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researcher

Dr Goreti Ribeiro Morais

PDRA

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailg.ribeiromorais@bradford.ac.uk

Research

I have been working at the interface of chemistry and biology and have developed skills ranging from Organic Chemistry, Medicinal Chemistry, Radiochemistry and Molecular Imaging. In Oct 2014, I returned to the ICT as Post-Doc to support the organic synthesis requirements across the Yorkshire Cancer Research Medicines Discovery programme. Precisely, I am participating in the: Development of duocarmycin synthetic derivatives as CYPs activated prodrugs Development of small molecule polysialyltransferase inhibitors as potential anti-metastatic agents Also, I have a leading role in developing chemical imaging tools to probe biological systems. I have been working at the interface of chemistry and biology and have developed skills ranging from Organic Chemistry, Medicinal Chemistry, Radiochemistry and Molecular Imaging. In Oct 2014, I returned to the ICT as Post-Doc to support the organic synthesis requirements across the Yorkshire Cancer Research Medicines Discovery programme. Precisely, I am participating in the: Development of duocarmycin synthetic derivatives as CYPs activated prodrugs Development of small molecule polysialyltransferase inhibitors as potential anti-metastatic agents Also, I have a leading role in developing chemical imaging tools to probe biological systems. Current Projects Team member of the project: Cancer Medicines Discovery, Yorkshire Cancer Research funded: Patterson, L.H. (P.I.), Falconer, R.A.; Pors, K.; Afarinkia, K.; Loadman, P.M.; Shnyder S.D. Current Projects Team member of the project: Cancer Medicines Discovery, Yorkshire Cancer Research funded: Patterson, L.H. (P.I.), Falconer, R.A.; Pors, K.; Afarinkia, K.; Loadman, P.M.; Shnyder S.D.

Publications

TitleAzodicarboxylate-mediated peptide cyclisation: application to disulfide bond formation in solution and solid phase. (2023)
AuthorsSerre, A.R.E.; Nwokolo, G.C.; Spencer, H.L.M.; Bell, T.J.; Barnieh, F.M.; Hughes, L.; Falconer, R.A.; Ribeiro Morais, G.
JournalEuropean Journal of Organic Chemistry
DOIDOI:10.1002/ejoc.202300789
 
TitleChemoselective Solution- and Solid-Phase Synthesis of Disulfide-Linked Glycopeptides (2022)
AuthorsBanisalman, K.F.; Polykandritou, A.; Barnieh, F.M.; Ribeiro Morais, G.; Falconer, R.A.
JournalJournal of Organic Chemistry
PublisherACS
DOIhttps://doi.org/10.1021/acs.joc.2c01651
 
TitleTargeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells (2022)
AuthorsBarnieh, F.M.; Ribeiro Morais, G.; Garland, H.; Loadman, P.M.; Falconer, R.A.
JournalBiochemical Pharmacology
PublisherElsevier
DOIhttps://doi.org/10.1016/j.bcp.2022.115095
 
TitleAn assay for quantitative analysis of polysialic acid expression in cancer cells (2021)
AuthorsGuo, X.; Elkashef, S.M.; Patel, A.; Ribeiro Morais, G.; Shnyder S.D.; Loadman, P.M.; Patterson, L.H.; Falconer, R.A.
JournalCarbohydrate Polymers
DOI10.1016/j.carbpol.2021.117741
 
TitleGlycosyl disulfides: importance, synthesis and application to chemical and biological systems (2021)
AuthorsRibeiro Morais, G.; Falconer, R.A.
JournalOrganic and Biomolecular Chemistry
DOI10.1039/D0OB02079F
 
TitleAn efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors. (2020)
AuthorsGuo X; Malcolm J.R.; Ali M.M.; Ribeiro Morais G; Shnyder S.D.; Loadman P.M.; Patterson L.H.; Falconer R.A.
JournalANALYST (PRINT)
DOI10.1039/d0an00721h
 
