Module code: CFS7029-B
Experimental design, sampling, sample preparation.
Calculations, dilutions, final concentrations from a given experimental method.
Health and Safety for chemical and biological samples (including human material). Reporting styles.
Method validation. International Council on Harmonisation (ICH) requirements. ISO. Selectivity/specificity, robustness, stability, precision, sensitivity, accuracy (SRMs). Quantification: External Standards, linearity. Internal Standards (quantification, drift). Blanks. Calibration curve uncertainty. LOD, LOQ, LOL: Dynamic Range.
Data analysis (Quality assurance and Quality control, Chemometrics). Selection of appropriate statistical methods. Numerical and IT skills. Descriptive methods. Frequency distributions. Cluster, trends, correlations. Multivariate analysis; Hierarchical, Principal Component Analysis. Outliers, Grubbs test.
Method Validation. Significance testing. Hypothesis testing. Samples and Populations. Confidence interval. T-test, F-tests, interpreting P values. Data presentation and visualisation.