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Dr. Jacobo Elies Gomez,
Associate Professor

Information about Dr. Jacobo Elies Gomez at the University of Bradford.

School of Pharmacy & Medical Sciences
(Faculty of Life Sciences)
Email:
j.eliesgomez@bradford.ac.uk
Telephone:
+44 1274 232132
Photo of Dr. Jacobo Elies Gomez

2

supervised researchers.

Biography

Dr Jacobo Elíes is Lecturer in Pharmacology at the Universityof Bradford. He studied Pharmacy and then undertook a PhD in Pharmacology atthe University of Santiago de Compostela (Spain). In 2009, Dr Elies moved tothe University of Leeds to join Professor Chris Peers’ group at the LeedsInstitute of Cardiovascular and Metabolic Medicine as a postdoctoralresearcher. Across two postdoctoral appointments, he studied themolecular mechanisms involved in the development of cardiovascular diseasesassociated with skin diseases, by investigating the regulation of ion channelsby gasotransmitters.

In 2015, Dr Elies was awarded a Wellcome Trust ISSF Junior Investigator DevelopmentFellowship at the University of Leeds to investigate the molecular mechanismsinvolved in cellular communication between different dermal cell types and howdysregulation of their functions can affect the skin microvasculature. Sincethen, he has continued to explore the origin of dermal endothelial dysfunctionin skin autoimmune diseases such as Systemic Sclerosis, Lupus erythematosus andPsoriasis. Current projects are focused on: in vitro organotypicco-cultures for the study of skin blood vessel formation, hypoxia, oxidativestress and calcium handling in dermal microvasculature. His main interestresides in cellular communication between mesenchymal and endothelial cells andhow dysregulation of integumentary system can affect the microvasculature.

Research

Research supervision

Dr. Jacobo Elies Gomez is responsible for the supervision of 2 postgraduate researchers at the University of Bradford.

Research collaborators

Information about people or organisations that Dr. Jacobo Elies Gomez collaborates with.
Name Company Country Type Role Theme Description
University of Leeds GB EXTERNAL Cardiovascular involvement of Autoimmune diseases

Professional activities

Information about education, employment and areas of particular interest for Dr. Jacobo Elies Gomez is as follows:

Employment

  • Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds - Wellcome Trust ISSF Junior Investigator Development Fellow in the year 2015 (specified as 01/09/2015)
  • University of Giessen, Germany - Visiting Research Fellow, Excellence Cluster Cardio-Pulmonary System in the year 2015 (specified as 01/05/2015)
  • University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Cardiovascular and Metabolic Medicine in the year 2012 (specified as 01/09/2012)
  • University of Valladolid, Spain - Visiting Research Fellow, Institute of Biology and Molecular Genetics (IBGM) in the year 2012 (specified as 01/06/2012)
  • University of Leeds - Postdoctoral Research Fellow, Leeds Institute of Genetics, Health and Therapeutics in the year 2009 (specified as 01/09/2009)
  • University of Cambridge - Visiting Research Fellow, Department of Pharmacology in the year 2006 (specified as 01/09/2006)
  • University of Santiago de Compostela, Spain - PhD student, Department of Pharmacology in the year 2005 (specified as 01/09/2005)
  • University of Bradford - Lecturer in Pharmacology in the year 2017 (specified as 01/03/2017)
  • University of Leeds - Research Fellow in the year 2009 (specified as 01/09/2009)

Publications

There are 38 publications involving or that are attributed to Dr. Jacobo Elies Gomez. They are listed as:

  • book (2)
  • book chapter (2)
  • conference publication (3)
  • editorial (1)
  • peer reviewed journal (30)

Book

Dr. Jacobo Elies Gomez has 2 publication(s) listed under book.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Inhibition of t-type calcium channels by hydrogen sulfide 2015 860 Elies, J.;Scragg, J.L.;Dallas, M.L.;Huang, D.;Huang, S.;Boyle, J.P.;Gamper, N.;Peers, C.; 978-3-319-18440-1 Springer, Cham 10.1007/978-3-319-18440-1_40
T-type Calcium channel regulation by CO: A mechanism for control of cell proliferation 2015 860 Duckles, H.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Boycott, H.E.;Dallas, M.L.;Porter, K.E.;Boyle, J.P.;Scragg, J.L.;Peers, C.; 978-3-319-18440-1 Springer, Cham 10.1007/978-3-319-18440-1_33

Book Chapter

Dr. Jacobo Elies Gomez has 2 publication(s) listed under book chapter.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Inhibition of T-type Ca2+ channels by hydrogen sulfide 2015 Elies, Jacobo; Scragg, J.L.; Dallas, M.L.; Huang, D.; Huang, S.; Boyle, J.P.; Gamper, N.; Peers, C.
T-type Ca2+ channel regulation by CO: a mechanism for control of cell proliferation 2015 Duckles, H.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Boycott, H.E.; Dallas, M.L.; Porter, K.E.; Boyle, J.P.; Scragg, J.L.; Peers, C.

