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Anne Graham

Head of School of Chemistry & Bioscience

Area
School of Chemistry & Biosciences
Faculty of Life Sciences
E-mail
A.Graham@bradford.ac.uk
Phone
+441274233570
Anne Graham
22 publications

Biography

Study of human endothelial cell genetic and functional responses in health and inflammatory disease (atherosclerosis, diabetes, cancer). These cells lining the blood vessels are master regulators of acute inflammation in health and chronic inflammation in disease. Low grade chronic inflammation at the blood vessel wall results in lesion formation and narrowing of the vessels (atherosclerotic plaques). Therefore cardiovascular disease and diabetes are key disorders where endothelial cells are dysfunctional. Skin disease such as psoriasis also have an important inflammatory vascular component. Intra-cellular signalling pathways important in endothelial cell proliferation, migration and apoptosis are currently under study in the Graham laboratory.
Outside the lab, interventions which reduce cardiovascular complications in diabetes, through development of patient self management is an active area of research, in collaboration with pharmacists and researchers in the School of Pharmacy and Medical Sciences and collaborators in Bangladesh (Professor Fatema Ashraf, Surawahardy  Hospital and Medical College

Research

Endothelial cell function in health and disease (atherosclerosis, diabetes, kidney disease, psoriasis) Mechanisms of compromised wound healing in chronic disease (diabetes). Epigenetic regulation of vascular cell function in diabetes. Mechanisms of angiogenesis relevant to cardiovascular disease and diabetes. 

 

Research collaborator

  • hypertension and atherosclerosis (First Affiliated Hospital, Sun Yat-Sen University)

Professional activities

  • University Research & Knowledge Transfer Research Strategy Committee,
  • Senate, Represent Faculty of Life Sciences Research & Knowledge Transfer interests

  • HEA - Fellow Higher Education Academy
  • University of Bradford -  PGCert
  • University of Glasgow - PhD
  • Strathclyde University -  Bsc (Hons)

  •  University of Bradford  - Member Ethics Committee (1 January 2015)
  •  University of Bradford  - Chair Director PGR Forum (1 January 2015)
  •  University of Bradford  - Acting Dean of Graduate Studies (1 January 2013)
  •  University of Bradford  - Member Research Degrees Committee (1 January 2011)
  • British Heart Foundation  - (1 January 1994)
  • Wellcome Trust - Postdoctoral researcher (1 January 1991)

  • Fellow/Member/Chair/Role Model: Role Model for Aurora Programme - Leadership Foundation (2015/16 & 2016/17) Member of editorial board of Journal of Inflammation (2001- ) Researcher Development Framework Champion, Vitae (2012- ) UK Council for Graduate Education “Structures” working group member (2014- ) British Inflammation Research Association committee (2001- ) Fellow Institute of Biomedical Sciences (2014- ) Fellow Higher Education Academy (2007- ) Member of British Pharmacology Society (1992- ) Member of Biochemical Society (1992- ) Member of British Society for Immunology (1999- ) Grant review panel Chair for Heart Research UK (2009)

  • Co-lead of a monthly public engagement with science meeting, in partnership with the National Science & Media Museum and Theatre in the Mill. Bringing scientists and refreshments to a local venue.

  • NC3Rs, Studentship Grant Panel member (8 January 2018)
  • Institute of Biomedical Science , Fellow (1 February 2016)
  • Heart Research UK, Translational Grant Panel member (1 January 2015)
  • Institute of Biomedical Science, Fellow (1 August 2014)
  • British Inflammation Research Association, Committee member

Publications