.;Waller S.;Bellenger K.;Gumbrell L.;Folkes L.;Halbert G. 0007-0920 10.1038/sj.bjc.6600885
High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide 2000 Journal of Chromatography B: Biomedical Sciences and Applications 742 239 - 245 Swaine D.;Loadman P.;Bibby M.;Graham M.;Patterson L. 1387-2273 10.1016/S0378-4347(00)00160-2
Chromatographie analysis of polysialic acid released from neural adhesion molecule presented on glioma cell membranes 2011 Kuwait Journal of Science and Engineering 38 107 - 130 Al-Hasawi N.;Volapato M.;Loadman P. 1024-8684
Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells 2010 Neoplasia 12 618 - 627 Hawcroft G.;Loadman P.;Belluzzi A.;Hull M. 1522-8002 10.1593/neo.10388
Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: Implications for enzyme-directed bioreductive drug development 2000 Cancer Research 60 6384 - 6390 Phillips R.;Burger A.;Loadman P.;Jarrett C.;Swaine D.;Fiebig H. 0008-5472
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation 2012 Bioorganic and Medicinal Chemistry Letters 22 7693 - 7696 Fournier-Dit-Chabert J.;Vinader V.;Santos A.;Redondo-Horcajo M.;Dreneau A.;Basak R.;Cosentino L.;Marston G.;Abdel-Rahman H.;Loadman P.;Shnyder S.;Díaz J.;Barasoain I.;Falconer R.;Pors K. 0960-894X 10.1016/j.bmcl.2012.09.104
Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP. 2004 International Journal of Oncology 24 1005 - 1010 Phillips R.;Basu S.;Brown J.;Flannigan G.;Loadman P.;Martin S.;Naylor B.;Puri R.;Shah T. 1019-6439
Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry 2007 Rapid Communications In Mass Spectrometry 21 1271 - 1276 Atkinson S.;Loadman P.;Sutton C.;Patterson L.;Clench M. 0951-4198 10.1002/rcm.2952
Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma 2000 Anticancer Research 20 229 - 233 Grosios K.;Loadman P.;Swaine D.;Pettit G.;Bibby M. 0250-7005
Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections 2009 Proteomics 9 2750 - 2763 Djidja M.;Francese S.;Loadman P.;Sutton C.;Scriven P.;Claude E.;Snel M.;Franck J.;Salzet M.;Clench M. 1615-9853 10.1002/pmic.200800624
Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability 2011 Bioorganic and Medicinal Chemistry 19 3650 - 3658 Benelkebir H.;Marie S.;Hayden A.;Lyle J.;Loadman P.;Crabb S.;Packham G.;Ganesan A. 0968-0896 10.1016/j.bmc.2011.02.024
Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: Correlation of MMP-14 mRNA expression and proteolytic activity 2007 European Journal of Cancer. Part A 43 1764 - 1771 Atkinson J.;Pennington C.;Martin S.;Anikin V.;Mearns A.;Loadman P.;Edwards D.;Gill J. 0959-8049 10.1016/j.ejca.2007.05.009
A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin 2018 Toxicology Letters 292 63 - 72 Spriggs, S.; Cubberley, R.; Loadman, Paul M.; Sheffield, D.; Wierzbicki, Antonia doi.org/10.1016/j.toxlet.2018.04.011
Structural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method 2018 Journal of Pharmaceutical and Biomedical Analysis 149 16 - 21 Kamble, Sharad R.; Loadman, Paul M.; Abraham, M.H.; Liu, Xiangli doi.org/10.1016/j.jpba.2017.10.022
Membrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting 2017 Journal of Cancer Metastasis and Treatment 3 315 - 327 Falconer, R.A.; Loadman, P.M. 10.20517/2394-4722.2017.40
Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate 2004 Kirwan, Ian G.; Loadman, Paul M.; Swaine, David J.; Anthoney, Alan; Pettit, G.R.; Lippert III, J.W.; Shnyder, Steven D.; Cooper, Patricia A.; Bibby, Michael C.
