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Dr S A Behruz Khaghani

Lecturer in Biomedical Engineering

Faculty/Dept/School Faculty of Eng & Digital Technologies
Telephone (mobile: +44 (0)7477651279)


Dr Seyed A. Behruz Khaghani is a Lecturer and Lead Technician in Biomedical and Electronics Engineering Department. He received BEng in Medical Engineering in 2006 and PhD in Cell and tissue Engineering/Regenerative Medicine in 2010 from University of Bradford. 
Behruz has strong research contributions in biorobotics, capsule endoscopy, additive manufacturing, fabrication of nanofibers using electrospinning of biopolymers for tissue regeneration, and fabrication of artificial connective and epithelial tissues such as cartilage, bone, ligament and skin by using various skills and suitable biomaterials, hydrogels and 3D printing of body parts and electrospinning techniques. 

Recent Publications

Peer-reviewed Journal papers:

1- S. A. Khaghani, G. Akbarova, C. F. Fhong, G. Dilbazi (2018). “Effect of transforming growth factor-β2 on biological regulation of multilayer primary chondrocyte culture”, Journal of Cell and Tissue Banking.
2- Tehmeena Israr Raja, Seyed Ali Khaghani, Muhammad Sohail Zafarb, Zohaib Khurshid, Masoud Mozafari, Mansour Youseffi, Farshid Sefat, 2018.  “Effect of TGF-β1 on water retention properties of healthy and osteoarthritic chondrocytes” Materialstoday. 5, 15717-15725.
3- Ehsaneh Daghigh Ahmadi, Tehmeena Israr Raja, Seyed Ali Khaghani, Chin Fhong Soon, Masoud Mozafari, Mansour Youseffi, Farshid Sefat, 2018. “The Role of Photonics and Natural Curing Agents of TGF-β1 in Treatment of Osteoarthritis”. Materials Today. 5, 15540-15549.
4- Seyed Ali Behruz Khaghani, Gunay Akbarova, Gulurkh Dilbazi. 2017. “Design of a Chitosan Based Bio-Scaffolding for Regenerative Medicine: Compatibility Analysis for Cartilage Regeneration” BIOLOGIJA. 2017. 63, 211–220.
5- Kaur P, Khaghani SA, Oluwadamilola A, Khurshid Z, Zafar MA et al. 2017. “Fabrication and Charachterization of Hydrogels for Cartilage Repair”. Adv Tissue Eng Regen Med Open Access 2(6)-00051. DOI: 10.15406/atroa.2017.02.00051
6- Seyed Ali Khaghani, Farshid Sefat, Mansour Youseffi, Chin Fhung Soon, Farideh Javid, 2016 “Effect of transforming growth factor-β3 on mono and multilayer chondrocytes”. Journal of Cytokine, 83, 118–126.
7- Chin Fhong Soon, Hiung Yin Yap, Mohd Khairul Ahmad, Mohd Zainizan Sahdan, Kian Sek Tee, Seyed Ali Khaghani, Mansour Youseffi. 2017. “Environmental Friendly Flow Focusing Microfluidics Device and Pump System for Microencapsulation of 3D Cells”. Journal of Engineering and Applied Sciences. 12, 6928-6933.
8- Farshid Sefat, Seyed Ali Khaghani, Touraj Nejatian, Mohammed Genedy, Ali Abdeldayem, Zoha Salehi Moghaddam, Morgan C.T. Denyer, Mansour Youseffi. 2015. “Transforming Growth Factor Beta (TGF-β) Isomers Influence Cell Detachment of MG-63 Bone Cells”. Journal of Tissue and Cell.
9- Chin Fhong Soon, Seyed Ali Khaghani, Mansour Youseffi, Nafarizal Nayan, Hashim Saim, Stephen Britland, Nick Blagden, Morgan Clive Thomas Denyer, 2013 “Interfacial study of cell adhesion to liquid crystals using widefield surface plasmon resonance microscopy”. Journal of Colloids and Surfaces B: Biointerfaces, 110, 156-162.
10- Khaghani, S. A., Denyer, M. C. T. & Youseffi, M. 2012. “Effect of Transforming Growth Factor-β1 in Biological Regulation of Primary Chondrocyte”. American Journal of Biomedical Engineering, 2, 1-8.

