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researcher

Kamyar Afarinkia

Senior Lecturer

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailk.afarinkia@bradford.ac.uk
Telephone +441274 235831

Biography

Kamyar Afarinkia graduated with 1st class honours BSc degree in Chemistry from Imperial College and obtained his PhD in Organic Chemistry under the supervision of Prof Charles Rees, FRS & Prof Sir John Cadogan. His PhD dissertation was funded by an Overseas Research Scholarship and an extramural studentship from BP and resulted in the first synthesis of 1,2-azaphosphetidine (analogues of ß-lactam in which the C=O bond is replaced by a P=O bond). He then took up a two year Postdoctoral Fellowship at the Johns Hopkins University, Baltimore, working with Prof Gary Posner on the synthesis of analogues of calcitriol (vitamin D3). After his postdoc, he joined Glaxo as a Senior Chemist working on projects ranging from diabetes to hypertension. He left pharma to become a lecturer and then senior lecturer in medicinal and synthetic organic chemistry at King’s College London, and moved to the University of Bradford to join the newly established Institute of Cancer Therapeutics (ICT). 

Research

Antagonists of CCR7 in the treatment of dry eye disease Clinical context and rationale About 5% of all 50+ years olds suffer from the dry eye disease but the current treatment (artificial tear) is merely palliative. The disease is initiated and exacerbated through migration of lymphocytes into exocrine glands, under the control of the CCL19/CCL21/CCR7 axis. Key achievements We have identified ICT5888 as a novel chemokine receptor CCR7 antagonist. Optimisation of the potency of this lead compound has led to the identification of ICT13069, and ICT13124, two novel, potent and have shown that they prevent CCL19/ CCL21 induced chemotactic migration, invasion and immune response. Clinical progression ICT13069 is being optimised for potency, water solubility and topical application (eye drop) in an animal model of the disease in an in vivo proof of concept. Subsequently, the plan is to initiate clinical progression of the compound. Antagonists of CCR7 as novel agents for treatment of head & neck and pancreatic cancers Clinical context and rationale 90% of cancer deaths are associated with metastasis, yet there are no clinical agents to prevent it. Our approach involves using a dual CXCR4/CCR7 antagonist to simultaneously prevent dissemination of cancer through vascular and lymphatic systems in cancers of the head & neck and pancreas. Key achievements Following on from our successful programme to identify novel CXCR4 antagonist ICT5122, and CCR7 antagonist ICT1313069 we are developing hybrid molecules with dual CXCR4 and CCR7 antagonism and have shown that it prevents chemotaxis, proliferation. Further preclinical investigation is on-going. Glycomic tools for drug discovery Objectives and rationale Remodelling of the cell surface glycoproteins is associated with progression of disease. Our group has been at the forefront of developing methods for synthesis of glycomimetics using a Diels-Alder cycloaddition methodology. Key achievements We have published on methods for preparation of pseudo-disaccharides, control of stereochemistry at the pseudoanomeric position, and the first divergent synthesis of a pseudo-disaccharide library. We have used these tools to successfully investigate highly important targets such as heparanase and Golgi mannosidase II. Targeting glioma cancer stem cells to combat disease resistance and recurrence A joint project with Dr Victoria Vinader.

Publications

Peer Reviewed Journal
TitleA new route to tricyclane sesquiterpenoids: total synthesis of α-ekasantalic acid (2019)
AuthorsLomba, L.; Afarinkia, Kamyar; Vinader, Victoria
 
TitleA new route to tricyclane sesquiterpenoids: total synthesis of α-ekasantalic acid. (2019)
AuthorsLomba L;Afarinkia K;Vinader V;
JournalOrganic and Biomolecular Chemistry
DOI10.1039/c9ob00630c
 
TitleHypoxia modulates CCR7 expression in head and neck cancers (2018)
AuthorsBasheer, Haneen A.; Pakanavicius, E.; Cooper, Patricia A.; Shnyder, Steven D.; Martin, L.; Hunter, K.D.; Vinader, Victoria; Afarinkia, Kamyar
 
TitleControl of the stereochemistry of C14 hydroxyl during the total synthesis of withanolide E and physachenolide C (2018)
AuthorsAnees, Muhammad; Nayak, Sanjit; Afarinkia, Kamyar; Vinader, Victoria
 
TitleAgarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines (2017)
AuthorsAhmed, Mohaned S.A.; Basheer, Haneen A.; Ayuso, J.M.; Ahmet, Djevdet; Mazzini, Marco; Patel, Roshan; Shnyder, Steven D.; Vinader, Victoria; Afarinkia, Kamyar
 
TitleAgarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines /631/1647/767/70 /631/154/1435 /123 /13/21 /14/63 /13/31 article (2017)
AuthorsAhmed M.;Basheer H.;Ayuso J.;Ahmet D.;Mazzini M.;Patel R.;Shnyder S.;Vinader V.;Afarinkia K.
JournalScientific Reports
DOI10.1038/s41598-017-00949-4
 
TitleThe role of substituents in retro Diels-Alder extrusion of CO2 from 2(H)-pyrone cycloadducts (2016)
AuthorsAbdullahi, Mohamed H.; Thompson, L.M.; Bearpark, M.J.; Vinader, Victoria; Afarinkia, Kamyar
 
TitleThe role of substituents in retro Diels–Alder extrusion of CO2from 2(H)-pyrone cycloadducts (2016)
AuthorsAbdullahi M.;Thompson L.;Bearpark M.;Vinader V.;Afarinkia K.
JournalTetrahedron
DOI10.1016/j.tet.2016.07.066
 
TitleProbing cytochrome P450-mediated activation with a truncated azinomycin analogue (2015)
AuthorsVinader, Victoria; Sadiq, Maria; Sutherland, Mark H.; Huang, M.Y.; Loadman, Paul M.; Elsalem, Lina M.I.; Shnyder, Steven D.; Cui, H.J.; Afarinkia, Kamyar; Searcey, M.; Patterson, Laurence H.; Pors, Klaus
 
TitleStudy of the chemotactic response of multicellular spheroids in a microfluidic device (2015)
AuthorsAyuso, J.M.; Basheer, Haneen A.; Monge, R.; Sánchez-Álvarez, P.; Doblare, M.; Shnyder, Steven D.; Vinader, Victoria; Afarinkia, Kamyar; Fernandez, L.J.; Ochoa, I.
 
TitleSynthesis of a pseudo-disaccharide library and its application to the characterisation of the heparanase catalytic site (2013)
AuthorsVinader V.;Haji-Abdullahi M.;Patterson L.;Afarinkia K.
JournalPLoS ONE
DOI10.1371/journal.pone.0082111
 
TitleDiscovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. (2013)
AuthorsVinader V.;Ahmet D.;Ahmed M.;Patterson L.;Afarinkia K.
JournalPLoS ONE
DOI10.1371/journal.pone.0078744
 
TitleCarbasugar probes to explore the enzyme binding pocket at the anomeric position: Application to the design of Golgi mannosidase II inhibitors (2013)
AuthorsVinader M.;Afarinkia K.
JournalCurrent Medicinal Chemistry
DOI10.2174/09298673113209990180
 
TitleAn agarose spot chemotaxis assay for chemokine receptor antagonists (2011)
AuthorsVinader V.;Al-Saraireh Y.;Wiggins H.;Rappoport J.;Shnyder S.;Patterson L.;Afarinkia K.
JournalJournal of Pharmacological and Toxicological Methods
DOI10.1016/j.vascn.2011.01.004
 
TitleA synthesis of oligomeric α-hydroxy phenylphosphinates and a study of the conformational preferences of the dimers (2010)
AuthorsAfarinkia K.;Royappa M.;Scowen I.;Steed J.;Yu H.
JournalOrganic and Biomolecular Chemistry
DOI10.1039/b917737j
 
TitleA synthesis of carbasugar-sugar pseudodisaccharides via a cycloaddition-cycloreversion reaction of 2 H -Pyran-2-ones (2010)
AuthorsAfarinkia K.;Abdullahi M.;Scowen I.
JournalOrganic Letters
DOI10.1021/ol102358s
 
TitleA new, general method for the synthesis of carbasugar-sugar pseudodisaccharides (2009)
AuthorsAfarinkia K.;Abdullahi M.;Scowen L.
JournalOrganic Letters
DOI10.1021/ol901960y
 
TitleA general synthesis of phenanthridinone alkaloids (2007)
AuthorsAfarinkia K.;Ndibwami A.
JournalSynlett
DOI10.1055/s-2007-984540
 
TitleSynthesis of hydrophobically modified analogues of adenophorine (2007)
AuthorsAfarinkia K.;Bahar A.;Neuss J.
JournalSynlett
DOI10.1055/s-2007-980359
 
TitleWhen Z′ = 2 is better than Z′ = 1 - supramolecular centrosymmetric hydrogen-bonded dimers in chiral systems (2006)
AuthorsAnderson K.;Afarinkia K.;Yu H.;Goeta A.;Steed J.
JournalCrystal Growth and Design
DOI10.1021/cg0603265
 
TitleAn Investigation of the Diels-Alder Cycloadditions of 2(H)-1,4-Oxazin-2-ones. (2005)
AuthorsAfarinkia, Kamyar; Bahar, A.; Bearpark, M.J.; Garcia-Ramos, J.; Ruggiero, A.; Neuse, J.; Vyas, M.
 
