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Biography

Pharmacokinetics and tumour drug metabolism of anti-cancer drugs
Professor Paul Loadman heads the drug metabolism team at the Institute of Cancer Therapeutics, University of Bradford and has >20years experience studying the pharmacokinetics and metabolism of anti-cancer drugs. The team in Bradford have studied a wide range of clinically available and novel small molecules including antimetabolites, platinating and alkylating agents, peptides and antivascular compounds. Prof Loadman is actively involved in the design, analysis and reporting of pre-clinical and clinical pharmacokinetic studies and acts as a pharmacokinetic and drug metabolism consultant for numerous pharmaceutical and biotechnology companies. Together with Prof Twelves (Clinical Director,) the DMPK team have established a Quality Management System within the ICT which has enabled a strong involvement in the pharmacokinetic monitoring of small molecules in major clinical trials. Other major clinical collaborations include with Professor Mark Hull at the University of Leeds (The seAFOod Polyp Prevention Trial, www.seafood-trial.co.uk) where the laboratory in Bradford are analyzing a series of bioactive lipid mediators such as ω-3 PUFAs, resolvin E1 and PGE-M in plasma, urine, erythrocytes and rectal mucosa in order to gain insights into the mechanism of action of EPA and aspirin.

Research

  • Pharmacokinetics and tumour drug metabolism of anti cancer drugs
  • Matrix metalloproteinases as targets for tumour-selective delivery of anticancer therapeutics
  • Drug delivery and prodrug design
  • Novel advances in analytical techniques. HPLC, GC, CE and LC/MS/MS
  • Drug interactions both in vitro and in vivo

Professional activities

  • University of Bradford - PhD
  • British Association for Cancer Research
  • Royal Society of Biology
  • American Association for Cancer Research
  • Pharmacokinetics and Molecular Mechanisms (PAMM) Group
  • European Association for Cancer Research
  • Drug Metabolism Discussion Group (DMDG)

Publications

Peer Reviewed Journal
TitleCellular uptake and efflux of palbociclib in vitro in single cell and spheroid models. (2019)
AuthorsJove M;Spencer JA;Hubbard ME;Holden EC;O'Dea RD;Brook BS;Phillips RM;Smye SW;Loadman P;Twelves CJ;
JournalJournal of Pharmacology and Experimental Therapeutics
DOI10.1124/jpet.119.256693
 
TitleInactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer (2019)
AuthorsRoger M. Phillips, Paul M. Loadman, Guru Reddy
JournalCancer Chemotherapy and Pharmacology
DOI10.1007/s00280-019-03812-7
 
TitleTheranostic nanoparticles enhance the response of glioblastomas to radiation (2019)
AuthorsWei Wu1*, Jessica L. Klockow1*, Suchismita Mohanty1, Kimberly S. Ku1, Maryam Aghighi1, Stavros Melemenidis2, Zixin Chen1, Kai Li1, Goreti Ribeiro Morais3, Ning Zhao1, Jürgen Schlegel4, Edward E. Graves1,2, Jianghong Rao1, Paul M. Loadman3, Robert A. Falconer3, Sudip Mukherjee1, Frederick T. Chin1, Heike E. Daldrup-Link1
JournalNanotheranostics
Publisherivyspring
DOI10.7150/ntno.35342
 
TitlePrecision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance (2019)
AuthorsMaria Jove, Jade Spencer; Malcolm Clench; Paul M Loadman; Chris Twelves,
JournalCritical Reviews in Oncology/Hematology
DOI10.1016/j.critrevonc.2019.06.008
 
TitleRecent advances in the analysis of polysialic acid from complex biological systems (2019)
AuthorsXiaoxiao Guo, Sara M. Elkashef, Mark Sutherland, Paul M. Loadman and Robert A. Falconer
JournalCarbohydrate Polymers
DOI10.1016/j.carbpol.2019.115145
 
TitleEicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial (2018)
AuthorsHull, M.A.; Sprange, K.; Hepburn, T.; Tan, W.; Shafayat, A.; Rees, C.J.; Clifford, G.; Logan, R.F.; Loadman, Paul M.; Williams, E.A.; Whitham, D.; Montgomery, A.A.
 
