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Dr Francis Mprah Barnieh

Research Associate

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)


Dr. Francis Mprah Barnieh is a STARTER Research Fellow at the University of Bradford.

Francis graduated with BSc (First Class Hon) in Biochemistry from the University of Ghana and went on to receive MSc (Distinction) in Cancer Pharmacology and PhD in Cancer Drug Discovery from the University of Bradford. His PhD was focused on the development of protease-activated peptide prodrugs of DNA Damage Response (DDR) inhibitors. He previously undertook a post-doctoral fellowship as part of the Institute of Cancer Therapeutics' YCR programme, developing an LC-MS based assay to investigate the CYP-mediated metabolism of novel duocarmycin prodrugs, and additionally a high-throughput microplate ELISA assay for screening of both competitive polysialyltransferase inhibitors, and inhibitors of the NCAM-polyST protein-protein interaction. 

Dr. Barnieh is currently undertaking his independent research, which is focused on understanding the tumour-specific glycosylation patterns of  proteins, and the associated impact on the tumour-specific functions of these proteins. Additionally, he has keen interest in DDR inhibitors with particular emphasis on targeted tumour delivery of these agents.


TitleCancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. (2023)
AuthorsBarnieh FM;Galuska SP;Loadman PM;Ward S;Falconer RA;El-Khamisy SF;
TitleTargeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells (2022)
AuthorsBarnieh, F.M.; Ribeiro Morais, G.; Garland, H.; Loadman, P.M.; Falconer, R.A.
JournalBiochemical Pharmacology
TitleChemoselective Solution- and Solid-Phase Synthesis of Disulfide-Linked Glycopeptides. (2022)
AuthorsBanisalman KAF;Polykandritou A;Barnieh FM;Ribeiro Morais G;Falconer RA;
JournalJournal of Organic Chemistry
TitleProbing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds (2021)
AuthorsNatalia Ortuzar, Kersti Karu, Daniela Presa, Goreti R. Morais, Helen M. Sheldrake, Steve D. Shnyder, Francis M. Barnieh, Paul M. Loadman, Laurence H. Patterson, Klaus Pors, Mark Searcey
Other typeReviews
TitleProgress towards a clinically-successful ATR inhibitor for cancer therapy (2021)
AuthorsBarnieh F.M.;Loadman P.M.;Falconer R.A.
JournalCurrent Research in Pharmacology and Drug Discovery
Other typeReviews
TitleIs tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique? (2021)
AuthorsBarnieh F.M.;Loadman P.M.;Falconer R.A.
JournalBiochimica et Biophysica Acta - Reviews on Cancer