Dr Jacobo Elies Gomez

Associate Professor

Faculty/Dept/School	School of Pharmacy and Medical Sciences (Faculty of Life Sciences)
Email	j.eliesgomez@bradford.ac.uk
Telephone	+441274 232132

Biography

Dr Jacobo Elíes is Lecturer in Pharmacology at the University of Bradford. He studied Pharmacy and then undertook a PhD in Pharmacology at the University of Santiago de Compostela (Spain). In 2009, Dr Elies moved to the University of Leeds to join Professor Chris Peers’ group at the Leeds Institute of Cardiovascular and Metabolic Medicine as a postdoctoral researcher. Across two postdoctoral appointments, he studied the molecular mechanisms involved in the development of cardiovascular diseases associated with skin diseases, by investigating the regulation of ion channels by gasotransmitters.

In 2015, Dr Elies was awarded a Wellcome Trust ISSF Junior Investigator Development Fellowship at the University of Leeds to investigate the molecular mechanisms involved in cellular communication between different dermal cell types and how dysregulation of their functions can affect the skin microvasculature. Since then, he has continued to explore the origin of dermal endothelial dysfunction in skin autoimmune diseases such as Systemic Sclerosis, Lupus erythematosus and Psoriasis. Current projects are focused on: in vitro organotypic co-cultures for the study of skin blood vessel formation, hypoxia, oxidative stress and calcium handling in dermal microvasculature. His main interest resides in cellular communication between mesenchymal and endothelial cells and how dysregulation of integumentary system can affect the microvasculature.

Professional activities

Employment

01-SEP-15: Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds - Wellcome Trust ISSF Junior Investigator Development Fellow
01-MAY-15: University of Giessen, Germany - Visiting Research Fellow, Excellence Cluster Cardio-Pulmonary System
01-SEP-12: University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Cardiovascular and Metabolic Medicine
01-JUN-12: University of Valladolid, Spain - Visiting Research Fellow, Institute of Biology and Molecular Genetics (IBGM)
01-SEP-09: University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Genetics, Health and Therapeutics
01-SEP-06: University of Cambridge - Visiting Research Fellow, Department of Pharmacology
01-SEP-05: University of Santiago de Compostela, Spain - PhD student, Department of Pharmacology
01-MAR-17: University of Bradford - Lecturer in Pharmacology
01-SEP-09: University of Leeds - Research Fellow

Association

01-APR-17: British Pharmacological Society, Full Member
04-MAY-20: Physiological Society, Full member

Awards

01-JAN-19: Fellow of the Higher Education Academy

Outreach

As a regional Director of the Society of Spanish Researchers in the UK (SRUK/CERU), I set up the CineScience series in 2017. We use cinema (in combination with round table sessions) as an engaging way of communicating science to the general public. CineScience provides a platform for criticism and discussion among the general public focused on current world challenges. Three events have been organised across different cities within Yorkshire focused on the elderly in current society, climate change and motor neuronal diseases. We are currently expanding CineScience into other regions of the UK, including London, Manchester, and Oxford.

Publications

Peer Reviewed Journals

Title	Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis (2022)
Authors	Ross RL, Mavria G, Del Galdo F and Elies J.
Journal	Front Physiology
Publisher	Frontiers
DOI	doi: 10.3389/fphys.2022.900631

Title	Investigation of Cell Adhesion and Cell Viability of the Endothelial and Fibroblast Cells on Electrospun PCL, PLGA and Coaxial Scaffolds for Production of Tissue Engineered Blood Vessel. (2022)
Authors	Bazgir M;Saeinasab M;Zhang W;Zhang X;Min Tsui K;Maasoumi Sarvestani A;Nawaz S;Coates P;Youseffi M;Elies J;Sefat F;
Journal	Journal Of Functional Biomaterials
DOI	10.3390/jfb13040282

Title	Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering. (2021)
Authors	Bazgir M;Zhang W;Zhang X;Elies J;Saeinasab M;Coates P;Youseffi M;Sefat F;
Journal	Materials
DOI	10.3390/ma14216295

Title	Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering. (2021)
Authors	Bazgir M;Zhang W;Zhang X;Elies J;Saeinasab M;Coates P;Youseffi M;Sefat F;
Journal	Materials
DOI	10.3390/ma14174773

Title	An Update to Calcium Binding Proteins. (2020)
Authors	Elíes J;Yáñez M;Pereira TMC;Gil-Longo J;MacDougall DA;Campos-Toimil M;
Journal	Advances in Experimental Medicine and Biology
DOI	10.1007/978-3-030-12457-1_8

Title	Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor (2018)
Authors	Liakouli, V.; Elies, Jacobo; El-Sherbiny, Y.M.; Scarcia, M.; Grant, G.; Abignano, G.; Derrett-Smith, E.C.; Esteves, F.; Cipriani, P.; Emery, P.; Denton, C.P.; Giacomelli, R.; Mavira, G.; Del Galdo, F.