Conference Publication

Dr. Jacobo Elies Gomez has 3 publication(s) listed under conference publication.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Expression of stable SOCS3 in human saphenous vein smooth muscle cells: potential therapy for vascular restenosis 2019 BSCR/BAS research meeting 2019 BSCR/BAS research meeting 2019 105 Florah T. Moshapa, Kirsten A.A. Munro, Jamie J.J.L. Williams, Jacobo Elies, Kirsten Riches-Suman, Timothy M. Palmer Heart http://dx.doi.org/10.1136/heartjnl-2019-BCS.192
Stabilisation of suppressor of cytokine signalling 3 (SOCS3) to inhibit human saphenous vein smooth muscle cell proliferation and vascular stenosis 2021 The British Society of Cardiovascular Research Annual Meeting. ‘Cardiology and the Environment’, 7–10 June 2021 The British Society of Cardiovascular Research Annual Meeting. ‘Cardiology and the Environment’, 7–10 June 2021 107 Tim Palmer, Florah Moshapa, Jamie Willliams, Kirsten Riches-Suman, Jacobo Elies BMJ Journals Heart http://dx.doi.org/10.1136/heartjnl-2021-BCS.219
Role of Hemoxygenase-1 in endothelial function in the context of systemic sclerosis 2022 Europhysiology 2022, 16-18 September 2022, Copenhagen Europhysiology 2022, 16-18 September 2022, Copenhagen Jacobo Elies, Rebecca Ross, Georgia Mavria, Francesco Del Galdo Acta Physiologica https://doi.org/10.1111/apha.13876

Editorial

Dr. Jacobo Elies Gomez has 1 publication(s) listed under editorial.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
Editorial: Trends post-COVID-19 attack: the cardiocerebral system safety remains of utmost concern. 2023 Frontiers in Physiology 14 Nader M;Haddad G;Elies J;Kentamneni S;AlBadarin F; 1664-042X 10.3389/fphys.2023.1224550