TitleA study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin (2018)
AuthorsSpriggs, S.; Cubberley, R.; Loadman, Paul M.; Sheffield, D.; Wierzbicki, Antonia
 
TitleStructural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method (2018)
AuthorsKamble, Sharad R.; Loadman, Paul M.; Abraham, M.H.; Liu, Xiangli
 
TitleRationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs (2017)
AuthorsJain, M.; Harburn, J.J.; Gill, Jason H.; Loadman, Paul M.; Falconer, Robert A.; Mooney, C.A.; Cobb, S.L.; Berry, David J.
JournalJournal of Medicinal Chemistry
DOIhttp://dx.doi.org/10.1021/acs.jmedchem.6b01472
 
TitleMembrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting (2017)
AuthorsFalconer, Robert A.; Loadman, Paul M.
 
TitleA liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples (2017)
AuthorsVolpato, Milène; Spencer, Jade A.; Race, Amanda D.; Munarini, A.; Belluzzi, A.; Cockbain, A.; Hull, M.; Loadman, Paul M.
 
TitleA randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota (2017)
AuthorsWatson, H.; Mitra, S.; Croden, F.C.; Taylor, M.; Wood, H.M.; Perry, S.L.; Spencer, Jade A.; Quirke, P.; Toogood, G.J.; Lawton, C.L.; Dye, L.; Loadman, Paul M.; Hull, M.A.
 
TitleA novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival (2017)
AuthorsMohanty, S.; Chen, Z.; Li, K.; Ribeiro Morais, Goreti; Klockow, J.; Yerneni, K.; Pasani, L.; Chin, F.T.; Mitra, S.; Cheshier, S.; Chang, E.; Gambhir, S.S.; Rao, J.; Loadman, Paul M.; Falconer, Robert A.; Daldrup-Link, H.E.
 
TitleDrug delivery in a tumour cord model: a computational simulation (2017)
AuthorsHubbard, M.E.; Jove, M.; Loadman, Paul M.; Phillips, Roger M.; Twelves, Christopher J.; Smye, S.W.
 
TitlePolysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment (2016)
AuthorsElkashef, Sara M.; Allison, Simon J.; Sadiq, Maria; Basheer, Haneen A.; Ribeiro Morais, Goreti; Loadman, Paul M.; Pors, Klaus; Falconer, Robert A.
JournalScientific Reports
DOIhttp://dx.doi.org/10.1038/srep33026
 
TitleProteases in cancer drug delivery (2016)
AuthorsVandooren, J.; Opdenakker, G.; Loadman, Paul M.; Edwards, D.R.
 
TitleMeasurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases (2016)
AuthorsWatson, H.; Cockbain, A.J.; Spencer, Jade A.; Race, Amanda D.; Volpato, Milène; Loadman, Paul M.; Toogood, G.J.; Hull, M.A.
 
TitleAn optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity (2016)
AuthorsElkashef, Sara M.; Sutherland, Mark H.; Patterson, Laurence H.; Loadman, Paul M.; Falconer, Robert A.
JournalANALYST (PRINT)
DOIhttp://dx.doi.org/10.1039/C6AN01073C
 
TitleProbing cytochrome P450-mediated activation with a truncated azinomycin analogue (2015)
AuthorsVinader, Victoria; Sadiq, Maria; Sutherland, Mark H.; Huang, M.Y.; Loadman, Paul M.; Elsalem, Lina M.I.; Shnyder, Steven D.; Cui, H.J.; Afarinkia, Kamyar; Searcey, M.; Patterson, Laurence H.; Pors, Klaus
 
TitleThin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA (2015)
AuthorsBatubara, A.; Carolan, V.A.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Clench, M.R.
 
