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Ritchie Williamson

Lecturer in Therapeutics

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Telephone +441274 236073


2019 -           Group Lead Pharmacology & Experimental Therapeutics, University of Bradford
2013 -           Lecturer in Therapeutics, University of Bradford
2011 - 2013  Postdoctoral researcher, College of Life Sciences, University of Dundee
2008 - 2011  Postdoctoral researcher, School of Medicine, University of Dundee
2001 - 2004  Alzheimer's Society Research Fellowship, Institute of Psychiatry, King's College London
1997 - 2001  Phd, Institute of Psychiatry, King's College London
1996 - 1997  MSc Neuroscience, Institute of Psychiatry, King's College London
1992 -1996   BSc Biochemistry, University of Bath


Peer Reviewed Journal
TitleLoss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. (2019)
AuthorsMuha V;Williamson R;Hills R;McNeilly AD;McWilliams TG;Alonso J;Schimpl M;Leney AC;Heck AJR;Sutherland C;Read KD;McCrimmon RJ;Brooks SP;van Aalten DMF;
JournalOpen Biology
TitleEndoplasmic reticulum stress signalling induces casein kinase 1-dependent formation of cytosolic TDP-43 Inclusions in motor neuron-like cells (2019)
AuthorsHicks, D.A.; Cross, Laura L.; Williamson, Ritchie; Rattray, Marcus
TitleBasal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes (2019)
AuthorsWeightman Potter, P.G.; Vlachaki Walker, J.M.; Robb, J.L.; Chilton, J.K.; Williamson, Ritchie; Randall, A.D.; Ellacott, K.L.J.; Beall, C.
TitleA mutant O-GlcNAcase enriches Drosophila developmental regulators (2017)
AuthorsSelvan, N.; Williamson, Ritchie; Mariappa, D.; Campbell, D.G.; Gourlay, R.; Ferenbach, A.T.; Aristotelous, T.; Hopkins-Navratilova, I.; Trost, M.; van Aalten, D.M.F.
TitlemRNA Cap Methylation in Pluripotency and Differentiation (2016)
AuthorsGrasso, L.; Suska, O.; Davidson, L.; Gonatopolous-Pournatzis, T.; Williamson, Ritchie; Wasmus, L.; Wiedlich, S.; Peggie, M.; Stavridis, M.P.; Cowling, V.H.
TitleClusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. (2014)
AuthorsKillick R;Ribe EM;Al-Shawi R;Malik B;Hooper C;Fernandes C;Dobson R;Nolan PM;Lourdusamy A;Furney S;Lin K;Breen G;Wroe R;To AW;Leroy K;Causevic M;Usardi A;Robinson M;Noble W;Williamson R;Lunnon K;Kellie S;Reynolds CH;Bazenet C;Hodges A;Brion JP;Stephenson J;Simons JP;Lovestone S;
JournalMolecular Psychiatry
TitleA high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin (2012)
AuthorsMcNeilly, A.D.; Williamson, Ritchie; Balfour, D.J.; Stewart, C.A.; Sutherland, C.
TitleInsulin resistance in the brain: an old-age or new-age problem? (2012)
AuthorsWilliamson R;McNeilly A;Sutherland C;
JournalBiochemical Pharmacology
TitleOligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons. (2012)
AuthorsMalik B;Fernandes C;Killick R;Wroe R;Usardi A;Williamson R;Kellie S;Anderton BH;Reynolds CH;
JournalNeurochemistry International
TitleHigh fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task. (2011)
AuthorsMcNeilly AD;Williamson R;Sutherland C;Balfour DJ;Stewart CA;
TitleCRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases. (2011)
AuthorsWilliamson R;van Aalten L;Mann DM;Platt B;Plattner F;Bedford L;Mayer J;Howlett D;Usardi A;Sutherland C;Cole AR;
JournalJournal of Alzheimer's Disease
TitleTyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. (2011)
