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researcher

Krzysztof Paluch

Senior Lecturer

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailk.j.paluch@bradford.ac.uk
Telephone +441274 236110

Biography

Krzysztof J. Paluch joined University of Bradford as a Lecturer in Medicines Development and Pharmaceutical Sciences. He holds an MSc in Pharmacy from Jagiellonian University Krakòw (2005) and Ph.D. in Pharmaceutical Sciences from Trinity College, University of Dublin (2011). He is a Project Management Associate (Irish Institute Project Management Ireland, 2012). His research interests focus on: screening and characterization of novel salts and co-crystals, characterization of amorphous forms, nanoparticles and spray dried microparticles. His collaborations include projects with: Trinity College Dublin, University of Silesia, University of Gdansk and others. To date, his research was funded by: Irish Research Council for Science, Engineering and Technology and Science Foundation Ireland.

Research

Research Interests
  • Solid-state and micromeritic characterisation of spray dried microparticles
  • Physicochemical characterisation of high-energy forms of active pharmaceutical ingredients
  • Nanoparticulate-based delivery systems
  • New salts and co-crystalline forms screening and characterisation

Current Projects
  • Impact of intermolecular interactions on quantitative heat induced evaporative nano-co-precipitation, 2015-2016, The Royal Society Research Grant
  • Impact of coformer on parallel artificial membrane permeability profile of active pharmaceutical ingredients, 2015-2016, Bradford School of Pharmacy Start Up Grant

Collaborations

Prof. Lidia Tajber, Trinity College, Dublin Prof. Marian Paluch, University of Silesia Prof. Anant Pardkar, University of Bradford Dr Khaled Assi, University of Bradford Dr Dolores Serrano Lopez, University of Mardid Dr Colin Seaton, University of Bradford

Publications

Peer Reviewed Journal
TitleFreeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection (2018)
AuthorsUmerska A.;Paluch K.;Santos-Martinez M.;Corrigan O.;Medina C.;Tajber L.
JournalInternational Journal of Pharmaceutics
DOI10.1016/j.ijpharm.2018.09.035
 
TitlePhase Diagrams of Polymer-Dispersed Liquid Crystal Systems of Itraconazole/Component Immiscibility Induced by Molecular Anisotropy (2018)
AuthorsKozyra A.;Mugheirbi N.;Paluch K.;Garbacz G.;Tajber L.
JournalMolecular Pharmaceutics
DOI10.1021/acs.molpharmaceut.8b00724
 
TitleAmorphous polymeric drug salts as ionic solid dispersion forms of ciprofloxacin (2017)
AuthorsMesallati, H.; Umerska, A.; Paluch, Krzysztof J.; Tajber, L.
 
TitleOptimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine (2017)
AuthorsDul, M.; Paluch, Krzysztof J.; Healy, A.M.; Sasse, A.; Tajber, L.
 
TitleCocrystal habit engineering to improve drug dissolution and alter derived powder properties (2016)
AuthorsSerrano, D.R.; O'Connell, P.; Paluch, Krzysztof J.; Walsh, D.; Healy, A.M.
 
TitleMolecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems (2016)
AuthorsKnapik, J.; Wojnarowska, Z.; Grzybowska, K.; Tajber, L.; Mesallati, H.; Paluch, Krzysztof J.; Paluch, M.
 
TitleMolecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2015)
AuthorsZhang T.;Paluch K.;Scalabrino G.;Frankish N.;Healy A.;Sheridan H.
JournalJournal of Molecular Structure
DOI10.1016/j.molstruc.2014.12.018
 
TitleSelf-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics (2015)
AuthorsDul, M.; Paluch, Krzysztof J.; Kelly, H.; Healy, A.M.; Sasse, A.; Tajber, L.
 
TitleChondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics (2015)
AuthorsUmerska, A.; Paluch, Krzysztof J.; Santos-Martinez, M.J.; Medina, C.; Corrigan, O.I.; Tajber, L.
 
TitleMolecular origin of enhanced proton conductivity in anhydrous ionic systems (2015)
AuthorsWojnarowska, Z.; Paluch, Krzysztof J.; Shoifet, E.; Schick, C.; Tajber, L.; Knapik, J.; Wlodarczyk, P.; Grzybowska, K.; Hensel-Bielowka, S.; Verevkin, S.P.; Paluch, M.
 
TitleMolecular structure studies of (1,2)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol (2015)
AuthorsZhang, T.; Paluch, Krzysztof J.; Scalabrino, G.; Frankish, N.; Healy, A.M.; Sheridan, H.
 
TitlePolymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties (2015)
AuthorsGrossjohann, C.; Serrano, D.R.; Paluch, Krzysztof J.; O'Connell, P.; Vella-Zarb, L.; Manesiotis, P.; McCabe, T.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
 
TitleComparative study of different methods for the prediction of drug-polymer solubility (2015)
AuthorsKnopp, M.M.; Tajber, L.; Tian, Y.; Olesen, N.E.; Jones, D.S.; Kozyra, A.; Lobmann, K.; Paluch, Krzysztof J.; Brennan, C.M.; Holm, R.; Healy, A.M.; Andrews, G.P.; Rades, T.
 
TitleCocrystal habit engineering to improve drug dissolution and alter derived powder properties. (2015)
AuthorsSerrano DR;O'Connell P;Paluch KJ;Walsh D;Healy AM;
 
TitleSelf-assembled hyaluronate/protamine polyelectrolyte nanoplexes: Synthesis, stability, biocompatibility and potential use as peptide carriers (2014)
AuthorsUmerska, A.; Paluch, Krzysztof J.; Santos Martinez, M.-J.; Corrigan, O.I.; Medina, C.; Tajber, L.
 
TitleDry powders for oral inhalation free of lactose carrier particles. (2014)
AuthorsHealy AM;Amaro MI;Paluch KJ;Tajber L;
DOI10.1016/j.addr.2014.04.005
 
TitleThe influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil. (2014)
AuthorsWlodarski K;Sawicki W;Paluch KJ;Tajber L;Grembecka M;Hawelek L;Wojnarowska Z;Grzybowska K;Talik E;Paluch M;
DOI10.1016/j.ejps.2014.05.026
 
TitleHeat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole (2014)
AuthorsMugheirbi, N.A.; Paluch, Krzysztof J.; Tajber, L.
 
TitleObservation of highly decoupled conductivity in protic ionic conductors (2014)
AuthorsWojnarowska, Z.; Wang, Y.; Paluch, Krzysztof J.; Sokolov, A.P.; Paluch, M.
 
TitleBiopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. (2014)
AuthorsStojković A;Tajber L;Paluch KJ;Djurić Z;Parojčić J;Corrigan OI;
DOI10.2478/acph-2014-0007
 
TitleFormation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid (2013)
AuthorsPaluch, Krzysztof J.; McCabe, T.; Müller-Bunz, B.; Corrigan, O.I.; Healy, A.M.; Tajber, L.
 
TitleImpact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability (2013)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
 
TitleSteroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. (2013)
AuthorsTewes F;Paluch KJ;Tajber L;Gulati K;Kalantri D;Ehrhardt C;Healy AM;
DOI10.1016/j.ejpb.2013.03.020
 
TitleDecoupling of conductivity relaxation from structural relaxation in protic ionic liquids and general properties. (2013)
AuthorsWojnarowska Z;Kołodziejczyk K;Paluch KJ;Tajber L;Grzybowska K;Ngai KL;Paluch M;
DOI10.1039/c3cp50627d
 
TitleMolecular dynamics, physical stability and solubility advantage from amorphous indapamide drug. (2013)
AuthorsWojnarowska Z;Grzybowska K;Hawelek L;Dulski M;Wrzalik R;Gruszka I;Paluch M;Pienkowska K;Sawicki W;Bujak P;Paluch KJ;Tajber L;Markowski J;
DOI10.1021/mp400116q
 
TitleImpact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials (2012)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Amaro, M.I.; Corrigan, O.I.; Healy, A.M.
 
TitleA novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability (2012)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Adamczyk, B.; Corrigan, O.I.; Healy, A.M.
 
TitleExploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers. (2012)
AuthorsUmerska A;Paluch KJ;Inkielewicz-Stępniak I;Santos-Martinez MJ;Corrigan OI;Medina C;Tajber L;
DOI10.1016/j.ijpharm.2012.07.011
 
TitleImpact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system (2012)
AuthorsPaluch, Krzysztof J.; Tajber, L.; Corrigan, O.I.; Healy, A.M.
 
TitleBiopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction. (2011)
AuthorsParojčić J;Stojković A;Tajber L;Grbić S;Paluch KJ;Djurić Z;Corrigan OI;
DOI10.1002/jps.22707
 
TitleSolid-state characterization of novel active pharmaceutical ingredients: cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt. (2011)
AuthorsPaluch KJ;Tajber L;Elcoate CJ;Corrigan OI;Lawrence SE;Healy AM;
DOI10.1002/jps.22569
 
TitlePreparation and characterisation of novel chlorothiazide potassium solid-state salt forms: Intermolecular self assembly suprastructures. (2011)
AuthorsPaluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM;
DOI10.1016/j.ejps.2010.11.012
 
TitlePreparation and solid state characterisation of chlorothiazide sodium intermolecular self-assembly suprastructure. (2010)
AuthorsPaluch KJ;Tajber L;McCabe T;O'Brien JE;Corrigan OI;Healy AM;
DOI10.1016/j.ejps.2010.08.013