Peer Reviewed Journal

Dr. Jacobo Elies Gomez has 30 publication(s) listed under peer reviewed journal.
Title Year Publication name Journal Volume Pages Authors Editors ISSN Publisher DOI Location
TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p 2017 Berrout, J.; Kyriakopoulou, E.; Moparthi, L.; Hogea, A.S.; Berrout, L.; Ivan, C.; Lorger, M.; Boyle, J.; Peers, C.; Muench, S.; Elies, Jacobo; Hu, X.; Hurst, C.; Hall, T.; Umamaheswaran, S.; Wesley, L.; Gagea, M.; Shires, M.; Manfield, I.; Knowles, M.A.; Davies, S.; Suhling, K.; Gonzalez, Y.T.; Carragher, N.; Macleod, K.; Abbott, N.J.; Calin, G.A.; Gamper, N.; Zygmunt, P.M.; Timsah, Z.
Diverse mechanisms underlying the regulation of ion channels by carbon monoxide 2015 Peers, C.; Boyle, J.P.; Scragg, J.L.; Dallas, M.L.; Al-Owais, M.M.; Hettiarachichi, N.T.; Elies, Jacobo; Johnson, E.; Gamper, N.; Steele, D.S.
H2S does not regulate proliferation via T-type Ca2+ channels 2015 Elies, Jacobo; Johnson, E.; Boyle, J.P.; Scragg, J.L.; Peers, C.
Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels 2015 Duckles, H.; Boycott, H.E.; Al-Owais, M.M.; Elies, Jacobo; Johnson, E.; Dallas, M.L.; Porter, K.E.; Giuntini, F.; Boyle, J.P.; Scragg, J.L.; Peers, C.
Hydrogen sulfide inhibits Cav3.2 T-type Ca2 channels 2014 Elies, Jacobo; Scragg, J.L.; Huang, S.; Dallas, M.L.; Huang, D.; MacDougall, D.; Boyle, J.P.; Gamper, N.; Peers, C.
Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide 2014 Elies, Jacobo; Dallas, M.L.; Boyle, J.P.; Scragg, J.L.; Duke, A.; Steele, D.S.; Peers, C.
PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production 2014 Garcia-Morales, V.; Cuíñas, A.; Elies, Jacobo; Campos-Toimil, M.
Novel ways to regulate T-type Ca2+ channels 2015 Peers, C.; Elies, Jacobo; Gamper, N.
Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor 2018 Liakouli, V.; Elies, Jacobo; El-Sherbiny, Y.M.; Scarcia, M.; Grant, G.; Abignano, G.; Derrett-Smith, E.C.; Esteves, F.; Cipriani, P.; Emery, P.; Denton, C.P.; Giacomelli, R.; Mavira, G.; Del Galdo, F.
Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K + channel Kv1.5 2017 Cell Death and Disease 8 Al-Owais M.;Hettiarachchi N.;Boyle J.;Scragg J.;Elies J.;Dallas M.;Lippiat J.;Steele D.;Peers C. 2041-4889 10.1038/cddis.2017.568
Novel ways to regulate T-type Ca2+ channels 2015 Channels Peers, C.;Elies, J.;Gamper, N.; 10.1080/19336950.2015.1017995
Regulation of the T-type Ca2+ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H2S in nociception 2016 Physiology 15 Elies, J.;Scragg, J.L.;Boyle, J.P.;Gamper, N.;Peers, C.; 10.1113/JP270963
Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry 2013 Vascular Pharmacology 1-2 98 - 104 Cuíñas A, Elíes J.;Orallo, F.;Campos-Toimil, M.; 10.1016/j.vph.2012.08.007
Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current 2012 American Journal of Respiratory and Critical Care Medicine Dallas, M.L.;Yang, Z.;Boyle, J.P.;Boycott, H.E.;Scragg, J.L.;Milligan, C.J.;Elies, J.;Duke, A.;Thireau, J.;Reboul, C.;Richard, S.;Bernus, O.;Steele, D.S.;Peers, C.; 10.1164/rccm.201204-0688OC
Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells 2005 Molecular Nutrition and Food Research Campos-Toimil, M.;Elíes, J.;Orallo, F.; 10.1002/mnfr.200400108
Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes 2007 European Journal of Pharmacology Campos-Toimil, M.;Elíes, J.;Álvarez, E.;Verde, I.;Orallo, F.; 10.1016/j.ejphar.2007.08.003
Trans-resveratrol simultaneously increases cytoplasmic Ca 2+ levels and nitric oxide release in human endothelial cells 2011 Molecular Nutrition and Food Research 55 1237 - 1248 Elies, J.;Cuinas, A.;Garcí­a-Morales, V.;Orallo, F.;Campos-Toimil, M.; WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 10.1002/mnfr.201100240
Carbon monoxide inhibition of Cav3.2 T-type Ca2 channels reveals tonic modulation by thioredoxin 2013 FASEB Journal Boycott, H.E.;Dallas, M.L.;Elies, J.;Pettinger, L.;Boyle, J.P.;Scragg, J.L.;Gamper, N.;Peers, C.; 10.1096/fj.13-227249
PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production 2014 Vascular Pharmacology 3 95 - 101 García-Morales V, Cuíñas A, Elíes J.;Campos-Toimil, M.; 10.1016/j.vph.2014.01.004
Trans-resveratrol down-regulates caveolin-1, up-regulates endothelial NO synthase and reduces their interaction in vascular smooth muscle and endothelial cells 2013 Food Bioscience 31 - 38 Elíes, J.;Cuíñas, A.;MacDougall, D.A.;Leiro, J.;Campos-Toimil, M.; 2212-4292 Elsevier Science 10.1016/j.fbio.2013.02.002
DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells 2007 Cancer Letters 10.1016/j.canlet.2006.12.037
Hydrogen sulfide inhibits Cav3.2 T-type Ca2+ channels 2014 FASEB Journal Elies, J.;Scragg, J.L.;Huang, S.;Dallas, M.L.;Huang, D.;MacDougall, D.;Boyle, J.P.;Gamper, N.;Peers, C.; 10.1096/fj.14-257113
H2S does not regulate proliferation via T-type Ca2+ channels 2015 Biochemical and Biophysical Research Communications Elies, J.;Johnson, E.;Boyle, J.P.;Scragg, J.L.;Peers, C.; 10.1016/j.bbrc.2015.04.087
Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca<sup>2+</sup> channels 2014 Pflugers Archiv European Journal of Physiology Duckles, H.;Boycott, H.E.;Al-Owais, M.M.;Elies, J.;Johnson, E.;Dallas, M.L.;Porter, K.E.;Giuntini, F.;Boyle, J.P.;Scragg, J.L.;Peers, C.; 10.1007/s00424-014-1503-5
An Update to Calcium Binding Proteins. 2020 Advances in Experimental Medicine and Biology 1131 Elíes J;Yáñez M;Pereira TMC;Gil-Longo J;MacDougall DA;Campos-Toimil M; 0065-2598 10.1007/978-3-030-12457-1_8
Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide. 2014 Journal of Biological Chemistry 289 Elies J;Dallas ML;Boyle JP;Scragg JL;Duke A;Steele DS;Peers C; 1083-351X 10.1074/jbc.M114.569996
Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering. 2021 Materials 14 Bazgir M;Zhang W;Zhang X;Elies J;Saeinasab M;Coates P;Youseffi M;Sefat F; 1996-1944 10.3390/ma14174773
Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering. 2021 Materials 14 Bazgir M;Zhang W;Zhang X;Elies J;Saeinasab M;Coates P;Youseffi M;Sefat F; 1996-1944 10.3390/ma14216295
Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis 2022 Front Physiology 13 Ross RL, Mavria G, Del Galdo F and Elies J. Frontiers doi: 10.3389/fphys.2022.900631
Investigation of Cell Adhesion and Cell Viability of the Endothelial and Fibroblast Cells on Electrospun PCL, PLGA and Coaxial Scaffolds for Production of Tissue Engineered Blood Vessel. 2022 Journal Of Functional Biomaterials 13 Bazgir M;Saeinasab M;Zhang W;Zhang X;Min Tsui K;Maasoumi Sarvestani A;Nawaz S;Coates P;Youseffi M;Elies J;Sefat F; 2079-4983 10.3390/jfb13040282