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researcher

Dr Amalia Ruiz estrada

Lecturer

Faculty/Dept/School School of Pharmacy and Medical Sciences
(Faculty of Life Sciences)
Emailg.ruizestrada@bradford.ac.uk
Telephone +441274 238635

Biography

Dr Ruiz graduated in Biochemistry from the University of Havana, Cuba. She completed her PhD in Advanced Materials and Nanotechnology at the Autonomous University of Madrid. Her PhD research project focused on developing magnetic nanoparticles for different biotechnological and biomedical applications. Previously, Dr Ruiz held different postdoctoral positions across Cuba and Europe. In 2014 she joined the Centre for Advanced Studies in Cuba to investigate novel formulations of iron oxide nanoparticles and their toxicological evaluation in different in vitro and in vivo models. In 2016, she joined the University of East Anglia in Norwich as Senior Research Associate (Marie Skłodowska-Curie Fellow) to work in the DNA-TRAP EU funded project to develop a range of antimicrobial nanoformulations and assess their therapeutic efficacy in in vitro models. Later, she moved to the Molecular and Cellular Biology Institute in Strasbourg to be part of the Graphene Flagship project, the European Union's biggest scientific research initiative, to assess the pharmacological behaviour of different graphene-based materials and their innovative application in cancer treatment. In November 2018, she started at the School of Pharmacy at Queen’s University Belfast, where her research was focused on the development of smart nanocarriers for targeted cancer therapy, as well as engineering novel nanoformulations to detect and treat aggressive metastatic prostate cancer. Currently, Dr Ruiz’s research focuses on the fabrication of multifunctional nanomaterials to target cancer and other diseases, developing novel nanomedicines for combinatory therapy and theragnostic applications and the safety evaluation of these nanomaterials applied to human health. Her long-term research career objective is to facilitate the translation of nanoparticle-based therapeutics from the lab to the clinic.

Research

I'm always open to PhD applications in the field of Nanomedicine, drug delivery systems, smart nanomaterials, nanotoxicology, hyperthermia, photothermal, photodynamic therapy, combination therapies and theragnostic applications

Publications

Peer Reviewed Journal
TitleHypoxia-targeted cupric-tirapazamine liposomes potentiate radiotherapy in prostate cancer spheroids. (2021)
AuthorsSilva VL;Ruiz A;Ali A;Pereira S;Seitsonen J;Ruokolainen J;Furlong F;Coulter J;Al-Jamal WT;
JournalInternational Journal of Pharmaceutics
DOI10.1016/j.ijpharm.2021.121018
 
TitlePD1 blockade potentiates the therapeutic efficacy of photothermally-activated and MRI-guided low temperature-sensitive magnetoliposomes. (2021)
AuthorsMa G;Kostevšek N;Monaco I;Ruiz A;Markelc B;Cheung CCL;Hudoklin S;Kreft ME;Hassan HAFM;Barker M;Conyard J;Hall C;Meech S;Mayes AG;Serša I;Čemažar M;Marković K;Ščančar J;Franchini MC;Al-Jamal WT;
JournalJournal of Controlled Release
DOI10.1016/j.jconrel.2021.03.002
 
TitleGenetically-engineered anti-PSMA exosome mimetics targeting advanced prostate cancer in vitro and in vivo (2021)
AuthorsSeveric M.;Ma G.;Pereira S.G.T.;Ruiz A.;Cheung C.C.L.;Al-Jamal W.T.
JournalJournal of Controlled Release
DOI10.1016/j.jconrel.2020.12.017
 
TitleDually targeted bioinspired nanovesicle delays advanced prostate cancer tumour growth in vivo. (2021)
AuthorsMa G;Severic M;Barker M;Pereira S;Ruiz A;Cheung CCL;Al-Jamal WT;
JournalActa Biomaterialia
DOI10.1016/j.actbio.2021.07.021
 
TitleEGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells. (2020)
AuthorsEloy JO;Ruiz A;de Lima FT;Petrilli R;Raspantini G;Nogueira KAB;Santos E;de Oliveira CS;Borges JC;Marchetti JM;Al-Jamal WT;Chorilli M;
JournalColloids and Surfaces B: Biointerfaces
DOI10.1016/j.colsurfb.2020.111185
 
TitleMultifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery. (2020)
AuthorsMontis C;Joseph P;Magnani C;Marín-Menéndez A;Barbero F;Estrada AR;Nepravishta R;Angulo J;Checcucci A;Mengoni A;Morris CJ;Berti D;
JournalColloids and Surfaces B: Biointerfaces
DOI10.1016/j.colsurfb.2020.111266
 
TitleToxicological evaluation of highly water dispersible few-layer graphene in vivo (2020)
AuthorsRuiz A.;Lucherelli M.A.;Murera D.;Lamon D.;Ménard-Moyon C.;Bianco A.
JournalCarbon
DOI10.1016/j.carbon.2020.08.023
 
TitleCytotoxicity of Mechanochemically Prepared Cu(II) Complexes (2020)
AuthorsMcCalmont A.S.;Ruiz A.;Lagunas M.C.;Al-Jamal W.T.;Crawford D.E.
JournalACS Sustainable Chemistry and Engineering
DOI10.1021/acssuschemeng.0c04950
 
TitleMicrofluidic production of lysolipid-containing temperature-sensitive liposomes (2020)
AuthorsCheung C.C.L.;Ma G.;Ruiz A.;Al-Jamal W.T.
JournalJournal of Visualized Experiments
DOI10.3791/60907
 