TitleAn experimental and computational investigation of the Diels-Alder cycloadditions of halogen-substituted 2(H)-pyran-2-ones. (2005)
AuthorsAfarinkia K;Bearpark MJ;Ndibwami A;
JournalJournal of Organic Chemistry
DOI10.1021/jo048213k
 
TitleInvestigation of the Diels-Alder cycloadditions of 2(H)-1,4-oxazin-2-ones. (2005)
AuthorsAfarinkia K;Bahar A;Bearpark MJ;Garcia-Ramos Y;Ruggiero A;Neuss J;Vyas M;
JournalJournal of Organic Chemistry
DOI10.1021/jo051646i
 
TitlePreparation of asymmetric alpha-ketophosphonates by [3,3]-sigmatropic shift of enolphosphonates. (2004)
AuthorsAfarinkia K;Twist AJ;Yu HW;
JournalJournal of Organic Chemistry
DOI10.1021/jo049133j
 
TitlePreparation of asymmetric alpha-ketophosphonates by [3,3]-sigmatropic shift of enolphosphonates. (2004)
AuthorsAfarinkia, Kamyar; Twist, A; Yu, H-w.
 
Title2(H)-1,4-Oxazin-2-ones as ambident azadienes (2004)
AuthorsAfarinkia K.;Bahar A.;Neuss J.;Ruggiero A.
JournalTetrahedron Letters
DOI10.1016/j.tetlet.2004.03.183
 
TitleControl of electron demand in the cycloadditions of 2(H)-1,4-oxazin-2-ones (2004)
AuthorsAfarinkia K.;Bahar A.;Neuss J.;Vyas M.
JournalTetrahedron Letters
DOI10.1016/j.tetlet.2004.07.105
 
TitleA Computational and Experimental Investigation of the Diels-Alder Cycloadditions of Halogen Substituted 2(H)-pyran-2-one (2003)
AuthorsAfarinkia, Kamyar; Bearpark, M.J.; Ndibwami, A.
 
TitleHewitt reaction revisited (2003)
AuthorsAfarinkia K.;Yu H.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(02)02647-3
 
TitleComputational and experimental investigation of the Diels-Alder cycloadditions of 4-chloro-2(H)-pyran-2-one. (2003)
AuthorsAfarinkia K;Bearpark MJ;Ndibwami A;
JournalJournal of Organic Chemistry
DOI10.1021/jo0348827
 
TitleConformational preferences in 2-alkyl, 2-alkanoyl and 2-aroyl-2-oxo-1,3,2-oxazaphosphorinanes (2001)
AuthorsAfarinkia K.;Angell R.;Jones C.;Lowman J.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(00)02050-5
 
TitleThe anionic route to tricyclanes (2000)
AuthorsAfarinkia K.;Mahmood F.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(99)02270-4
 
TitleDiels-Alder cycloaddition of 5-aryl-2-pyrones (2000)
AuthorsAfarinkia K.;Berna-Canovas J.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(00)00744-9
 
TitleAsymmetric nucleophilic addition to vinylphosphonates (part II) (2000)
AuthorsAfarinkia, K; Binch, HM; Forristal, I
JournalSynlett
 
TitleAsymmetric nucleophilic addition to vinylphosphonates (part I) (2000)
AuthorsAfarinkia, K; Binch, HM; De Pascale, E
JournalSynlett
 
TitleA novel and concise synthesis of (±) 2-epi-Validamine (1999)
AuthorsAfarinkia K.;Mahmood F.
JournalTetrahedron
DOI10.1016/S0040-4020(99)00071-X
 
TitleAcceleration of nucleophilic addition to vinylphosphonates and vinyl phosphine oxides by chlorotrimethylsilane (1998)
AuthorsAfarinkia K.;Binch H.;Modi C.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(98)01612-8
 
TitleA novel synthesis of (±) 2-epi-validamine (1998)
AuthorsAfarinkia K.;Mahmood F.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(98)01610-4
 
