Dr Jacobo Elies Gomez
Lecturer in Pharmacology
| Faculty/Dept/School |
School of Pharmacy and Medical Sciences (Faculty of Life Sciences) |
|---|---|
| j.eliesgomez@bradford.ac.uk | |
| Telephone | +441274 232132 |
Biography
Dr Jacobo Elíes is Lecturer in Pharmacology at the University of Bradford. He studied Pharmacy and then undertook a PhD in Pharmacology at the University of Santiago de Compostela (Spain). In 2009, Dr Elies moved to the University of Leeds to join Professor Chris Peers’ group at the Leeds Institute of Cardiovascular and Metabolic Medicine as a postdoctoral researcher. Across two postdoctoral appointments, he studied the molecular mechanisms involved in the development of cardiovascular diseases associated with skin diseases, by investigating the regulation of ion channels by gasotransmitters.
In 2015, Dr Elies was awarded a Wellcome Trust ISSF Junior Investigator Development Fellowship at the University of Leeds to investigate the molecular mechanisms involved in cellular communication between different dermal cell types and how dysregulation of their functions can affect the skin microvasculature. Since then, he has continued to explore the origin of dermal endothelial dysfunction in skin autoimmune diseases such as Systemic Sclerosis, Lupus erythematosus and Psoriasis. Current projects are focused on: in vitro organotypic co-cultures for the study of skin blood vessel formation, hypoxia, oxidative stress and calcium handling in dermal microvasculature. His main interest resides in cellular communication between mesenchymal and endothelial cells and how dysregulation of integumentary system can affect the microvasculature.
Professional activities
- 01-SEP-15: Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds - Wellcome Trust ISSF Junior Investigator Development Fellow
- 01-MAY-15: University of Giessen, Germany - Visiting Research Fellow, Excellence Cluster Cardio-Pulmonary System
- 01-SEP-12: University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Cardiovascular and Metabolic Medicine
- 01-JUN-12: University of Valladolid, Spain - Visiting Research Fellow, Institute of Biology and Molecular Genetics (IBGM)
- 01-SEP-09: University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Genetics, Health and Therapeutics
- 01-SEP-06: University of Cambridge - Visiting Research Fellow, Department of Pharmacology
- 01-SEP-05: University of Santiago de Compostela, Spain - PhD student, Department of Pharmacology
- 01-MAR-17: University of Bradford - Lecturer in Pharmacology
- 01-SEP-09: University of Leeds - Research Fellow
- 01-APR-17: British Pharmacological Society, Full Member
- 01-JAN-19: - Fellow of the Higher Education Academy
- As a regional Director of the Society of Spanish Researchers in the UK (SRUK/CERU), I set up the CineScience series in 2017. We use cinema (in combination with round table sessions) as an engaging way of communicating science to the general public. CineScience provides a platform for criticism and discussion among the general public focused on current world challenges. Three events have been organised across different cities within Yorkshire focused on the elderly in current society, climate change and motor neuronal diseases. We are currently expanding CineScience into other regions of the UK, including London, Manchester, and Oxford.
Publications
| Peer Reviewed Journal | |
|---|---|
| Title | Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor (2018) |
| Authors | Liakouli, V.; Elies, Jacobo; El-Sherbiny, Y.M.; Scarcia, M.; Grant, G.; Abignano, G.; Derrett-Smith, E.C.; Esteves, F.; Cipriani, P.; Emery, P.; Denton, C.P.; Giacomelli, R.; Mavira, G.; Del Galdo, F. |
| Title | TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p (2017) |
| Authors | Berrout, J.; Kyriakopoulou, E.; Moparthi, L.; Hogea, A.S.; Berrout, L.; Ivan, C.; Lorger, M.; Boyle, J.; Peers, C.; Muench, S.; Elies, Jacobo; Hu, X.; Hurst, C.; Hall, T.; Umamaheswaran, S.; Wesley, L.; Gagea, M.; Shires, M.; Manfield, I.; Knowles, M.A.; Davies, S.; Suhling, K.; Gonzalez, Y.T.; Carragher, N.; Macleod, K.; Abbott, N.J.; Calin, G.A.; Gamper, N.; Zygmunt, P.M.; Timsah, Z. |
