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researcher

Professor Sherif El-Khamisy

Director - Institute Cancer Therapeutics

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emails.el-khamisy@bradford.ac.uk
Telephone +441274 238458

Research

I am a pharmacist interested in understanding how cells maintain genomic integrity. I use interdisciplinary approach fusing genetics, cell biology, biochemistry and spectroscopy with clinical expertise. To further strengthen our translational agenda, I recently took up a joint appointment between the University of Sheffield and the University of Bradford to head the Institute of Cancer Therapeutics. My contributions led to discovery of novel genetic pathways, influenced healthcare practice and developed new technologies. My early work demonstrated a role for PARP1 and CK2 during chromosomal single-strand break (SSB) repair (NAR 2003, Cell 2004). I then moved into more translational aspects, which led to the identification, for the first time, of a defect in SSB repair in two human disorders (Nature 2005 and 2006). Following training at St Jude Hospital in the US, I employed mice to demonstrate the importance of SSB repair for organismal function (EMBO J 2007 and Nature Neuroscience 2009). My interest in this area led to a search for novel activities that repair topoisomerase-linked DNA breaks and resulted in the discovery of the enzyme that repairs topoisomerase 2 - mediated DNA damage, TDP2 (Nature 2009). This seminal finding is critical for a broad range of human disease including cancer. I demonstrated that topoisomerase-induced DNA breaks are pathogenic in other disorders (Hum Mol Gent 2010, Nature Genetics 2014, Nature Neuroscience 2017) and identified key posttranslational modifications and functions (Nature Communications 2012, NAR 2012 & 2016 and Cell Reports 2018). I reviewed the importance of topoisomerase-mediated DNA repair (Nature Rev Cancer 2015, Brain 2018) and described how it maintains mitochondrial gene transcription (Science Advances 2017). We uncovered a novel mechanism by which typhoid toxin exhausts the DNA repair machinery (Nature Communications 2019) and identified TEX264 as a novel component of the topoisomerase-mediated DNA repair pathway (Nature Communications 2020).

Teaching

Teaching interests

For lab details please visit: https://www.elkhamisylab.com

Professional activities

  • 01-JAN-05: University of Sussex - PhD
  • 01-JAN-02: American university in Cairo - Diploma in Business Administration
  • 01-JAN-00: Ain Shams University - Pharm Sciences
  • 01-JAN-97: Cairo University - PharmB
  • University of Sheffield - Co-Founder of the Healthy Lifespan institute
  • University of Sheffield - Director of Research and Innovation DoMBB
  • University of Sussex - Group Leader and Wellcome Trust Fellow
  • Royal Society of Chemistry, Fellow
  • Royal Society of Biology , Fellow
  • The Lister Institute, Fellow
  • The Pharmaceutical Society, Member
  • HELSI Exec Board,
  • Neuroscience Exec Board ,
  • Res Exec Board,
  • Promotion Committee,
  • 01-JAN-18: - Fellow of the Royal Society of Chemistry
  • 01-JAN-17: - Fellow of the Royal Society of Biology
  • 01-JAN-16: - Shoman Award for Medical Sciences
  • 01-JAN-15: - Wellcome Trust Investigator Award
  • 01-JAN-15: - Lister Research Fellowship Prize
  • 01-JAN-11: - The State Award for Medical Sciences
  • 01-JAN-08: - Welcome Trust Fellowship
  • 01-JAN-04: - Biochemical Society Award
  • Head of ICT
  • Mol Biol and Biotechnology
  • Healthy Life Span Institute
  • Arabic
  • German

Publications

Peer Reviewed Journal
TitleNucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells. (2020)
AuthorsHalliwell JA;Frith TJR;Laing O;Price CJ;Bower OJ;Stavish D;Gokhale PJ;Hewitt Z;El-Khamisy SF;Barbaric I;Andrews PW;
JournalStem Cell Reports
DOI10.1016/j.stemcr.2020.04.004
 
TitleInvestigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. (2020)
AuthorsKim HR;Santhakumar K;Markham E;Baldera D;Greenald D;Bryant HE;El-Khamisy SF;van Eeden FJ;
JournalOncotarget
DOI10.18632/oncotarget.27521
 
TitleTEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. (2020)
AuthorsFielden J;Wiseman K;Torrecilla I;Li S;Hume S;Chiang SC;Ruggiano A;Narayan Singh A;Freire R;Hassanieh S;Domingo E;Vendrell I;Fischer R;Kessler BM;Maughan TS;El-Khamisy SF;Ramadan K;
JournalNature Communications
DOI10.1038/s41467-020-15000-w
 
TitleNucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. (2019)
AuthorsOsman DI;El-Sheikh SM;Sheta SM;Ali OI;Salem AM;Shousha WG;El-Khamisy SF;Shawky SM;
JournalBiosensors and Bioelectronics
DOI10.1016/j.bios.2019.111451
 
TitleTyphoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. (2019)
AuthorsIbler AEM;ElGhazaly M;Naylor KL;Bulgakova NA;F El-Khamisy S;Humphreys D;
JournalNature Communications
DOI10.1038/s41467-019-12064-1
 
TitleDNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms. (2019)
AuthorsAbugable AA;Morris JLM;Palminha NM;Zaksauskaite R;Ray S;El-Khamisy SF;
JournalDNA Repair
DOI10.1016/j.dnarep.2019.102669
 
TitleUVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy. (2018)
AuthorsKassouf N;Kay CWM;Volkov A;Chiang SC;Birch-Machin MA;El-Khamisy SF;Haywood RM;
JournalFree Radical Biology and Medicine
DOI10.1016/j.freeradbiomed.2018.07.019
 
TitleStudying TDP1 Function in DNA Repair. (2018)
AuthorsChiang SC;Liversidge K;El-Khamisy SF;
JournalMethods in molecular biology (Clifton, N.J.)
DOI10.1007/978-1-4939-7459-7_13
 
TitleRecent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's. (2018)
AuthorsFleifel D;Rahmoon MA;AlOkda A;Nasr M;Elserafy M;El-Khamisy SF;
JournalGenetic Engineering and Biotechnology Journal
DOI10.1016/j.jgeb.2018.09.002
 
TitleUCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. (2018)
AuthorsLiao C;Beveridge R;Hudson JJR;Parker JD;Chiang SC;Ray S;Ashour ME;Sudbery I;Dickman MJ;El-Khamisy SF;
JournalCell Reports
DOI10.1016/j.celrep.2018.05.033
 
TitlemiR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. (2018)
AuthorsMohamed Z;Hassan MK;Okasha S;Mitamura T;Keshk S;Konno Y;Kato T;El-Khamisy SF;Ohba Y;Watari H;
JournalOncotarget
DOI10.18632/oncotarget.25698
 
TitlePerturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. (2018)
AuthorsWalker C;El-Khamisy SF;
JournalBrain
DOI10.1093/brain/awy076
 
TitleCompeting endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer. (2018)
AuthorsSamir N;Matboli M;El-Tayeb H;El-Tawdi A;Hassan MK;Waly A;El-Akkad HAE;Ramadan MG;Al-Belkini TN;El-Khamisy S;El-Asmar F;
JournalJournal of Cellular Biochemistry
DOI10.1002/jcb.26884
 
TitleStudy of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells. (2018)
AuthorsMoradzadeh M;Ghorbani A;Erfanian S;Mohaddes ST;Rahimi H;Karimiani EG;Mashkani B;Chiang SC;El-Khamisy SF;Tabarraei A;Sadeghnia HR;
JournalJournal of Cellular Biochemistry
DOI10.1002/jcb.27489
 
TitleGold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. (2018)
AuthorsShawky SM;Awad AM;Abugable AA;El-Khamisy SF;
JournalInternational journal of nanomedicine
DOI10.2147/IJN.S181732
 
TitleRad5, HLTF, and SHPRH: A Fresh View of an Old Story. (2018)
AuthorsElserafy M;Abugable AA;Atteya R;El-Khamisy SF;
JournalTrends in Genetics
DOI10.1016/j.tig.2018.04.006
 
TitleA thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. (2018)
AuthorsSoutham HM;Smith TW;Lyon RL;Liao C;Trevitt CR;Middlemiss LA;Cox FL;Chapman JA;El-Khamisy SF;Hippler M;Williamson MP;Henderson PJF;Poole RK;
JournalRedox Biology
DOI10.1016/j.redox.2018.06.008
 
