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researcher

Jacobo Elies Gomez

Lecturer in Pharmacology

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailj.eliesgomez@bradford.ac.uk
Telephone +441274 232132

Biography

Dr Jacobo Elíes is Lecturer in Pharmacology at the University of Bradford. He studied Pharmacy and then undertook a PhD in Pharmacology at the University of Santiago de Compostela (Spain). In 2009, Dr Elies moved to the University of Leeds to joined Professor Chris Peers’ group at the Leeds Institute of Cardiovascular and Metabolic Medicine as a postdoctoral researcher.  Across two postdoctoral appointments, he studied the molecular mechanisms involved in the development of cardiovascular diseases associated with skin diseases, by investigating the regulation of ion channels by gasotransmitters.
In 2015 Dr Elies was awarded a Wellcome Trust ISSF junior investigator at the University of Leeds to investigate the molecular mechanism involved in cellular communication between different dermal cell types and how dysregulation of their functions can affect the skin microvasculature. In particular, he is investigating the origin of dermal endothelial dysfunction in skin autoimmune diseases such as Systemic Sclerosis, Lupus erythematosus and Psoriasis. Specific projects are focused on:  in vitro organotypic co-cultures for the study of skin blood vessel formation, hypoxia, oxidative stress and calcium handling in dermal microvasculature. His main interest resides in cellular communication between mesenchymal and endothelial cells and how dysregulation of integumentary system can affect the microvasculature.    

Professional activities

  • 01-SEP-15: Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds - Wellcome Trust ISSF Junior Investigator Development Fellow
  • 01-MAY-15: University of Giessen, Germany - Visiting Research Fellow, Excellence Cluster Cardio-Pulmonary System
  • 01-SEP-12: University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Cardiovascular and Metabolic Medicine
  • 01-JUN-12: University of Valladolid, Spain - Visiting Research Fellow, Institute of Biology and Molecular Genetics (IBGM)
  • 01-SEP-09: University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Genetics, Health and Therapeutics
  • 01-SEP-06: University of Cambridge - Visiting Research Fellow, Department of Pharmacology
  • 01-SEP-05: University of Santiago de Compostela, Spain - PhD student, Department of Pharmacology
  • 01-MAR-17: University of Bradford - Lecturer in Pharmacology
  • 01-SEP-09: University of Leeds - Research Fellow

  • 01-APR-17: British Pharmacological Society, Full Member

  • 01-JAN-19: - Fellow of the Higher Education Academy

  • From the society of Spanish Researchers in the UK (SRUK/CERU) I set up this inniciative in 2017. We used cinema (in combination with round table sessions) as an engaging way of communicating science to the general public. The iniciative CineSciene has opened criticism and discussion among general public by combining the 7th Art and round table focused on current World Challenges. Three editions have been organised across different cities within Yorkshire focused on the Elderly in the current society, Climate Change and Motor neuronal diseases: Amyotrophic Lateral Sclerosis. We have currently expanded this event into other regions of the UK (London, Manchester, Oxford, ...).

Publications

Peer Reviewed Journal
TitleScleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor (2018)
AuthorsLiakouli, V.; Elies, Jacobo; El-Sherbiny, Y.M.; Scarcia, M.; Grant, G.; Abignano, G.; Derrett-Smith, E.C.; Esteves, F.; Cipriani, P.; Emery, P.; Denton, C.P.; Giacomelli, R.; Mavira, G.; Del Galdo, F.
 
TitleTRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p (2017)
AuthorsBerrout, J.; Kyriakopoulou, E.; Moparthi, L.; Hogea, A.S.; Berrout, L.; Ivan, C.; Lorger, M.; Boyle, J.; Peers, C.; Muench, S.; Elies, Jacobo; Hu, X.; Hurst, C.; Hall, T.; Umamaheswaran, S.; Wesley, L.; Gagea, M.; Shires, M.; Manfield, I.; Knowles, M.A.; Davies, S.; Suhling, K.; Gonzalez, Y.T.; Carragher, N.; Macleod, K.; Abbott, N.J.; Calin, G.A.; Gamper, N.; Zygmunt, P.M.; Timsah, Z.
 
TitleRegulation of the T-type Ca2+ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H2S in nociception (2016)
AuthorsElies, J.;Scragg, J.L.;Boyle, J.P.;Gamper, N.;Peers, C.;
JournalPhysiology
DOI10.1113/JP270963
 
TitleHeme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels (2015)
AuthorsDuckles, H.; Boycott, H.E.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Dallas, M.L.; Porter, K.E.; Giuntini, F.; Boyle, J.P.; Scragg, J.L.; Peers, C.
 
