researcher

Marcus Rattray

Professor of Pharmacology

RoleProfessor of Pharmacology
Faculty/Dept/SchoolFaculty of Life Sciences / School of Pharmacy & Medical Sciences
EmailM.Rattray@bradford.ac.uk
Telephone+441274234675

Biography

2018                     Elected Fellow of the British Pharmacological Society

2017-2019           Head, School of Pharmacy & Medical Sciences, University of Bradford

2013-                    Professor of Pharmacology, University of Bradford

2013-2017            Head, School of Pharmacy, University of Bradford

2013-2016            Visiting Honorary Researcher, School of Pharmacy, University of Reading

2010-2013            Director of Research, School of Pharmacy, University of Reading

2009-2013            Director of Pharmacology & Therapeutics, School of Pharmacy, University of Reading

2008-2013            Reader in Pharmacology, University of Reading

2008-2012           Visiting Honorary Researcher, Wolfson Centre for Age-Related Diseases, King's College London

2006                     Churchill Fellow

1998-2008           Senior Lecturer in Biochemistry, Wolfson Centre for Age-Related Diseases (from 2004), King's College London

1997-1998           Senior Lecturer in Biochemistry, United Medical & Dental Schools of Guys & St Thomas' Hospitals, University of London

1989-1997           Lecturer in Biochemistry, United Medical & Dental Schools of Guys & St Thomas' Hospitals, University of London

1988-1989           Visiting Fellow, National Institutes of Drug Abuse, Baltimore, USA

1984-1987           PhD, Charing Cross & Westminster Medical School, University of London and Glaxo Group Research, Ware

1981-1984         BSc Biochemistry, University of Leeds

Teaching

Teaching interests

Pharmacology
Biochemistry
Neuroscience
Neurodegeneration
Evidence-based medicine

Research

In my laboratory, the primary research interest is the properties and functions of transporter proteins in the central nervous system, and in particular their importance in neurodegeneration. We use mainly molecular biological and cell biological techniques. Other related work is to understand the intracellular events underlying neurodegeneration and neuroprotection, in particular the role of co-ordinated gene expression in astrocytes in protecting neurones. Much of our recent work has focussed on the glutamate transporter proteins. These proteins are expressed mainly by astrocytes (glial cells) in the central nervous system where they are important in controlling the levels of the neurotransmitter glutamate in the synaptic cleft. If glutamate transporters are impaired then elevated glutamate levels contribute to neuronal death. This process of excitotoxicity has been strongly implicated in a number of neurological illnesses, including Motor Neurone Disease and diseases associated with ageing such as Alzheimers Disease and Parkinsons Disease. We are carrying out work to understand how glutamate transporters are down-regulated, and the consequences of this down-regulation, mostly using cell culture models. Other interests include drugs of abuse, particularly MDMA, the development of new treatments for addiction, and the mechanisms of action of neuroprotective drugs. In my laboratory, the primary research interest is the properties and functions of transporter proteins in the central nervous system, and in particular their importance in neurodegeneration. We use mainly molecular biological and cell biological techniques. Other related work is to understand the intracellular events underlying neurodegeneration and neuroprotection, in particular the role of co-ordinated gene expression in astrocytes in protecting neurones. Much of our recent work has focussed on the glutamate transporter proteins. These proteins are expressed mainly by astrocytes (glial cells) in the central nervous system where they are important in controlling the levels of the neurotransmitter glutamate in the synaptic cleft. If glutamate transporters are impaired then elevated glutamate levels contribute to neuronal death. This process of excitotoxicity has been strongly implicated in a number of neurological illnesses, including Motor Neurone Disease and diseases associated with ageing such as Alzheimers Disease and Parkinsons Disease. We are carrying out work to understand how glutamate transporters are down-regulated, and the consequences of this down-regulation, mostly using cell culture models. Other interests include drugs of abuse, particularly MDMA, the development of new treatments for addiction, and the mechanisms of action of neuroprotective drugs. Current Projects Drug screening for anti-TDP43 Aggregation (funded by Motor Neurone Disease Association) Increasing uptake of cancer screening in BME women in Bradford (Yorkshire Cancer Research) Current Projects Drug screening for anti-TDP43 Aggregation (funded by Motor Neurone Disease Association) Increasing uptake of cancer screening in BME women in Bradford (Yorkshire Cancer Research)