A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival 2017 Molecular Cancer Therapeutics 16 1909 - 1921 Mohanty, S.; Chen, Z.; Li, K.; Ribeiro Morais, G.; Klockow, J.; Yerneni, K.; Pasani, L.; Chin, F.T.; Mitra, S.; Cheshier, S.; Chang, E.; Gambhir, S.S.; Rao, J.; Loadman, P.M.; Falconer, R.A.; Daldrup-Link, H.E. 10.1158/1535-7163.MCT-17-0022
Drug delivery in a tumour cord model: a computational simulation 2017 Royal Society Open Science 4 170014 Hubbard, M.E.; Jove, M.; Loadman, Paul M.; Phillips, Roger M.; Twelves, Christopher J.; Smye, S.W. doi.org/10.1098/rsos.170014
A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples 2017 J Chromatography B 1055 125 - 134 Volpato, Milène; Spencer, Jade A.; Race, Amanda D.; Munarini, A.; Belluzzi, A.; Cockbain, A.; Hull, M.; Loadman, Paul M. doi.org/10.1016/j.jchromb.2017.04.030
Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs 2017 Journal of Medicinal Chemistry 60 4496 - 4502 Jain, M.; Harburn, J.J.; Gill, J.H.; Loadman, P.M.; Falconer, R.A.; Mooney, C.A.; Cobb, S.L.; Berry, David J. 10.1021/acs.jmedchem.6b01472
A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota 2018 Gut 67 1974 - 1983 Watson, H.; Mitra, S.; Croden, F.C.; Taylor, M.; Wood, H.M.; Perry, S.L.; Spencer, Jade A.; Quirke, P.; Toogood, G.J.; Lawton, C.L.; Dye, L.; Loadman, Paul M.; Hull, M.A. doi: 10.1136/gutjnl-2017-314968
Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota 2014 International Journal of Cancer 135 204 - 213 Piazzi, G.; D'Argenio, G.; Prossomariti, A.; Lembo, V.; Mazzone, G.; Candela, M.; Biagi, E.; Brigidi, P.; Vitaglione, P.; Fogliano, V.; D'Angelo, L.; Fazio, C.; Munarini, A.; Belluzzi, A.; Ceccarelli, C.; Chieco, P.; Balbi, T.; Loadman, Paul M.; Hull, M.A.; Romano, M.; Bazzoli, F.; Ricciardiello, L. doi.org/10.1002/ijc.28853
Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid 2014 Gut 63 1760 - 1768 Cockbain, A.J.; Volpato, Milène; Race, Amanda D.; Munarini, A.; Fazio, C.; Belluzzi, A.; Loadman, Paul M.; Toogood, G.J.; Hull, M.A. doi.org/10.1136/gutjnl-2013-306445
Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity 2013 Sheldrake, Helen M.; Travica, S.; Johansson, I.; Loadman, Paul M.; Sutherland, Mark H.; Elsalem, Lina M.I.; Illingworth, Nicola A.; Cresswell, Alexander J.; Reuillon, Tristan; Shnyder, Steven D.; Mkrtchian, S.; Searcey, M.; Ingelman-Sundberg, M.; Patterson, Laurence H.; Pors, Klaus
Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass 2014 Bmc Obesity 22 202 - 210 Kant, P.; Perry, S.L.; Dexter, S.P.; Race, Amanda D.; Loadman, Paul M. doi.org/10.1002/oby.20493
Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases 2016 Prostaglandins Leukotrienes and Essential Fatty Acids 115 Watson, H.; Cockbain, A.J.; Spencer, Jade A.; Race, Amanda D.; Volpato, Milène; Loadman, Paul M.; Toogood, G.J.; Hull, M.A. dx.doi.org/10.1016/j.plefa.2016.10.003
Proteases in cancer drug delivery 2016 Advanced Drug Delivery Reviews 97 144 - 145 Vandooren, J.; Opdenakker, G.; Loadman, Paul M.; Edwards, D.R. dx.doi.org/10.1016/j.addr.2015.12.020
In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog 2014 Investigational New Drugs 32 806 - 814 Wong, C.C.; Periasamy, Nagarajan; Sagineedu, S.R.; Sidik, S.; Sumon, S.H.; Loadman, Paul M.; Phillips, Roger M.; Lajis, N.H.; Stanslas, J. doi.org/10.1007/s10637-014-0105-6
