Professor Marcus Rattray
Professor of Pharmacology
| Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
|---|---|
| m.rattray@bradford.ac.uk | |
| Telephone | +441274 234675 |
Biography
Joined the University of Bradford as Professor of Pharmacology and Head of the School of Pharmacy & Medical Sciences (Jan 2013-July 2019). He is currently University academic lead for the Wolfson Centre for Applied Health Research. Previously Reader in Pharmacology at the University of Reading (2008-2013), Senior Lecturer in Biochemistry King's College London (1998-2007), Lecturer in Biochemistry United Medical & Dental Schools of Guys & St Thomas' Hospitals (1989-1997) and Gene Neuroscience Fellow at NIDA/NIH, Baltimore (1988-1989). Marcus is a Fellow of the British Pharmacological Society and a Scientist member of the Royal Pharmaceutical Society.
Research
I have a background in neuroscience and molecular pharmacology, with the majority of my published research being in the area of neurotransmission, neurotransmitter transporters, drugs of abuse and neurodegeneration (Alzheimer's, Motor Neurone Disease).My current work is in the area of Applied Health Research. I work within the Medicines Optimisation Research Group at the University of Bradford. Current projects include studying the implementation and utility of pharmacogenomics tools for patient benefit to reduce hospital admissions in the elderly. I am also involved in research on community-based activity (health champions) who can help improve knowledge of symptoms and health systems to support people to have better health and access health services.
My current work links to the Wolfson Centre for Applied Health Research, a collaboration between Bradford Teaching Hospitals NHS Foundation Trust, University of Bradford and University of Leeds, and I am the University of Bradford academic lead for this major project.
Teaching
Teaching interests
Pharmacology
Biochemistry
Neuroscience
Neurodegeneration
Evidence-based medicine
Professional activities
- 01-JAN-84: University of Leeds - BSc
- 01-JAN-87: University of London - PhD
- 01-APR-17: University of Bradford - Head, School of Pharmacy & Medical Sciences
- 01-JAN-13: University of Bradford - Head, School of Pharmacy
- 01-FEB-13: University of Reading - Visiting Senior Research Fellow
- 01-JAN-08: King’s College London - Visiting Senior Research Fellow
- 01-JAN-08: University of Reading - Reader in Pharmacology, Reading School of Pharmacy
- 01-OCT-11: University of Reading - Director of Research
- 01-SEP-09: University of Reading - Director of Pharmacology and Therapeutics
- 01-MAR-08: University of Reading - Director of Therapeutics
- 01-OCT-06: Winston Churchill Memorial - Winston Churchill Memorial Trust Fellow
- 01-AUG-98: King’s College London - Senior Lecturer in Biochemistry
- 01-OCT-97: University of London - Senior Lecturer in Biochemistry
- 01-OCT-89: University of London - Lecturer in Biochemistry
- 01-FEB-88: NIH, Addiction Research Center, Baltimore, USA - Visiting Fellow
- 01-JAN-17: - FBPhS
- @BfdCafe twitter & facebook Monthly events bringing a scientist to a venue near you.
