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researcher

Dr Krzysztof Paluch

Assoc. Professor Dep. Dean Res. and Inno

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailk.j.paluch@bradford.ac.uk
Telephone +441274 236110

Biography

Krzysztof J. Paluch is an Assoc. Prof. in Medicines Development and Pharmaceutical Sciences, Director of Postgraduate Studies and Dep. Assoc. Dean of Research and Innovation in Faculty of Life Sciences, University of Bradford.

Krzysztof is a pharmacist with a particular interest in pharmaceutical technology, pharmaceutical sciences (PhD, Trinity College Dublin, 2011) and project management (Assoc. Project Manager). 

His research interests focus on synthesis, physicochemical and biopharmaceutical characterisation of drugs particularly pro-antibiotics and pro-antioxidants. Krzysztof has expertise in screening and characterisation of novel salts, co-crystals and characterization of amorphous forms. Process technologies applied in his research group comprise; production of nanoparticles, spray drying, freeze-drying, hot-melt extrusion, tabletting and others. Krzysztof has supervised 8 PhD students.

Krzysztof teaches undergraduate and postgraduate programmes namely: Pharmacy, Clinical Sciences and Pharmaceutical Technology and Medicines Control MSc. Krzysztof developed and as a Programme Lead oversees the delivery of Social Sciences Research for Healthcare Programme affiliated with White Rose Social Sciences Research Doctoral Training Partnership. 

In his role as the Director of Postgraduate Studies In the Faculty of Life Sciences, he oversees the wellbeing and successful progression of PhD Students in Schools of Pharmacy and Medical Sciences, Chemistry and Biosciences, Optometry and Vision Sciences and Archaeology and Forensic Sciences. 
As Dep. Assoc. Dean of Research and Innovation, Krzysztof has shared responsibility for the development and delivery of the Faculty's Research and Innovation strategy promoting interdisciplinary themes of Interface of Chemistry, Biology and Materials, The Life Course, Computational and Data-driven Science and, Health Society People and Place.

 

Research

Research Interests
  • Synthesis of pro-antibiotics and pro-antioxidants

  • Physicochemical, micromeritic and biopharmaceutical characterisation of drugs

  • Co-crystallisation and amorphisation of drugs for improved solubility

  • Pharmaceutical processing and preformulation; spray-drying, hot-melt extrusion, nanonisation, tabletting.

Current Projects

  • Pro-antibiotics for improved permeability and oral bioavailability

  • Pro-antibiotics for prolonged-release ocular drug delivery systems

  • Semi-synthetic pro-antioxidants for improved oral bioavailability and targeted delivery
  • Production of ternary, heterogenic solid dispersions for improved solubility and stability of amorphous drugs

Publications

Peer Reviewed Journal
TitleEx vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide (2020)
AuthorsAloum F.;Al Ayoub Y.;Mohammad M.A.;Obeed M.;Paluch K.;Assi K.H.
JournalPowder Technology
DOI10.1016/j.powtec.2020.06.037
 
TitlePhase Diagrams of Polymer-Dispersed Liquid Crystal Systems of Itraconazole/Component Immiscibility Induced by Molecular Anisotropy (2018)
AuthorsKozyra A.;Mugheirbi N.;Paluch K.;Garbacz G.;Tajber L.
JournalMolecular Pharmaceutics
DOI10.1021/acs.molpharmaceut.8b00724
 
TitleFreeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection (2018)
AuthorsUmerska A.;Paluch K.;Santos-Martinez M.;Corrigan O.;Medina C.;Tajber L.
JournalInternational Journal of Pharmaceutics
DOI10.1016/j.ijpharm.2018.09.035
 
TitleOptimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine (2017)
AuthorsDul, M.; Paluch, Krzysztof J.; Healy, A.M.; Sasse, A.; Tajber, L.
 
TitleAmorphous polymeric drug salts as ionic solid dispersion forms of ciprofloxacin (2017)
AuthorsMesallati, H.; Umerska, A.; Paluch, Krzysztof J.; Tajber, L.
 
TitleCocrystal habit engineering to improve drug dissolution and alter derived powder properties (2016)
AuthorsSerrano, D.R.; O'Connell, P.; Paluch, Krzysztof J.; Walsh, D.; Healy, A.M.
 
TitleMolecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems (2016)
AuthorsKnapik, J.; Wojnarowska, Z.; Grzybowska, K.; Tajber, L.; Mesallati, H.; Paluch, Krzysztof J.; Paluch, M.
 
TitleMolecular origin of enhanced proton conductivity in anhydrous ionic systems (2015)
AuthorsWojnarowska, Z.; Paluch, Krzysztof J.; Shoifet, E.; Schick, C.; Tajber, L.; Knapik, J.; Wlodarczyk, P.; Grzybowska, K.; Hensel-Bielowka, S.; Verevkin, S.P.; Paluch, M.
 
TitleMolecular structure studies of (1,2)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2015)
AuthorsZhang, T.; Paluch, Krzysztof J.; Scalabrino, G.; Frankish, N.; Healy, A.M.; Sheridan, H.
 
TitleMolecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2015)
AuthorsZhang T.;Paluch K.;Scalabrino G.;Frankish N.;Healy A.;Sheridan H.
JournalJournal of Molecular Structure
DOI10.1016/j.molstruc.2014.12.018
 
TitleSelf-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics (2015)
AuthorsDul, M.; Paluch, Krzysztof J.; Kelly, H.; Healy, A.M.; Sasse, A.; Tajber, L.
 
TitleChondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics (2015)
AuthorsUmerska, A.; Paluch, Krzysztof J.; Santos-Martinez, M.J.; Medina, C.; Corrigan, O.I.; Tajber, L.
 
TitleCocrystal habit engineering to improve drug dissolution and alter derived powder properties. (2015)
AuthorsSerrano DR;O'Connell P;Paluch KJ;Walsh D;Healy AM;
 
TitleComparative study of different methods for the prediction of drug-polymer solubility (2015)
AuthorsKnopp, M.M.; Tajber, L.; Tian, Y.; Olesen, N.E.; Jones, D.S.; Kozyra, A.; Lobmann, K.; Paluch, Krzysztof J.; Brennan, C.M.; Holm, R.; Healy, A.M.; Andrews, G.P.; Rades, T.
 
TitlePolymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties (2015)
AuthorsGrossjohann, C.; Serrano, D.R.; Paluch, Krzysztof J.; O'Connell, P.; Vella-Zarb, L.; Manesiotis, P.; McCabe, T.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
 
TitleObservation of highly decoupled conductivity in protic ionic conductors (2014)
AuthorsWojnarowska, Z.; Wang, Y.; Paluch, Krzysztof J.; Sokolov, A.P.; Paluch, M.
 
TitleBiopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. (2014)
AuthorsStojković A;Tajber L;Paluch KJ;Djurić Z;Parojčić J;Corrigan OI;
DOI10.2478/acph-2014-0007
 
TitleSelf-assembled hyaluronate/protamine polyelectrolyte nanoplexes: Synthesis, stability, biocompatibility and potential use as peptide carriers (2014)
AuthorsUmerska, A.; Paluch, Krzysztof J.; Santos Martinez, M.-J.; Corrigan, O.I.; Medina, C.; Tajber, L.
 
TitleHeat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole (2014)
AuthorsMugheirbi, N.A.; Paluch, Krzysztof J.; Tajber, L.
 
TitleDry powders for oral inhalation free of lactose carrier particles. (2014)
AuthorsHealy AM;Amaro MI;Paluch KJ;Tajber L;
DOI10.1016/j.addr.2014.04.005
 
TitleThe influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil. (2014)
AuthorsWlodarski K;Sawicki W;Paluch KJ;Tajber L;Grembecka M;Hawelek L;Wojnarowska Z;Grzybowska K;Talik E;Paluch M;
DOI10.1016/j.ejps.2014.05.026
 
TitleImpact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability (2013)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
 
TitleFormation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid (2013)
AuthorsPaluch, Krzysztof J.; McCabe, T.; Müller-Bunz, B.; Corrigan, O.I.; Healy, A.M.; Tajber, L.
 
TitleSteroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. (2013)
AuthorsTewes F;Paluch KJ;Tajber L;Gulati K;Kalantri D;Ehrhardt C;Healy AM;
DOI10.1016/j.ejpb.2013.03.020
 
TitleDecoupling of conductivity relaxation from structural relaxation in protic ionic liquids and general properties. (2013)
AuthorsWojnarowska Z;Kołodziejczyk K;Paluch KJ;Tajber L;Grzybowska K;Ngai KL;Paluch M;
DOI10.1039/c3cp50627d
 
TitleMolecular dynamics, physical stability and solubility advantage from amorphous indapamide drug. (2013)
AuthorsWojnarowska Z;Grzybowska K;Hawelek L;Dulski M;Wrzalik R;Gruszka I;Paluch M;Pienkowska K;Sawicki W;Bujak P;Paluch KJ;Tajber L;Markowski J;
DOI10.1021/mp400116q
 
TitleExploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers. (2012)
AuthorsUmerska A;Paluch KJ;Inkielewicz-Stępniak I;Santos-Martinez MJ;Corrigan OI;Medina C;Tajber L;
DOI10.1016/j.ijpharm.2012.07.011
 
TitleImpact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system (2012)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
 
TitleImpact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials (2012)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Amaro, M.I.; Corrigan, O.I.; Healy, A.M.
 
TitleA novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability (2012)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Adamczyk, B.; Corrigan, O.I.; Healy, A.M.
 
TitleBiopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction. (2011)
AuthorsParojčić J;Stojković A;Tajber L;Grbić S;Paluch KJ;Djurić Z;Corrigan OI;
DOI10.1002/jps.22707
 
TitleSolid-state characterization of novel active pharmaceutical ingredients: cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt. (2011)
AuthorsPaluch KJ;Tajber L;Elcoate CJ;Corrigan OI;Lawrence SE;Healy AM;
DOI10.1002/jps.22569
 
TitlePreparation and characterisation of novel chlorothiazide potassium solid-state salt forms: Intermolecular self assembly suprastructures. (2011)
AuthorsPaluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM;
DOI10.1016/j.ejps.2010.11.012
 
TitlePreparation and solid state characterisation of chlorothiazide sodium intermolecular self-assembly suprastructure. (2010)
AuthorsPaluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM;
DOI10.1016/j.ejps.2010.08.013