Dr Anna Wu
Lecturer in Bio-Organic Chemistry
| Faculty/Dept/School |
School of Chemistry and Bioscience (Faculty of Life Sciences) |
|---|---|
| n.wu1@bradford.ac.uk |
Biography
Dr. Na (also Anna) Wu has embarked on an international journey to pursue her research career. She studied organic synthesis first at the Shann’xi Normal University (BS in Chemistry) and then at Peking University (2006-2010, MS & Ph.D. in Synthesis & Catalysis, emphasizing the use of Pauson-Khand reaction (PKR) in the total synthesis of (±)-Pentalenolactone-a Methyl Ester) with Prof. Zhen Yang, formally graduating in June 2012. Anna was a visiting researcher at Durham University from 2010-11, hosted by Prof Todd Marder where she studied palladium-thiourea catalyzed enyne domino reactions. This was followed by a postdoctoral research assistant position with Prof. Simon Woodward at University of Nottingham in 2013, where she studied the trichloromethide addition mechanism. She held the Research Fellowship at Guangxi Normal University in 2015. In 2018, Anna was awarded the prestigious Royal Society Newton International Research Fellowship to work at the University of Oxford under the supervision of Prof. Edward Anderson. Anna came to Durham University in June 2018 to continue the fellowship under the supervision of Prof. Andy Whiting. In 2020, she takes up the position of Lecturer in Bioorganic Chemistry at the University of Bradford, which allows her to start an independent research on organic synthesis and catalysis.
Dr. Wu is the recipient of national and international awards and research grants: UK-China joint training doctoral students scholarship awarded by CSC (Chinese Scholarship Council), 2010-2011, Guangxi Province Key Laboratory grant, 2014-2017, Research Grant awarded by National Nature Science Foundation of China, 2015-2018, Young Investigator Research Grant awarded by Guangxi Provincial Nature Science Foundation, 2015-2017, Research Grant from Peking University Shenzhen graduate school, 2016, Newton International Research Fellowship, awarded by the UK Royal Society, Marie Sklodowska-Curie Actions Seal of Excellence, awarded by European Commission, 2018. She is also a member of the RSC.
For full publications, see https://orcid.org/0000-0003-1668-6652
Research
To develop an easy-to-handle, ready-to-scale-up method that would be attractive in industry to access diversified ynamides, via copper-free Sonogashira coupling reaction in water. The currently environmentally-friendly simple route allows for large scale preparation of ynamides, and further, providing a practical perspective on the de novo synthesis of complex natural product-based ynamides.To synthesize polyenes that are linked with electron-donors and acceptors as potential energy storage materials and near-infrared luminescience.
Catalyst free one-pot esterification and amidation.
Palladium-catalysed reductive Heck cycloisomerisation of en-ynamides and the mechanistic study.
Teaching
Teaching highlights
carbene, nitrene, radicals, photosynthesis, Hammett plots, kinetic isotope effect, aromatic chemistry, analysis and synthesis of medium-size rings
Professional activities
- 01-JAN-10: Durham University - visiting PhD
- 01-JAN-12: Peking University - PhD
- 01-JAN-08: Peking University - Msc.
- 01-JAN-06: Shann'xi Normal University - Bachelor
- 06-FEB-20: University of Bradford - Lecturer in Bio-Organic Chemistry
- 04-JUN-18: Durham University - Newton International Fellow
- 15-JAN-18: University of Oxford - Newton International Fellow
- 01-JAN-15: Guangxi Normal University - Research Fellow
- 03-JAN-13: University of Nottingham - Postdoctoral Research Assistant
- 14-MAR-14: Guangxi Normal University - Teaching Fellow
- Royal Society of Chemistry, member
- Royal Society, Newton International Fellow alumni
- 01-JAN-19: ‘Light of Spring’ Short-Term Residence Research Travel Grant
- 01-JAN-19: Summer Bursary Studentship
- 01-JAN-19: Ring-Fenced Carbon Management Budget
- 01-JAN-18: Interdisciplinary Small Grant
- 01-JAN-18: Travel Grant
- 01-JAN-18: Marie Sklodowska-Curie Actions Seal of Excellence
- 01-JAN-18: Newton International Fellowship
- 01-JAN-16: visiting research grant
- 01-JAN-15: Undergraduates Innovation Studentship
- 01-JAN-15: Young Investigator Research Grant
- 01-JAN-15: Young Investigator Research Grant
- 01-JAN-14: Research Grant
- 01-JAN-15: National Research Grant
- 01-JAN-14: Dean Grant
- 01-JAN-11: 3rd prize in new energy and low-carbon economy PhD forum
- 01-JAN-10: Research Honorable Mention for The Synthetic Study of Natural Bioactive Product Cortistatin A
- 01-JAN-10: UK-China joint PhD scholarship
- 01-JAN-08: Ph.D. national scholarship
- 01-JAN-06: Postgraduate national scholarship
- English