TitleIncreased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. (2018)
AuthorsHegazy MT;Allam WR;Hussein MA;Zoheir N;Quartuccio L;El-Khamisy SF;Ragab G; ;
JournalEbiomedicine
DOI10.1016/j.ebiom.2018.08.007
 
TitleChoose your yeast strain carefully: the RAD5 gene matters. (2018)
AuthorsElserafy M;El-Khamisy SF;
JournalNature Reviews Molecular Cell Biology
DOI10.1038/s41580-018-0005-2
 
TitleViral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits. (2017)
AuthorsHerranz-Martin S;Chandran J;Lewis K;Mulcahy P;Higginbottom A;Walker C;Valenzuela IMY;Jones RA;Coldicott I;Iannitti T;Akaaboune M;El-Khamisy SF;Gillingwater TH;Shaw PJ;Azzouz M;
JournalDisease models & mechanisms
DOI10.1242/dmm.029892
 
TitleRole of Protein Linked DNA Breaks in Cancer. (2017)
AuthorsAllam WR;Ashour ME;Waly AA;El-Khamisy S;
JournalAdvances in Experimental Medicine and Biology
DOI10.1007/978-3-319-60733-7_3
 
TitlePersonalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism. (2017)
AuthorsAbugable AA;Awwad DA;Fleifel D;Ali MM;El-Khamisy S;Elserafy M;
JournalAdvances in Experimental Medicine and Biology
DOI10.1007/978-3-319-60733-7_9
 
TitleMitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. (2017)
AuthorsChiang SC;Meagher M;Kassouf N;Hafezparast M;McKinnon PJ;Haywood R;El-Khamisy SF;
JournalScience Advances
DOI10.1126/sciadv.1602506
 
TitleSRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. (2017)
AuthorsHautbergue GM;Castelli LM;Ferraiuolo L;Sanchez-Martinez A;Cooper-Knock J;Higginbottom A;Lin YH;Bauer CS;Dodd JE;Myszczynska MA;Alam SM;Garneret P;Chandran JS;Karyka E;Stopford MJ;Smith EF;Kirby J;Meyer K;Kaspar BK;Isaacs AM;El-Khamisy SF;De Vos KJ;Ning K;Azzouz M;Whitworth AJ;Shaw PJ;
JournalNature Communications
DOI10.1038/ncomms16063
 
TitleC9orf72 expansion disrupts ATM-mediated chromosomal break repair. (2017)
AuthorsWalker C;Herranz-Martin S;Karyka E;Liao C;Lewis K;Elsayed W;Lukashchuk V;Chiang SC;Ray S;Mulcahy PJ;Jurga M;Tsagakis I;Iannitti T;Chandran J;Coldicott I;De Vos KJ;Hassan MK;Higginbottom A;Shaw PJ;Hautbergue GM;Azzouz M;El-Khamisy SF;
JournalNature Neuroscience
DOI10.1038/nn.4604
 
TitleChemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. (2017)
AuthorsAtteya R;Ashour ME;Ibrahim EE;Farag MA;El-Khamisy SF;
JournalMechanisms of Ageing and Development
DOI10.1016/j.mad.2016.04.012
 