TitleDevelopment of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy (2014)
AuthorsAnsari, C.; Tikhomirov, G.A.; Hong, S.H.; Falconer, Robert A.; Loadman, Paul M.; Gill, Jason H.; Castaneda, R.; Hazard, F.K.; Tong, L.; Lenkov, O.D.; Felsher, D.W.; Rao, J.; Daldrup-Link, H.E.
JournalSmall
DOI10.1002/smll.201301456
 
TitleAnticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (2014)
AuthorsCockbain, A.J.; Volpato, Milène; Race, Amanda D.; Munarini, A.; Fazio, C.; Belluzzi, A.; Loadman, Paul M.; Toogood, G.J.; Hull, M.A.
 
TitleEicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota (2014)
AuthorsPiazzi, G.; D'Argenio, G.; Prossomariti, A.; Lembo, V.; Mazzone, G.; Candela, M.; Biagi, E.; Brigidi, P.; Vitaglione, P.; Fogliano, V.; D'Angelo, L.; Fazio, C.; Munarini, A.; Belluzzi, A.; Ceccarelli, C.; Chieco, P.; Balbi, T.; Loadman, Paul M.; Hull, M.A.; Romano, M.; Bazzoli, F.; Ricciardiello, L.
 
TitleMathematical and computational models of drug transport in tumours (2014)
AuthorsGroh, C.M.; Hubbard, M.E.; Jones, P.F.; Loadman, Paul M.; Periasamy, Nagarajan; Sleeman, B.D.; Smye, S.W.; Twelves, Christopher J.; Phillips, Roger M.
 
TitleIn vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog (2014)
AuthorsWong, C.C.; Periasamy, Nagarajan; Sagineedu, S.R.; Sidik, S.; Sumon, S.H.; Loadman, Paul M.; Phillips, Roger M.; Lajis, N.H.; Stanslas, J.
 
TitleMucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass (2014)
AuthorsKant, P.; Perry, S.L.; Dexter, S.P.; Race, Amanda D.; Loadman, Paul M.
 
TitleTumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity (2014)
AuthorsGill J.;Loadman P.;Shnyder S.;Cooper P.;Atkinson J.;Ribeiro Morais G.;Patterson L.;Falconer R.
JournalMolecular Pharmaceutics
DOI10.1021/mp400760b
 
TitleThe Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity (2014)
AuthorsGill, Jason H.; Loadman, Paul M.; Shnyder, Steven D.; Cooper, Patricia A.; Atkinson, Jennifer M.; Ribeiro Morais, Goreti; Patterson, Laurence H.; Falconer, Robert A.
JournalMolecular Pharmaceutics
DOI10.1021/mp400760b
 
TitleRe-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity (2013)
AuthorsSheldrake, Helen M.; Travica, S.; Johansson, I.; Loadman, Paul M.; Sutherland, Mark H.; Elsalem, Lina M.I.; Illingworth, Nicola A.; Cresswell, Alexander J.; Reuillon, Tristan; Shnyder, Steven D.; Mkrtchian, S.; Searcey, M.; Ingelman-Sundberg, M.; Patterson, Laurence H.; Pors, Klaus
 
TitleColon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins (2013)
AuthorsTravica, S.; Pors, Klaus; Loadman, Paul M.; Shnyder, Steven D.; Johansson, I.; Alandas, Mohammed N.; Sheldrake, Helen M.; Mkrtchian, S.; Patterson, Laurence H.; Ingelman-Sundberg, M.
 
TitleIdentification of Stage-Specific Breast Markers using Quantitative Proteomics (2013)
AuthorsShaheed, Sadr-ul; Rustogi, Nitin; Scally, Andy J.; Wilson, J.; Thygesen, H.; Loizidou, M.A.; Hadjisavvas, A.; Hanby, A.; Speirs, V.; Loadman, Paul M.; Linforth, R.; Kyriacou, K.; Sutton, Chris W.
 
TitleA randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): Study protocol for a randomized controlled trial (2013)
AuthorsHull M.;Sandell A.;Montgomery A.;Logan R.;Clifford G.;Rees C.;Loadman P.;Whitham D.
JournalTrials
DOI10.1186/1745-6215-14-237
 
TitleTargeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging (2013)
AuthorsDjidja, M-C.; Francese, S.; Claude, E.; Loadman, Paul M.; Sutton, Chris W.; Shnyder, Steven D.; Cooper, Patricia A.; Patterson, Laurence H.; Carolan, V.A.; Clench, M.R.
 
