Professor Colin Wright
Professor of Pharmacognosy
| Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
|---|---|
| c.w.wright@bradford.ac.uk | |
| Telephone | +441274 234739 |
Biography
I started my career as a hospital pharmacist and became interested in tropical diseases as well as traditional medicine while working as a pharmacist in India (1980-1982). This led to my long-term interest in pharmacognosy and research in traditional medicines used in the treatment of infectious diseases and cancer. I have taught pharmacognosy for more than 20 years with the principal aims of highlighting the importance of natural products in medicine & drug discovery as well as revealing their fascinating chemistry and pharmacological effects. When I started at Bradford School of Pharmacy in 1994, the teaching of Pharmacognosy was fairly traditional including analytical microscopy. Working with Dr Peter Linley, I developed this subject area to provide modules that were more relevant to modern pharmacy practice by illustrating through lectures and lab workshops why a knowledge of herbal medicines and natural products is necessary for the practising pharmacist. Similarly, I developed a module on natural products for the (former) M.Sc in Pharmaceutical Services and Medicines Control. Although pharmacognosy as a subject is no longer in the new pharmacy curriculum, I have been able to include some content e.g. in unit FS2 which includes the origins of drugs and eco-pharmacy and a number of applications exercises present problems involving herbal medicines/natural products. Also, herbal medicines is a topic for student selected components and I offer natural product-related laboratory research projects. My research has focussed mainly on the investigation of traditional medicines used for the treatment of malaria with the aim of identifying lead antimalarial compounds. In collaboration with Bradford’s Institute for Cancer Research I have also investigated plants including marine algae (seaweeds) for their potential to yield anticancer compounds. I also have an interest in anti-TB natural products. My main research achievement has been the study of cryptolepine for which I received funding from WHO and is described in more detail below. I have successfully supervised 20 PhD students whose work, together with the help of many collaborators has resulted in the publication of 98 research papers and more than 100 conference contributions. In addition, I am regularly invited to present my research at conferences and seminars. I actively participate in two of the research groups in the School of Pharmacy especially in the Medicines Development and Pharmaceutical Science group in which I line manage 7 academic staff and have a role in facilitating the group’s research ambitions and strategy.
Publications
| Title | Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats (2017) |
|---|---|
| Authors | Forkuo, A.D.; Ansah, C.; Pearson, D.; Gertsch, W.; Cirello, A.; Amaral, A.; Spear, J.; Wright, Colin W.; Rynn, C. |
| Title | Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae) (2017) |
| Authors | Taiwo, Bamigboye J.; Fatokun, Amos A.; Olubiyi, O.O.; Bamigboye-Taiwo, O.T.; van Heerden, F.R.; Wright, Colin W. |
| Title | In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine (2017) |
| Authors | Forkuo, A.D.; Ansah, C.; Mensah, K.B.; Annan, K.; Gyan, B.; Theron, A.; Mancama, D.; Wright, Colin W. |
| Title | Synthesis and biological evaluation of N-cyanoalkyl-, Naminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents (2016) |
| Authors | Sola, I.; Artigas, A.; Taylor, M.C.; Perez-Areales, F.J.; Viayna, E.; Clos, M.V.; Perez, B.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. |
| Title | A new embelin from the mangrove Aegiceras corniculatum. (2015) |
| Authors | Thota, S.P.R.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. |
| Title | Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection. (2015) |
| Authors | Gbedema, Stephen Y.; Bayor, M.T.; Annan, K.; Wright, Colin W. |