| Title | Regulation of the T-type Ca2+ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H |
| Authors | Elies, J.;Scragg, J.L.;Boyle, J.P.;Gamper, N.;Peers, C.; |
| Journal | Physiology |
| DOI | 10.1113/JP270963 |
| Title | Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels (2015) |
| Authors | Duckles, H.; Boycott, H.E.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Dallas, M.L.; Porter, K.E.; Giuntini, F.; Boyle, J.P.; Scragg, J.L.; Peers, C. |
| Title | Diverse mechanisms underlying the regulation of ion channels by carbon monoxide (2015) |
| Authors | Peers, C.; Boyle, J.P.; Scragg, J.L.; Dallas, M.L.; Al-Owais, M.M.; Hettiarachichi, N.T.; Elies, Jacobo; Johnson, E.; Gamper, N.; Steele, D.S. |
| Title | Novel ways to regulate T-type Ca2+ channels (2015) |
| Authors | Peers, C.;Elies, J.;Gamper, N.; |
| Journal | Channels |
| DOI | 10.1080/19336950.2015.1017995 |
| Title | H |
| Authors | Elies, J.;Johnson, E.;Boyle, J.P.;Scragg, J.L.;Peers, C.; |
| Journal | Biochemical and Biophysical Research Communications |
| DOI | 10.1016/j.bbrc.2015.04.087 |
| Title | PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production (2014) |
| Authors | Garcia-Morales, V.; Cuíñas, A.; Elies, Jacobo; Campos-Toimil, M. |
| Title | Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide (2014) |
| Authors | Elies, Jacobo; Dallas, M.L.; Boyle, J.P.; Scragg, J.L.; Duke, A.; Steele, D.S.; Peers, C. |
| Title | Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca<sup>2+</sup> channels (2014) |
| Authors | Duckles, H.;Boycott, H.E.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Dallas, M.L.;Porter, K.E.;Giuntini, F.;Boyle, J.P.;Scragg, J.L.;Peers, C.; |
| Journal | Pflugers Archiv European Journal of Physiology |
| DOI | 10.1007/s00424-014-1503-5 |
| Title | Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels (2014) |
| Authors | Elies, J.;Scragg, J.L.;Huang, S.;Dallas, M.L.;Huang, D.;MacDougall, D.;Boyle, J.P.;Gamper, N.;Peers, C.; |
| Journal | FASEB Journal |
| DOI | 10.1096/fj.14-257113 |
| Title | Trans-resveratrol down-regulates caveolin-1, up-regulates endothelial NO synthase and reduces their interaction in vascular smooth muscle and endothelial cells (2013) |
| Authors | Elíes, J.;Cuíñas, A.;MacDougall, D.A.;Leiro, J.;Campos-Toimil, M.; |
| Journal | Food Bioscience |
| Publisher | Elsevier Science |
| DOI | 10.1016/j.fbio.2013.02.002 |
| Title | Carbon monoxide inhibition of Cav3.2 T-type Ca2 channels reveals tonic modulation by thioredoxin (2013) |
| Authors | Boycott, H.E.;Dallas, M.L.;Elies, J.;Pettinger, L.;Boyle, J.P.;Scragg, J.L.;Gamper, N.;Peers, C.; |
| Journal | FASEB Journal |
| DOI | 10.1096/fj.13-227249 |
| Title | Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry (2013) |
| Authors | Cuíñas A, Elíes J.;Orallo, F.;Campos-Toimil, M.; |
| Journal | Vascular Pharmacology |
| DOI | 10.1016/j.vph.2012.08.007 |
| Title | Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current (2012) |
| Authors | Dallas, M.L.;Yang, Z.;Boyle, J.P.;Boycott, H.E.;Scragg, J.L.;Milligan, C.J.;Elies, J.;Duke, A.;Thireau, J.;Reboul, C.;Richard, S.;Bernus, O.;Steele, D.S.;Peers, C.; |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| DOI | 10.1164/rccm.201204-0688OC |
| Title | DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells (2007) |
| Journal | Cancer Letters |
| DOI | 10.1016/j.canlet.2006.12.037 |
| Title | Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells (2005) |
| Authors | Campos-Toimil, M.;ElÃes, J.;Orallo, F.; |
| Journal | Molecular Nutrition and Food Research |
| DOI | 10.1002/mnfr.200400108 |
| Book | |
|---|---|
| Title | T-type Calcium channel regulation by CO: A mechanism for control of cell proliferation (2015) |
| Authors | Duckles, H.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Boycott, H.E.;Dallas, M.L.;Porter, K.E.;Boyle, J.P.;Scragg, J.L.;Peers, C.; |
| Publisher | Springer, Cham |
| DOI | 10.1007/978-3-319-18440-1_33 |
| Title | Inhibition of t-type calcium channels by hydrogen sulfide (2015) |
| Authors | Elies, J.;Scragg, J.L.;Dallas, M.L.;Huang, D.;Huang, S.;Boyle, J.P.;Gamper, N.;Peers, C.; |
| Publisher | Springer, Cham |
| DOI | 10.1007/978-3-319-18440-1_40 |