- Presenter Research Matters Radio Programme on BCB. Programme every 4 weeks highlighting research and research events in Bradford & Relevant to Bradford. BCB106.6FM http://www.bcbradio.co.uk/
- Trustee: Trustee, European Society for Neurochemistry
Publications
| Peer Reviewed Journal | |
|---|---|
| Title | Endoplasmic reticulum stress signalling induces casein kinase 1-dependent formation of cytosolic TDP-43 Inclusions in motor neuron-like cells (2019) |
| Authors | Hicks, D.A.; Cross, Laura L.; Williamson, Ritchie; Rattray, Marcus |
| Journal | Neurochemical Research |
| DOI | 10.1007/s11064-019-02832-2 |
| Title | Riluzole-Triazole Hybrids as Novel Chemical Probes for Neuroprotection in Amyotrophic Lateral Sclerosis (2018) |
| Authors | Sweeney J.;Rattray M.;Pugh V.;Powell L. |
| Journal | ACS Medicinal Chemistry Letters |
| DOI | 10.1021/acsmedchemlett.8b00103 |
| Title | Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection (2017) |
| Authors | Ugbode C.;Smith I.;Whalley B.;Hirst W.;Rattray M. |
| Journal | Journal of Neurochemistry |
| DOI | 10.1111/jnc.14064 |
| Title | Astrocytic Transporters in Alzheimer’s disease (2017) |
| Authors | Ugbode, Christopher I.; Yuhan, H.; Whalley, B.J.; Peers, C.; Rattray, Marcus; Dallas, M. |
| Journal | Biochemical Journal |
| DOI | https://doi.org/10.1042/BCJ20160505 |
| Title | Astrocytes Grown in Alvetex®Three Dimensional Scaffolds Retain a Non-reactive Phenotype (2016) |
| Authors | Ugbode C.;Hirst W.;Rattray M. |
| Journal | Neurochemical Research |
| DOI | 10.1007/s11064-016-1911-3 |
| Title | Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. (2015) |
| Authors | Smith, I.; Haag, M.; Ugbode, Christopher I.; Tams, D.; Rattray, Marcus; Przyborski, S.; Bithell, A.; Whalley, B.J. |
| Title | Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan (2014) |
| Authors | Leoni, G.; Rattray, Marcus; Fulton, D.; Rivera, A.; Butt, A.M. |
| Journal | Journal of Anatomy |
| DOI | 10.1111/joa.12141 |
| Title | Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes. (2014) |
| Authors | Ugbode, Christopher I.; Hirst, W.D.; Rattray, Marcus |
| Title | SUMO-1 conjugation blocks beta-amyloid-induced astrocyte reactivity. (2013) |
| Authors | Hoppe, J.B.; Rattray, Marcus; Tu, H.; Salbego, C.G.; Cimarosti, H. |
| Title | Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor (2013) |
| Authors | Rendeiro, C.; Vauzour, D.; Rattray, Marcus; Waffo-Téguo, P.; Mérillon, J.M.; Butler, L.T.; Williams, C.M.; Spencer, J.P.E. |
| Title | Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. (2012) |
| Authors | Spilsbury, A.; Vauzour, D.; Spencer, J.P.E.; Rattray, Marcus |
| Title | New insights on regulation of LMTK2, a membrane kinase integrating pathways central to neurodegeneration. (2012) |
| Authors | Rattray, Marcus |
| Title | Riluzole neuroprotection in a parkinson’s disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. (2012) |
| Authors | Carbone, M.; Duty, S.; Rattray, Marcus |
| Title | Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. (2012) |
| Authors | Bahia, P.K.; Pugh, V.; Hoyland, K.; Rattray, Marcus; Williams, R.J. |
| Title | Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. (2012) |
| Authors | Rendeiro C;Vauzour D;Kean RJ;Butler LT;Rattray M;Spencer JP;Williams CM; |
| Journal | Psychopharmacology |
| DOI | 10.1007/s00213-012-2719-8 |
| Title | Riluzole elevates GLT-1 activity and levels in striatal astrocytes (2012) |
| Authors | Carbone, M.; Duty, S.; Rattray, Marcus |
| Title | Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration (2010) |
| Authors | Rainey-Smith, S.R.; Andersson, D.A.; Williams, R.J.; Rattray, Marcus |
| Title | The four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies (2009) |
| Authors | Peacey, E.; Miller, C.C.; Dunlop, J.; Rattray, Marcus |
| Title | Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. (2008) |
| Authors | Rainey-Smith S;Schroetke LW;Bahia P;Fahmi A;Skilton R;Spencer JP;Rice-Evans C;Rattray M;Williams RJ; |
| Journal | Neuroscience Letters |