Title	Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K + channel Kv1.5 (2017)
Authors	Al-Owais M.;Hettiarachchi N.;Boyle J.;Scragg J.;Elies J.;Dallas M.;Lippiat J.;Steele D.;Peers C.
Journal	Cell Death and Disease
DOI	10.1038/cddis.2017.568

Title	TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p (2017)
Authors	Berrout, J.; Kyriakopoulou, E.; Moparthi, L.; Hogea, A.S.; Berrout, L.; Ivan, C.; Lorger, M.; Boyle, J.; Peers, C.; Muench, S.; Elies, Jacobo; Hu, X.; Hurst, C.; Hall, T.; Umamaheswaran, S.; Wesley, L.; Gagea, M.; Shires, M.; Manfield, I.; Knowles, M.A.; Davies, S.; Suhling, K.; Gonzalez, Y.T.; Carragher, N.; Macleod, K.; Abbott, N.J.; Calin, G.A.; Gamper, N.; Zygmunt, P.M.; Timsah, Z.

Title	Regulation of the T-type Ca²⁺ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H2S in nociception (2016)
Authors	Elies, J.;Scragg, J.L.;Boyle, J.P.;Gamper, N.;Peers, C.;
Journal	Physiology
DOI	10.1113/JP270963

Title	Diverse mechanisms underlying the regulation of ion channels by carbon monoxide (2015)
Authors	Peers, C.; Boyle, J.P.; Scragg, J.L.; Dallas, M.L.; Al-Owais, M.M.; Hettiarachichi, N.T.; Elies, Jacobo; Johnson, E.; Gamper, N.; Steele, D.S.

Title	H2S does not regulate proliferation via T-type Ca²⁺ channels (2015)
Authors	Elies, J.;Johnson, E.;Boyle, J.P.;Scragg, J.L.;Peers, C.;
Journal	Biochemical and Biophysical Research Communications
DOI	10.1016/j.bbrc.2015.04.087

Title	H2S does not regulate proliferation via T-type Ca2+ channels (2015)
Authors	Elies, Jacobo; Johnson, E.; Boyle, J.P.; Scragg, J.L.; Peers, C.

Title	Novel ways to regulate T-type Ca²⁺ channels (2015)
Authors	Peers, C.;Elies, J.;Gamper, N.;
Journal	Channels
DOI	10.1080/19336950.2015.1017995

Title	Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels (2015)
Authors	Duckles, H.; Boycott, H.E.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Dallas, M.L.; Porter, K.E.; Giuntini, F.; Boyle, J.P.; Scragg, J.L.; Peers, C.

Title	Novel ways to regulate T-type Ca2+ channels (2015)
Authors	Peers, C.; Elies, Jacobo; Gamper, N.

Title	PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production (2014)
Authors	García-Morales V, Cuíñas A, Elíes J.;Campos-Toimil, M.;
Journal	Vascular Pharmacology
DOI	10.1016/j.vph.2014.01.004

Title	Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca<sup>2+</sup> channels (2014)
Authors	Duckles, H.;Boycott, H.E.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Dallas, M.L.;Porter, K.E.;Giuntini, F.;Boyle, J.P.;Scragg, J.L.;Peers, C.;
Journal	Pflugers Archiv European Journal of Physiology
DOI	10.1007/s00424-014-1503-5

Title	Hydrogen sulfide inhibits Cav3.2 T-type Ca²⁺ channels (2014)
Authors	Elies, J.;Scragg, J.L.;Huang, S.;Dallas, M.L.;Huang, D.;MacDougall, D.;Boyle, J.P.;Gamper, N.;Peers, C.;
Journal	FASEB Journal
DOI	10.1096/fj.14-257113

Title	Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide. (2014)
Authors	Elies J;Dallas ML;Boyle JP;Scragg JL;Duke A;Steele DS;Peers C;
Journal	Journal of Biological Chemistry
DOI	10.1074/jbc.M114.569996

Title	PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production (2014)
Authors	Garcia-Morales, V.; Cuíñas, A.; Elies, Jacobo; Campos-Toimil, M.

Title	Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide (2014)
Authors	Elies, Jacobo; Dallas, M.L.; Boyle, J.P.; Scragg, J.L.; Duke, A.; Steele, D.S.; Peers, C.

Title	Hydrogen sulfide inhibits Cav3.2 T-type Ca2 channels (2014)
Authors	Elies, Jacobo; Scragg, J.L.; Huang, S.; Dallas, M.L.; Huang, D.; MacDougall, D.; Boyle, J.P.; Gamper, N.; Peers, C.