TitleTheranostic nanoparticles enhance the response of glioblastomas to radiation (2019)
AuthorsWu, W.; Klockow, J.L.; Mohanty, S.; Ku, K.S.; Aghighi, M.; Melemenidis, S.; Chen, Z.; Li, K.; Ribeiro Morais, Goreti; Zhao, N.; Schlegel, J.; Graves, E.E.; Rao, J.; Loadman, Paul M.; Falconer, R.A.; Mukherjee, S.; Chin, F.T.; Daldrup-Link, H.E.
JournalNanotheranostics
DOI10.7150/ntno.35342
 
TitleProbing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones (2018)
AuthorsErrington, R.J.; Sadiq, M.; Cosentino, L.; Wiltshire, M.; Sadiq, O.; Sini, Marcella; Lizano, E.; Pujol, M.D.; Ribeiro Morais, Goreti; Pors, Klaus
 
TitleA novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival (2017)
AuthorsMohanty, S.; Chen, Z.; Li, K.; Ribeiro Morais, G.; Klockow, J.; Yerneni, K.; Pasani, L.; Chin, F.T.; Mitra, S.; Cheshier, S.; Chang, E.; Gambhir, S.S.; Rao, J.; Loadman, P.M.; Falconer, R.A.; Daldrup-Link, H.E.
JournalMolecular Cancer Therapeutics
DOI10.1158/1535-7163.MCT-17-0022
 
TitlePolysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment (2016)
AuthorsElkashef, Sara M.; Allison, Simon J.; Sadiq, Maria; Basheer, Haneen A.; Ribeiro Morais, Goreti; Loadman, Paul M.; Pors, Klaus; Falconer, Robert A.
JournalScientific Reports
DOI10.1038/srep33026
 
TitleNovel strategies for the synthesis of unsymmetrical glycosyl disulfides (2016)
AuthorsRibeiro Morais, Goreti; Springett, Bradley R.; Pauze, Martin; Schröder, Lisa; Northrop, Matthew; Falconer, Robert A.
JournalOrganic and Biomolecular Chemistry
DOI10.1039/c6ob00230g
 
TitleTumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity (2014)
AuthorsGill, Jason H.; Loadman, Paul M.; Shnyder, Steven D.; Cooper, Patricia A.; Atkinson, Jennifer M.; Ribeiro Morais, Goreti; Patterson, Laurence H.; Falconer, Robert A.
JournalMolecular Cancer Therapeutics
DOI10.1021/mp400760b
 
TitleCarbohydrate-based molecules for Molecular Imaging in Nuclear Medicine (2013)
AuthorsRibeiro Morais G.;Falconer R.;Santos I.
JournalEuropean Journal of Organic Chemistry
DOI10.1002/ejoc.201201457
 
TitlePharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration (2013)
AuthorsAl-Saraireh, Yousef M.J.; Sutherland, Mark H.; Springett, Bradley R.; Freiberger, F.; Ribeiro Morais, Goreti; Loadman, Paul M.; Errington, R.J.; Smith, P.J.; Fukuda, M.; Gerardy-Schahn, R.; Patterson, Laurence H.; Shnyder, Steven D.; Falconer, Robert A.
JournalPLoS ONE
DOI10.1371/journal.pone.0073366
 
TitleA facile preparation of trehalose analogues: 1,1-thiodisaccharides (2009)
AuthorsRibeiro Morais, Goreti; Humphrey, Andrew J.; Falconer, Robert A.
JournalCarbohydrate Research
 
TitleIdentification of an acetyl disulfide derivative in the synthesis of thiosialosides (2009)
AuthorsRibeiro Morais, Goreti; Oliveira, Inês P.F.; Humphrey, Andrew J.; Falconer, Robert A.
 
TitleSelective synthesis of Neu5Ac2en and its oxazoline derivative using BF3.Et2O (2009)
AuthorsRibeiro Morais, Goreti; Oliveira, Rudi S.; Falconer, Robert A.
 
TitleApplication of HOF.CH3CN to the synthesis of glycosyl sulphones (2008)
AuthorsRibeiro Morais, Goreti; Humphrey, Andrew J.; Falconer, Robert A.
 
TitleEfficient one-pot synthesis of glycosyl disulfides (2007)
AuthorsRibeiro Morais G.;Falconer R.
JournalTetrahedron Letters
DOI10.1016/j.tetlet.2007.08.106