| Title | Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death (2015) |
| Authors | Passreiter, C.M.; Suckow-Schnitker, A-K.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Wätjen, W. |
| Title | Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity. (2015) |
| Authors | Sola, I.; Castellà, S.; Viayna, E.; Galdeano, C.; Taylor, M.C.; Gbedema, Stephen Y.; Pérez, B.; Clos, M.V.; Jones, D.C.; Fairlamb, A.H.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. |
| Title | Anticandida Agents from a Tanzanian Plant Albizia anthelmintica. (2015) |
| Authors | Runyoro, D.K.B.; Joseph, C.C.; Ngassapa, O.D.; Darokar, M.P.; Srivastava, S.K.; Matee, M.I.N.; Wright, Colin W. |
| Title | Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. (2014) |
| Authors | Sola, I.; Artigas, A.; Taylor, M.C.; Gbedema, Stephen Y.; Perez, B.; Clos, M.V.; Wright, Colin W.; Kelly, J.M.; Muñoz-Torrero, D. |
| Title | Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38 MAPK inhibition. (2013) |
| Authors | Olajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L. |
| Title | Cajachalcone: An Antimalarial Compound from Cajanus cajan Leaf Extract (2013) |
| Authors | Ajaiyeoba, E.O.; Ogbole, O.O.; Abiodun, O.O.; Ashidi, J.S.; Houghton, P.J.; Wright, Colin W. |
| Title | Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine. (2013) |
| Authors | Olajide, O.A.; Bhatia, H.S.; de Oliveira, A.C.P.; Wright, Colin W.; Fiebich, B.L. |
| DOI | Olajide, O.A., Bhatia, H., A.C., de Oliveira, A.C.P., Wright, C.W. and Fiebich, B.L. (2013) Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evidence-Based Complementary and Alternative Medicine, Article ID 459723. http://dx.doi.org/10.1155/2013/459723 |
| Title | Antileishmanial activity of cryptolepine analogues and apoptotic effects of 2,7-dibromocryptolepine against Leishmania donovani promastigotes. (2012) |
| Authors | Hazra, S.; Ghosh, S.; Debnath, S.; Seville, Scott; Prajapati, V.K.; Wright, Colin W.; Sundar, S.; Hazra, B. |
| Title | Screening Indian plant species for antiplasmodial properties – ethnopharmacological compared to random selection. (2012) |
| Authors | Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. |
| Title | Complete NMR assignments of tubulosine (2012) |
| Authors | Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W. |
| Title | Screening indian plant species for antiplasmodial properties - Ethnopharmacological compared with random selection (2012) |
| Authors | Kantamreddi V.;Wright C. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/ptr.4651 |
| Title | Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase (2012) |
| Authors | Stell, J. Godfrey P.; Wheelhouse, Richard T.; Wright, Colin W. |
| Title | Traditional remedies: an ally in the fight against infectious diseases? (2012) |
| Authors | Wright, Colin W. |
| Title | Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. (2011) |
| Authors | Rasoanaivo, P.; Wright, Colin W.; Willcox, M.L.; Gilbert, B. |
| Title | Low Temperature X-Ray Crystallographic Structure of the Antiplasmodial Compound 5-N-Hydroxyethanequindoline Hydrochloride 0.5CH3OH. (2011) |
| Authors | Hampson, Hannah C.; Ho, Chung Y.; Palmer, R.A.; Potter, B.S.; Helliwell, M.; Wright, Colin W. |
| Title | Effects of the antimalarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay (2011) |
| Authors | Gopalan, Rajendran C.; Emerce, E.; Wright, Colin W.; Karahalil, B.; Karakaya, A.E.; Anderson, Diana |
| Title | Low temperature X-ray crystallographic structure of the antiplasmodial compound 5-N-hydroxyethanequindoline hydrochloride 0.5CH |
| Authors | Hampson H.;Ho C.;Palmer R.;Potter B.;Helliwell M.;Wright C. |
| Journal | Journal of Chemical Crystallography |
| DOI | 10.1007/s10870-011-0169-5 |
| Title | Huprines as a new family of dual acting trypanocidal-antiplasmodial agents (2011) |
| Authors | Defaux J.;Sala M.;Formosa X.;Galdeano C.;Taylor M.;Alobaid W.;Kelly J.;Wright C.;Camps P.;Muñoz-Torrero D. |
| Journal | Bioorganic and Medicinal Chemistry |