| DOI | 10.1016/j.neulet.2008.04.056 |
| Title | Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes (2008) |
| Authors | Bahia, P.K.; Rattray, Marcus; Williams, R.J. |
| Title | (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. (2007) |
| Authors | Schroeter H;Bahia P;Spencer JP;Sheppard O;Rattray M;Cadenas E;Rice-Evans C;Williams RJ; |
| Journal | Journal of Neurochemistry |
| DOI | 10.1111/j.1471-4159.2006.04434.x |
| Title | Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels. (2006) |
| Authors | Marshall AJ;Rattray M;Vaughan PF; |
| Journal | Journal of Brain Research |
| DOI | 10.1016/j.brainres.2006.05.008 |
| Title | Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. (2006) |
| Authors | Hayat S;Williams RJ;Rattray M; |
| Journal | Journal of Psychopharmacology |
| DOI | 10.1177/0269881106063273 |
| Title | Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities? (2006) |
| Authors | Rattray M;Bendotti C; |
| Journal | Experimental Neurology |
| DOI | 10.1016/j.expneurol.2006.05.001 |
| Title | Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. (2005) |
| Authors | Dolman D;Drndarski S;Abbott NJ;Rattray M; |
| Journal | Journal of Neurochemistry |
| DOI | 10.1111/j.1471-4159.2005.03111.x |
| Title | Technology evaluation: colostrinin, ReGen. (2005) |
| Authors | Rattray M; |
| Journal | Current Opinion in Molecular Therapeutics |
| Title | Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. (2004) |
| Authors | Tortarolo M;Crossthwaite AJ;Conforti L;Spencer JP;Williams RJ;Bendotti C;Rattray M; |
| Journal | Journal of Neurochemistry |
| Title | Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. (2003) |
| Authors | File SE;Hartley DE;Alom N;Rattray M; |
| Journal | Neuroscience Letters |
| Title | The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. (2003) |
| Authors | Suchak SK;Baloyianni NV;Perkinton MS;Williams RJ;Meldrum BS;Rattray M; |
| Journal | Journal of Neurochemistry |
| Title | Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. (2001) |
| Authors | Ramirez MJ;Heslop KE;Francis PT;Rattray M; |
| Journal | Journal of Brain Research |
| Title | Nicotine regulates 5-HT(1A) receptor gene expression in the cerebral cortex and dorsal hippocampus. (2001) |
| Authors | Kenny PJ;File SE;Rattray M; |
| Journal | European Journal of Neuroscience |
| Title | Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels. (2001) |
| Authors | Bendotti C;Tortarolo M;Suchak SK;Calvaresi N;Carvelli L;Bastone A;Rizzi M;Rattray M;Mennini T; |
| Journal | Journal of Neurochemistry |
| Title | Is there nicotinic modulation of nerve growth factor? Implications for cholinergic therapies in Alzheimer's disease. (2001) |
| Authors | Rattray M; |
| Journal | Biological Psychiatry |
| Title | Elevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate. (2001) |
| Authors | Yip PK;Meldrum BS;Rattray M; |
| Journal | Journal of Neurochemistry |
| Title | Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus. (2000) |
| Authors | Kenny PJ;File SE;Rattray M; |
| Journal | Molecular Brain Research |
| Title | Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. (1999) |
| Authors | French SJ;Humby T;Horner CH;Sofroniew MV;Rattray M; |
| Journal | Molecular Brain Research |
| Title | Intraregional variation in expression of serotonin transporter messenger RNA by 5-hydroxytryptamine neurons. (1999) |
| Authors | Rattray M;Michael GJ;Lee J;Wotherspoon G;Bendotti C;Priestley JV; |
| Journal | Neuroscience |
| Title | Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles. (1998) |
| Authors | Hirst WD;Price GW;Rattray M;Wilkin GP; |
| Journal | Neurochemistry International |
| Title | Variation in the expression of the mRNA for protein kinase C isoforms in the rat suprachiasmatic nuclei, caudate putamen and cerebral cortex. (1998) |
| Authors | Cagampang FR;Rattray M;Campbell IC;Powell JF;Coen CW; |
| Journal | Molecular Brain Research |
| Title | Effects of hypophysectomy and growth hormone administration on the mRNA levels of collagen I, III and insulin-like growth factor-I in rat skeletal muscle. (1998) |