Title	Trans-resveratrol down-regulates caveolin-1, up-regulates endothelial NO synthase and reduces their interaction in vascular smooth muscle and endothelial cells (2013)
Authors	Elíes, J.;Cuíñas, A.;MacDougall, D.A.;Leiro, J.;Campos-Toimil, M.;
Journal	Food Bioscience
Publisher	Elsevier Science
DOI	10.1016/j.fbio.2013.02.002

Title	Carbon monoxide inhibition of Cav3.2 T-type Ca2 channels reveals tonic modulation by thioredoxin (2013)
Authors	Boycott, H.E.;Dallas, M.L.;Elies, J.;Pettinger, L.;Boyle, J.P.;Scragg, J.L.;Gamper, N.;Peers, C.;
Journal	FASEB Journal
DOI	10.1096/fj.13-227249

Title	Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry (2013)
Authors	Cuíñas A, Elíes J.;Orallo, F.;Campos-Toimil, M.;
Journal	Vascular Pharmacology
DOI	10.1016/j.vph.2012.08.007

Title	Carbon monoxide induces cardiac arrhythmia via induction of the late Na⁺ current (2012)
Authors	Dallas, M.L.;Yang, Z.;Boyle, J.P.;Boycott, H.E.;Scragg, J.L.;Milligan, C.J.;Elies, J.;Duke, A.;Thireau, J.;Reboul, C.;Richard, S.;Bernus, O.;Steele, D.S.;Peers, C.;
Journal	American Journal of Respiratory and Critical Care Medicine
DOI	10.1164/rccm.201204-0688OC

Title	Trans-resveratrol simultaneously increases cytoplasmic Ca ²⁺ levels and nitric oxide release in human endothelial cells (2011)
Authors	Elies, J.;Cuinas, A.;García-Morales, V.;Orallo, F.;Campos-Toimil, M.;
Journal	Molecular Nutrition and Food Research
Publisher	WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
DOI	10.1002/mnfr.201100240

Title	Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes (2007)
Authors	Campos-Toimil, M.;ElÃes, J.;Ãlvarez, E.;Verde, I.;Orallo, F.;
Journal	European Journal of Pharmacology
DOI	10.1016/j.ejphar.2007.08.003

Title	DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells (2007)
Journal	Cancer Letters
DOI	10.1016/j.canlet.2006.12.037

Title	Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells (2005)
Authors	Campos-Toimil, M.;ElÃes, J.;Orallo, F.;
Journal	Molecular Nutrition and Food Research
DOI	10.1002/mnfr.200400108

Books

Title	Inhibition of t-type calcium channels by hydrogen sulfide (2015)
Authors	Elies, J.;Scragg, J.L.;Dallas, M.L.;Huang, D.;Huang, S.;Boyle, J.P.;Gamper, N.;Peers, C.;
Publisher	Springer, Cham
DOI	10.1007/978-3-319-18440-1_40

Title	T-type Calcium channel regulation by CO: A mechanism for control of cell proliferation (2015)
Authors	Duckles, H.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Boycott, H.E.;Dallas, M.L.;Porter, K.E.;Boyle, J.P.;Scragg, J.L.;Peers, C.;
Publisher	Springer, Cham
DOI	10.1007/978-3-319-18440-1_33

Book Chapters

Title	T-type Ca2+ channel regulation by CO: a mechanism for control of cell proliferation (2015)
Authors	Duckles, H.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Boycott, H.E.; Dallas, M.L.; Porter, K.E.; Boyle, J.P.; Scragg, J.L.; Peers, C.

Title	Inhibition of T-type Ca2+ channels by hydrogen sulfide (2015)
Authors	Elies, Jacobo; Scragg, J.L.; Dallas, M.L.; Huang, D.; Huang, S.; Boyle, J.P.; Gamper, N.; Peers, C.

Other Publications

Other type	Editorial
Title	Editorial: Trends post-COVID-19 attack: the cardiocerebral system safety remains of utmost concern. (2023)
Authors	Nader M;Haddad G;Elies J;Kentamneni S;AlBadarin F;
Journal	Frontiers in Physiology
DOI	10.3389/fphys.2023.1224550

Conference Publications

Title	Author(s)
Role of Hemoxygenase-1 in endothelial function in the context of systemic sclerosis (2022)	Jacobo Elies, Rebecca Ross, Georgia Mavria, Francesco Del Galdo
Stabilisation of suppressor of cytokine signalling 3 (SOCS3) to inhibit human saphenous vein smooth muscle cell proliferation and vascular stenosis (2021)	Tim Palmer, Florah Moshapa, Jamie Willliams, Kirsten Riches-Suman, Jacobo Elies
Expression of stable SOCS3 in human saphenous vein smooth muscle cells: potential therapy for vascular restenosis (2019)	Florah T. Moshapa, Kirsten A.A. Munro, Jamie J.J.L. Williams, Jacobo Elies, Kirsten Riches-Suman, Timothy M. Palmer