Publications

Peer Reviewed Journal
TitleEndoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells (2019)
AuthorsHicks D.;Cross L.;Williamson R.;Rattray M.
JournalNeurochemical Research
DOI10.1007/s11064-019-02832-2
 
TitleRiluzole-Triazole Hybrids as Novel Chemical Probes for Neuroprotection in Amyotrophic Lateral Sclerosis (2018)
AuthorsSweeney J.;Rattray M.;Pugh V.;Powell L.
JournalACS Medicinal Chemistry Letters
DOI10.1021/acsmedchemlett.8b00103
 
TitleSonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection (2017)
AuthorsUgbode C.;Smith I.;Whalley B.;Hirst W.;Rattray M.
JournalJournal of Neurochemistry
DOI10.1111/jnc.14064
 
TitleAstrocytic Transporters in Alzheimer’s disease (2017)
AuthorsUgbode, Christopher I.; Yuhan, H.; Whalley, B.J.; Peers, C.; Rattray, Marcus; Dallas, M.
 
TitleAstrocytes Grown in Alvetex®Three Dimensional Scaffolds Retain a Non-reactive Phenotype (2016)
AuthorsUgbode C.;Hirst W.;Rattray M.
JournalNeurochemical Research
DOI10.1007/s11064-016-1911-3
 
TitleNeuronal-glial populations form functional networks in a biocompatible 3D scaffold. (2015)
AuthorsSmith, I.; Haag, M.; Ugbode, Christopher I.; Tams, D.; Rattray, Marcus; Przyborski, S.; Bithell, A.; Whalley, B.J.
 
TitleNeuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes. (2014)
AuthorsUgbode, Christopher I.; Hirst, W.D.; Rattray, Marcus
 
TitleSUMO-1 conjugation blocks beta-amyloid-induced astrocyte reactivity. (2013)
AuthorsHoppe, J.B.; Rattray, Marcus; Tu, H.; Salbego, C.G.; Cimarosti, H.
 
TitleDietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor (2013)
AuthorsRendeiro, C.; Vauzour, D.; Rattray, Marcus; Waffo-Téguo, P.; Mérillon, J.M.; Butler, L.T.; Williams, C.M.; Spencer, J.P.E.
 
TitleRegulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. (2012)
AuthorsSpilsbury, A.; Vauzour, D.; Spencer, J.P.E.; Rattray, Marcus
 
TitleRiluzole elevates GLT-1 activity and levels in striatal astrocytes (2012)
AuthorsCarbone, M.; Duty, S.; Rattray, Marcus
 
TitleNeuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. (2012)
AuthorsBahia, P.K.; Pugh, V.; Hoyland, K.; Rattray, Marcus; Williams, R.J.
 
TitleBlueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. (2012)
AuthorsRendeiro C;Vauzour D;Kean RJ;Butler LT;Rattray M;Spencer JP;Williams CM;
JournalPsychopharmacology
DOI10.1007/s00213-012-2719-8
 
TitleRiluzole neuroprotection in a parkinson’s disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. (2012)
AuthorsCarbone, M.; Duty, S.; Rattray, Marcus
 
TitleNew insights on regulation of LMTK2, a membrane kinase integrating pathways central to neurodegeneration. (2012)
AuthorsRattray, Marcus
 
TitleTumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration (2010)
AuthorsRainey-Smith, S.R.; Andersson, D.A.; Williams, R.J.; Rattray, Marcus
 
TitleThe four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies (2009)
AuthorsPeacey, E.; Miller, C.C.; Dunlop, J.; Rattray, Marcus
 
TitleNeuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. (2008)
AuthorsRainey-Smith S;Schroetke LW;Bahia P;Fahmi A;Skilton R;Spencer JP;Rice-Evans C;Rattray M;Williams RJ;
JournalNeuroscience Letters
DOI10.1016/j.neulet.2008.04.056
 
TitleDietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes (2008)
AuthorsBahia, P.K.; Rattray, Marcus; Williams, R.J.
 