| DOI | 10.1016/j.bmc.2011.01.028 |
| Title | Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. (2011) |
| Authors | Sengupta, S.; Chowdhury, S.; BoseDasgupta, S.; Wright, Colin W.; Majumder, H.K. |
| Title | Huprines as a new family of dual acting trypanocidal–antiplasmodial agents (2011) |
| Authors | Defaux, J.; Sala, M.; Formosa, X.; Galdeano, C.; Taylor, M.C.; Kelly, J.M.; Wright, Colin W.; Camps, P.; Muñoz-Torrero, D.; Alobaid, Waleed A.A. |
| Title | New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly). (2010) |
| Authors | Rao, T.S.P.; Sarma, N.S.; Murthy, Y.L.N.; Kantamreddi, Venkata Siva Satya Narayana; Wright, Colin W.; Parameswaran, P.S. |
| Title | Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus. (2010) |
| Authors | Maregesi, S.; Van Miert, S.; Pannecouque, C.; Feiz-Haddad, M.H.; Hermans, N.; Wright, Colin W.; Vlietinck, A. J.; Aspers, S.; Pieters, L. |
| Title | Anti-inflammatory properties of cryptolepine. (2010) |
| Authors | Olajide, O.A.; Ajayi, A.A.; Wright, Colin W. |
| Title | Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. (2010) |
| Authors | Wright, Colin W.; Linley, Peter A.; Brun, R.; Wittlin, S.; Hsu, E. |
| Title | Recent developments in research on terrestrial plants used for the treatment of malaria. (2010) |
| Authors | Wright, Colin W. |
| Title | Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. (2009) |
| Authors | Laryea, D.; Isaksson, A.; Wright, Colin W.; Larsson, R.; Nygren, P. |
| Title | Phytotherapy used in Orissa State India, for treating malaria. (2009) |
| Authors | Kantamreddi, Venkata Siva Satya Narayana; Parida, S.; Kommula, S.M.; Wright, Colin W. |
| Title | Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis. (2009) |
| Authors | Oluwafemi, A.J.; Okanla, O.; Camps, P.; Muñoz-Torrero, D.; Mackey, Z.B.; Chiang, P.K.; Seville, Scott; Wright, Colin W. |
| Title | Structure of the antiplasmodial compound 7,9-dinitrocryptolepine hydrochloride methanol solvate. (2008) |
| Authors | Lisgarten, J.N.; Potter, B.S.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W. |
| Title | Antiplasmodial compounds from Cassia siamea stem bark extract. (2008) |
| Authors | Ajaiyeoba, E.O.; Ashidi, J.S.; Okpako, Larry Commander; Houghton, P.J.; Wright, Colin W. |
| Title | Investigation of Indian Diospyros species for antiplasmodial properties (2008) |
| Authors | Kantamreddi V.;Wright C. |
| Journal | Evidence-based Complementary and Alternative Medicine |
| DOI | 10.1093/ecam/nem019 |
| Title | A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana (2008) |
| Authors | Bayor, M.T.;Ayim, J.S.K.;Marston, G.;Phillips, R.M.;Shnyder, S.D.;Wheelhouse, R.T.;Wright, C.W.; |
| Journal | Natural product communications |
| Title | X-ray crystallographic structure of the potent antiplasmodial compound 2,7-dibromocryptolepine acetic acid solvate. (2008) |
| Authors | Potter, B.S.; Lisgarten, J.N.; Pitts, J.E.; Palmer, R.A.; Wright, Colin W. |
| Title | A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations in Ghana (2008) |
| Authors | Bayor, M.T.; Ayim, J.S.K.; Marston, G.; Phillips, Roger M.; Shnyder, Steven D.; Wheelhouse, Richard T.; Wright, Colin W. |
| Title | Genomewide expression profiling of the cryptolepine-induced toxicity in Saccharomyces cerevisiae. (2008) |
| Authors | Rojas, M.; Wright, Colin W.; Pina, B.; Portugal, J. |
| Title | Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. (2008) |
| Authors | Watjen, W.; Suckow-Schnitker, A-K.; Rohrig, R.; Kulawik, A.; Addae-Kyereme, Jonathan A.; Wright, Colin W.; Passreiter, C.M. |
| Title | Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae (2008) |
| Authors | Rojas M.;Wright C.;Piña B.;Portugal J. |
| Journal | Antimicrobial Agents and Chemotherapy |
| DOI | 10.1128/AAC.00532-08 |
| Title | Recent developments in naturally derived antimalarials: Cryptolepine analogues (2007) |
| Authors | Wright C. |
| Journal | Journal of Pharmacy and Pharmacology |
| DOI | 10.1211/jpp.59.6.0017 |