Conference papers:
1- SA Khaghani, F Sefat, M Youseffi, R Rehman, CF Soon, G Akbarova. “Effect of transforming growth factor-β on up/down regulation of integrin-β1 in primary chondrocyte culture” 2016, European Cells and Materials Vol. 32. Suppl. 4, 2016 (page 56.
2- Nurul Hamizah Md Sai’aan, Chin Fhong Soon, Kian Sek Tee, Mohd Khairul Ahmad, Mansour Youseffi, Seyed Ali Khaghani. “Characterisation of Encapsulated Cells in Calcium Alginate Microcapsules”, (2016), IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES.)
3- E. Michailidou, S.A. Khaghani and M. Youseffi, (2015), “Development of Novel Hydrogels Based on Chitosan/Gelatin/B-Glycerophosphate for Replacement and Repair of Diseased Articular Cartilage”: A Dynamic Characterization, MEIbioeng15 Conference, Leeds, UK, 7th-8th September 2015. (Accepted and presented 7-8 September 2015).
4- E. Michailidou, S.A. Khaghani, P. Twigg and M. Youseffi, (2015), “Osteoblast and Chondrocyte Cells Culture and Seeding in Polymer Based Substrates Mixed with Calcium Phosphate”, MEIbioeng15 Conference, Leeds, UK, 7th-8th September 2015. (Accepted and presented 7-8 September 2015)
5- C. F. Soon, M. Youseffi, N. Blagden, S. Khaghani, M. C. T. Denyer, “Widefield surface plasmon resonance imaging of cell adhesion to liquid crystals”, Proceedings of National Conference on Electrical and Electronic Engineering (NCEE 2012), 8-9 May 2012, page 43-47.
6- A. Abdeldayem, M. Yousseffi, S.A. Khaghani, M. Genedy, M.C.T. Denyer, “The Effect of Different Concentrations of Cannabinoid (WIN 55,212-2) on Wound Healing of Chondrocytes Monolayer”, 14th International Conference on Aerospace Sciences and Aviation Technology (ASAT-14), 2011, Cairo, Egypt.
7- M. Genedy, M. Youseffi, F. Sefat, S.A. Khaghani, A. Abdeldayem, M.C.T. Denyer, “Effect of Cannabinoids (WIN55, 212-2)  in Acceleration of Wound Healing in Bone Cell Monolayer,” 14th International Conference on Aerospace Sciences and Aviation Technology (ASAT-14), 2011, Cairo, Egypt.
8- F. Sefat, R.F. Berends, M.C.T Denyer, S.A. Khaghani and M. Youseffi, “The anti-scarring (wound closure) properties of TGF-β3, BSA/HCl and HCl in cultured human bone cell monolayer,” World congress on engineering (WCE) 2009, ISBN: 978-988-18210-1-0 pp 1866-1871.
9- Seyedali Khaghani, Morgan Denyer, Mansour Youseffi, Samira Lobo, and Farideh A. Javid, ”Effect of latent transforming growth Factor-β1 in biological regulation of primary Chondrocyte,” 15th International Biomedical Science and Technology Symposium, 16-19, August 2009, METU-Northern Cyprus (Güzelyurt), ISBN: 978-975-01656-5-8, p. 68-68.
10- M. Mahadi Abdul Jamil, S. B. Lobo, F. Sefat, S.A. Khaghani,   F. A. Javid, M. Youseffi, S.T. Britland, S. Liu, C.W. See, M.G. Somekh and M.C.T. Denyer, “Cell imaging with the Widefield Surface Plasmon Microscope”. 4th Kuala Lumpur International Conference on Biomedical Engineering 2008, Volume 21 of the series IFMBE Proceedings pp 528-531                                   

1- Seyed Ali (Bheruz) Khaghani. Cell and Tissue Engineering of Cartilage: Regulation of Chondrocyte by TGF-β and ECM-Proteins, (LAP Lambert Academic Publishing, Saarbruecken, 2012).

Book Chapter:

1- Seyed Ali (Behruz) Khaghani, Gunay Akbarova, Chin Fhong Soon, Gulrukh Dilbazi (2018). Effect of Manipulated TGF-β on Integrin-β1 Synthesis of Chondrocyte Cell Sheets. Naznin Sultana, Sanchita Bandyopadhyay-Ghosh, Soon Chin Fhong (Eds.), Tissue Engineering Strategies for Organ Regeneration. Science Publishers (An Imprint of CRC Press/ Taylor & Francis Group) (Editing)