Mathematical and computational models of drug transport in tumours 2014 Journal of the Royal Society Interface 11 94 Groh, C.M.; Hubbard, M.E.; Jones, P.F.; Loadman, Paul M.; Periasamy, Nagarajan; Sleeman, B.D.; Smye, S.W.; Twelves, Christopher J.; Phillips, Roger M. doi.org/10.1098/rsif.2013.1173
Probing cytochrome P450-mediated activation with a truncated azinomycin analogue 2015 MedChemComm 6 187 - 191 Vinader, Victoria; Sadiq, Maria; Sutherland, Mark H.; Huang, M.Y.; Loadman, Paul M.; Elsalem, Lina M.I.; Shnyder, Steven D.; Cui, H.J.; Afarinkia, Kamyar; Searcey, M.; Patterson, Laurence H.; Pors, Klaus dx.doi.org/10.1039/c4md00411f
A randomised controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod (Systematic Evaluation of Aspirin and Fish Oil) Polyp Prevention Trial 2013 Hull, M.A.; Sandell, A.C.; Montgomery, A.A.; Logan, R.F.A.; Clifford, G.M.; Rees, C.J.; Loadman, Paul M.; Whitham, D.
Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging 2013 Djidja, M-C.; Francese, S.; Claude, E.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Cooper, Patricia A.; Patterson, Laurence H.; Carolan, V.A.; Clench, M.R.
Identification of Stage-Specific Breast Markers using Quantitative Proteomics 2013 Shaheed, Sadr-ul; Rustogi, Nitin; Scally, Andy J.; Wilson, J.; Thygesen, H.; Loizidou, M.A.; Hadjisavvas, A.; Hanby, A.; Speirs, V.; Loadman, Paul M.; Linforth, R.; Kyriacou, K.; Sutton, Chris W.
An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity 2016 ANALYST (PRINT) 141 5849 - 5856 Elkashef, Sara M.; Sutherland, Mark H.; Patterson, Laurence H.; Loadman, Paul M.; Falconer, Robert A. 10.1039/c6an01073c
Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration 2013 PLoS ONE 8 e73366 Al-Saraireh, Yousef M.J.; Sutherland, Mark H.; Springett, Bradley R.; Freiberger, F.; Ribeiro Morais, Goreti; Loadman, Paul M.; Errington, R.J.; Smith, P.J.; Fukuda, M.; Gerardy-Schahn, R.; Patterson, Laurence H.; Shnyder, Steven D.; Falconer, Robert A. 10.1371/journal.pone.0073366
Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy 2014 Small 10 565 - 575 Ansari, C.; Tikhomirov, G.A.; Hong, S.H.; Falconer, Robert A.; Loadman, Paul M.; Gill, Jason H.; Castaneda, R.; Hazard, F.K.; Tong, L.; Lenkov, O.D.; Felsher, D.W.; Rao, J.; Daldrup-Link, H.E. 10.1002/smll.201301456
Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity 2014 Molecular Cancer Therapeutics 11 1294 - 1300 Gill, Jason H.; Loadman, Paul M.; Shnyder, Steven D.; Cooper, Patricia A.; Atkinson, Jennifer M.; Ribeiro Morais, Goreti; Patterson, Laurence H.; Falconer, Robert A. 10.1021/mp400760b
Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment 2016 Scientific Reports 6 33026 Elkashef, Sara M.; Allison, Simon J.; Sadiq, Maria; Basheer, Haneen A.; Ribeiro Morais, Goreti; Loadman, Paul M.; Pors, Klaus; Falconer, Robert A. 10.1038/srep33026
Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA 2015 Rapid Communications In Mass Spectrometry 29 1288 - 1296 Batubara, A.; Carolan, V.A.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Clench, M.R. doi.org/10.1002/rcm.7223
NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C. 2004 Basu, Saurajyoti; Brown, John E.; Flannigan, G. Michael; Gill, Jason H.; Loadman, Paul M.; Martin, Sandie W.; Naylor, Brian; Puri, Rajiv; Scally, Andy J.; Seargent, Jill M.; Shah, Tariq K.; Phillips, Roger M.
Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins 2013 Travica, S.; Pors, Klaus; Loadman, Paul M.; Shnyder, Steven D.; Johansson, I.; Alandas, Mohammed N.; Sheldrake, Helen M.; Mkrtchian, S.; Patterson, Laurence H.; Ingelman-Sundberg, M.
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder 2013 Sutherland, Mark H.; Gill, Jason H.; Loadman, Paul M.; Laye, Jonathan P.; Sheldrake, Helen M.; Illingworth, Nicola A.; Alandas, Mohammed N.; Cooper, Patricia A.; Searcey, M.; Pors, Klaus; Shnyder, Steven D.; Patterson, Laurence H.
Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: Relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy 2004 Basu, Saurajyoti; Brown, John E.; Flannigan, G. Michael; Gill, Jason H.; Loadman, Paul M.; Naylor, Brian; Scally, Andy J.; Seargent, Jill M.; Shah, Tariq K.; Puri, Rajiv; Phillips, Roger M.; Martin, Sandie W.
Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors 2009 Hochhauser, D.; Meyer, T.; Spanswick, V.J.; Wu, J.; Clingen, P.H.; Loadman, Paul M.; Cobb, M.; Gumbrell, L.; Begent, R.H.; Hartley, J.A.; Jodrell, D.
Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity 2011 Pors, Klaus; Loadman, Paul M.; Shnyder, Steven D.; Sutherland, Mark H.; Sheldrake, Helen M.; Guino, M.; Kiakos, K.; Hartley, J.A.; Searcey, M.; Patterson, Laurence H.
Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells 2010 Hawcroft, G.; Loadman, Paul M.; Belluzzi, A.; Hull, M.A.
Development of a novel tumor-targeted vascular disrupting agent activated by Membrane-type Matrix Metalloproteinases (MT-MMPs) 2010 Atkinson, Jennifer M.; Falconer, Robert A.; Edwards, D.R.; Pennington, C.J.; Siller, Catherine S.; Shnyder, Steven D.; Bibby, Michael C.; Patterson, Laurence H.; Loadman, Paul M.; Gill, Jason H.
Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours. 2010 Isambert, N.; Campone, M.; Bourbouloux, E.; Drouin, M.; Major, A.; Yin, W.; Loadman, Paul M.; Capizzi, R.; Grieshaber, C.; Fumoleau, P.
In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenograft. 2009 Williams, K.J.; Albertella, M.R.; Fitzpatrick, B.; Loadman, Paul M.; Shnyder, Steven D.; Chinje, E.C.; Telfer, B.A.; Dunk, C.R.; Harris, P.A.; Stratford, I.J.
Detergent addition to trypsin digest and Ion Mobility Separation prior to MS/MS improves peptide yield and Protein Identification for in situ Proteomic Investigation of Frozen and FFPE Adenocarcinoma tissue sections. 2009 Djidja, M-C.; Francese, S.; Loadman, Paul M.; Sutton, Chris W.; Scriven, P.; Claude, E.; Snel, M.F.; Franck, J.; Salzet, M.; Clench, M.R.
A mathematical model of doxorubicin penetration through multicellular layers, 2009 Evans, C.J.; Phillips, Roger M.; Jones, P.F.; Loadman, Paul M.; Sleeman, B.D.; Twelves, Christopher J.; Smye, S.W.
Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging. 2008 Djidja, M-C.; Carolan, V.A.; Loadman, Paul M.; Clench, M.R.
Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1-targeted tripartite quinone drug delivery system 2007 Volpato, Milène; Abou-Zeid, N.; Tanner, R.W.; Glassbrook, L.T.; Taylor, James P.; Stratford, I.J.; Loadman, Paul M.; Jaffar, M.; Phillips, Roger M.
Fluorescent 7-Diethylaminocoumarin Pyrrolobenzodiazepine conjugates: Synthesis, DNA-Interaction, Cytotoxicity and Differential Cellular Localization. 2008 Wells, G.; Suggitt, Marie; Coffils, M.; Baig, M.A.H.; Howard, P.W.; Loadman, Paul M.; Hartley, J.A.; Jenkins, Terence C.; Thurston, D.E.
Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase 1 study 2008 Albertella, M.R.; Loadman, Paul M.; Jones, P.H.; Phillips, Roger M.; Rampling, R.; Burnet, N.; Alcock, C.; Anthoney, Alan; Vjaters, E.; Dunk, C.R.; Harris, P.A.; Wong, A.; Lalani, A.S.; Twelves, Christopher J.
Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent. 2004 Wilkinson, Gary P.; Taylor, James P.; Shnyder, Steven D.; Loadman, Paul M.; Cooper, Patricia A.; Howard, P.W.; Thurston, D.E.; Jenkins, Terence C.
Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119). 2007 Burger, A.M.; Loadman, Paul M.; Thurston, D.E.; Schultz, R.; Fiebig, H.H.; Bibby, Michael C.
Pharmacological and biological evaluation of a series of substituted 1,4 naphthoquinone bioreductive drugs. 2004 Phillips, Roger M.; Loadman, Paul M.; Maitland, Derek J.; Shnyder, Steven D.; Jaffar, M.; Steans, Gillian; Cooper, Patricia A.; Race, Amanda D.; Patterson, A.V.; Stratford, I.J.
The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study. 2009 Steward, W.P.; Middleton, M.; Benghiat, A.; Loadman, Paul M.; Hayward, C.; Walter, S.; Ford, S.; Halbert, G.; Patterson, Laurence H.; Talbot, D.
Membrane Type MMPs Show Differential Expression in Non-Small Cell Lung Cancer (NSCLC) Compared to Normal Lung; Correlation of MMP-14 mRNA Expression and Proteolytic Activity. 2007 Atkinson, Jennifer M.; Gill, Jason H.; Loadman, Paul M.; Martin, Sandie W.; Pennington, J.; Anikin, V.A.; Mearns, A.J.; Edwards, D.R.
Phase I/II Pilot Study of Intravesical Apaziquone (EO9) for Superficial Bladder Cancer 2006 Puri, Rajiv; Palit, V.; Loadman, Paul M.; Flannigan, G. Michael; Shah, T.K.; Choudry, G.A.; Basu, Saurajyoti; Double, John A.; Lenaz, G.; Chawla, S.; Beer, M.; Kalken, C.V.; de Boer, R.; Beijnen, J.H.; Twelves, Christopher J.; Phillips, Roger M.
MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas 2004 Gill, Jason H.; Kirwan, Ian G.; Seargent, Jill M.; Martin, Sandie W.; Tijani, S.; Anikin, V.A.; Mearns, A.J.; Bibby, Michael C.; Anthoney, Alan; Loadman, Paul M.

Reviews

Professor Paul Loadman has 5 publication(s) listed under reviews.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance 2019 Critical Reviews in Oncology/Hematology 141 153 - 162 Jove M.;Spencer J.;Clench M.;Loadman P.;Twelves C. 1040-8428 10.1016/j.critrevonc.2019.06.008
Proteases in cancer drug delivery 2016 Advanced Drug Delivery Reviews 97 144 - 155 Vandooren J.;Opdenakker G.;Loadman P.;Edwards D. 0169-409X 10.1016/j.addr.2015.12.020
Current advances in the inhibition of the auto-regulatory interaction between the p53 tumour suppressor protein and MDM2 protein 2001 Expert Opinion on Therapeutic Patents 11 1825 - 1835 Picksley S.;Dart D.;Mansoor M.;Loadman P. 1354-3776 10.1517/13543776.11.12.1825
Use of matrix-assisted laser desorption/ionisation mass spectrometry in cancer research 2011 Journal of Pharmacological and Toxicological Methods 64 197 - 206 Bateson H.;Saleem S.;Loadman P.;Sutton C. 1056-8719 10.1016/j.vascn.2011.04.003
Separation methods for anthraquinone related anti-cancer drugs 2001 Journal of Chromatography B: Biomedical Sciences and Applications 764 193 - 206 Loadman P.;Calabrese C. 1387-2273 10.1016/S0378-4347(01)00281-X