| Title | Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation (2007) |
| Authors | Wätjen W.;Kulawik A.;Suckow-Schnitker A.;Chovolou Y.;Rohrig R.;Ruhl S.;Kampkötter A.;Addae-Kyereme J.;Wright C.;Passreiter C. |
| Journal | Toxicology |
| DOI | 10.1016/j.tox.2007.09.010 |
| Title | Synthetic cryptolepine inhibits DNA binding of NF-κB (2007) |
| Authors | Olajide O.;Heiss E.;Schachner D.;Wright C.;Vollmar A.;Dirsch V. |
| Journal | Bioorganic and Medicinal Chemistry |
| DOI | 10.1016/j.bmc.2006.10.018 |
| Title | Synthesis of cryptolepine analogues as potential bioreducible anticancer agents (2007) |
| Authors | Seville S.;Phillips R.;Shnyder S.;Wright C. |
| Journal | Bioorganic and Medicinal Chemistry |
| DOI | 10.1016/j.bmc.2007.06.062 |
| Title | Synthesis of novel halogenated cryptolepine analogues (2006) |
| Authors | Gouni S.;Carrington S.;Wright C. |
| Journal | Journal of Heterocyclic Chemistry |
| DOI | 10.1002/jhet.5570430126 |
| Title | Seasonal variation in bromophenol content of Polysiphonia lanosa (2006) |
| Authors | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wright C. |
| Journal | Natural product communications |
| Title | Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. (2005) |
| Authors | Wright, Colin W.; Onyeibor, O.; Phillips, Roger M.; Shnyder, Steven D.; Croft, S.L.; Dodson, Hilary I. |
| Title | In vitro anti-plasmodial and cytotoxic activities of plants used as antimalarial agents in the southwest Nigerian ethnomedicine (2005) |
| Authors | Ajaiyeoba E.;Bolaji O.;Akinboye D.;Falade C.;Gbotosho G.;Ashidi J.;Okpako L.;Oduola O.;Falade M.;Itiola O.;Houghton P.;Wright C.;Ogundahunsi O.;Oduola A. |
| Journal | Journal of Natural Remedies |
| Title | Phytochemistry and preliminary biological evaluation of Cyathostemma argenteum, a Malaysian plant used traditionally for the treatment of breast cancer (2004) |
| Authors | Khamis S.;Bibby M.;Brown J.;Cooper P.;Scowen I.;Wright C. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/ptr.1318 |
| Title | In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers (2004) |
| Authors | Shoeib N.;Bibby M.;Blunden G.;Linley P.;Swaine D.;Wheelhouse R.;Wright C. |
| Journal | Journal of Natural Products |
| DOI | 10.1021/np0305268 |
| Title | Antimalarial ethnobotany: In vitro antiplasmodial activity of seven plants identified in the Nigerian Middle Belt (2004) |
| Authors | Ajaiyeoba E.;Ashidi J.;Abiodun O.;Okpako L.;Ogbole O.;Akinboye D.;Falade C.;Bolaji O.;Gbotosho G.;Falade M.;Itiola O.;Houghton P.;Wright C.;Oduola A. |
| Journal | Pharmaceutical Biology |
| DOI | 10.1080/13880200490902455 |
| Title | Antiplasmodial principles from Cassia nigricans (2004) |
| Authors | Obodozie O.;Okpako L.;Tarfa F.;Orisadipe A.;Okogun J.;Inyang U.;Ajaiyeoba E.;Wright C. |
| Journal | Pharmaceutical Biology |
| DOI | 10.1080/13880200490902545 |
| Title | Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone. (2003) |
| Authors | Wright, Colin W.; Kirby, G.C; Phillipson, J.D; Warhurst, D.C.; Lang'at-Thoruwa, C.; Watt, R.A. |
| Title | Evaluation of Some Egyptian Plant Species for in vitro Antimycobacterial and Cytotoxic Activities (2003) |
| Authors | Abou El Seoud K.;Bibby M.;Shoeib N.;Wright C. |
| Journal | Pharmaceutical Biology |
| DOI | 10.1076/phbi.41.6.463.17831 |
| Title | Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: A preliminary study (2003) |
| Authors | Wright C.;Gott M.;Grayson B.;Hanna M.;Smith A.;Sunter A.;Neill J. |
| Journal | Journal of Psychopharmacology |
| DOI | 10.1177/0269881103174018 |
| Title | Enhancement of the Antiplasmodial Activity of Quassin by Transformation into a γ-Lactone (2003) |
| Authors | Lang'at-Thoruwa C.;Kirby G.;Phillipson J.;Warhurst D.;Watt R.;Wright C. |
| Journal | Journal of Natural Products |
| Title | Cryptolepine hydrochloride: A potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta (2003) |
| Authors | Gibbons S.;Fallah F.;Wright C. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/ptr.1284 |