TitleHighly efficient Diels-Alder cycloadditions of 2-pyridones with bulky N-sulfonyl substituent (1998)
AuthorsAfarinkia K.;Mahmood F.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(97)10585-8
 
TitleA mild and stereoselective synthesis of β-phosphonylacrylates (1998)
AuthorsAfarinkia K.;Evans M.;Graham J.;Jimenez-Bueno G.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(97)10540-8
 
TitleUnusual stereoselectivity in Diels-Alder cycloaddition of 5-bromopyrone (1997)
AuthorsAfarinkia K.;Daly N.;Gomez-Farnos S.;Joshi S.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(97)00352-3
 
TitleFacile enolisation of α-ketophosphonates (1997)
AuthorsAfarinkia K.;Echenique J.;Nyburg S.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(97)00157-3
 
TitleA reinvestigation of the structure of the erythro and xanthoapocyanine dyes: Some unusual aspects of quinoline chemistry (1996)
AuthorsAfarinkia K.;Ansari M.;Bird C.;Gyambibi I.
JournalTetrahedron Letters
DOI10.1016/0040-4039(96)00940-9
 
TitleAsymmetric Total Synthesis, X-ray Crystallography, and Preliminary Biological Evaluation of 1-(1′-Hydroxyethyl)-25-hydroxyvitamin D3 Analogs of Natural Calcitriol (1993)
AuthorsPosner G.;Dai H.;Afarinkia K.;Murthy N.;Guyton K.;Kensler T.
JournalJournal of Organic Chemistry
DOI10.1021/jo00077a052
 
TitleDiels-Alder Cycloadditions Using Nucleophilic 2-Pyridones. Regiocontrolled and Stereocontrolled Synthesis of Unsaturated, Bridged, Bicyclic Lactams (1992)
AuthorsPosner G.;Vinader V.;Afarinkia K.
JournalJournal of Organic Chemistry
DOI10.1021/jo00041a010
 
TitleSynthesis of 1,2-azaphosphetidines (1992)
AuthorsAfarinkia K.;Cadogan J.;Rees C.
JournalJournal of the Chemical Society - Series Chemical Communications
DOI10.1039/C39920000285
 
Title5-Bromo-2-pyrone: An easily prepared ambiphilic diene and a synthetic equivalent of 2-pyrone in mild, thermal, Diels-Alder cycloadditions (1992)
AuthorsAfarinkia K.;Posner G.
JournalTetrahedron Letters
DOI10.1016/S0040-4039(00)74757-5
 
TitleDiels-Alder cycloadditions of 2-pyrones and 2-pyridones (1992)
AuthorsAfarinkia K.;Vinader V.;Nelson T.;Posner G.
JournalTetrahedron
DOI10.1016/S0040-4020(01)85607-6
 
TitleADDITION OF SILYL PHOSPHITES TO ALPHA,BETA-UNSATURATED IMINES (1992)
AuthorsAFARINKIA, K; CADOGAN, JIG; REES, CW
JournalSynlett
 
TitleDIASTEREOSELECTIVITY IN THE FORMATION OF PHOSPHORUS CARBON BONDS (1992)
AuthorsAFARINKIA, K; CADOGAN, JIG; REES, CW
JournalSynlett
 
TitleFour-membered heterocycles containing one phosphorus and one other heteroatom (1992)
AuthorsAfarinkia K.
JournalHeterocycles
DOI10.3987/REV-91-437
 
Title3-BROMO-2-PYRONE - AN EASILY PREPARED CHAMELEON DIENE AND A SYNTHETIC EQUIVALENT OF 2-PYRONE IN THERMAL DIELS-ALDER CYCLOADDITIONS (1991)
AuthorsPOSNER, GH; NELSON, TD; KINTER, CM; AFARINKIA, K
JournalTETRAHEDRON LETT
 
TitleSYNTHESIS OF PHOSPHINIC AND PHOSPHONIC ANALOGS AND C-ARYLGLYCINES (1990)
AuthorsAFARINKIA, K; CADOGAN, JIG; REES, CW
JournalSynlett
 
TitleSYNTHESIS OF ORGANOPHOSPHORUS COMPOUNDS VIA SILYL ESTERS OF PHOSPHORUS-ACIDS (1990)
AuthorsAFARINKIA, K; REES, CW; CADOGAN, JIG
JournalTetrahedron
DOI10.1016/S0040-4020(01)87899-6