TitleA randomised controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod (Systematic Evaluation of Aspirin and Fish Oil) Polyp Prevention Trial (2013)
AuthorsHull, M.A.; Sandell, A.C.; Montgomery, A.A.; Logan, R.F.A.; Clifford, G.M.; Rees, C.J.; Loadman, Paul M.; Whitham, D.
 
TitlePharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration (2013)
AuthorsAl-Saraireh, Yousef M.J.; Sutherland, Mark H.; Springett, Bradley R.; Freiberger, F.; Ribeiro Morais, Goreti; Loadman, Paul M.; Errington, R.J.; Smith, P.J.; Fukuda, M.; Gerardy-Schahn, R.; Patterson, Laurence H.; Shnyder, Steven D.; Falconer, Robert A.
JournalPLoS ONE
DOI10.1371/journal.pone.0073366
 
TitleAntitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder (2013)
AuthorsSutherland, Mark H.; Gill, Jason H.; Loadman, Paul M.; Laye, Jonathan P.; Sheldrake, Helen M.; Illingworth, Nicola A.; Alandas, Mohammed N.; Cooper, Patricia A.; Searcey, M.; Pors, Klaus; Shnyder, Steven D.; Patterson, Laurence H.
 
TitleFGFR1-induced Epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms (2012)
AuthorsTomlinson D.;Baxter E.;Loadman P.;Hull M.;Knowles M.
JournalPLoS ONE
DOI10.1371/journal.pone.0038972
 
TitleSynthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties (2012)
AuthorsCosentino L.;Redondo-Horcajo M.;Zhao Y.;Santos A.;Chowdury K.;Vinader V.;Abdallah Q.;Abdel-Rahman H.;Fournier-Dit-Chabert J.;Shnyder S.;Loadman P.;Fang W.;Díaz J.;Barasoain I.;Burns P.;Pors K.
JournalJournal of Medicinal Chemistry
DOI10.1021/jm301151t
 
TitleSynthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation (2012)
AuthorsFournier-Dit-Chabert J.;Vinader V.;Santos A.;Redondo-Horcajo M.;Dreneau A.;Basak R.;Cosentino L.;Marston G.;Abdel-Rahman H.;Loadman P.;Shnyder S.;Díaz J.;Barasoain I.;Falconer R.;Pors K.
JournalBioorganic and Medicinal Chemistry Letters
DOI10.1016/j.bmcl.2012.09.104
 
TitleThe omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility (2012)
AuthorsHawcroft G.;Volpato M.;Marston G.;Ingram N.;Perry S.;Cockbain A.;Race A.;Munarini A.;Belluzzi A.;Loadman P.;Coletta P.;Hull M.
JournalBritish Journal of Pharmacology
DOI10.1111/j.1476-5381.2012.01882.x
 
TitleAnti-colorectal cancer activity of an organometallic osmium arene azopyridine complex (2011)
AuthorsShnyder S.;Fu Y.;Habtemariam A.;Van Rijt S.;Cooper P.;Loadman P.;Sadler P.
JournalMedChemComm
DOI10.1039/c1md00075f
 
TitleChromatographie analysis of polysialic acid released from neural adhesion molecule presented on glioma cell membranes (2011)
AuthorsAl-Hasawi N.;Volapato M.;Loadman P.
JournalKuwait Journal of Science and Engineering
 
TitleTotal synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability (2011)
AuthorsBenelkebir H.;Marie S.;Hayden A.;Lyle J.;Loadman P.;Crabb S.;Packham G.;Ganesan A.
JournalBioorganic and Medicinal Chemistry
DOI10.1016/j.bmc.2011.02.024
 
TitleModification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity (2011)
AuthorsPors, Klaus; Loadman, Paul M.; Shnyder, Steven D.; Sutherland, Mark H.; Sheldrake, Helen M.; Guino, M.; Kiakos, K.; Hartley, J.A.; Searcey, M.; Patterson, Laurence H.
 
