Dr. Jacobo Elies Gomez
Associate Professor
- Area
- School of Pharmacy & Medical SciencesFaculty of Life Sciences
- Phone
Biography
Dr Jacobo Elíes is Associate Professor in Pharmacology at the University of Bradford. He studied Pharmacy and then undertook a PhD in Pharmacology at the University of Santiago de Compostela (Spain). In 2009, Dr Elies moved to the University of Leeds to join Professor Chris Peers’ group at the Leeds Institute of Cardiovascular and Metabolic Medicine as a postdoctoral researcher. Across two postdoctoral appointments, he studied the molecular mechanisms involved in the development of cardiovascular diseases associated with skin diseases, by investigating the regulation of ion channels by gasotransmitters.
In 2015, Dr Elies was awarded a Wellcome Trust ISSF Junior Investigator Development Fellowship at the University of Leeds to investigate the molecular mechanisms involved in cellular communication between different dermal cell types and how dysregulation of their functions can affect the skin microvasculature. Since then, he has continued to explore the origin of dermal endothelial dysfunction in skin autoimmune diseases such as Systemic Sclerosis, Lupus erythematosus and Psoriasis. Current projects are focused on: in vitro organotypic co-cultures for the study of skin blood vessel formation, hypoxia, oxidative stress and calcium handling in dermal microvasculature. His main interest resides in cellular communication between mesenchymal and endothelial cells and how dysregulation of integumentary system can affect the microvasculature.
Research
Professional activities
Awards (1)
- Fellow of the Higher Education Academy (1 July 2019)
Employment (9)
- University of Bradford - Lecturer in Pharmacology (1 March 2017)
- Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds - Wellcome Trust ISSF Junior Investigator Development Fellow (1 September 2015)
- University of Giessen, Germany - Visiting Research Fellow, Excellence Cluster Cardio-Pulmonary System (1 May 2015)
- University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Cardiovascular and Metabolic Medicine (1 September 2012)
- University of Valladolid, Spain - Visiting Research Fellow, Institute of Biology and Molecular Genetics (IBGM) (1 June 2012)
- University of Leeds - Research Fellow (1 September 2009)
- University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Genetics, Health and Therapeutics (1 September 2009)
- University of Cambridge - Visiting Research Fellow, Department of Pharmacology (1 September 2006)
- University of Santiago de Compostela, Spain - PhD student, Department of Pharmacology (1 September 2005)
Outreach activities (1)
- As a regional Director of the Society of Spanish Researchers in the UK (SRUK/CERU), I set up the CineScience series in 2017. We use cinema (in combination with round table sessions) as an engaging way of communicating science to the general public. CineScience provides a platform for criticism and discussion among the general public focused on current world challenges. Three events have been organised across different cities within Yorkshire focused on the elderly in current society, climate change and motor neuronal diseases. We are currently expanding CineScience into other regions of the UK, including London, Manchester, and Oxford.
Professional associations (2)
- Physiological Society, Full member (4 May 2020)
- British Pharmacological Society, Full Member (1 April 2017)
Publications
Book (2)
Inhibition of t-type calcium channels by hydrogen sulfide
Elies, J.;Scragg, J.L.;Dallas, M.L.;Huang, D.;Huang, S.;Boyle, J.P.;Gamper, N.;Peers, C.; (2015) Springer, Cham.
T-type Calcium channel regulation by CO: A mechanism for control of cell proliferation
Duckles, H.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Boycott, H.E.;Dallas, M.L.;Porter, K.E.;Boyle, J.P.;Scragg, J.L.;Peers, C.; (2015) Springer, Cham.
Book chapter (2)
T-type Ca2+ channel regulation by CO: a mechanism for control of cell proliferation
Duckles, H.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Boycott, H.E.; Dallas, M.L.; Porter, K.E.; Boyle, J.P.; Scragg, J.L.; Peers, C. (2015)
Inhibition of T-type Ca2+ channels by hydrogen sulfide
Elies, Jacobo; Scragg, J.L.; Dallas, M.L.; Huang, D.; Huang, S.; Boyle, J.P.; Gamper, N.; Peers, C. (2015)
Conference publication (3)
Role of Hemoxygenase-1 in endothelial function in the context of systemic sclerosis
Jacobo Elies, Rebecca Ross, Georgia Mavria, Francesco Del Galdo (2022) Europhysiology 2022, 16-18 September 2022, Copenhagen.