| Authors | Wilson VJ;Rattray M;Thomas CR;Moreland BH;Schulster D; |
| Journal | Growth Hormone and IGF Research |
| Title | Genes encoding multiple forms of phospholipase A2 are expressed in rat brain. (1998) |
| Authors | Molloy GY;Rattray M;Williams RJ; |
| Journal | Neuroscience Letters |
| Title | Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase. (1998) |
| Authors | Hirst WD;Cheung NY;Rattray M;Price GW;Wilkin GP; |
| Journal | Molecular Brain Research |
| Title | Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder. (1998) |
| Authors | Oddiah D;Anand P;McMahon SB;Rattray M; |
| Journal | NeuroReport |
| Title | Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. (1998) |
| Authors | Akbar MT;Rattray M;Williams RJ;Chong NW;Meldrum BS; |
| Journal | Neuroscience |
| Title | Selective up-regulation of protein kinase C epsilon in granule cells after kainic acid-induced seizures in rat. (1997) |
| Authors | Guglielmetti F;Rattray M;Baldessari S;Butelli E;Samanin R;Bendotti C; |
| Journal | Molecular Brain Research |
| Title | TrkA immunoreactive neurones in the rat spinal cord. (1997) |
| Authors | Michael GJ;Kaya E;Averill S;Rattray M;Clary DO;Priestley JV; |
| Journal | Journal of Comparative Neurology |
| Title | Expression of GABA transporter mRNAs in the developing and adult rat optic nerve. (1997) |
| Authors | Howd AG;Rattray M;Butt AM; |
| Journal | Neuroscience Letters |
| Title | Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. (1997) |
| Authors | Michael GJ;Averill S;Nitkunan A;Rattray M;Bennett DL;Yan Q;Priestley JV; |
| Journal | Journal of Neuroscience |
| Title | Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. (1997) |
| Authors | Hirst WD;Price GW;Rattray M;Wilkin GP; |
| Journal | British Journal of Pharmacology |
| DOI | 10.1038/sj.bjp.0700921 |
| Title | Circadian changes of glutamate decarboxylase 65 and 67 mRNA in the rat suprachiasmatic nuclei. (1996) |
| Authors | Cagampang FR;Rattray M;Powell JF;Campbell IC;Coen CW; |
| Journal | NeuroReport |
| Title | p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. (1996) |
| Authors | Rattray M;Baldessari S;Gobbi M;Mennini T;Samanin R;Bendotti C; |
| Journal | Journal of Neurochemistry |
| Title | Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. (1996) |
| Authors | Akbar MT;Rattray M;Powell JF;Meldrum BS; |
| Journal | Molecular Brain Research |
| Title | Circadian variation of EAAC1 glutamate transporter messenger RNA in the rat suprachiasmatic nuclei. (1996) |
| Authors | Cagampang FR;Rattray M;Powell JF;Chong NW;Campbell IC;Coen CW; |
| Journal | Molecular Brain Research |
| Title | Growth hormone increases IGF-I, collagen I and collagen III gene expression in dwarf rat skeletal muscle. (1995) |
| Authors | Wilson VJ;Rattray M;Thomas CR;Moreland BH;Schulster D; |
| Journal | Molecular and Cellular Endocrinology |
| Title | Analysis of the neuronal promoter of the rat aromatic L-amino acid decarboxylase gene. (1995) |
| Authors | Aguanno A;Lee MR;Marden CM;Rattray M;Gault A;Albert VR; |
| Journal | Journal of Neurochemistry |
| Title | Repeated administration of MDMA down-regulates preprocholecystokinin mRNA expression but not tyrosine hydroxylase mRNA expression in neurones of the rat substantia nigra. (1994) |
| Authors | Wotherspoon G;Savery D;Priestley JV;Rattray M; |
| Journal | Molecular Brain Research |
| Title | Serotonin and NADPH-diaphorase in the dorsal raphe nucleus of the adult rat. (1994) |
| Authors | Wotherspoon G;Albert M;Rattray M;Priestley JV; |
| Journal | Neuroscience Letters |
| Title | Down-regulation of protein kinase C isoform gene expression in degenerating thalamic neurones--lack of induction in reactive glial cells. (1994) |
| Authors | Wilson VJ;Oddiah D;Sofroniew MV;Panni MK;Rattray M; |
| Journal | Biochemical Society Transactions |
| Title | Distribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene-related peptide in the midbrain periaqueductal grey in the rat. (1994) |
