Dr. Goreti Ribeiro Morais,PDRA
Information about Dr. Goreti Ribeiro Morais at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- g.ribeiromorais@bradford.ac.uk
Biography
Research
I have been working at the interface of chemistry and biology and have developed skills ranging from Organic Chemistry, Medicinal Chemistry, Radiochemistry and Molecular Imaging. In Oct 2014, I returned to the ICT as Post-Doc to support the organic synthesis requirements across the Yorkshire Cancer Research Medicines Discovery programme. Precisely, I am participating in the:Development of duocarmycin synthetic derivatives as CYPs activated prodrugsDevelopment of small molecule polysialyltransferase inhibitors as potential anti-metastatic agentsAlso, I have a leading role in developing chemical imaging tools to probe biological systems.I have been working at the interface of chemistry and biology and have developed skills ranging from Organic Chemistry, Medicinal Chemistry, Radiochemistry and Molecular Imaging. In Oct 2014, I returned to the ICT as Post-Doc to support the organic synthesis requirements across the Yorkshire Cancer Research Medicines Discovery programme. Precisely, I am participating in the:Development of duocarmycin synthetic derivatives as CYPs activated prodrugsDevelopment of small molecule polysialyltransferase inhibitors as potential anti-metastatic agentsAlso, I have a leading role in developing chemical imaging tools to probe biological systems.Current ProjectsTeam member of the project: Cancer Medicines Discovery, Yorkshire Cancer Research funded: Patterson, L.H. (P.I.), Falconer, R.A.; Pors, K.; Afarinkia, K.; Loadman, P.M.; Shnyder S.D.Current ProjectsTeam member of the project: Cancer Medicines Discovery, Yorkshire Cancer Research funded: Patterson, L.H. (P.I.), Falconer, R.A.; Pors, K.; Afarinkia, K.; Loadman, P.M.; Shnyder S.D.Publications
There are 19 publications involving or that are attributed to Dr. Goreti Ribeiro Morais.
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Application of HOF.CH3CN to the synthesis of glycosyl sulphones | 2008 | Ribeiro Morais, Goreti; Humphrey, Andrew J.; Falconer, Robert A. | |||||||||
| Selective synthesis of Neu5Ac2en and its oxazoline derivative using BF3.Et2O | 2009 | Ribeiro Morais, Goreti; Oliveira, Rudi S.; Falconer, Robert A. | |||||||||
| A facile preparation of trehalose analogues: 1,1-thiodisaccharides | 2009 | Carbohydrate Research | 344 | 1039 - 1045 | Ribeiro Morais, Goreti; Humphrey, Andrew J.; Falconer, Robert A. | ||||||
| Identification of an acetyl disulfide derivative in the synthesis of thiosialosides | 2009 | Ribeiro Morais, Goreti; Oliveira, Inês P.F.; Humphrey, Andrew J.; Falconer, Robert A. | |||||||||
| Novel strategies for the synthesis of unsymmetrical glycosyl disulfides | 2016 | Organic and Biomolecular Chemistry | 14 | 2749 - 2754 | Ribeiro Morais, Goreti; Springett, Bradley R.; Pauze, Martin; Schröder, Lisa; Northrop, Matthew; Falconer, Robert A. | 10.1039/c6ob00230g | |||||
| Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment | 2016 | Scientific Reports | 6 | 33026 | Elkashef, Sara M.; Allison, Simon J.; Sadiq, Maria; Basheer, Haneen A.; Ribeiro Morais, Goreti; Loadman, Paul M.; Pors, Klaus; Falconer, Robert A. | 10.1038/srep33026 | |||||
| Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity | 2014 | Molecular Cancer Therapeutics | 11 | 1294 - 1300 | Gill, Jason H.; Loadman, Paul M.; Shnyder, Steven D.; Cooper, Patricia A.; Atkinson, Jennifer M.; Ribeiro Morais, Goreti; Patterson, Laurence H.; Falconer, Robert A. | 10.1021/mp400760b | |||||
| Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration | 2013 | PLoS ONE | 8 | e73366 | Al-Saraireh, Yousef M.J.; Sutherland, Mark H.; Springett, Bradley R.; Freiberger, F.; Ribeiro Morais, Goreti; Loadman, Paul M.; Errington, R.J.; Smith, P.J.; Fukuda, M.; Gerardy-Schahn, R.; Patterson, Laurence H.; Shnyder, Steven D.; Falconer, Robert A. | 10.1371/journal.pone.0073366 | |||||
| A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival | 2017 | Molecular Cancer Therapeutics | 16 | 1909 - 1921 | Mohanty, S.; Chen, Z.; Li, K.; Ribeiro Morais, G.; Klockow, J.; Yerneni, K.; Pasani, L.; Chin, F.T.; Mitra, S.; Cheshier, S.; Chang, E.; Gambhir, S.S.; Rao, J.; Loadman, P.M.; Falconer, R.A.; Daldrup-Link, H.E. | 10.1158/1535-7163.MCT-17-0022 | |||||
| Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones | 2018 | Errington, R.J.; Sadiq, M.; Cosentino, L.; Wiltshire, M.; Sadiq, O.; Sini, Marcella; Lizano, E.; Pujol, M.D.; Ribeiro Morais, Goreti; Pors, Klaus | |||||||||
| Efficient one-pot synthesis of glycosyl disulfides | 2007 | Tetrahedron Letters | 48 | 7637 - 7641 | Ribeiro Morais G.;Falconer R. | 0040-4039 | 10.1016/j.tetlet.2007.08.106 | ||||
| Carbohydrate-based molecules for Molecular Imaging in Nuclear Medicine | 2013 | European Journal of Organic Chemistry | 8 | 1401 - 1414 | Ribeiro Morais G.;Falconer R.;Santos I. | 1434-193X | 10.1002/ejoc.201201457 | ||||
| Theranostic nanoparticles enhance the response of glioblastomas to radiation | 2019 | Nanotheranostics | 3 | 299 - 310 | Wu, W.; Klockow, J.L.; Mohanty, S.; Ku, K.S.; Aghighi, M.; Melemenidis, S.; Chen, Z.; Li, K.; Ribeiro Morais, Goreti; Zhao, N.; Schlegel, J.; Graves, E.E.; Rao, J.; Loadman, Paul M.; Falconer, R.A.; Mukherjee, S.; Chin, F.T.; Daldrup-Link, H.E. | 10.7150/ntno.35342 | |||||
| An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors. | 2020 | ANALYST (PRINT) | 145 | 4512 - 4521 | Guo X; Malcolm J.R.; Ali M.M.; Ribeiro Morais G; Shnyder S.D.; Loadman P.M.; Patterson L.H.; Falconer R.A. | 1364-5528 | 10.1039/d0an00721h | ||||
| Glycosyl disulfides: importance, synthesis and application to chemical and biological systems | 2021 | Organic and Biomolecular Chemistry | 19 | Ribeiro Morais, G.; Falconer, R.A. | 10.1039/D0OB02079F | ||||||
| An assay for quantitative analysis of polysialic acid expression in cancer cells | 2021 | Carbohydrate Polymers | 259 | Guo, X.; Elkashef, S.M.; Patel, A.; Ribeiro Morais, G.; Shnyder S.D.; Loadman, P.M.; Patterson, L.H.; Falconer, R.A. | 10.1016/j.carbpol.2021.117741 | ||||||
| Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells | 2022 | Biochemical Pharmacology | 201 | Barnieh, F.M.; Ribeiro Morais, G.; Garland, H.; Loadman, P.M.; Falconer, R.A. | Elsevier | https://doi.org/10.1016/j.bcp.2022.115095 | |||||
| Azodicarboxylate-mediated peptide cyclisation: application to disulfide bond formation in solution and solid phase. | 2023 | European Journal of Organic Chemistry | 26 | Serre, A.R.E.; Nwokolo, G.C.; Spencer, H.L.M.; Bell, T.J.; Barnieh, F.M.; Hughes, L.; Falconer, R.A.; Ribeiro Morais, G. | DOI:10.1002/ejoc.202300789 | ||||||
| Chemoselective Solution- and Solid-Phase Synthesis of Disulfide-Linked Glycopeptides | 2022 | Journal of Organic Chemistry | 87 | Banisalman, K.F.; Polykandritou, A.; Barnieh, F.M.; Ribeiro Morais, G.; Falconer, R.A. | ACS | https://doi.org/10.1021/acs.joc.2c01651 |