Stabilisation of suppressor of cytokine signalling 3 (SOCS3) to inhibit human saphenous vein smooth muscle cell proliferation and vascular stenosis
Tim Palmer, Florah Moshapa, Jamie Willliams, Kirsten Riches-Suman, Jacobo Elies (2021) The British Society of Cardiovascular Research Annual Meeting. ‘Cardiology and the Environment’, 7–10 June 2021. 107
Expression of stable SOCS3 in human saphenous vein smooth muscle cells: potential therapy for vascular restenosis
Florah T. Moshapa, Kirsten A.A. Munro, Jamie J.J.L. Williams, Jacobo Elies, Kirsten Riches-Suman, Timothy M. Palmer (2019) BSCR/BAS research meeting 2019. 105
Editorial (1)
Editorial: Trends post-COVID-19 attack: the cardiocerebral system safety remains of utmost concern.
Nader M;Haddad G;Elies J;Kentamneni S;AlBadarin F; (2023) Frontiers in Physiology. 14
Peer reviewed journal (30)
Investigation of Cell Adhesion and Cell Viability of the Endothelial and Fibroblast Cells on Electrospun PCL, PLGA and Coaxial Scaffolds for Production of Tissue Engineered Blood Vessel.
Bazgir M;Saeinasab M;Zhang W;Zhang X;Min Tsui K;Maasoumi Sarvestani A;Nawaz S;Coates P;Youseffi M;Elies J;Sefat F; (2022) Journal Of Functional Biomaterials. 13
Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis
Ross RL, Mavria G, Del Galdo F and Elies J. (2022) Front Physiology. 13
Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering.
Bazgir M;Zhang W;Zhang X;Elies J;Saeinasab M;Coates P;Youseffi M;Sefat F; (2021) Materials. 14
Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering.
Bazgir M;Zhang W;Zhang X;Elies J;Saeinasab M;Coates P;Youseffi M;Sefat F; (2021) Materials. 14
An Update to Calcium Binding Proteins.
Elíes J;Yáñez M;Pereira TMC;Gil-Longo J;MacDougall DA;Campos-Toimil M; (2020) Advances in Experimental Medicine and Biology. 1131
Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor
Liakouli, V.; Elies, Jacobo; El-Sherbiny, Y.M.; Scarcia, M.; Grant, G.; Abignano, G.; Derrett-Smith, E.C.; Esteves, F.; Cipriani, P.; Emery, P.; Denton, C.P.; Giacomelli, R.; Mavira, G.; Del Galdo, F. (2018)
TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
Berrout, J.; Kyriakopoulou, E.; Moparthi, L.; Hogea, A.S.; Berrout, L.; Ivan, C.; Lorger, M.; Boyle, J.; Peers, C.; Muench, S.; Elies, Jacobo; Hu, X.; Hurst, C.; Hall, T.; Umamaheswaran, S.; Wesley, L.; Gagea, M.; Shires, M.; Manfield, I.; Knowles, M.A.; Davies, S.; Suhling, K.; Gonzalez, Y.T.; Carragher, N.; Macleod, K.; Abbott, N.J.; Calin, G.A.; Gamper, N.; Zygmunt, P.M.; Timsah, Z. (2017)
Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K + channel Kv1.5
Al-Owais M.;Hettiarachchi N.;Boyle J.;Scragg J.;Elies J.;Dallas M.;Lippiat J.;Steele D.;Peers C. (2017) Cell Death and Disease. 8
Regulation of the T-type Ca2+ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H
2S in nociceptionElies, J.;Scragg, J.L.;Boyle, J.P.;Gamper, N.;Peers, C.; (2016) Physiology. 15
H2S does not regulate proliferation via T-type Ca2+ channels
Elies, Jacobo; Johnson, E.; Boyle, J.P.; Scragg, J.L.; Peers, C. (2015)
H
2S does not regulate proliferation via T-type Ca2+ channelsElies, J.;Johnson, E.;Boyle, J.P.;Scragg, J.L.;Peers, C.; (2015) Biochemical and Biophysical Research Communications.