| Authors | Smith GS;Savery D;Marden C;López Costa JJ;Averill S;Priestley JV;Rattray M; |
| Journal | Journal of Comparative Neurology |
| DOI | 10.1002/cne.903500103 |
| Title | Chronic D-fenfluramine decreases serotonin transporter messenger RNA expression in dorsal raphe nucleus. (1994) |
| Authors | Rattray M;Wotherspoon G;Savery D;Baldessari S;Marden C;Priestley JV;Bendotti C; |
| Journal | European Journal of Pharmacology |
| Title | Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection. (1994) |
| Authors | Panni MK;Wilson VJ;Capoor U;Sofroniew MV;Rattray M; |
| Journal | NeuroReport |
| Title | A combined in situ hybridization and immunofluorescence procedure allowing visualisation of peptide mRNA and serotonin in single sections. (1993) |
| Authors | Priestley JV;Wotherspoon G;Savery D;Averill S;Rattray M; |
| Journal | Journal of Neuroscience Methods |
| Title | Benzodiazepines increase preprocholecystokinin messenger RNA levels in rat brain. (1993) |
| Authors | Rattray M;Singhvi S;Wu PY;Andrews N;File SE; |
| Journal | European Journal of Pharmacology |
| Title | Differential expression of GABA transporter-1 messenger RNA in subpopulations of GABA neurones. (1993) |
| Authors | Rattray M;Priestley JV; |
| Journal | Neuroscience Letters |
| Title | Amplification of members of the neurotransmitter transporter superfamily using PCR. (1992) |
| Authors | Jomary C;Jones SE;Rattray M; |
| Journal | Biochemical Society Transactions |
| Title | Regulation of glutamate decarboxylase and enkephalin mRNA levels in rat striatum by chronic benzodiazepine treatment. (1992) |
| Authors | Rattray M;Singhvi S;Andrews N;File SE;Wu PY; |
| Journal | Biochemical Society Transactions |
| Title | A preliminary analysis of the hybridization kinetics of an oligonucleotide to mRNA in tissue sections. (1992) |
| Authors | Savery D;Priestley JV;Rattray M; |
| Journal | Biochemical Society Transactions |
| Title | Two populations of cells that express preprocholecystokinin mRNA in ventral periaqueductal grey. (1992) |
| Authors | Rattray M;Savery D;Wotherspoon G;Priestley JV;Smith GS; |
| Journal | Neuroscience Letters |
| Title | Intraperitoneal insulin is more potent than subcutaneous insulin at restoring hepatic insulin-like growth factor-I mRNA levels in the diabetic rat: a functional role for the portal vascular link. (1992) |
| Authors | Russell-Jones DL;Rattray M;Wilson VJ;Jones RH;Sönksen PH;Thomas CR; |
| Journal | Journal of Molecular Endocrinology |
| Title | Ecstasy: towards an understanding of the biochemical basis of the actions of MDMA. (1991) |
| Authors | Rattray M; |
| Journal | Essays in Biochemistry |
| Title | Ligand autoradiographic receptor screening: receptor cDNA expression in replicas of transfected COS cells. (1990) |
| Authors | Rattray M;Lautar SL;Uhl GR; |
| Journal | Molecular Brain Research |
| Title | Caerulein-induced antinociception: interaction with morphine and opioid antagonists in the rat. (1989) |
| Authors | Rattray M;Jordan CC;de Belleroche J; |
| Journal | Neuropeptides |
| Title | A new method of screening receptor cDNAs: influence of plasmid competition on receptor expression. (1989) |
| Authors | Rattray M;Lautar SL;Uhl GR; |
| Journal | Biochemical Society Transactions |
| Title | The novel CCK antagonist L364,718 abolished caerulein- but potentiates morphine-induced antinociception. (1988) |
| Authors | Rattray M;Jordan CC;De Belleroche J; |
| Journal | European Journal of Pharmacology |
| Title | Morphine action on cholecystokinin octapeptide release from rat periaqueductal grey slices: sensitisation by naloxone. (1987) |
| Authors | Rattray M;de Belleroche J; |
| Journal | Neuropeptides |
| Title | The metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P. (1985) |
| Authors | Matsas R;Rattray M;Kenny AJ;Turner AJ; |
| Journal | Biochemical Journal |
| Book | |
|---|---|
| Title | Neurodegenerative Diseases: Pathology, Mechanisms and Potential Therapeutic Targets (2017) |
| Authors | Beart, P.; Robinson, M.; Rattray, Marcus; Maragakis, N. |