| Title | The antimalarial and cytotoxic drug cryptolepine intercalates into dna at cytosine-cytosine sites (2002) |
| Authors | Lisgarten J.;Coll M.;Portugal J.;Wright C.;Aymami J. |
| Journal | Nature Structural Biology |
| DOI | 10.1038/nsb729 |
| Title | The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis (2002) |
| Authors | Newton S.;Lau C.;Gurcha S.;Besra G.;Wright C. |
| Journal | Journal of Ethnopharmacology |
| DOI | 10.1016/S0378-8741(01)00350-6 |
| Title | Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: In vivo antimalarial activity and x-ray crystal structure of normelicopicine (2002) |
| Authors | Muriithi M.;Abraham W.;Addae-Kyereme J.;Scowen I.;Croft S.;Gitu P.;Kendrick H.;Njagi E.;Wright C. |
| Journal | Journal of Natural Products |
| DOI | 10.1021/np0106182 |
| Title | Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. (2001) |
| Authors | Wright, Colin W.; Addae-Kyereme, Jonathan A.; Breen, Anthony G.; Brown, John E.; Cox, Marlene F.; Croft, S.L.; Gokcek, Yaman; Kendrick, H.; Phillips, Roger M.; Pollet, Pamela L. |
| Title | Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine (2001) |
| Authors | Addae-Kyereme J.;Croft S.;Kendrick H.;Wright C. |
| Journal | Journal of Ethnopharmacology |
| DOI | 10.1016/S0378-8741(01)00212-4 |
| Title | The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. (2001) |
| Authors | Lisgarten, J.N.; Coll, M.; Portugal, J.; Wright, Colin W.; Aymami, J. |
| Title | Synthesis and antiplasmodial activities of some halogenated cryptolepine derivatives (2000) |
| Authors | Wright C.;Addae-Kyereme J.;Brown J.;Cox M.;Gokcek Y.;Pollet P. |
| Journal | Journal of Pharmacy and Pharmacology |
| Title | Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone (2000) |
| Authors | Marshall S.;Russell P.;Phillipson J.;Kirby G.;Warhurst D.;Wright C. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/1099-1573(200008)14:5<356::AID-PTR636>3.0.CO;2-Z |
| Title | In-vitro cytotoxicity and thermodenaturation studies for cryptolepine and analogues (2000) |
| Authors | Gokcek Y.;Pollet P.;Wright C.;Brown J. |
| Journal | Journal of Pharmacy and Pharmacology |
| Title | In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids (2000) |
| Authors | Wright C.;Marshall S.;Russell P.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff J. |
| Journal | Journal of Natural Products |
| DOI | 10.1021/np000144r |
| Title | In-vitro antimycobacterial screening of some plant species used in traditional medicine for the treatment of tuberculosis (2000) |
| Authors | Newton S.;Lau C.;Wright C. |
| Journal | Journal of Pharmacy and Pharmacology |
| Title | In-vitro antiplasmodial and cytotoxic activities of some British species of marine algae (2000) |
| Authors | Shoeib N.;Bibby M.;Cooper P.;Blunden G.;Wright C. |
| Journal | Journal of Pharmacy and Pharmacology |
| Title | Structure of the tetraphenyl borate complex of the indoloquinoline alkaloid cryptolepine (1999) |
| Authors | Wright C.;Philpson J.;Lisgarten J.;Palmer R. |
| Journal | Journal of Chemical Crystallography |
| DOI | 10.1023/A:1009519211938 |
| Title | Sesquiterpene lactones from Neurolaena oaxacana (1999) |
| Authors | Passreiter C.;Sandoval-Ramirez J.;Wright C. |
| Journal | Journal of Natural Products |
| DOI | 10.1021/np990038t |
| Title | Alkaloids from Narcissus cantabricus (1995) |
| Authors | Bastida J.;Contreras J.;Codina C.;Wright C.;David Phillipson J. |
| Journal | Phytochemistry |
| DOI | 10.1016/0031-9422(95)00448-G |
| Title | Antiprotozoal activities of Centipeda minima (1994) |
| Authors | Yu H.;Wright C.;Cai Y.;Yang S.;Phillipson J.;Kirby G.;Warhurst D. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/ptr.2650080713 |
| Title | Selective antiprotozoal activity of some Strychnos alkaloids (1994) |
| Authors | Wright C.;Allen D.;Cai Y.;Chen Z.;Phillipson J.;Kirby G.;Warhurst D.;Tits M.;Angenot L. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/ptr.2650080306 |
| Title | In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids (1994) |