TitleEffect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells (2010)
AuthorsHawcroft, G.; Loadman, Paul M.; Belluzzi, A.; Hull, M.A.
 
TitleEvaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours. (2010)
AuthorsIsambert, N.; Campone, M.; Bourbouloux, E.; Drouin, M.; Major, A.; Yin, W.; Loadman, Paul M.; Capizzi, R.; Grieshaber, C.; Fumoleau, P.
 
TitleDevelopment of a novel tumor-targeted vascular disrupting agent activated by Membrane-type Matrix Metalloproteinases (MT-MMPs) (2010)
AuthorsAtkinson, Jennifer M.; Falconer, Robert A.; Edwards, D.R.; Pennington, C.J.; Siller, Catherine S.; Shnyder, Steven D.; Bibby, Michael C.; Patterson, Laurence H.; Loadman, Paul M.; Gill, Jason H.
 
TitleDevelopment of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases (2010)
AuthorsAtkinson J.;Falconer R.;Edwards D.;Pennington C.;Siller C.;Shnyder S.;Bibby M.;Patterson L.;Loadman P.;Gill J.
JournalCancer Research
DOI10.1158/0008-5472.CAN-10-1440
 
TitleEffect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells (2010)
AuthorsHawcroft G.;Loadman P.;Belluzzi A.;Hull M.
JournalNeoplasia
DOI10.1593/neo.10388
 
TitleA mathematical model of doxorubicin penetration through multicellular layers, (2009)
AuthorsEvans, C.J.; Phillips, Roger M.; Jones, P.F.; Loadman, Paul M.; Sleeman, B.D.; Twelves, Christopher J.; Smye, S.W.
 
TitleDetergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections (2009)
AuthorsDjidja M.;Francese S.;Loadman P.;Sutton C.;Scriven P.;Claude E.;Snel M.;Franck J.;Salzet M.;Clench M.
JournalProteomics
DOI10.1002/pmic.200800624
 
TitlePhase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors (2009)
AuthorsHochhauser, D.; Meyer, T.; Spanswick, V.J.; Wu, J.; Clingen, P.H.; Loadman, Paul M.; Cobb, M.; Gumbrell, L.; Begent, R.H.; Hartley, J.A.; Jodrell, D.
 
TitleIn vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts (2009)
AuthorsWilliams K.;Albertella M.;Fitzpatrick B.;Loadman P.;Shnyder S.;Chinje E.;Telfer B.;Dunk C.;Harris P.;Stratford I.
JournalMolecular Cancer Therapeutics
DOI10.1158/1535-7163.MCT-09-0396
 
TitleIn vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenograft. (2009)
AuthorsWilliams, K.J.; Albertella, M.R.; Fitzpatrick, B.; Loadman, Paul M.; Shnyder, Steven D.; Chinje, E.C.; Telfer, B.A.; Dunk, C.R.; Harris, P.A.; Stratford, I.J.
 
TitleDetergent addition to trypsin digest and Ion Mobility Separation prior to MS/MS improves peptide yield and Protein Identification for in situ Proteomic Investigation of Frozen and FFPE Adenocarcinoma tissue sections. (2009)
AuthorsDjidja, M-C.; Francese, S.; Loadman, Paul M.; Sutton, Chris W.; Scriven, P.; Claude, E.; Snel, M.F.; Franck, J.; Salzet, M.; Clench, M.R.
 
TitleThe use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study. (2009)
AuthorsSteward, W.P.; Middleton, M.; Benghiat, A.; Loadman, Paul M.; Hayward, C.; Walter, S.; Ford, S.; Halbert, G.; Patterson, Laurence H.; Talbot, D.
 
TitleHypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: Results of a phase I study (2008)
AuthorsAlbertella M.;Loadman P.;Jones P.;Phillips R.;Rampling R.;Burnet N.;Alcock C.;Anthoney A.;Vjaters E.;Dunk C.;Harris P.;Wong A.;Lalani A.;Twelves C.
JournalClinical Cancer Research
DOI10.1158/1078-0432.CCR-07-4020
 
TitleMethod development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging. (2008)
AuthorsDjidja, M-C.; Carolan, V.A.; Loadman, Paul M.; Clench, M.R.
 
TitleFluorescent 7-Diethylaminocoumarin Pyrrolobenzodiazepine conjugates: Synthesis, DNA-Interaction, Cytotoxicity and Differential Cellular Localization. (2008)
AuthorsWells, G.; Suggitt, Marie; Coffils, M.; Baig, M.A.H.; Howard, P.W.; Loadman, Paul M.; Hartley, J.A.; Jenkins, Terence C.; Thurston, D.E.
 
TitleHypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase 1 study (2008)
AuthorsAlbertella, M.R.; Loadman, Paul M.; Jones, P.H.; Phillips, Roger M.; Rampling, R.; Burnet, N.; Alcock, C.; Anthoney, Alan; Vjaters, E.; Dunk, C.R.; Harris, P.A.; Wong, A.; Lalani, A.S.; Twelves, Christopher J.
 
TitleExamination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry (2007)
AuthorsAtkinson S.;Loadman P.;Sutton C.;Patterson L.;Clench M.
JournalRapid Communications In Mass Spectrometry
DOI10.1002/rcm.2952
 
TitleMembrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: Correlation of MMP-14 mRNA expression and proteolytic activity (2007)
AuthorsAtkinson J.;Pennington C.;Martin S.;Anikin V.;Mearns A.;Loadman P.;Edwards D.;Gill J.
JournalEuropean Journal of Cancer. Part A
DOI10.1016/j.ejca.2007.05.009
 
TitleChemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1-targeted tripartite quinone drug delivery system (2007)
AuthorsVolpato M.;Abou-Zeid N.;Tanner R.;Glassbrook L.;Taylor J.;Stratford I.;Loadman P.;Jaffar M.;Phillips R.
JournalMolecular Cancer Therapeutics
DOI10.1158/1535-7163.MCT-07-0519
 
TitleChemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1-targeted tripartite quinone drug delivery system (2007)
AuthorsVolpato, Milène; Abou-Zeid, N.; Tanner, R.W.; Glassbrook, L.T.; Taylor, James P.; Stratford, I.J.; Loadman, Paul M.; Jaffar, M.; Phillips, Roger M.
 
TitleThe use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study (2007)
AuthorsSteward W.;Middleton M.;Benghiat A.;Loadman P.;Hayward C.;Waller S.;Ford S.;Halbert G.;Patterson L.;Talbot D.
JournalAnnals of Oncology
DOI10.1093/annonc/mdm120
 
TitleMembrane Type MMPs Show Differential Expression in Non-Small Cell Lung Cancer (NSCLC) Compared to Normal Lung; Correlation of MMP-14 mRNA Expression and Proteolytic Activity. (2007)
AuthorsAtkinson, Jennifer M.; Gill, Jason H.; Loadman, Paul M.; Martin, Sandie W.; Pennington, J.; Anikin, V.A.; Mearns, A.J.; Edwards, D.R.
 
TitlePreclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119). (2007)
AuthorsBurger, A.M.; Loadman, Paul M.; Thurston, D.E.; Schultz, R.; Fiebig, H.H.; Bibby, Michael C.
 
TitlePhase I/II Pilot Study of Intravesical Apaziquone (EO9) for Superficial Bladder Cancer (2006)
AuthorsPuri, Rajiv; Palit, V.; Loadman, Paul M.; Flannigan, G. Michael; Shah, T.K.; Choudry, G.A.; Basu, Saurajyoti; Double, John A.; Lenaz, G.; Chawla, S.; Beer, M.; Kalken, C.V.; de Boer, R.; Beijnen, J.H.; Twelves, Christopher J.; Phillips, Roger M.
 