Title(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. (2007)
AuthorsSchroeter H;Bahia P;Spencer JP;Sheppard O;Rattray M;Cadenas E;Rice-Evans C;Williams RJ;
JournalJournal of Neurochemistry
DOI10.1111/j.1471-4159.2006.04434.x
 
TitleSerotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. (2006)
AuthorsHayat S;Williams RJ;Rattray M;
JournalJournal of Psychopharmacology
DOI10.1177/0269881106063273
 
TitleDoes excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities? (2006)
AuthorsRattray M;Bendotti C;
JournalExperimental Neurology
DOI10.1016/j.expneurol.2006.05.001
 
TitleChronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels. (2006)
AuthorsMarshall AJ;Rattray M;Vaughan PF;
JournalJournal of Brain Research
DOI10.1016/j.brainres.2006.05.008
 
TitleTechnology evaluation: colostrinin, ReGen. (2005)
AuthorsRattray M;
JournalCurrent Opinion in Molecular Therapeutics
 
TitleInduction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. (2005)
AuthorsDolman D;Drndarski S;Abbott NJ;Rattray M;
JournalJournal of Neurochemistry
DOI10.1111/j.1471-4159.2005.03111.x
 
TitleExpression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. (2004)
AuthorsTortarolo M;Crossthwaite AJ;Conforti L;Spencer JP;Williams RJ;Bendotti C;Rattray M;
JournalJournal of Neurochemistry
 
TitleThe 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. (2003)
AuthorsSuchak SK;Baloyianni NV;Perkinton MS;Williams RJ;Meldrum BS;Rattray M;
JournalJournal of Neurochemistry
 
TitleSoya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. (2003)
AuthorsFile SE;Hartley DE;Alom N;Rattray M;
JournalNeuroscience Letters
 
TitleTransgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels. (2001)
AuthorsBendotti C;Tortarolo M;Suchak SK;Calvaresi N;Carvelli L;Bastone A;Rizzi M;Rattray M;Mennini T;
JournalJournal of Neurochemistry
 
TitleElevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate. (2001)
AuthorsYip PK;Meldrum BS;Rattray M;
JournalJournal of Neurochemistry
 
TitleIs there nicotinic modulation of nerve growth factor? Implications for cholinergic therapies in Alzheimer's disease. (2001)
AuthorsRattray M;
JournalBiological Psychiatry
 
TitleExpression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. (2001)
AuthorsRamirez MJ;Heslop KE;Francis PT;Rattray M;
JournalJournal of Brain Research
 
TitleNicotine regulates 5-HT(1A) receptor gene expression in the cerebral cortex and dorsal hippocampus. (2001)
AuthorsKenny PJ;File SE;Rattray M;
JournalEuropean Journal of Neuroscience
 
TitleAcute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus. (2000)
AuthorsKenny PJ;File SE;Rattray M;
JournalMolecular Brain Research
 
TitleIntraregional variation in expression of serotonin transporter messenger RNA by 5-hydroxytryptamine neurons. (1999)
AuthorsRattray M;Michael GJ;Lee J;Wotherspoon G;Bendotti C;Priestley JV;
JournalNeuroscience
 
TitleHippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. (1999)
AuthorsFrench SJ;Humby T;Horner CH;Sofroniew MV;Rattray M;
JournalMolecular Brain Research
 
TitleCultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase. (1998)
AuthorsHirst WD;Cheung NY;Rattray M;Price GW;Wilkin GP;
JournalMolecular Brain Research
 
TitleVariation in the expression of the mRNA for protein kinase C isoforms in the rat suprachiasmatic nuclei, caudate putamen and cerebral cortex. (1998)
AuthorsCagampang FR;Rattray M;Campbell IC;Powell JF;Coen CW;
JournalMolecular Brain Research
 
TitleEffects of hypophysectomy and growth hormone administration on the mRNA levels of collagen I, III and insulin-like growth factor-I in rat skeletal muscle. (1998)
AuthorsWilson VJ;Rattray M;Thomas CR;Moreland BH;Schulster D;
JournalGrowth Hormone and IGF Research
 
TitleGenes encoding multiple forms of phospholipase A2 are expressed in rat brain. (1998)
AuthorsMolloy GY;Rattray M;Williams RJ;
JournalNeuroscience Letters
 
TitleSerotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles. (1998)
AuthorsHirst WD;Price GW;Rattray M;Wilkin GP;
JournalNeurochemistry International
 
TitleRapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder. (1998)
AuthorsOddiah D;Anand P;McMahon SB;Rattray M;
JournalNeuroReport
 
TitleReduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. (1998)
AuthorsAkbar MT;Rattray M;Williams RJ;Chong NW;Meldrum BS;
JournalNeuroscience
 
TitleTrkA immunoreactive neurones in the rat spinal cord. (1997)
AuthorsMichael GJ;Kaya E;Averill S;Rattray M;Clary DO;Priestley JV;
JournalJournal of Comparative Neurology
 
TitleSelective up-regulation of protein kinase C epsilon in granule cells after kainic acid-induced seizures in rat. (1997)
AuthorsGuglielmetti F;Rattray M;Baldessari S;Butelli E;Samanin R;Bendotti C;
JournalMolecular Brain Research
 
TitleNerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. (1997)
AuthorsMichael GJ;Averill S;Nitkunan A;Rattray M;Bennett DL;Yan Q;Priestley JV;
JournalJournal of Neuroscience
 
TitleExpression of GABA transporter mRNAs in the developing and adult rat optic nerve. (1997)
AuthorsHowd AG;Rattray M;Butt AM;
JournalNeuroscience Letters
 
TitleIdentification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. (1997)
AuthorsHirst WD;Price GW;Rattray M;Wilkin GP;
JournalBritish Journal of Pharmacology
DOI10.1038/sj.bjp.0700921
 
Titlep-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. (1996)
AuthorsRattray M;Baldessari S;Gobbi M;Mennini T;Samanin R;Bendotti C;
JournalJournal of Neurochemistry
 
TitleAltered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. (1996)
AuthorsAkbar MT;Rattray M;Powell JF;Meldrum BS;
JournalMolecular Brain Research
 
TitleCircadian variation of EAAC1 glutamate transporter messenger RNA in the rat suprachiasmatic nuclei. (1996)
AuthorsCagampang FR;Rattray M;Powell JF;Chong NW;Campbell IC;Coen CW;
JournalMolecular Brain Research
 
TitleCircadian changes of glutamate decarboxylase 65 and 67 mRNA in the rat suprachiasmatic nuclei. (1996)
AuthorsCagampang FR;Rattray M;Powell JF;Campbell IC;Coen CW;
JournalNeuroReport
 
TitleGrowth hormone increases IGF-I, collagen I and collagen III gene expression in dwarf rat skeletal muscle. (1995)
AuthorsWilson VJ;Rattray M;Thomas CR;Moreland BH;Schulster D;
JournalMolecular and Cellular Endocrinology
 
TitleAnalysis of the neuronal promoter of the rat aromatic L-amino acid decarboxylase gene. (1995)
AuthorsAguanno A;Lee MR;Marden CM;Rattray M;Gault A;Albert VR;
JournalJournal of Neurochemistry
 
TitleRepeated administration of MDMA down-regulates preprocholecystokinin mRNA expression but not tyrosine hydroxylase mRNA expression in neurones of the rat substantia nigra. (1994)
AuthorsWotherspoon G;Savery D;Priestley JV;Rattray M;
JournalMolecular Brain Research
 
TitleSerotonin and NADPH-diaphorase in the dorsal raphe nucleus of the adult rat. (1994)
AuthorsWotherspoon G;Albert M;Rattray M;Priestley JV;
JournalNeuroscience Letters
 
TitleSerotonin and NADPH-diaphorase in the dorsal raphe nucleus of the adult rat. (1994)
AuthorsWotherspoon G;Albert M;Rattray M;Priestley JV;
JournalNeuroscience Letters
 
TitleDown-regulation of protein kinase C isoform gene expression in degenerating thalamic neurones--lack of induction in reactive glial cells. (1994)
AuthorsWilson VJ;Oddiah D;Sofroniew MV;Panni MK;Rattray M;
JournalBiochemical Society Transactions
 
TitleDistribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene-related peptide in the midbrain periaqueductal grey in the rat. (1994)
AuthorsSmith GS;Savery D;Marden C;López Costa JJ;Averill S;Priestley JV;Rattray M;
JournalJournal of Comparative Neurology
DOI10.1002/cne.903500103
 