Diverse mechanisms underlying the regulation of ion channels by carbon monoxide
Peers, C.; Boyle, J.P.; Scragg, J.L.; Dallas, M.L.; Al-Owais, M.M.; Hettiarachichi, N.T.; Elies, Jacobo; Johnson, E.; Gamper, N.; Steele, D.S. (2015)
Novel ways to regulate T-type Ca2+ channels
Peers, C.; Elies, Jacobo; Gamper, N. (2015)
Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels
Duckles, H.; Boycott, H.E.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Dallas, M.L.; Porter, K.E.; Giuntini, F.; Boyle, J.P.; Scragg, J.L.; Peers, C. (2015)
Novel ways to regulate T-type Ca2+ channels
Peers, C.;Elies, J.;Gamper, N.; (2015) Channels.
Hydrogen sulfide inhibits Cav3.2 T-type Ca2 channels
Elies, Jacobo; Scragg, J.L.; Huang, S.; Dallas, M.L.; Huang, D.; MacDougall, D.; Boyle, J.P.; Gamper, N.; Peers, C. (2014)
PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production
García-Morales V, Cuíñas A, Elíes J.;Campos-Toimil, M.; (2014) Vascular Pharmacology. 3, 95-101.
Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide.
Elies J;Dallas ML;Boyle JP;Scragg JL;Duke A;Steele DS;Peers C; (2014) Journal of Biological Chemistry. 289
Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels
Elies, J.;Scragg, J.L.;Huang, S.;Dallas, M.L.;Huang, D.;MacDougall, D.;Boyle, J.P.;Gamper, N.;Peers, C.; (2014) FASEB Journal.
Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide
Elies, Jacobo; Dallas, M.L.; Boyle, J.P.; Scragg, J.L.; Duke, A.; Steele, D.S.; Peers, C. (2014)
Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels
Duckles, H.;Boycott, H.E.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Dallas, M.L.;Porter, K.E.;Giuntini, F.;Boyle, J.P.;Scragg, J.L.;Peers, C.; (2014) Pflugers Archiv European Journal of Physiology.
PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production
Garcia-Morales, V.; Cuíñas, A.; Elies, Jacobo; Campos-Toimil, M. (2014)
Trans-resveratrol down-regulates caveolin-1, up-regulates endothelial NO synthase and reduces their interaction in vascular smooth muscle and endothelial cells
Elíes, J.;Cuíñas, A.;MacDougall, D.A.;Leiro, J.;Campos-Toimil, M.; (2013) Food Bioscience., 31-38.
Carbon monoxide inhibition of Cav3.2 T-type Ca2 channels reveals tonic modulation by thioredoxin
Boycott, H.E.;Dallas, M.L.;Elies, J.;Pettinger, L.;Boyle, J.P.;Scragg, J.L.;Gamper, N.;Peers, C.; (2013) FASEB Journal.
Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry
Cuíñas A, Elíes J.;Orallo, F.;Campos-Toimil, M.; (2013) Vascular Pharmacology. 1-2, 98-104.
Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current
Dallas, M.L.;Yang, Z.;Boyle, J.P.;Boycott, H.E.;Scragg, J.L.;Milligan, C.J.;Elies, J.;Duke, A.;Thireau, J.;Reboul, C.;Richard, S.;Bernus, O.;Steele, D.S.;Peers, C.; (2012) American Journal of Respiratory and Critical Care Medicine.
Trans-resveratrol simultaneously increases cytoplasmic Ca 2+ levels and nitric oxide release in human endothelial cells
Elies, J.;Cuinas, A.;García-Morales, V.;Orallo, F.;Campos-Toimil, M.; (2011) Molecular Nutrition and Food Research. 55, 1237-1248.
Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes
Campos-Toimil, M.;ElÃes, J.;Ãlvarez, E.;Verde, I.;Orallo, F.; (2007) European Journal of Pharmacology.
Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells
Campos-Toimil, M.;ElÃes, J.;Orallo, F.; (2005) Molecular Nutrition and Food Research.