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researcher

Dr Ibrahim Khot

Assistant Professor

Faculty/Dept/School School of Chemistry and Bioscience
(Faculty of Life Sciences)
Emailm.i.khot2@bradford.ac.uk

Biography

Dr. Ibrahim Khot was appointed as Assistant Professor in Biochemistry within the School of Chemistry and Biosciences in 2023. Prior to this Ibrahim was a lecturer at the University of Leeds and completed his Postdoctoral Research Fellowship within the Schools of Medicine and Physics & Astronomy at the University of Leeds and his research was funded by Leeds NIHR BRC, UKRI EPSRC, Wellcome Trust, The Royal Society and Bowel Cancer UK.

In 2013, he completed a BSc with First Class honours in Biomedical Sciences and in 2014, completed an MSc with Distinction in Cancer Pharmacology, both from the University of Bradford. He then undertook his doctoral studies at the University of Leeds, earning a PhD in Medicine and Biology in 2019.

Ibrahim’s research focus is pre-clinical evaluation and clinical translational of novel cancer technologies, focussing on the development of cutting-edge patient-derived cancer organoids to study the impact of biofilms in bowel cancers and to develop personalised treatments. His research experience also extends to developing multimodal nanoparticles to fluorescently image and deliver photodynamic therapy to treat bowel cancers. This is in conjunction with the use of complex in vitro cell models of cancer, specifically three-dimensional cell cultures and state-of-the-art patient-derived organoids. Ongoing multi-collaborative research includes the development of high-throughput microfluidic platforms for therapeutic screening applications and miniature implantable LED devices to deliver metronomic photodynamic therapies. Through his research career, Ibrahim has developed multiple academic and industrial collaborators on different projects.

Outputs from Ibrahim’s research includes multiple high impact publications, conference presentations, grant funding and a patent on wireless LED technologies.

For academic appointments, Ibrahim has lectured on different undergraduate and postgraduate biology and medicine programmes and serves as primary supervisor to a cohort of postgraduate research students including MD, PhD, MRes, MSc and BSc students. He also serves as internal and external university examiner for doctoral transfer and final thesis examinations.

Professional activities

  • 01-JAN-13: University of Bradford - BSc (Hons)
  • 01-JAN-14: University of Bradford - MSc (Dist)
  • 01-JAN-19: University of Leeds - PhD
  • 01-JAN-23: University of Leeds - FHEA

  • 01-OCT-18: University of Leeds - Research Fellow
  • 01-OCT-20: University of Leeds - Lecturer

  • Institute of Biomedical Sciences , Fellow (FIBMS)
  • Royal Society of Biology, Chartered Biologist (CBiol)
  • Royal Society of Biology, Member (MRSB)
  • Royal Society of Medicine, Member

  • 01-JAN-19: Wellcome Trust Visiting Researcher Fellowship
  • 01-JAN-22: University Recognition Scheme Award

  • 18-OCT-22: U.S. Patent Application No. 63/417,040 - Biocompatible, miniaturized dual-channel wireless optoelectronics for photodynamic therapy

Publications

TitleFluorescent imaging using novel conjugated polymeric nanoparticles-affimer probes in complex in vitro models of colorectal cancer. (2023)
AuthorsJolugbo P;Willott T;Lin WH;Maisey T;O'Callaghan D;Green MA;Jayne DG;Khot MI;
JournalNanoscale
DOI10.1039/d3nr02160b
 
TitleA digitally driven manufacturing process for high resolution patterning of cell formations. (2023)
AuthorsSmith MAA;Khot MI;Taccola S;Fry NR;Muhonen PL;Tipper JL;Jayne DG;Kay RW;Harris RA;
JournalBiomedical Microdevices
DOI10.1007/s10544-023-00655-1
 
TitleAI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy. (2022)
AuthorsKim WS;Khot MI;Woo HM;Hong S;Baek DH;Maisey T;Daniels B;Coletta PL;Yoon BJ;Jayne DG;Park SI;
JournalNature Communications
DOI10.1038/s41467-022-29878-1
 
TitleA novel fluorescent c-met targeted imaging agent for intra-operative colonic tumour mapping: Translation from the laboratory into a clinical trial. (2022)
AuthorsArmstrong GR;Khot MI;Portal C;West NP;Perry SL;Maisey TI;Tiernan JP;Hughes TA;Tolan DJ;Jayne DG;
JournalSurgical Oncology
DOI10.1016/j.suronc.2021.101679
 
TitleThe utility of c-Met as a diagnostic tissue biomarker in primary colorectal cancer. (2021)
AuthorsArmstrong GR;Khot MI;Tiernan JP;West NP;Perry SL;Maisey TI;Hughes TA;Jayne DG;
JournalInternational Journal of Experimental Pathology
DOI10.1111/iep.12395
 
TitleThe role of ABCG2 in modulating responses to anti-cancer photodynamic therapy. (2020)
AuthorsKhot MI;Downey CL;Armstrong G;Svavarsdottir HS;Jarral F;Andrew H;Jayne DG;
JournalPhotodiagnosis and Photodynamic Therapy
DOI10.1016/j.pdpdt.2019.10.014
 
TitleCharacterising a PDMS based 3D cell culturing microfluidic platform for screening chemotherapeutic drug cytotoxic activity. (2020)
AuthorsKhot MI;Levenstein MA;de Boer GN;Armstrong G;Maisey T;Svavarsdottir HS;Andrew H;Perry SL;Kapur N;Jayne DG;
JournalScientific Reports
DOI10.1038/s41598-020-72952-1
 
TitleA Review on the Scope of Photothermal Therapy-Based Nanomedicines in Preclinical Models of Colorectal Cancer. (2019)
AuthorsKhot MI;Andrew H;Svavarsdottir HS;Armstrong G;Quyn AJ;Jayne DG;
JournalClinical Colorectal Cancer
DOI10.1016/j.clcc.2019.02.001
 
TitleInhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer. (2018)
AuthorsKhot MI;Perry SL;Maisey T;Armstrong G;Andrew H;Hughes TA;Kapur N;Jayne DG;
JournalPhotodiagnosis and Photodynamic Therapy
DOI10.1016/j.pdpdt.2018.06.027
 
TitleRational development of novel activity probes for the analysis of human cytochromes P450 (2016)
AuthorsSellars, J.D.; Skipsey, M.; Sadr-ul-Shaheed; Gravell, Sebastian; Abumansour, Hamza M.A.; Kashtl, Ghasaq; Irfan, Jawaria; Khot, Mohamed; Pors, Klaus; Patterson, Laurence H.; Sutton, Chris W.
JournalChemMedChem
 

Other typeReviews
TitleA Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer (2019)
AuthorsKhot M.I.;Andrew H.;Svavarsdottir H.S.;Armstrong G.;Quyn A.J.;Jayne D.G.
JournalClinical Colorectal Cancer
DOI10.1016/j.clcc.2019.02.001