TitleChronic D-fenfluramine decreases serotonin transporter messenger RNA expression in dorsal raphe nucleus. (1994)
AuthorsRattray M;Wotherspoon G;Savery D;Baldessari S;Marden C;Priestley JV;Bendotti C;
JournalEuropean Journal of Pharmacology
 
TitleChanges in CCK mRNA in hippocampal neurones following fimbria fornix transection. (1994)
AuthorsPanni MK;Wilson VJ;Capoor U;Sofroniew MV;Rattray M;
JournalNeuroReport
 
TitleA combined in situ hybridization and immunofluorescence procedure allowing visualisation of peptide mRNA and serotonin in single sections. (1993)
AuthorsPriestley JV;Wotherspoon G;Savery D;Averill S;Rattray M;
JournalJournal of Neuroscience Methods
 
TitleBenzodiazepines increase preprocholecystokinin messenger RNA levels in rat brain. (1993)
AuthorsRattray M;Singhvi S;Wu PY;Andrews N;File SE;
JournalEuropean Journal of Pharmacology
 
TitleDifferential expression of GABA transporter-1 messenger RNA in subpopulations of GABA neurones. (1993)
AuthorsRattray M;Priestley JV;
JournalNeuroscience Letters
 
TitleAmplification of members of the neurotransmitter transporter superfamily using PCR. (1992)
AuthorsJomary C;Jones SE;Rattray M;
JournalBiochemical Society Transactions
 
TitleRegulation of glutamate decarboxylase and enkephalin mRNA levels in rat striatum by chronic benzodiazepine treatment. (1992)
AuthorsRattray M;Singhvi S;Andrews N;File SE;Wu PY;
JournalBiochemical Society Transactions
 
TitleTwo populations of cells that express preprocholecystokinin mRNA in ventral periaqueductal grey. (1992)
AuthorsRattray M;Savery D;Wotherspoon G;Priestley JV;Smith GS;
JournalNeuroscience Letters
 
TitleA preliminary analysis of the hybridization kinetics of an oligonucleotide to mRNA in tissue sections. (1992)
AuthorsSavery D;Priestley JV;Rattray M;
JournalBiochemical Society Transactions
 
TitleIntraperitoneal insulin is more potent than subcutaneous insulin at restoring hepatic insulin-like growth factor-I mRNA levels in the diabetic rat: a functional role for the portal vascular link. (1992)
AuthorsRussell-Jones DL;Rattray M;Wilson VJ;Jones RH;Sönksen PH;Thomas CR;
JournalJournal of Molecular Endocrinology
 
TitleEcstasy: towards an understanding of the biochemical basis of the actions of MDMA. (1991)
AuthorsRattray M;
JournalEssays in Biochemistry
 
TitleLigand autoradiographic receptor screening: receptor cDNA expression in replicas of transfected COS cells. (1990)
AuthorsRattray M;Lautar SL;Uhl GR;
JournalMolecular Brain Research
 
TitleA new method of screening receptor cDNAs: influence of plasmid competition on receptor expression. (1989)
AuthorsRattray M;Lautar SL;Uhl GR;
JournalBiochemical Society Transactions
 
TitleCaerulein-induced antinociception: interaction with morphine and opioid antagonists in the rat. (1989)
AuthorsRattray M;Jordan CC;de Belleroche J;
JournalNeuropeptides
 
TitleThe novel CCK antagonist L364,718 abolished caerulein- but potentiates morphine-induced antinociception. (1988)
AuthorsRattray M;Jordan CC;De Belleroche J;
JournalEuropean Journal of Pharmacology
 
TitleMorphine action on cholecystokinin octapeptide release from rat periaqueductal grey slices: sensitisation by naloxone. (1987)
AuthorsRattray M;de Belleroche J;
JournalNeuropeptides
 
TitleThe metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P. (1985)
AuthorsMatsas R;Rattray M;Kenny AJ;Turner AJ;
JournalBiochemical Journal
 
Book
TitleNeurodegenerative Diseases: Pathology, Mechanisms and Potential Therapeutic Targets (2017)
AuthorsBeart, P.; Robinson, M.; Rattray, Marcus; Maragakis, N.