TitleDiverse mechanisms underlying the regulation of ion channels by carbon monoxide (2015)
AuthorsPeers, C.; Boyle, J.P.; Scragg, J.L.; Dallas, M.L.; Al-Owais, M.M.; Hettiarachichi, N.T.; Elies, Jacobo; Johnson, E.; Gamper, N.; Steele, D.S.
 
TitleNovel ways to regulate T-type Ca2+ channels (2015)
AuthorsPeers, C.;Elies, J.;Gamper, N.;
JournalChannels
DOI10.1080/19336950.2015.1017995
 
TitleH2S does not regulate proliferation via T-type Ca2+ channels (2015)
AuthorsElies, J.;Johnson, E.;Boyle, J.P.;Scragg, J.L.;Peers, C.;
JournalBiochemical and Biophysical Research Communications
DOI10.1016/j.bbrc.2015.04.087
 
TitlePKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production (2014)
AuthorsGarcia-Morales, V.; Cuíñas, A.; Elies, Jacobo; Campos-Toimil, M.
 
TitleInhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide (2014)
AuthorsElies, Jacobo; Dallas, M.L.; Boyle, J.P.; Scragg, J.L.; Duke, A.; Steele, D.S.; Peers, C.
 
TitleHeme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca<sup>2+</sup> channels (2014)
AuthorsDuckles, H.;Boycott, H.E.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Dallas, M.L.;Porter, K.E.;Giuntini, F.;Boyle, J.P.;Scragg, J.L.;Peers, C.;
JournalPflugers Archiv European Journal of Physiology
DOI10.1007/s00424-014-1503-5
 
TitleHydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels (2014)
AuthorsElies, J.;Scragg, J.L.;Huang, S.;Dallas, M.L.;Huang, D.;MacDougall, D.;Boyle, J.P.;Gamper, N.;Peers, C.;
JournalFASEB Journal
DOI10.1096/fj.14-257113
 
TitleTrans-resveratrol down-regulates caveolin-1, up-regulates endothelial NO synthase and reduces their interaction in vascular smooth muscle and endothelial cells (2013)
AuthorsElíes, J.;Cuíñas, A.;MacDougall, D.A.;Leiro, J.;Campos-Toimil, M.;
JournalFood Bioscience
PublisherElsevier Science
DOI10.1016/j.fbio.2013.02.002
 
TitleCarbon monoxide inhibition of Cav3.2 T-type Ca2 channels reveals tonic modulation by thioredoxin (2013)
AuthorsBoycott, H.E.;Dallas, M.L.;Elies, J.;Pettinger, L.;Boyle, J.P.;Scragg, J.L.;Gamper, N.;Peers, C.;
JournalFASEB Journal
DOI10.1096/fj.13-227249
 
TitleCyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry (2013)
AuthorsCuíñas A, Elíes J.;Orallo, F.;Campos-Toimil, M.;
JournalVascular Pharmacology
DOI10.1016/j.vph.2012.08.007
 
TitleCarbon monoxide induces cardiac arrhythmia via induction of the late Na+ current (2012)
AuthorsDallas, M.L.;Yang, Z.;Boyle, J.P.;Boycott, H.E.;Scragg, J.L.;Milligan, C.J.;Elies, J.;Duke, A.;Thireau, J.;Reboul, C.;Richard, S.;Bernus, O.;Steele, D.S.;Peers, C.;
JournalAmerican Journal of Respiratory and Critical Care Medicine
DOI10.1164/rccm.201204-0688OC
 
TitleDNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells (2007)
JournalCancer Letters
DOI10.1016/j.canlet.2006.12.037
 
TitleTrans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells (2005)
AuthorsCampos-Toimil, M.;Elíes, J.;Orallo, F.;
JournalMolecular Nutrition and Food Research
DOI10.1002/mnfr.200400108
 

Book
TitleT-type Calcium channel regulation by CO: A mechanism for control of cell proliferation (2015)
AuthorsDuckles, H.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Boycott, H.E.;Dallas, M.L.;Porter, K.E.;Boyle, J.P.;Scragg, J.L.;Peers, C.;
PublisherSpringer, Cham
DOI10.1007/978-3-319-18440-1_33
 
TitleInhibition of t-type calcium channels by hydrogen sulfide (2015)
AuthorsElies, J.;Scragg, J.L.;Dallas, M.L.;Huang, D.;Huang, S.;Boyle, J.P.;Gamper, N.;Peers, C.;
PublisherSpringer, Cham
DOI10.1007/978-3-319-18440-1_40