AuthorsUsardi A;Pooler AM;Seereeram A;Reynolds CH;Derkinderen P;Anderton B;Hanger DP;Noble W;Williamson R;
JournalFEBS Journal
TitleTyrosine phosphorylation of tau by the SRC family kinases lck and fyn. (2011)
AuthorsScales TM;Derkinderen P;Leung KY;Byers HL;Ward MA;Price C;Bird IN;Perera T;Kellie S;Williamson R;Anderton BH;Reynolds CH;
JournalMolecular Neurodegeneration
TitleNeuronal membranes are key to the pathogenesis of Alzheimer's disease: the role of both raft and non-raft membrane domains. (2011)
AuthorsWilliamson R;Sutherland C;
JournalCurrent Alzheimer Research
TitleIsolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition. (2010)
AuthorsWilliamson R;Thompson AJ;Abu M;Hye A;Usardi A;Lynham S;Anderton BH;Hanger DP;
JournalBMC Neuroscience
TitleBiguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling (2010)
AuthorsKickstein, E.; Krauss, S.; Thornhill, P.; Rutschow, D.; Zeller, R.; Sharkey, J.; Williamson, Ritchie; Fuchs, M.; Kohler, A.; Glossmann, H.; Schneider, R.; Sutherland, C.; Schweiger, S.
TitleEvidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain (2010)
AuthorsSoutar, M.P.; Kim, W.Y.; Williamson, Ritchie; Peggie, M.; Hastie, C.J.; McLauchlan, H.; Snider, W.D.; Gordon-Weeks, P.R.; Sutherland, C.
TitleThe microtubule-associated protein tau is also phosphorylated on tyrosine. (2009)
AuthorsLebouvier T;Scales TM;Williamson R;Noble W;Duyckaerts C;Hanger DP;Reynolds CH;Anderton BH;Derkinderen P;
JournalJournal of Alzheimer's Disease
TitleQuantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts. (2009)
AuthorsThompson AJ;Williamson R;Schofield E;Stephenson J;Hanger D;Anderton B;
TitleMembrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism (2008)
AuthorsWilliamson, Ritchie; Usardi, A.; Hanger, D.P.; Anderton, B.H.
TitleTyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. (2005)
AuthorsDerkinderen P;Scales TM;Hanger DP;Leung KY;Byers HL;Ward MA;Lenz C;Price C;Bird IN;Perera T;Kellie S;Williamson R;Noble W;Van Etten RA;Leroy K;Brion JP;Reynolds CH;Anderton BH;
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
TitleThe antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. (2003)
AuthorsPariante CM;Hye A;Williamson R;Makoff A;Lovestone S;Kerwin RW;
TitleRapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. (2002)
AuthorsWilliamson R;Scales T;Clark BR;Gibb G;Reynolds CH;Kellie S;Bird IN;Varndell IM;Sheppard PW;Everall I;Anderton BH;
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
TitleLobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine (1998)
AuthorsTerry A.;Williamson R.;Gattu M.;Beach J.;McCurdy C.;Sparks J.;Pauly J.
Book Chapter
TitleTranscriptomic analysis of oligomeric amyloid-β treated primary cortical neurons reveals dysregulation of genes involved in the biosynthesis of steroids and cholesterol (2014)
AuthorsMalik B.;Fernandes C.;Killick R.;Usardi A.;Williamson R.;Kellie S.;Anderton B.;Reynolds C.
JournalMicroarrays: Principles, Applications and Technologies
TitleProtocol for quantitative proteomics of cellular membranes and membrane rafts. (2010)
AuthorsThompson AJ;Williamson R;
JournalLC-Ms/MS in Proteomics: Methods and Applications
Other Publication
Other typeReviews
TitleNeuronal membranes are key to the pathogenesis of Alzheimer's disease: The role of both raft and non-raft membrane domains (2011)
AuthorsWilliamson R.;Sutherland C.
JournalCurrent Alzheimer Research