Publications
| Peer Reviewed Journal | |
|---|---|
| Title | Synthesis of Orthogonal Push-Pull Chromophores via Click Reaction of Arylynamines (2022) |
| Authors | Shuangping Huang, Jing Ma, Yikun Yi, Mingtao Li, Ping Cai and Na Wu* |
| Journal | Org Biomol Chem |
| Title | Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water. (2021) |
| Authors | Zhao L;Yang H;Li R;Tao Y;Guo XF;Anderson EA;Whiting A;Wu N; |
| Journal | Journal of Organic Chemistry |
| DOI | 10.1021/acs.joc.0c02326 |
| Title | Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water (2021) |
| Authors | Lei Zhao, Hongyi Yang, Ruikun Li, Ye Tao, Xiao-Feng Guo, Edward A. Anderson, Andy Whiting and Na Wu* |
| Journal | Journal of Organic Chemistry |
| Title | Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides (2019) |
| Authors | Hou, Y; Ma, J; Yang, H; Anderson, EA; Whiting, A; Wu Na |
| Journal | Chemical Communications (Cambridge, England) |
| Title | A concise and straightforward approach to total synthesis of (+)-Strictifolione and formal synthesis of Cryptofolione via a unified strategy (2019) |
| Authors | Li, X; Wang, G; Zhang, Z; Wu, Na; Yang, Q; Huang, S; Wang, X |
| Journal | Synthetic Communications |
| Title | Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarazone ligands (2018) |
| Authors | Deng, J; Yu, P; Zhang, Z; Wang, J; Cai, J; Wu, Na; Sun, W; Liang, H; Yang, F |
| Journal | European Journal of Medicinal Chemistry |
| Title | Application of dehydroabietic acid in palladium-catalysed enyne cycloisomerisation (2017) |
| Authors | Wu, N; Li, R; Cui, F; Pan, Y |
| Journal | Advanced Synthesis and Catalysis |
| DOI | 10.1002/adsc.201700061 |
| Title | TfOH-Catalyzed Reaction of Bispropargyl Alcohols with 1,3-Dicarbonyl Compounds (2016) |
| Authors | Teng, Q; Mo, S; Pan, J; Wu, Na; Wang, H; Pan Y |
| Journal | Synthesis |
| Title | A nordehydroabietyl amide-containing chiral diene for rhodium-catalysed asymmetric arylation to nitroolefins (2016) |
| Authors | Li, R; Wen, Z; Wu, Na |
| Journal | Organic and Biomolecular Chemistry |
| Title | Atom-economical chemoselective synthesis of furocoumarins via cascade palladium catalyzed oxidative aloxylation of 4-oxohydrocoumarins and alkenes (2015) |
| Authors | Tan, X; Zhao, H; Pan, Y; Wu, Na; Wang, H; Chen, Z |
| Journal | RSC Advances |
| DOI | 10.1039/c4ra15732j |
| Title | 1,4-addition of TMSCCI |
| Authors | Wu, Na; Wahl, B; Woodward, S; Lewis, W |
| Journal | Chemistry - A European Journal |
| DOI | 10.1002/chem.201402394 |
| Title | One-pot stepwise approach to β-enaminoketoesters through "masked" 1,3-aza-dipoles (2014) |
| Authors | Yan ZM;Wu N;Liang D;Wang HS;Pan YM; |
| Journal | Organic Letters |
| DOI | 10.1021/ol501930f |
| Title | Reverse regioselectivity in the palladium(II) thiourea catalyzed intermolecular Pauson-Khand reaction. (2013) |
| Authors | Wu N;Deng L;Liu L;Liu Q;Li C;Yang Z; |
| Journal | Chemistry - An Asian Journal |
| DOI | 10.1002/asia.201200783 |
| Title | Palladium(II)-catalysed tandem cyclisation of electron-deficient aromatic enynes. (2012) |
| Authors | Wu N;Messinis A;Batsanov AS;Yang Z;Whiting A;Marder TB; |
| Journal | Chemical Communications |
| DOI | 10.1039/c2cc35114e |
| Title | An irreversible phase transition in 1-n-butylindeno[2,1-c]pyran-3,9-dione. (2012) |
| Authors | Batsanov AS;Howard JA;Wu N;Yang Z;Marder TB; |
| Journal | Acta Crystallographica Section C: Crystal Structure Communications |
| DOI | 10.1107/S010827011203805X |
| Title | Total synthesis of (±)-pentalenolactone A methyl ester. (2012) |
| Authors | Liu Q;Yue G;Wu N;Lin G;Li Y;Quan J;Li CC;Wang G;Yang Z; |
| Journal | Angewandte Chemie - International Edition |
| DOI | 10.1002/anie.201206705 |
| Title | A model study for the concise construction of the oxapentacyclic core of cortistatins through intramolecular Diels-Alder and oxidative dearomatization-cyclization reactions (2009) |
| Authors | Liu L.;Gao Y.;Che C.;Wu N.;Wang D.Z.;Li C.C.;Yang Z. |
| Journal | Chemical Communications |
| DOI | 10.1039/b817376a |
| Title | Unexpected regioselectivity in the synthesis of pyranonaphthoquinone via the Diels-Alder reaction. (2009) |
| Authors | Cui Y;Jiang H;Li Z;Wu N;Yang Z;Quan J; |
| Journal | Organic Letters |
| DOI | 10.1021/ol901902v |
| Title | Diversity-oriented synthesis of fused pyran gamma-lactones via an efficient Pd-thiourea-catalyzed alkoxycarbonylative annulation. (2008) |
| Authors | Li Z;Gao Y;Jiao Z;Wu N;Wang DZ;Yang Z; |
| Journal | Organic Letters |
| DOI | 10.1021/ol802115u |
| Book Chapters | |
|---|---|
| Title | The Chemistry of Ynamide and Its Application in Organic Synthesis (2020) |
| Authors | Siyu Ye, Na Wu |
| Journal | Advances in Organic Synthesis |
| Publisher | Bentham Science Publishers |