| Authors | Marshall S.;Russell P.;Wright C.;Anderson M.;Phillipson J.;Kirby G.;Warhurst D.;Schiff P. |
| Journal | Antimicrobial Agents and Chemotherapy |
| DOI | 10.1128/AAC.38.1.96 |
| Title | Toward the chemical ecology of medicinal plant use in chimpanzees: The case of Vernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases (1994) |
| Authors | Ohigashi H.;Huffman M.;Izutsu D.;Koshimizu K.;Kawanaka M.;Sugiyama H.;Kirby G.;Warhurst D.;Allen D.;Wright C.;David Phillipson J.;Timon-David P.;Delmas F.;Elias R.;Balansard G. |
| Journal | Journal of Chemical Ecology |
| DOI | 10.1007/BF02059596 |
| Title | Alstonia species: are they effective in malaria treatment? (1993) |
| Authors | Wright C.;Allen D.;Phillipson J.;Kirby G.;Warhurst D.;Massiot G.;Le Men-Olivier L. |
| Journal | Journal of Ethnopharmacology |
| DOI | 10.1016/0378-8741(93)90087-L |
| Title | Alkaloids from Cephaelis dichroa (1993) |
| Authors | Solis P.;Wright C.;Gupta M.;Phillipson J. |
| Journal | Phytochemistry |
| DOI | 10.1016/0031-9422(93)85033-N |
| Title | In vitro antimalarial and cytotoxic activities of semisynthetic derivatives of brusatol (1993) |
| Authors | Allen D.;Toth I.;Wright C.;Kirby G.;Warhurst D.;Phillipson J. |
| Journal | European Journal of Medicinal Chemistry |
| DOI | 10.1016/0223-5234(93)90143-3 |
| Title | A microwell cytotoxicity assay using Artemia salina (brine shrimp) (1993) |
| Authors | Solis P.;Wright C.;Anderson M.;Gupta M.;Phillipson J. |
| Journal | Planta Medica |
| Title | Quassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro (1993) |
| Authors | WRIGHT C.;ANDERSON M.;ALLEN D.;PHILLIPSON J.;KIRBY G.;WARHURST D.;CHANG H. |
| Journal | Journal of Eukaryotic Microbiology |
| DOI | 10.1111/j.1550-7408.1993.tb04910.x |
| Title | Pharmacy Education: Understanding drug abuse (1993) |
| Authors | Wright, C.W. |
| Journal | Pharmaceutical Journal |
| Title | In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots (1992) |
| Authors | Wright C.;Allen D.;Cai Y.;Phillipson J.;Said I.;Kirby G.;Warhurst D. |
| Journal | Phytotherapy Research |
| DOI | 10.1002/ptr.2650060303 |
| Title | Determination of anti-giardial activity in vitro by means of soluble formazan production (1992) |
| Authors | Wright C.;Melwani S.;David Phillipson J.;Warhurst D. |
| Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| DOI | 10.1016/0035-9203(92)90093-R |
| Title | A new alkaloid from the roots of alstonia angustifolia (1992) |
| Authors | Said I.;Din L.;Yusoff N.;Wright C.;Cai Y.;Phillipson J. |
| Journal | Journal of Natural Products |
| DOI | 10.1021/np50087a025 |
| Title | Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico). (1992) |
| Authors | Heinrich M;Kuhnt M;Wright CW;Rimpler H;Phillipson JD;Schandelmaier A;Warhurst DC; |
| Journal | Journal of Ethnopharmacology |
| Title | Can ethnopharmacology contribute to the development of antimalarial agents? (1991) |
| Authors | David Phillipson J.;Wright C. |
| Journal | Journal of Ethnopharmacology |
| DOI | 10.1016/0378-8741(91)90113-R |
| Title | Molecular modelling of usambarensine, tubulosine and emetine, three cytotoxic amoebicide alkaloids (1991) |
| Authors | Quetin-Leclercq J.;Dupont L.;Wright C.;Phillipson J.;Warhurst D.;Angenot L. |
| Journal | Journal de Pharmacie de Belgique |
| Title | Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. (1991) |
| Authors | Wright CW;Bray DH;O'Neill MJ;Warhurst DC;Phillipson JD;Quetin-Leclercq J;Angenot L; |
| Journal | Planta Medica |
| DOI | 10.1055/s-2006-960112 |
| Title | Plants as sources of antimalarial drugs, part 6: Activities of Simarouba amara fruits (1988) |
| Authors | O'Neill M.;Bray D.;Boardman P.;Wright C.;David Phillipson J.;Warhurst D.;Gupta M.;Correya M.;Solis P. |
| Journal | Journal of Ethnopharmacology |
| DOI | 10.1016/0378-8741(88)90126-2 |
| Title | Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. (1988) |
| Authors | Wright CW;O'Neill MJ;Phillipson JD;Warhurst DC; |
| Journal | Antimicrobial Agents and Chemotherapy |