Dr. Amalia Ruiz Estrada
Information about Dr. Amalia Ruiz Estrada at the University of Bradford.
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Biography
Dr Ruiz graduated in Biochemistry from the University of Havana, Cuba. She completed her PhD in Advanced Materials and Nanotechnology at the Autonomous University of Madrid. Her PhD research project focused on developing magnetic nanoparticles for different biotechnological and biomedical applications. Previously, Dr Ruiz held different postdoctoral positions across Cuba and Europe. In 2014 she joined the Centre for Advanced Studies in Cuba to investigate novel formulations of iron oxide nanoparticles and their toxicological evaluation in different in vitro and in vivo models. In 2016, she joined the University of East Anglia in Norwich as Senior Research Associate (Marie Skłodowska-Curie Fellow) to work in the DNA-TRAP EU funded project to develop a range of antimicrobial nanoformulations and assess their therapeutic efficacy in in vitro models. Later, she moved to the Molecular and Cellular Biology Institute in Strasbourg to be part of the Graphene Flagship project, the European Union's biggest scientific research initiative, to assess the pharmacological behaviour of different graphene-based materials and their innovative application in cancer treatment. In November 2018, she started at the School of Pharmacy at Queen’s University Belfast, where her research was focused on the development of smart nanocarriers for targeted cancer therapy, as well as engineering novel nanoformulations to detect and treat aggressive metastatic prostate cancer. Currently, Dr Ruiz’s research focuses on the fabrication of multifunctional nanomaterials to target cancer and other diseases, developing novel nanomedicines for combinatory therapy and theragnostic applications and the safety evaluation of these nanomaterials applied to human health. Her long-term research career objective is to facilitate the translation of nanoparticle-based therapeutics from the lab to the clinic.Research
I'm always open to PhD applications in the field of Nanomedicine, drugdelivery systems, smart nanomaterials, nanotoxicology, hyperthermia,photothermal, photodynamic therapy, combination therapies and theragnosticapplications
Publications
There are 24 publications involving or that are attributed to Dr. Amalia Ruiz Estrada. They are listed as:
- peer reviewed journal (22)
- reviews (2)
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hypoxia-targeted cupric-tirapazamine liposomes potentiate radiotherapy in prostate cancer spheroids. | 2021 | International Journal of Pharmaceutics | 607 | Silva VL;Ruiz A;Ali A;Pereira S;Seitsonen J;Ruokolainen J;Furlong F;Coulter J;Al-Jamal WT; | 1873-3476 | 10.1016/j.ijpharm.2021.121018 | |||||
| Dually targeted bioinspired nanovesicle delays advanced prostate cancer tumour growth in vivo. | 2021 | Acta Biomaterialia | 134 | Ma G;Severic M;Barker M;Pereira S;Ruiz A;Cheung CCL;Al-Jamal WT; | 1878-7568 | 10.1016/j.actbio.2021.07.021 | |||||
| PD1 blockade potentiates the therapeutic efficacy of photothermally-activated and MRI-guided low temperature-sensitive magnetoliposomes. | 2021 | Journal of Controlled Release | 332 | Ma G;Kostevšek N;Monaco I;Ruiz A;Markelc B;Cheung CCL;Hudoklin S;Kreft ME;Hassan HAFM;Barker M;Conyard J;Hall C;Meech S;Mayes AG;Serša I;Čemažar M;Marković K;Ščančar J;Franchini MC;Al-Jamal WT; | 1873-4995 | 10.1016/j.jconrel.2021.03.002 | |||||
| Genetically-engineered anti-PSMA exosome mimetics targeting advanced prostate cancer in vitro and in vivo | 2021 | Journal of Controlled Release | 330 | 101 - 110 | Severic M.;Ma G.;Pereira S.G.T.;Ruiz A.;Cheung C.C.L.;Al-Jamal W.T. | 0168-3659 | 10.1016/j.jconrel.2020.12.017 | ||||
| Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes | 2020 | ACS Sustainable Chemistry and Engineering | 8 | 15243 - 15249 | McCalmont A.S.;Ruiz A.;Lagunas M.C.;Al-Jamal W.T.;Crawford D.E. | 2168-0485 | 10.1021/acssuschemeng.0c04950 | ||||
| Encapsulated doxorubicin crystals influence lysolipid temperature-sensitive liposomes release and therapeutic efficacy in vitro and in vivo | 2020 | Journal of Controlled Release | 328 | 665 - 678 | Ruiz A.;Ma G.;Seitsonen J.;Pereira S.G.T.;Ruokolainen J.;Al-Jamal W.T. | 0168-3659 | 10.1016/j.jconrel.2020.09.032 | ||||
| Toxicological evaluation of highly water dispersible few-layer graphene in vivo | 2020 | Carbon | 170 | 347 - 360 | Ruiz A.;Lucherelli M.A.;Murera D.;Lamon D.;Ménard-Moyon C.;Bianco A. | 0008-6223 | 10.1016/j.carbon.2020.08.023 | ||||
| Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery. | 2020 | Colloids and Surfaces B: Biointerfaces | 195 | Montis C;Joseph P;Magnani C;Marín-Menéndez A;Barbero F;Estrada AR;Nepravishta R;Angulo J;Checcucci A;Mengoni A;Morris CJ;Berti D; | 1873-4367 | 10.1016/j.colsurfb.2020.111266 | |||||
| EGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells. | 2020 | Colloids and Surfaces B: Biointerfaces | 194 | Eloy JO;Ruiz A;de Lima FT;Petrilli R;Raspantini G;Nogueira KAB;Santos E;de Oliveira CS;Borges JC;Marchetti JM;Al-Jamal WT;Chorilli M; | 1873-4367 | 10.1016/j.colsurfb.2020.111185 | |||||
| Microfluidic production of lysolipid-containing temperature-sensitive liposomes | 2020 | Journal of Visualized Experiments | 2020 | Cheung C.C.L.;Ma G.;Ruiz A.;Al-Jamal W.T. | 1940-087X | 10.3791/60907 | |||||
| Toxicity and biodegradation of zinc ferrite nanoparticles in Xenopus laevis | 2019 | Journal of Nanoparticle Research | 21 | Rivero M.;Marín-Barba M.;Gutiérrez L.;Lozano-Velasco E.;Wheeler G.N.;Sánchez-Marcos J.;Muñoz-Bonilla A.;Morris C.J.;Ruiz A. | 1388-0764 | 10.1007/s11051-019-4631-1 | |||||
| A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy | 2019 | Advanced Functional Materials | 29 | Martín C.;Ruiz A.;Keshavan S.;Reina G.;Murera D.;Nishina Y.;Fadeel B.;Bianco A. | 1616-301X | 10.1002/adfm.201901761 | |||||
| Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles. | 2019 | Materials | 12 | Ruiz A;Alpízar A;Beola L;Rubio C;Gavilán H;Marciello M;Rodríguez-Ramiro I;Ciordia S;Morris CJ;Morales MDP; | 1996-1944 | 10.3390/ma12142218 | |||||
| "Ultramixing": A Simple and Effective Method To Obtain Controlled and Stable Dispersions of Graphene Oxide in Cell Culture Media. | 2019 | ACS applied materials & interfaces | 11 | Reina G;Ruiz A;Murera D;Nishina Y;Bianco A; | 1944-8252 | 10.1021/acsami.8b18304 | |||||
| Unravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model. | 2018 | Nanoscale | 10 | Marín-Barba M;Gavilán H;Gutiérrez L;Lozano-Velasco E;Rodríguez-Ramiro I;Wheeler GN;Morris CJ;Morales MP;Ruiz A; | 2040-3372 | 10.1039/c7nr06020c | |||||
| Oriented Attachment of Recombinant Proteins to Agarose-Coated Magnetic Nanoparticles by Means of a β-Trefoil Lectin Domain. | 2016 | Bioconjugate Chemistry | 27 | Acebrón I;Ruiz-Estrada AG;Luengo Y;Morales MD;Guisán JM;Mancheño JM; | 1520-4812 | 10.1021/acs.bioconjchem.6b00504 | |||||
| Dose-Response Bioconversion and Toxicity Analysis of Magnetite Nanoparticles | 2016 | IEEE Magnetics Letters | 7 | Ruiz A.;Mancebo A.;Beola L.;Sosa I.;Gutiérrez L. | 1949-307X | 10.1109/LMAG.2016.2535414 | |||||
| Biotransformation of magnetic nanoparticles as a function of coating in a rat model. | 2015 | Nanoscale | 7 | Ruiz A;Gutiérrez L;Cáceres-Vélez PR;Santos D;Chaves SB;Fascineli ML;Garcia MP;Azevedo RB;Morales MP; | 2040-3372 | 10.1039/c5nr03780h | |||||
| Hematotoxicity of magnetite nanoparticles coated with polyethylene glycol: In vitro and in vivo studies | 2015 | Toxicology Research | 4 | 1555 - 1564 | Ruiz A.;Ali L.M.A.;Cáceres-Vélez P.R.;Cornudella R.;Gutiérrez M.;Moreno J.A.;Piñol R.;Palacio F.;Fascineli M.L.;De Azevedo R.B.;Morales M.P.;Millán A. | 2045-452X | 10.1039/c4tx00241e | ||||
| Biodistribution and pharmacokinetics of uniform magnetite nanoparticles chemically modified with polyethylene glycol. | 2013 | Nanoscale | 5 | Ruiz A;Hernández Y;Cabal C;González E;Veintemillas-Verdaguer S;Martínez E;Morales MP; | 2040-3372 | 10.1039/c3nr01412f | |||||
| Short-chain PEG molecules strongly bound to magnetic nanoparticle for MRI long circulating agents. | 2013 | Acta Biomaterialia | 9 | Ruiz A;Salas G;Calero M;Hernández Y;Villanueva A;Herranz F;Veintemillas-Verdaguer S;Martínez E;Barber DF;Morales MP; | 1878-7568 | 10.1016/j.actbio.2012.12.032 | |||||
| Detection of PEGylated proteins in polyacrylamide gels by reverse staining with zinc and imidazole salts. | 2008 | Electrophoresis | 29 | Hardy E;Ramón J;Saez V;Báez R;Tejeda Y;Ruiz A; | 0173-0835 | 10.1002/elps.200700781 |
Reviews
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Does black phosphorus hold potential to overcome graphene oxide? A comparative review of their promising application for cancer therapy | 2021 | 3 | 4029 - 4036 | Ruiz A.;Martín C.;Reina G. | 2516-0230 | 10.1039/d1na00203a | |||||
| Magnetic nanoparticles coated with dimercaptosuccinic acid: development, characterization, and application in biomedicine | 2014 | Journal of Nanoparticle Research | 16 | Ruiz A.;Morais P.C.;Bentes de Azevedo R.;Lacava Z.G.M.;Villanueva A.;del Puerto Morales M. | 1388-0764 | 10.1007/s11051-014-2589-6 |