TitleBuilding Bridges through Science. (2017)
AuthorsLissek T;Adams M;Adelman J;Ahissar E;Akaaboune M;Akil H;al'Absi M;Arain F;Arango-Lasprilla JC;Atasoy D;Avila J;Badawi A;Bading H;Baig AM;Baleriola J;Belmonte C;Bertocchi I;Betz H;Blakemore C;Blanke O;Boehm-Sturm P;Bonhoeffer T;Bonifazi P;Brose N;Campolongo P;Celikel T;Chang CC;Chang TY;Citri A;Cline HT;Cortes JM;Cullen K;Dean K;Delgado-Garcia JM;Desroches M;Disterhoft JF;Dowling JE;Draguhn A;El-Khamisy SF;El Manira A;Enam SA;Encinas JM;Erramuzpe A;Esteban JA;Fariñas I;Fischer E;Fukunaga I;Gabilondo I;Ganten D;Gidon A;Gomez-Esteban JC;Greengard P;Grinevich V;Gruart A;Guillemin R;Hariri AR;Hassan B;Häusser M;Hayashi Y;Hussain NK;Jabbar AA;Jaber M;Jahn R;Janahi EM;Kabbaj M;Kettenmann H;Kindt M;Knafo S;Köhr G;Komai S;Krugers H;Kuhn B;Ghazal NL;Larkum ME;London M;Lutz B;Matute C;Martinez-Millan L;Maroun M;McGaugh J;Moustafa AA;Nasim A;Nave KA;Neher E;Nikolich K;Outeiro T;Palmer LM;Penagarikano O;Perez-Otano I;Pfaff DW;Poucet B;Rahman AU;Ramos-Cabrer P;Rashidy-Pour A;Roberts RJ;Rodrigues S;Sanes JR;Schaefer AT;Segal M;Segev I;Shafqat S;Siddiqui NA;Soreq H;Soriano-García E;Spanagel R;Sprengel R;Stuart G;Südhof TC;Tønnesen J;Treviño M;Uthman BM;Venter JC;Verkhratsky A;Weiss C;Wiesel TN;Yaksi E;Yizhar O;Young LJ;Young P;Zawia NH;Zugaza JL;Hasan MT;
JournalNeuron
DOI10.1016/j.neuron.2017.09.028
 
TitleEpigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. (2017)
AuthorsMeisenberg C;Ashour ME;El-Shafie L;Liao C;Hodgson A;Pilborough A;Khurram SA;Downs JA;Ward SE;El-Khamisy SF;
JournalNucleic Acids Research
DOI10.1093/nar/gkw1026
 
TitleGold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. (2017)
AuthorsShawky SM;Awad AM;Allam W;Alkordi MH;El-Khamisy SF;
JournalBiosensors and Bioelectronics
DOI10.1016/j.bios.2016.11.001
 
TitleA Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. (2016)
AuthorsMazouzi A;Stukalov A;Müller AC;Chen D;Wiedner M;Prochazkova J;Chiang SC;Schuster M;Breitwieser FP;Pichlmair A;El-Khamisy SF;Bock C;Kralovics R;Colinge J;Bennett KL;Loizou JI;
JournalCell Reports
DOI10.1016/j.celrep.2016.03.077
 
TitleIsoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. (2016)
AuthorsElsayed W;El-Shafie L;Hassan MK;Farag MA;El-Khamisy SF;
JournalScientific Reports
DOI10.1038/srep26626
 
TitleExpression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. (2015)
AuthorsCarroll J;Page TK;Chiang SC;Kalmar B;Bode D;Greensmith L;Mckinnon PJ;Thorpe JR;Hafezparast M;El-Khamisy SF;
JournalHuman Molecular Genetics
DOI10.1093/hmg/ddu500
 
TitleClinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. (2015)
AuthorsMeisenberg C;Gilbert DC;Chalmers A;Haley V;Gollins S;Ward SE;El-Khamisy SF;
JournalMolecular Cancer Therapeutics
DOI10.1158/1535-7163.MCT-14-0762
 
TitleTopoisomerase-mediated chromosomal break repair: an emerging player in many games. (2015)
AuthorsAshour ME;Atteya R;El-Khamisy SF;
JournalNature Reviews. Cancer
DOI10.1038/nrc3892
 
TitleP18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane. (2015)
AuthorsHassan MK;Watari H;Mitamura T;Mohamed Z;El-Khamisy SF;Ohba Y;Sakuragi N;
JournalONCOSCIENCE
DOI10.18632/oncoscience.143
 
TitleTDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. (2014)
AuthorsMeisenberg C;Ward SE;Schmid P;El-Khamisy SF;
JournalJournal of Cancer Science and Therapy
DOI10.4172/1948-5956.1000280
 
TitleTDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. (2014)
AuthorsGómez-Herreros F;Schuurs-Hoeijmakers JH;McCormack M;Greally MT;Rulten S;Romero-Granados R;Counihan TJ;Chaila E;Conroy J;Ennis S;Delanty N;Cortés-Ledesma F;de Brouwer AP;Cavalleri GL;El-Khamisy SF;de Vries BB;Caldecott KW;
JournalNature Genetics
DOI10.1038/ng.2929
 
TitleDevelopment of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. (2014)
AuthorsWalker S;Meisenberg C;Bibby RA;Askwith T;Williams G;Rininsland FH;Pearl LH;Oliver AW;El-Khamisy S;Ward S;Atack JR;
JournalAnalytical Biochemistry
DOI10.1016/j.ab.2014.03.004
 
TitleTDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. (2014)
AuthorsAlagoz M;Wells OS;El-Khamisy SF;
JournalNucleic Acids Research
DOI10.1093/nar/gkt1260
 
TitleATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. (2013)
AuthorsAlagoz M;Chiang SC;Sharma A;El-Khamisy SF;
JournalPLoS ONE
DOI10.1371/journal.pone.0058239
 
TitleTopoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets. (2012)
AuthorsGilbert DC;Chalmers AJ;El-Khamisy SF;
JournalBritish Journal of Cancer
DOI10.1038/bjc.2011.498
 
TitleSUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair. (2012)
AuthorsHudson JJ;Chiang SC;Wells OS;Rookyard C;El-Khamisy SF;
JournalNature Communications
DOI10.1038/ncomms1739
 
TitleDNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets. (2012)
AuthorsAlagoz M;Gilbert DC;El-Khamisy S;Chalmers AJ;
JournalCurrent Medicinal Chemistry
DOI10.2174/092986712802002590
 
TitleTDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. (2012)
AuthorsZeng Z;Sharma A;Ju L;Murai J;Umans L;Vermeire L;Pommier Y;Takeda S;Huylebroeck D;Caldecott KW;El-Khamisy SF;
JournalNucleic Acids Research
DOI10.1093/nar/gks622
 
TitleTyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites. (2012)
AuthorsLebedeva NA;Rechkunova NI;El-Khamisy SF;Lavrik OI;
JournalBIOCHIMIE
DOI10.1016/j.biochi.2012.04.004
 
TitleTDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. (2011)
AuthorsZeng Z;Cortés-Ledesma F;El Khamisy SF;Caldecott KW;
JournalJournal of Biological Chemistry
DOI10.1074/jbc.M110.181016
 
TitleTo live or to die: a matter of processing damaged DNA termini in neurons. (2011)
AuthorsEl-Khamisy SF;
JournalEMBO Molecular Medicine
DOI10.1002/emmm.201000114
 
TitleTDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage. (2010)
AuthorsChiang SC;Carroll J;El-Khamisy SF;
JournalCell Cycle
DOI10.4161/cc.9.3.10598
 
TitleMutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. (2010)
AuthorsKerzendorfer C;Whibley A;Carpenter G;Outwin E;Chiang SC;Turner G;Schwartz C;El-Khamisy S;Raymond FL;O'Driscoll M;
JournalHuman Molecular Genetics
DOI10.1093/hmg/ddq008
 
TitleThe genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. (2009)
AuthorsLee Y;Katyal S;Li Y;El-Khamisy SF;Russell HR;Caldecott KW;McKinnon PJ;
JournalNature Neuroscience
DOI10.1038/nn.2375
 
TitleDefective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia (2009)
AuthorsReynolds J.;El-Khamisy S.;Katyal S.;Clements P.;McKinnon P.;Caldecott K.
JournalMolecular and Cellular Biology
DOI10.1128/MCB.01471-08
 
TitleShort-patch single-strand break repair in ataxia oculomotor apraxia-1. (2009)
AuthorsReynolds JJ;El-Khamisy SF;Caldecott KW;
JournalBiochemical Society Transactions
DOI10.1042/BST0370577
 
TitleA human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. (2009)
AuthorsCortes Ledesma F;El Khamisy SF;Zuma MC;Osborn K;Caldecott KW;
JournalNature
DOI10.1038/nature08444
 
TitleSynergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. (2009)
AuthorsEl-Khamisy SF;Katyal S;Patel P;Ju L;McKinnon PJ;Caldecott KW;
JournalDNA Repair
DOI10.1016/j.dnarep.2009.02.002
 
TitleTDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. (2007)
AuthorsEl-Khamisy SF;Hartsuiker E;Caldecott KW;
JournalDNA Repair
DOI10.1016/j.dnarep.2007.04.015
 
TitleTDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. (2007)
AuthorsKatyal S;el-Khamisy SF;Russell HR;Li Y;Ju L;Caldecott KW;McKinnon PJ;
JournalEMBO Journal
DOI10.1038/sj.emboj.7601869
 
TitleDNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. (2007)
AuthorsEl-Khamisy SF;Caldecott KW;
JournalNeuroscience
DOI10.1016/j.neuroscience.2006.08.048
 
TitleAPLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. (2007)
AuthorsIles N;Rulten S;El-Khamisy SF;Caldecott KW;
JournalMolecular and Cellular Biology
DOI10.1128/MCB.02269-06
 
TitleThe neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. (2006)
AuthorsAhel I;Rass U;El-Khamisy SF;Katyal S;Clements PM;McKinnon PJ;Caldecott KW;West SC;
JournalNature
DOI10.1038/nature05164
 
TitleTDP1-dependent DNA single-strand break repair and neurodegeneration. (2006)
AuthorsEl-Khamisy SF;Caldecott KW;
JournalMutagenesis
DOI10.1093/mutage/gel024
 
TitleMeasurement of Chromosomal DNA Single-Strand Breaks and Replication Fork Progression Rates (2006)
AuthorsBreslin C.;Clements P.;El-Khamisy S.;Petermann E.;Iles N.;Caldecott K.
JournalMethods in Enzymology
DOI10.1016/S0076-6879(05)09024-5
 
TitleDefective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. (2005)
AuthorsEl-Khamisy SF;Saifi GM;Weinfeld M;Johansson F;Helleday T;Lupski JR;Caldecott KW;
JournalNature
DOI10.1038/nature03314
 
TitleThe protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks (2004)
AuthorsLoizou J.;El-Khamisy S.;Zlatanou A.;Moore D.;Chan D.;Qin J.;Sarno S.;Meggio F.;Pinna L.;Caldecott K.
JournalCell
DOI10.1016/S0092-8674(04)00206-5
 
TitleA requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. (2003)
AuthorsEl-Khamisy SF;Masutani M;Suzuki H;Caldecott KW;
JournalNucleic Acids Research
DOI10.1093/nar/gkg761
 
Book Chapters
TitleStudying TDP1 function in DNA repair (2018)
AuthorsChiang S.;Liversidge K.;El-Khamisy S.
JournalMethods in molecular biology (Clifton, N.J.)
DOI10.1007/978-1-4939-7459-7_13
 
TitleRole of protein linked DNA breaks in cancer (2017)
AuthorsAllam W.;Ashour M.;Waly A.;El-Khamisy S.
JournalAdvances in Experimental Medicine and Biology
DOI10.1007/978-3-319-60733-7_3
 
Other Publications
Other typeReviews
TitleDNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms (2019)
AuthorsAbugable A.A.;Morris J.L.M.;Palminha N.M.;Zaksauskaite R.;Ray S.;El-Khamisy S.F.
JournalDNA Repair
DOI10.1016/j.dnarep.2019.102669
 
Other typeReviews
TitleNucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis (2019)
AuthorsOsman D.I.;El-Sheikh S.M.;Sheta S.M.;Ali O.I.;Salem A.M.;Shousha W.G.;EL-Khamisy S.F.;Shawky S.M.
JournalBiosensors and Bioelectronics
DOI10.1016/j.bios.2019.111451
 
Other typeReviews
TitlePerturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia (2018)
AuthorsWalker C.;El-Khamisy S.
JournalBrain
DOI10.1093/brain/awy076
 
Other typeReviews
TitleTopoisomerase i inhibition in colorectal cancer: Biomarkers and therapeutic targets (2012)
AuthorsGilbert D.;Chalmers A.;El-Khamisy S.
JournalBritish Journal of Cancer
DOI10.1038/bjc.2011.498
 
Other typeReviews
TitleTo live or to die: A matter of processing damaged DNA termini in neurons (2011)
AuthorsEl-Khamisy S.
JournalEMBO Molecular Medicine
DOI10.1002/emmm.201000114
 
Other typeReviews
TitleDNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 (2007)
AuthorsEl-Khamisy S.;Caldecott K.
JournalNeuroscience
DOI10.1016/j.neuroscience.2006.08.048
 
Other typeReviews
TitleTDP1-dependent DNA single-strand break repair and neurodegeneration (2006)
AuthorsEl-Khamisy S.;Caldecott K.
JournalMutagenesis
DOI10.1093/mutage/gel024