TitleDesign, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates (2006)
AuthorsWells G.;Martin C.;Howard P.;Sands Z.;Laughton C.;Tiberghien A.;Woo C.;Masterson L.;Stephenson M.;Hartley J.;Jenkins T.;Shnyder S.;Loadman P.;Waring M.;Thurston D.
JournalJournal of Medicinal Chemistry
DOI10.1021/jm051199z
 
TitleFormation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity (2005)
AuthorsVolpato M.;Seargent J.;Loadman P.;Phillips R.
JournalEuropean Journal of Cancer. Part A
DOI10.1016/j.ejca.2005.03.014
 
TitleExpression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma (2005)
AuthorsSeargent J.;Loadman P.;Martin S.;Naylor B.;Bibby M.;Gill J.
JournalUrology
DOI10.1016/j.urology.2004.11.016
 
TitleDetection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP. (2004)
AuthorsPhillips R.;Basu S.;Brown J.;Flannigan G.;Loadman P.;Martin S.;Naylor B.;Puri R.;Shah T.
JournalInternational Journal of Oncology
 
TitleMMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas (2004)
AuthorsGill, Jason H.; Kirwan, Ian G.; Seargent, Jill M.; Martin, Sandie W.; Tijani, S.; Anikin, V.A.; Mearns, A.J.; Bibby, Michael C.; Anthoney, Alan; Loadman, Paul M.
 
TitlePharmacological and biological evaluation of a series of substituted 1,4 naphthoquinone bioreductive drugs. (2004)
AuthorsPhillips, Roger M.; Loadman, Paul M.; Maitland, Derek J.; Shnyder, Steven D.; Jaffar, M.; Steans, Gillian; Cooper, Patricia A.; Race, Amanda D.; Patterson, A.V.; Stratford, I.J.
 
TitlePreliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent. (2004)
AuthorsWilkinson, Gary P.; Taylor, James P.; Shnyder, Steven D.; Loadman, Paul M.; Cooper, Patricia A.; Howard, P.W.; Thurston, D.E.; Jenkins, Terence C.
 
TitleNAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C. (2004)
AuthorsBasu, Saurajyoti; Brown, John E.; Flannigan, G. Michael; Gill, Jason H.; Loadman, Paul M.; Martin, Sandie W.; Naylor, Brian; Puri, Rajiv; Scally, Andy J.; Seargent, Jill M.; Shah, Tariq K.; Phillips, Roger M.
 
TitleImmunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: Relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy (2004)
AuthorsBasu, Saurajyoti; Brown, John E.; Flannigan, G. Michael; Gill, Jason H.; Loadman, Paul M.; Naylor, Brian; Scally, Andy J.; Seargent, Jill M.; Shah, Tariq K.; Puri, Rajiv; Phillips, Roger M.; Martin, Sandie W.
 
TitleComparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate (2004)
AuthorsKirwan, Ian G.; Loadman, Paul M.; Swaine, David J.; Anthoney, Alan; Pettit, G.R.; Lippert III, J.W.; Shnyder, Steven D.; Cooper, Patricia A.; Bibby, Michael C.
 
Title5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study (2003)
AuthorsRustin G.;Bradley C.;Galbraith S.;Stratford M.;Loadman P.;Waller S.;Bellenger K.;Gumbrell L.;Folkes L.;Halbert G.
JournalBritish Journal of Cancer
DOI10.1038/sj.bjc.6600885
 
TitleCytochrome P450 1B1 (CYP1B1) is over-expressed in human colon adeno-carcinomas relative to normal colon: Implications for drug development. (2003)
AuthorsGibson, Paul; Gill, Jason H.; Khan, Parveen A.; Seargent, Jill M.; Martin, Sandie W.; Batman, Philip A.; Griffith, John; Bradley, C.; Double, John A.; Bibby, Michael C.; Loadman, Paul M.
 