TitleEncapsulated doxorubicin crystals influence lysolipid temperature-sensitive liposomes release and therapeutic efficacy in vitro and in vivo (2020)
AuthorsRuiz A.;Ma G.;Seitsonen J.;Pereira S.G.T.;Ruokolainen J.;Al-Jamal W.T.
JournalJournal of Controlled Release
DOI10.1016/j.jconrel.2020.09.032
 
TitleUnderstanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles. (2019)
AuthorsRuiz A;Alpízar A;Beola L;Rubio C;Gavilán H;Marciello M;Rodríguez-Ramiro I;Ciordia S;Morris CJ;Morales MDP;
JournalMaterials
DOI10.3390/ma12142218
 
TitleToxicity and biodegradation of zinc ferrite nanoparticles in Xenopus laevis (2019)
AuthorsRivero M.;Marín-Barba M.;Gutiérrez L.;Lozano-Velasco E.;Wheeler G.N.;Sánchez-Marcos J.;Muñoz-Bonilla A.;Morris C.J.;Ruiz A.
JournalJournal of Nanoparticle Research
DOI10.1007/s11051-019-4631-1
 
Title"Ultramixing": A Simple and Effective Method To Obtain Controlled and Stable Dispersions of Graphene Oxide in Cell Culture Media. (2019)
AuthorsReina G;Ruiz A;Murera D;Nishina Y;Bianco A;
JournalACS applied materials & interfaces
DOI10.1021/acsami.8b18304
 
TitleA Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy (2019)
AuthorsMartín C.;Ruiz A.;Keshavan S.;Reina G.;Murera D.;Nishina Y.;Fadeel B.;Bianco A.
JournalAdvanced Functional Materials
DOI10.1002/adfm.201901761
 
TitleUnravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a Xenopus laevis model. (2018)
AuthorsMarín-Barba M;Gavilán H;Gutiérrez L;Lozano-Velasco E;Rodríguez-Ramiro I;Wheeler GN;Morris CJ;Morales MP;Ruiz A;
JournalNanoscale
DOI10.1039/c7nr06020c
 
TitleOriented Attachment of Recombinant Proteins to Agarose-Coated Magnetic Nanoparticles by Means of a β-Trefoil Lectin Domain. (2016)
AuthorsAcebrón I;Ruiz-Estrada AG;Luengo Y;Morales MD;Guisán JM;Mancheño JM;
JournalBioconjugate Chemistry
DOI10.1021/acs.bioconjchem.6b00504
 
TitleDose-Response Bioconversion and Toxicity Analysis of Magnetite Nanoparticles (2016)
AuthorsRuiz A.;Mancebo A.;Beola L.;Sosa I.;Gutiérrez L.
JournalIEEE Magnetics Letters
DOI10.1109/LMAG.2016.2535414
 
TitleHematotoxicity of magnetite nanoparticles coated with polyethylene glycol: In vitro and in vivo studies (2015)
AuthorsRuiz A.;Ali L.M.A.;Cáceres-Vélez P.R.;Cornudella R.;Gutiérrez M.;Moreno J.A.;Piñol R.;Palacio F.;Fascineli M.L.;De Azevedo R.B.;Morales M.P.;Millán A.
JournalToxicology Research
DOI10.1039/c4tx00241e
 
TitleBiotransformation of magnetic nanoparticles as a function of coating in a rat model. (2015)
AuthorsRuiz A;Gutiérrez L;Cáceres-Vélez PR;Santos D;Chaves SB;Fascineli ML;Garcia MP;Azevedo RB;Morales MP;
JournalNanoscale
DOI10.1039/c5nr03780h
 
TitleBiodistribution and pharmacokinetics of uniform magnetite nanoparticles chemically modified with polyethylene glycol. (2013)
AuthorsRuiz A;Hernández Y;Cabal C;González E;Veintemillas-Verdaguer S;Martínez E;Morales MP;
JournalNanoscale
DOI10.1039/c3nr01412f
 
TitleShort-chain PEG molecules strongly bound to magnetic nanoparticle for MRI long circulating agents. (2013)
AuthorsRuiz A;Salas G;Calero M;Hernández Y;Villanueva A;Herranz F;Veintemillas-Verdaguer S;Martínez E;Barber DF;Morales MP;
JournalActa Biomaterialia
DOI10.1016/j.actbio.2012.12.032
 
TitleDetection of PEGylated proteins in polyacrylamide gels by reverse staining with zinc and imidazole salts. (2008)
AuthorsHardy E;Ramón J;Saez V;Báez R;Tejeda Y;Ruiz A;
JournalElectrophoresis
DOI10.1002/elps.200700781
 
Other Publications
Other typeReviews
TitleDoes black phosphorus hold potential to overcome graphene oxide? A comparative review of their promising application for cancer therapy (2021)
AuthorsRuiz A.;Martín C.;Reina G.
JournalNanoscale Advances
DOI10.1039/d1na00203a
 
Other typeReviews
TitleMagnetic nanoparticles coated with dimercaptosuccinic acid: development, characterization, and application in biomedicine (2014)
AuthorsRuiz A.;Morais P.C.;Bentes de Azevedo R.;Lacava Z.G.M.;Villanueva A.;del Puerto Morales M.
JournalJournal of Nanoparticle Research
DOI10.1007/s11051-014-2589-6