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Dr. Francis Mprah Barnieh,
Research Associate

Information about Dr. Francis Mprah Barnieh at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
Photo of Dr. Francis Mprah Barnieh


Dr. Francis Mprah Barnieh is a STARTER Research Fellow at the University of Bradford.

Francis graduated with BSc (First Class Hon) in Biochemistry from the University of Ghana and went on to receive MSc (Distinction) in Cancer Pharmacology and PhD in Cancer Drug Discovery from the University of Bradford. His PhD was focused on the development of protease-activated peptide prodrugs of DNA Damage Response (DDR) inhibitors. He previously undertook a post-doctoral fellowship as part of the Institute of Cancer Therapeutics' YCR programme, developing an LC-MS based assay to investigate the CYP-mediated metabolism of novel duocarmycin prodrugs, and additionally a high-throughput microplate ELISA assay for screening of both competitive polysialyltransferase inhibitors, and inhibitors of the NCAM-polyST protein-protein interaction.

Dr. Barnieh is currently undertaking his independent research, which is focused on understanding the tumour-specific glycosylation patterns of proteins, and the associated impact on the tumour-specific functions of these proteins. Additionally, he has keen interest in DDR inhibitors with particular emphasis on targeted tumour delivery of these agents.


There are 6 publications involving or that are attributed to Dr. Francis Mprah Barnieh. They are listed as:

  • peer reviewed journal (4)
  • reviews (2)

Peer Reviewed Journal

Dr. Francis Mprah Barnieh has 4 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells 2022 Biochemical Pharmacology 201 Barnieh, F.M.; Ribeiro Morais, G.; Garland, H.; Loadman, P.M.; Falconer, R.A. Elsevier
Chemoselective Solution- and Solid-Phase Synthesis of Disulfide-Linked Glycopeptides. 2022 Journal of Organic Chemistry 87 Banisalman KAF;Polykandritou A;Barnieh FM;Ribeiro Morais G;Falconer RA; 1520-6904 10.1021/acs.joc.2c01651
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds 2021 BIOORGANIC & MEDICINAL CHEMISTRY 40 Natalia Ortuzar, Kersti Karu, Daniela Presa, Goreti R. Morais, Helen M. Sheldrake, Steve D. Shnyder, Francis M. Barnieh, Paul M. Loadman, Laurence H. Patterson, Klaus Pors, Mark Searcey 10.1016/j.bmc.2021.116167
Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. 2023 Iscience 26 Barnieh FM;Galuska SP;Loadman PM;Ward S;Falconer RA;El-Khamisy SF; 2589-0042 10.1016/j.isci.2023.108219


Dr. Francis Mprah Barnieh has 2 publication(s) listed under reviews.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Is tumour-expressed aminopeptidase N (APN/CD13) structurally and functionally unique? 2021 Biochimica et Biophysica Acta - Reviews on Cancer 1876 Barnieh F.M.;Loadman P.M.;Falconer R.A. 0304-419X 10.1016/j.bbcan.2021.188641
Progress towards a clinically-successful ATR inhibitor for cancer therapy 2021 Current Research in Pharmacology and Drug Discovery 2 Barnieh F.M.;Loadman P.M.;Falconer R.A. 2590-2571 10.1016/j.crphar.2021.100017