TitleComet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action. (2003)
AuthorsSuggitt M.;Fearnley J.;Swaine D.;Volpato M.;Phillips R.;Bibby M.;Loadman P.;Anderson D.
JournalTeratogenesis Carcinogenesis and Mutagenesis
 
TitlePharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9 (2002)
AuthorsLoadman P.;Bibby M.;Phillips R.
JournalBritish Journal of Pharmacology
DOI10.1038/sj.bjp.0704916
 
TitleA preclinical pharmacokinetic study of the bioreductive drug AQ4N (2001)
AuthorsLoadman P.;Swaine D.;Bibby M.;Welham K.;Patterson L.
JournalDrug Metabolism and Disposition
 
TitleHigh-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide (2000)
AuthorsSwaine D.;Loadman P.;Bibby M.;Graham M.;Patterson L.
JournalJournal of Chromatography B: Biomedical Sciences and Applications
DOI10.1016/S0378-4347(00)00160-2
 
TitlePredicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: Implications for enzyme-directed bioreductive drug development (2000)
AuthorsPhillips R.;Burger A.;Loadman P.;Jarrett C.;Swaine D.;Fiebig H.
JournalCancer Research
 
TitlePharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice (2000)
AuthorsLoadman P.;Phillips R.;Lim L.;Bibby M.
JournalBiochemical Pharmacology
DOI10.1016/S0006-2952(99)00391-3
 
TitleCombination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma (2000)
AuthorsGrosios K.;Loadman P.;Swaine D.;Pettit G.;Bibby M.
JournalAnticancer Research
 
TitlePharmacokinetics of PK1 and doxorubicin in experimental colon tumor models with differing responses to PK1 (1999)
AuthorsLoadman P.;Bibby M.;Double J.;Al-Shakhaa W.;Duncan R.
JournalClinical Cancer Research
 
TitleIn vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans (1999)
AuthorsCalabrese C.;Loadman P.;Lim L.;Bibby M.;Double J.;Brown J.;Lamb J.
JournalDrug Metabolism and Disposition
 
Book Chapter
TitleWnt Signaling as a Therapeutic Target in Cancer and Metastasis (2017)
AuthorsMorgan, Richard; Ankrah, R.; El-Tanani, S.; Patterson, Laurence H.; Loadman, Paul M.; Rudland, P.S.; El-Tanani, Mohamed
 
TitlePractical aspects of pharmacokinetics and pharmacodynamics (2015)
AuthorsLoadman, Paul M.
 
TitleDevelopment of tumour selective and endoprotease-activated anticancer therapeutics. (2008)
AuthorsGill, Jason H.; Loadman, Paul M.
 
TitleDevelopment of tumour-selective and endoprotease-activated anticancer therapeutics (2008)
AuthorsGill J.;Loadman P.
JournalThe Cancer Degradome: Proteases and Cancer Biology
DOI10.1007/978-0-387-69057-5_40
 
Other Publication
Other typeReviews
TitlePrecision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance (2019)
AuthorsJove M.;Spencer J.;Clench M.;Loadman P.;Twelves C.
JournalCritical Reviews in Oncology/Hematology
DOI10.1016/j.critrevonc.2019.06.008
 
Other typeReviews
TitleProteases in cancer drug delivery (2016)
AuthorsVandooren J.;Opdenakker G.;Loadman P.;Edwards D.
JournalAdvanced Drug Delivery Reviews
DOI10.1016/j.addr.2015.12.020
 
Other typeReviews
TitleUse of matrix-assisted laser desorption/ionisation mass spectrometry in cancer research (2011)
AuthorsBateson H.;Saleem S.;Loadman P.;Sutton C.
JournalJournal of Pharmacological and Toxicological Methods
DOI10.1016/j.vascn.2011.04.003
 
Other typeReviews
TitleCurrent advances in the inhibition of the auto-regulatory interaction between the p53 tumour suppressor protein and MDM2 protein (2001)
AuthorsPicksley S.;Dart D.;Mansoor M.;Loadman P.
JournalExpert Opinion on Therapeutic Patents
DOI10.1517/13543776.11.12.1825
 
Other typeReviews
TitleSeparation methods for anthraquinone related anti-cancer drugs (2001)
AuthorsLoadman P.;Calabrese C.
JournalJournal of Chromatography B: Biomedical Sciences and Applications
DOI10.1016/S0378-4347(01)00281-X